21. Sandostatin.com - Acromegaly And GEP NE Tumor Information Information on acromegaly and GEP tumors, the dosing, preparation and injection of Sandostatin, case studies, physicians roster, journal articles and slide library. http://www.sandostatin.com/home.jsp

22. EMedicine - Acromegaly : Article By Santiago A Centurion, MD, MS acromegaly Excess secretion of growth hormone (GH) induces gigantismin prepubertal children and acromegaly in adults. acromegaly. http://www.emedicine.com/derm/topic593.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Acromegaly Last Updated: August 28, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: growth hormone, GH, gigantism, GH-secreting pituitary adenomas, somatomedins, SMs, somatotropin-mediating hormones, insulinlike growth factors, IGFs AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Santiago A Centurion, MD, MS , Staff Physician, Department of Dermatology, UMDNJ-New Jersey Medical School Coauthor(s): Robert A Schwartz, MD, MPH , Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School Santiago A Centurion, MD, MS, is a member of the following medical societies: American Academy of Dermatology American Medical Association , and Sigma Xi Editor(s): Shyam Verma, MBBS, DVD, FAAD

23. MEDLINEplus Medical Encyclopedia: Acromegaly acromegaly. Definition Return to top acromegaly is a chronic metabolicdisorder caused by the presence of too much growth hormone. http://www.nlm.nih.gov/medlineplus/ency/article/000321.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Acromegaly Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Endocrine glands Alternative names Return to top Somatotroph adenoma; Growth hormone excess Definition Return to top Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Causes, incidence, and risk factors Return to top Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor.

24. The Pituitary Society - Information For The Public Patient's guide to acromegaly diagnosis therapy http://pituitarysociety.med.nyu.edu/patients_guide.htm

Information for the Public THIS INFORMATION WAS DEVELOPED BY DAVID M. COOK, M.D. IT IS NOT INTENDED TO SUBSTITUTE FOR A FULL AND FRANK CONSULTATION WITH QUALIFIED MEDICAL PERSONNEL, WHICH IS THE PRIMARY MEANS FOR A PATIENT TO OBTAIN CARE AND TREATMENT. THE INFORMATION WAS BELIEVED TO BE CURRENT ON MAY 15, 2001, AND WITH THE LAPSE OF TIME, CERTAIN OF THIS MATERIAL WILL BE OUTDATED. by David M. Cook, M.D. Oregon Health Sciences University What is Acromegaly? What happens when there is too much growth hormone secreted? Because the pituitary tumor may be large enough to put pressure on the eye nerves, which are near by, there may be visual changes or headache, which might prompt an opthalmologic or neurologic exam. Specialists in these latter two disciplines are often the first to consider the patient may have acromegaly. The neurologist may also be involved because of the development of entrapment of the nerve that runs through the carpal tunnel and the development of carpal tunnel symptoms- a frequent development in acromegaly. Lastly, the presence of the pituitary tumor may cause decreased pituitary function, especially the cells which control the testes and ovaries resulting in symptoms of decreased sexual function. As the reader can appreciate, there are a number of body systems which can be involved when a patient develops acromegaly and it is up to the physician who sees the patient to think of the diagnosis. Because the signs and symptoms develop so slowly this diagnosis is often missed or overlooked.

25. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Acromegaly Similar pages More results from www.nlm.nih.gov acromegaly acromegaly,, Print this article, acromegaly can result in periosteal bone formation,leading to widening of osseous structures and enlargement of soft tissue. http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Acromegaly

26. Pituitary Network Association Facts, diagnosis, and treatment information about acromegaly, a serious systemic condition caused in over 98% of cases by an adenoma (i.e., benign tumor) of the pituitary gland that secretes excessive growth hormone (GH). http://www.pituitary.org/disorders/acromegaly.php

27. Acromegaly.org -- Pituitary Network Association Info on support, diagnosis, and treatment of acromegaly. http://www.acromegaly.org

Home Questionnaires Feedback Bulletin Board ... Links The new issue of NETWORK featuring Acromegaly is now available. Please click here to view and/or print new issue of this magazine Acromegaly Multimedia Library PNA has introduced a multimedia library featuring information about acromegaly and other health topics. Acromegaly is a hormonal disorder that most commonly occurs in middle-aged men and women. The prevalence of acromegaly is approximately 60 cases per million population, and the incidence is 3.3 new cases per million per year. The name "acromegaly" comes from the Greek words for "extremities" (acro) and "great" (megaly), because one of the most common symptoms of this condition is abnormal growth of the hands and feet. The symptoms of acromegaly can vary and they develop gradually over time; therefore, a diagnosis of this condition may be difficult. Early detection is a goal in the management of acromegaly because the pathologic effects of increased growth hormone (GH) production are progressive. US FOOD AND DRUG ADMINISTRATION APPROVES SOMAVERT® FOR THE TREATMENT OF ACROMEGALY Multimedia Library PNA has introduced a multimedia library featuring information about acromegaly and other health topics.

28. Neuromuscular + Endocrine Disease acromegaly Cushing The pituitary body its disorders. Before disease,Disease onset. Square hand, Phalanges Tufting; Exostoses. acromegaly. http://www.neuro.wustl.edu/neuromuscular/msys/mend.htm

Front Search Index Links ... Adrenal Carcinoid myopathy Corticosteroid Diabetes Gonadal Dysgenesis Gynecomastia Insulinoma Parathyroid ... Hypothyroid From Bramwell : Atlas of Clinical Medicine Myxedema THYROID DISEASE Hyperthyroid Myopathy Ophthalmopathy ... Testing From Bramwell : Atlas of Clinical Medicine Hypothyroidism Adult History Muscle pain cramps Fatigue Paresthesias Myopathy Weakness Mild (4/5) Symmetric Proximal Occasional: Posterior neck Cramps (40%) Muscle contraction: Slow; Delayed relaxation Muscle enlargement : Occasional (Hoffman's syndrome) Myoedema (33%): Local contracture after muscle tap or pinch Myokymia Associated with Na loss May be associated with ptosis Tendon reflexes: Reduced or Delayed Rhabdomyolysis Course Progression of weakness: Slow over months Resolution of weakness after treatment: Slow over months Neuropathy Carpal tunnel syndrome Cranial nerves : Deafness; Hoarse voice (Local vocal cord lesion) Polyneuropathy (19%): Sensory; Axonal Tendon reflexes: Reduced Ankle reflex Lab Low free thyroxine TSH Primary hypothyroidism: High Pituitary-Hypothalamic disease: Low CK Very High in some patients No correlation with weakness EMG: Normal or mildly myopathic Muscle pathology Usual: Non-specific Pale central regions on NADH Some patients: Accumulation of PAS staining material in muscle fibers Reduced b Treatment: Thyroid replacement Strength recovers Weakness Slow movements Muscle hypertrophy Growth retardation Hypothyroid: Other associated neuromuscular disorders Myasthenia gravis : Exacerbation of preexisting disease Entrapment neuropathies:

29. Acromegaly - Wikipedia acromegaly. Causes. In over 90 percent of acromegaly patients, the overproductionof GH is caused by a benign tumor of the pituitary gland, called an adenoma. http://www.wikipedia.org/wiki/Acromegaly

30. The Pituitary Foundation | Patient Leaflet | Acromegaly Online version of the patient information leaflet on acromegaly produced byThe Pituitary Foundation. . About The Pituitary Foundation . acromegaly. http://www.pituitary.org.uk/resources/acromegaly.shtml

Text version Skip header links Home News ... Skip search box SEARCH THIS SITE Advanced search RESOURCES Skip section links The Pituitary Gland and its Hormones Acromegaly Adult GH Replacement ... Resources Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Acromegaly What is acromegaly? What does it feel like to have acromegaly? Coping with the stress of acromegaly How is acromegaly diagnosed? ... What acromegaly has meant to me What is acromegaly? Acromegaly is a disease of the pituitary gland . Your pituitary gland is a small, but very important, gland at the base of your brain behind the bridge of your nose. Sometimes it can be affected by a tumour. These are almost invariably benign rather than cancerous and therefore do not spread anywhere else. Acromegaly is caused when your pituitary gland has a tumour which produces too much growth hormone Acromegaly is a very rare condition and only four new cases per million of population are diagnosed each year. It usually develops in adults between the ages of 30 and 50, but you can be affected at any age. If acromegaly develops before you have stopped growing (which usually occurs around 15 to 17 years of age), it causes gigantism because growth hormone promotes growth of legs and arms.

31. The Pituitary Foundation | Disorders | Acromegaly acromegaly is caused when a tumour on the pituitary gland produces too muchgrowth hormone (GH). . About The Pituitary Foundation . acromegaly. http://www.pituitary.org.uk/disorders/acromegaly.shtml

Text version Skip header links Home News ... Skip search box SEARCH THIS SITE Advanced search DISORDERS Skip section links Acromegaly Adult GH Deficiency Craniopharyngioma ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Acromegaly Acromegaly is caused when a tumour on the pituitary gland produces too much growth hormone (GH). These tumours are almost always benign (i.e. not cancerous) and therefore do not spread to other areas of the body. Acromegaly is a very rare condition and usually develops between the ages of 30 and 50. If the condition develops before a person has stopped growing (which usually occurs between the ages of 15 to 17 years of age), it causes gigantism because growth hormone promotes growth of bones in the body. Typical symptoms coarsening of facial features enlarged hands and feet thickening of the soft tissue in the palms and soles of the feet carpal tunnel syndrome (tingling feeling or pains in the hands) excessive sweating and oily skin headaches vision disturbance sleep apnoea general tiredness irregular periods (oligomenorrhoea) or loss of normal menstrual function (amenorrhoea) - adult females impotence - adult males reduced fertility decrease in sex drive All these symptoms tend to develop gradually and the changes may not be noticed for some time.

32. U.S. Sandostatin – Acromegaly Causes What Causes acromegaly? acromegaly In the case of acromegaly, a pituitarytumor causes excessive production of growth hormone. To http://www.acromegalyinfo.com/acromegalyinfo/gen_pub/living/Causes.html

Causes Symptoms Diagnosis Treatment The Information contained within this website is appropriate for U.S residents only. What Causes Acromegaly? Acromegaly is a disease caused by overproduction of growth hormone (GH), which is produced by your pituitary, a tiny gland about the size of a pea located just below your brain, behind your eyes. Your pituitary controls normal growth, metabolism, and reproductive activity. In the case of acromegaly, a pituitary tumor causes excessive production of growth hormone. To understand the causes and treatment of acromegaly, you need to know about 3 important hormones. These hormones circulate throughout your body to regulate the normal activity of many of your organs and glands. GH - produced by the pituitary IGF-I (insulin-like growth factor I) - produced primarily by the liver in response to GH Somatostatin - produced by the hypothalamus, a region of the brain that influences the pituitary Growth Hormone Everyone’s pituitary releases GH in short spurts throughout the day and night, resulting in constantly varying levels. Thus, a single measurement of GH provides only limited information. When a person has acromegaly, abnormally high levels of GH are released by the pituitary. Excessive GH causes changes in physical characteristics and metabolism. back to top Insulin-Like Growth Factor I IGF-I levels rise whenever GH levels rise; however, IGF-I is released more evenly than GH, and IGF-I levels remain higher longer. This means that IGF-I can be a more accurate reflection of total GH production. Researchers believe that elevated IGF-I levels also cause some of the physical changes that are associated with acromegaly.

33. ThirdAge - Adam - Acromegaly acromegaly. Definition acromegaly is a chronic metabolic disordercaused by the presence of too much growth hormone. It results http://www.thirdage.com/health/adam/ency/article/000321.htm

document.write(''); document.write(''); document.write('<'); document.write('/SCRIPT>'); document.write(''); document.write(''); document.write('<'); document.write('/A>'); document.write('<'); document.write('/NOSCRIPT>'); document.write('<'); document.write('/IFRAME>'); Activities Computers Family Tree Health ... Prevention Acromegaly Definition: Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Alternative Names: Somatotroph adenoma; Growth hormone excess Causes, incidence, and risk factors: Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor.

34. What Is Acromegaly? What Is acromegaly? acromegaly is a hormonal disorder that resultswhen the pituitary gland produces excess growth hormone (GH). http://seniorhealth.about.com/library/conditions/bl_acro1.htm

zfp=-1 About Senior Health Search in this topic on About on the Web in Products Web Hosting Senior Health with Marian Eure Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS First Time Here FAQ Glossary of Senior Health Terms ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement What Is Acromegaly? Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. Overgrowth of bone and cartilage often leads to arthritis. When tissue thickens, it may trap nerves, causing carpal tunnel syndrome, characterized by numbness and weakness of the hands. Other symptoms of acromegaly include thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; abnormalities of the menstrual cycle and sometimes breast discharge in women; and impotence in men. There may be enlargement of body organs, including the liver, spleen, kidneys and heart.

35. Acromegaly Diagnosis How is acromegaly Diagnosed? If The glucose tolerance test is the most reliablemethod of confirming a diagnosis of acromegaly. Physicians http://seniorhealth.about.com/library/conditions/bl_acro4.htm

zfp=-1 About Senior Health Search in this topic on About on the Web in Products Web Hosting Senior Health with Marian Eure Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS First Time Here FAQ Glossary of Senior Health Terms ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement How is Acromegaly Diagnosed? If a doctor suspects acromegaly, he or she can measure the GH level in the blood after a patient has fasted overnight to determine if it is elevated. However, a single measurement of an elevated blood GH level is not enough to diagnose acromegaly, because GH is secreted by the pituitary in spurts and its concentration in the blood can vary widely from minute to minute. At a given moment, a patient with acromegaly may have a normal GH level, whereas a GH level in a healthy person may be five times higher. Because of these problems, more accurate information can be obtained when GH is measured under conditions in which GH secretion is normally suppressed. Physicians often use the oral glucose tolerance test to diagnose acromegaly, because ingestion of 75 g of the sugar glucose lowers blood GH levels less than 2 ng/ml in healthy people. In patients with GH overproduction, this reduction does not occur. The glucose tolerance test is the most reliable method of confirming a diagnosis of acromegaly. Physicians also can measure IGF-1 levels in patients with suspected acromegaly. As mentioned earlier, elevated GH levels increase IGF-1 blood levels. Because IGF-1 levels are much more stable over the course of the day, they are often a more practical and reliable measure than GH levels. Elevated IGF-1 levels almost always indicate acromegaly. However, a pregnant woman's IGF-1 levels are two to three times higher than normal. In addition, physicians must be aware that IGF-1 levels decline in aging people and may be abnormally low in patients with poorly controlled diabetes mellitus.

36. Novartis Pharmaceutical- A Through Z - Acromegaly Diseases Conditions / A through Z / acromegaly acromegaly (akro-MEG-aly)is a rare disease. Where can I learn more about acromegaly? http://www.pharma.us.novartis.com/conditions/az/acromegaly.jsp

37. Novartis Pharmaceutical- For Caregivers - Acromegaly Diseases Conditions / For Caregivers / acromegaly acromegaly (akro-MEG-aly)is a rare disease. Where can I learn more about acromegaly? http://www.pharma.us.novartis.com/conditions/caregivers/acromegaly.jsp

38. 1Up Health > Acromegaly > Causes, Incidence, And Risk Factors Of Acromegaly (Gro Comprehesive information on acromegaly (Growth hormone excess , Somatotroph adenoma). acromegalyCauses, Incidence, and Risk Factors. Alternative names http://www.1uphealth.com/health/acromegaly_info.html

1Up Health Acromegaly Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Acromegaly Information Acromegaly Causes, Incidence, and Risk Factors Alternative names : Growth hormone excess , Somatotroph adenoma Definition : Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Causes, Incidence, and Risk Factors Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor. Previous Next Jump to Another Section of this Guide Definition Causes, Incidence, and Risk Factors

39. 1Up Health > Acromegaly > Causes, Incidence, And Risk Factors Of Acromegaly (Gro acromegaly . Read detailed information about acromegaly . Includesa set of questions and answers related to acromegaly , as well http://www.1uphealth.com/medical/disease/endocrine-hormone-disease/acromegaly.ht

1Up Health Acromegaly Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Acromegaly Information Acromegaly Causes, Incidence, and Risk Factors Alternative names : Growth hormone excess , Somatotroph adenoma Definition : Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Causes, Incidence, and Risk Factors Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor. Previous Next Jump to Another Section of this Guide Definition Causes, Incidence, and Risk Factors

40. Antithyroid Drug acromegaly, Book, Home Page. http://www.fpnotebook.com/END146.htm

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