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21. Influence of the genetic polymorphism
 
22. From Genotype to Phenotype
 
23. Phenotype-genotype dichotomy:
 
24. Genotype-proteotype-phenotype
 
25. From Genotype to Phenotype
 
26. Neurofibromatosis Type I: From
 
27. From Genotype to Phenotype (Human
 
$1.45
28. Individual: An entry from Thomson
 
$1.45
29. Wild type: An entry from Thomson
 
$6.90
30. Genes: An entry from Macmillan
31. Punnett Square: Punnett Square,
 
32. Genetic heterogeneity within an
$87.00
33. Pharmacogenomics in Drug Discovery
$7.95
34. Dissecting the attention deficit
 
$7.90
35. Inheritance Patterns: An entry
 
$6.90
36. Patterns of Inheritance: An entry
$80.10
37. Mouse Phenotypes: A Handbook of
 
38. Johannsen's terminology as applied
$104.51
39. Phenotypic Plasticity: Functional
$59.95
40. Phenotypic Evolution: A Reaction

21. Influence of the genetic polymorphism in the 5'-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers [An article ... Toxicology and Environmental Mutagenesis]
by S. Pavanello, A. Pulliero, S. Lupi, P. Gregorio
Digital: Pages
list price: US$8.95 -- used & new: US$8.95
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Asin: B000RR826A
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This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
The functional significance of genetic polymorphisms on tobacco smoke-induced CYP1A2 activity was examined. The influence of three polymorphisms of the cytochrome P450 1A2 gene (CYP1A2) (-3860 G->A (allele *1C), -2467 T->delT (allele *1D), -163C->A (allele *1F)), located in the 5'-noncoding promoter region of the gene, on CYP1A2 activity (measured as caffeine metabolic ratio, CMR), was studied in Caucasian current smokers (n=95). Tobacco smoke intake was calculated from the number of cigarettes/day. Also, studied was the influence of these CYP1A2 genotypes on smoking-associated urinary mutagenicity, detected in Salmonella typhimurium strain YG1024 with S9 mix, considering the urinary excretion of nicotine plus its metabolites as an internal indicator of tobacco smoke exposure. Smokers with at least one of the variant alleles CYP1A2 -3860A and -2467 delT showed a significantly increased CYP1A2 CMR (-3860 G/A versus G/G, p<0.05; -2467 delT/delT versus T/delT and T/T, p<0.01). Multiple regression analysis showed that the increase in CYP1A2 CMR (ln values) was again significantly related to the presence of CYP1A2 variants -2467delT and also to variant -163A (p<0.05), but moderately to -3860A (p=0.084). No influence of the number of cigarettes smoked per day by each subject was found. Heavy smokers (n=48, with urinary nicotine plus its metabolites>=0.69mg/mmol creatinine) with variant allele -2467delT or -163A had significantly increased urinary mutagenicity (p<0.01 and <0.05). CYP1A2 genetic polymorphisms are shown to influence the CYP1A2 phenotype in smokers, -2467 T->delT having the main effect. This information is of interest for future studies assessing the possible role of tobacco smoke-inducible CYP1A2 genotypes as individual susceptibility factors in exposure to carcinogens. ... Read more


22. From Genotype to Phenotype
 Paperback: 142 Pages (1994-07-31)
list price: US$168.00
Isbn: 0792388658
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The articles in Issue 4 of JOURNAL OF INHERITED METABOLICDISEASE, Volume 17 (1994), contain the main lectures presented atthe 31st Annual Symposium of the Society for the Study of InbornErrors of Metabolism (SSIEM), Manchester, UK, 1993, the theme of whichwas `From Genotype to Phenotype'. Topics discussed include: phenotype expression in homocystinuria,human genome mapping and inherited metabolic disease, geneticimprinting, 21-hydroxylase deficiency, dysmorphic disorders andembryogenesis, signals on proteins, peroxisomal disorders, primaryhyperoxaluria type I, metachromatic leukodystrophy, and replacementtherapy in Gaucher disease. Participants from many countries provided a state-of-the-art reviewwhich will be of interest to clinicians and research workers alike inmany different countries. ... Read more


23. Phenotype-genotype dichotomy: An essay in theoretical biology
by Piotr Lenartowicz
 Unknown Binding: Pages (1975)

Asin: B0006E6ST2
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24. Genotype-proteotype-phenotype Relationships in Neurodegenerative Disease
by Jeffrey (EDT) Cummings
 Paperback: Pages (1980)

Asin: B000N6F9LG
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25. From Genotype to Phenotype
by S E Humphries
 Hardcover: Pages

Asin: B001IOJHYM
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26. Neurofibromatosis Type I: From Genotype to Phenotype (A Volume in the Human Molecular Genetics Series) (Human Molecular Genetics)
by M. Upadhyaya
 Hardcover: Pages (1980)

Asin: B000MUD59Q
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27. From Genotype to Phenotype (Human Molecular Genetics)
by Sue Malcolm
 Paperback: Pages (2001)

Asin: B000OHHEG2
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28. Individual: An entry from Thomson Gale's <i>Gale Encyclopedia of Science, 3rd ed.</i>
by Bill Freedman
 Digital: 1 Pages (2004)
list price: US$1.45 -- used & new: US$1.45
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Asin: B000M5A64S
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The “Gale Encyclopedia of Science” is written at a level somewhere between the introductory sources and the highly technical texts currently available. This six-volume set covers all major areas of science and engineering, as well as mathematics and the medical and health sciences, while providing a comprehensive overview of current scientific knowledge and technology. Alphabetically arranged entries provide a user-friendly format that makes the broad scope of information easy to access and decipher. Entries typically describe scientific concepts, provide overviews of scientific areas and, in some cases, define terms.

... Read more

29. Wild type: An entry from Thomson Gale's <i>Gale Encyclopedia of Science, 3rd ed.</i>
 Digital: 2 Pages (2004)
list price: US$1.45 -- used & new: US$1.45
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Asin: B000M5AFGW
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Editorial Review

Product Description

The “Gale Encyclopedia of Science” is written at a level somewhere between the introductory sources and the highly technical texts currently available. This six-volume set covers all major areas of science and engineering, as well as mathematics and the medical and health sciences, while providing a comprehensive overview of current scientific knowledge and technology. Alphabetically arranged entries provide a user-friendly format that makes the broad scope of information easy to access and decipher. Entries typically describe scientific concepts, provide overviews of scientific areas and, in some cases, define terms.

... Read more

30. Genes: An entry from Macmillan Reference USA's <i>Macmillan Reference USA Science Library: Animal Sciences</i>
by Todd A. Schlenke
 Digital: 7 Pages (2002)
list price: US$6.90 -- used & new: US$6.90
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Asin: B00263Z8O2
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This digital document is an article from Macmillan Reference USA Science Library: Animal Sciences, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 2415 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.This interdisciplinary resource explores the wide-ranging diversity that exists within the animal kingdom. Entries examine how animals develop, animal ecology and behavior, and the connection between animals and humans. Also includes biographies of key scientists who have contributed to the study of animal life, as well as career opportunities within the field. ... Read more


31. Punnett Square: Punnett Square, Reginald Punnett, Probability, Genotype, Allele, Gamete, Dominance Genetics, Phenotype, Mendelian Inheritance, Monohybrid Cross, Dihybrid Cross
Paperback: 120 Pages (2010-01-26)
list price: US$55.00
Isbn: 6130350686
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High Quality Content by WIKIPEDIA articles! The Punnett square is a diagram that is used to predict an outcome of a particular cross or breeding experiment. It is named after Reginald C. Punnett, who devised the approach, and is used by biologists to determine the probability of an offspring having a particular genotype. The Punnett square is a summary of every possible combination of one maternal allele with one paternal allele for each gene being studied in the cross. In this example, both organisms have the genotype Bb. They can produce gametes that contain either the B or b allele. (It is conventional in genetics to use capital letters to indicate dominant alleles and lower-case letters to indicate recessive alleles.) The probability of an individual offspring having the genotype BB is 25%, Bb is 50%, and bb is 25%. ... Read more


32. Genetic heterogeneity within an electrophoretic phenotype of glucose phosphate isomerase in a Japanese population (Technical report)
by C Satoh
 Unknown Binding: 13 Pages (1978)

Asin: B0007C2H98
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33. Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology)
Paperback: 487 Pages (2010-11-02)
list price: US$109.00 -- used & new: US$87.00
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Asin: 1617378259
Average Customer Review: 5.0 out of 5 stars
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The field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.

... Read more

Customer Reviews (1)

5-0 out of 5 stars A timely book on personalized medicine for all levels
From fundamental concepts to advanced technologies in pharmacogenomics, this comprehensive book is useful for those interested in personalized medicine at all levels. The book discusses pharmacogenomics in three parts: technologies, molecules, and diseases and treatments. The first part of the book introduces cutting-edge technologies in pharmacogenomics, including bioinformatics, microarray, and association studies. The second part of the book discusses biomarkers and molecules including membrane transporters, receptors, and enzymes. This part includes three chapters on pharmacogenomics of G protein-coupled receptors (GPCR), providing a complete discussion on GPCR genetic variations, their relationships with diseases, and their potential uses as drug targets.The third part of this book focuses on diseases and treatments including psychiatric disorders, cardiovascular diseases, cancer, Alzheimer's disease, gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome, autoimmune diseases such as asthma and rheumatoid arthritis, and infectious diseases and vaccines. ... Read more


34. Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: Sustained attention, response variability and spatial attentional asymmetries ... genotype [An article from: Neuropsychologia]
by M.A. Bellgrove, Z. Hawi, A. Kirley, M. Gill, Rober
Digital: Pages (2005-01)
list price: US$7.95 -- used & new: US$7.95
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Asin: B000RR4TYY
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This digital document is a journal article from Neuropsychologia, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
ADHD is a childhood-onset behavioural disorder with a heterogeneous profile of neuropsychological impairment. Neuropsychological heterogeneity may, in part, reflect underlying genetic differences. Here we examined sustained attention, response variability and spatial attentional asymmetries in a sample of children and adolescents with ADHD (n=22) in relation to dopamine transporter genotype (DAT1) and also controls (n=20). Participants performed the sustained attention to response task (SART) (testing sustained attention and response variability) and the greyscales task (a perceptual measure of attentional bias). The latter has previously been shown to yield a robust leftward attentional asymmetry in healthy subjects. The 10-repeat allele of the DAT1 gene has been associated with ADHD in a number of studies and appears to have biological significance. The ADHD group was sub-divided into those individuals with two copies of the ''high-risk'' 10-repeat allele (high-risk DAT1) versus those with one or no copies of this allele (low-risk DAT1). The high-risk DAT1 ADHD group displayed greater response variability on the SART than either the low-risk DAT1 group or healthy controls, whereas the latter two groups did not differ. Further, the high-risk DAT1 group showed an attenuated spatial asymmetry, relative to the low-risk DAT1 ADHD group, who showed the typical leftward attentional asymmetry. Our results suggest that the 10-repeat DAT1 allele may mediate neuropsychological impairment in ADHD. The application of molecular genetics may help to define neuropsychological impaired subgroups of ADHD. ... Read more


35. Inheritance Patterns: An entry from Macmillan Reference USA's <i>Macmillan Reference USA Science Library: Genetics</i>
by Richard Robinson
 Digital: 9 Pages (2003)
list price: US$7.90 -- used & new: US$7.90
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Asin: B002676OJQ
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This digital document is an article from Macmillan Reference USA Science Library: Genetics, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 3530 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.A comprehensive collection of articles on all aspects of genetics, from Mendel to the decoding of the human genome. Explains the workings of genes and chromosomes, genetic diseases, and biotechnology. Covers the ethical, legal, and social issues connected to genetic science and includes coverage of careers in the field. ... Read more


36. Patterns of Inheritance: An entry from Macmillan Reference USA's <i>Macmillan Reference USA Science Library: Biology</i>
by Karen E. Kirk
 Digital: 8 Pages (2002)
list price: US$6.90 -- used & new: US$6.90
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Asin: B002676K8G
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This digital document is an article from Macmillan Reference USA Science Library: Biology, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 2729 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.A comprehensive collection of articles on all aspects of biological science, including its history and issues. Includes articles on biology-related careers and important individuals, as well as topics from active transport to zoology research. ... Read more


37. Mouse Phenotypes: A Handbook of Mutation Analysis (Manual)
by Virginia E. Papaioannou, Richard R. Behringer
Hardcover-spiral: 235 Pages (2004-11-01)
list price: US$89.00 -- used & new: US$80.10
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Asin: 0879696400
Average Customer Review: 5.0 out of 5 stars
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The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step by step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects. ... Read more

Customer Reviews (1)

5-0 out of 5 stars Excellent Overview
This text is an excellent addition to "Manipulating The Mouse Embryo". It has a step-by-step approach to breeding and characterizing genetically altered mouse lines. I recommend it for any investigator and especially for those working directly with such mice. ... Read more


38. Johannsen's terminology as applied to Adler's theory of personality
by Heinz Ludwig Ansbacher
 Unknown Binding: Pages (1935)

Asin: B0008CZFAU
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39. Phenotypic Plasticity: Functional and Conceptual Approaches (Life Sciences)
Hardcover: 272 Pages (2004-01-15)
list price: US$114.99 -- used & new: US$104.51
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Asin: 0195138961
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Phenotypic plasticity is the range and process of variation in body plan and physiology.This book pulls together recent theoretical advances in phenotypic plasticity, as influenced by evolution and development.The editors and the chapter authors are among the leaders of this exciting and active subfield. The volume begins with a primer on the basic principles of the subject, and companion chapters on phenotypic plasticity in plants and animals. Of interest to a wide range of researchers on evolution, development, and their interface. ... Read more


40. Phenotypic Evolution: A Reaction Norm Perspective
by Carl D. Schlichting, Massimo Pigliucci
Paperback: 387 Pages (1998-05-02)
list price: US$59.95 -- used & new: US$59.95
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Asin: 0878937994
Average Customer Review: 5.0 out of 5 stars
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Understanding the process of adaptive evolution of phenotypes is a fundamental problem in evolutionary biology. It has been approached from the point of view of population and quantitative genetics, optimality theory, or developmental biology. In the last decade, there has been an explosion of research on phenotypic plasticity (the environmentally induced production of different phenotypes by a single genotype) as well as on the molecular details of development, reflecting the increased recognition of their importance in shaping phenotypic evolution. However, the "hardening" of the neodarwinian synthesis in the '40s led to the largely independent investigation of genetic, developmental and environmental bases of phenotypic expression. As a result, these different perspectives have not been integrated into a satisfying cohesive view of phenotypic evolution.

Phenotypic Evolution explicitly recognizes organisms as complex genetic-epigenetic systems developing in response to changing internal and external environments. As a key to a better understanding of how phenotypes evolve, the authors have developed a framework that centers on the concept of the Developmental Reaction Norm. This encompasses their views: (1) that organisms are better considered as integrated units than as disconnected parts (allometry and phenotypic integration); (2) that an understanding of ontogeny is vital for evaluating evolution of adult forms (ontogenetic trajectories, epigenetics, and constraints); and (3) that environmental heterogeneity is ubiquitous and must be acknowledged for its pervasive role in phenotypic expression.

Phenotypic Evolution: A Reaction Norm Perspective can serve as a text for graduate-level courses and seminars on phenotypic evolution or evolutionary developmental biology, and as a supplemental text for evolutionary biology. The extensive references provide links to a wide variety of studies examining the diversity of phenotypes. The book will also be of interest to organismal biologists in general, including ecologists, developmental biologists, and systematists. ... Read more

Customer Reviews (1)

5-0 out of 5 stars Not an introduction, but a great foundation
This book introduced me to 'reaction norms' and 'phenotypic plasticity.'Believe me, these are critical notions for any discussion of evolution.Phenotypic plasticity is the notion that different environments produce different phenotypic expressions despite identical genetic material.The book discusses a variety of cases pulled from the animal and plant kingdom.For example, many plant have develop into different 'forms' depending upon the altitude of their environment.In the animal kingdom, twin spiders will build different types of webs depending upon their environment.The 'reaction norm' represents the 'normal' phenotypic response to the environment, something we often mistake as being the genetic 'design.'

The book covers the somewhat daunting topics of allometry, ontogeny and epigentics, but does so in a very readable way.The books is accessible to the interested scientific reader regardless of background.Additionally, the book includes brief historical outlines of major lines of evolutionary thought.These provide an alternative avenue for accessing the theory when the terminology gets difficult.

In short, its the best reference on evolutionary theory I've found. ... Read more


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