41. Acromegaly InfoSource - Patients And Caregivers Homepage The Information contained within this website is appropriate forUS residents only. Welcome to the acromegaly InfoSource. If you http://www.us.sandostatin.com/acromegalyinfo/gen_pub/

42. Living With Acromegaly - Introduction Introduction. acromegaly is not always easy to recognize. But whatever yoursymptoms, you need to know that acromegaly is a complex condition. http://www.us.sandostatin.com/acromegalyinfo/gen_pub/living/default.html

43. Pituitary Network Association - Disorders - Acromegaly Pituitary Network Association Pituitary Network Association - Disorders- acromegaly. acromegaly. acromegaly is a serious systemic http://www.pituitary.com/disorders/acromegaly.php

Home Join Now Donate For Reporters ... Members Acromegaly Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma (i.e., benign tumor) of the pituitary gland that secretes excessive growth hormone (GH). The clinical features associated with acromegaly include the effects of GH over-production, and in some instances by the tumor compressing and injuring the normal pituitary gland, optic nerves and optic chiasm. Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet, sleep apnea, and carpal tunnel syndrome. More serious problems may include accelerated cardiovascular disease, hypertension, diabetes mellitus and possibly an increased risk of colon cancer. If the tumor develops before bone growth is completed in adolescence, the result will be gigantism. Because of the serious systemic changes resulting from GH excess, treatment is essential, typically with transsphenoidal surgery. Symptoms and signs may include: Soft tissue thickening of the palms of the hands and soles of the feet Enlargement of hands (ring size), feet (shoe size) and head (hat size)

44. NEWS SECTION About acromegaly. Living with acromegaly. A Patient's Guide to Treatment View and print brochure in English View and print brochure in Spanish. http://www.acromegaly.org/AboutAcromegaly.htm

45. UCLA NEUROSURGERY | Pituitary Disorders & Diseases PITUITARY TUMOR NEUROENDOCRINE DISEASES DISORDERSacromegaly (Growth Hormone Secreting Adenoma). http://neurosun.medsch.ucla.edu/Diagnoses/Pituitary/PituitaryDis_7.html

Acromegaly (Growth Hormone Secreting Adenoma) PITUITARY TUMOR PROGRAM PITUITARY DIAGNOSES INDEX Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma of the pituitary gland that secretes excessive growth hormone (GH). The clinical features associated with acromegaly include the effects of GH oversecretion, and in some instances by the tumor compressing and injuring the normal pituitary gland, optic nerves and optic chiasm. Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet, sleep apnea, and carpal tunnel syndrome. More serious problems may include accelerated cardiovascular disease, hypertension, diabetes mellitus and an increased risk of colon cancer. If the tumor develops before bone growth is completed in adolescence, gigantism is the result. Because of the serious systemic changes resulting from GH excess, treatment is essential, typically with transsphenoidal surgery Symptoms and signs may include: Soft tissue thickening on the palms of the hand Enlargement of hands (ring size), feet (shoe size) and head (hat size)

46. Acromegaly Subject acromegaly Topic Area Neurology General Forum The Neurology andNeurosurgery Forum Question Posted By Candy on Sunday, April 20, 1997 . http://www.medhelp.org/forums/neuro/archive/213.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Acromegaly Topic Area: Neurology - General Forum: The Neurology and Neurosurgery Forum Question Posted By: Candy on Sunday, April 20, 1997 Posted by CCF Neurology on April 30, 1997 at 14:31:05: In Reply to: Acromegaly posted by Candy on April 20, 1997 at 17:08:29: : My stepbrother is undergoing tests right now and the doctors believe he may have Acromegaly. The doctors seem very hesitate to give him a definite diagnosis as none of them have ever actually seen a case of it. We are trying to find out if there is a specialist in Acrogegaly in the Buffalo area. I would appreciate hearing from anyone with any information on Acromegaly. Hello, I found under www.endo.org a listing for acromegaly under an organization of www.niddk.nih.gov. This information was copied from them and it is quite detailed. I hope you will find it helpful. In addition there is an organization that you may call to get a recommendation for an endocrinologist in Buffalo. If this is not helpful give the Cleveland Clinic Endocrinology department a call 1-800-CCF-CARE, and ask for the extension for endocrinology. Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and

47. ACROMEGALY acromegaly A condition that results from the excess productionof growth hormone in the anterior lobe of the pituitary gland. http://www.medhelp.org/glossary2/new/GLS_0092.HTM

ACROMEGALY - A condition that results from the excess production of growth hormone in the anterior lobe of the pituitary gland Acromegaly is characterized by enlarged facial features, enlarged jaw, enlarged frontal bone of skull, widely spaced teeth, and enlargement of the bones of the extremities, Other features include enlargement of the lips and nose, thickening of the soft tissues of the face, somnolence , moodiness, and decreased libido. Med Help Home Search Ask the Doctor Patient Network The medical glossary has been made possible by a generous donation from:

48. Acromegaly Basic Information (advertentie). acromegaly basic information, Web Power Internet Technology. acromegalyis a rare disease caused by a noncancerous tumour on the pituitary. http://www.nvacp.nl/page.php?main=5&sub=37

49. Tall Persons Club GB & Ireland · Medical Information · Acromegaly/Gigantism acromegaly/Gigantism, back to Medical Information. If unchecked, the person willtake on the characteristic appearance of one suffering from acromegaly. http://www.tallclub.co.uk/medical/acromegaly.asp

Home Bulletin Board (BBS) Chat Room Events ... Member Login Acromegaly/Gigantism back to Medical Information Gigantism: growth hormone is secreted by the anterior lobe of the pituitary gland. It controls the rate of growth of the individual, as well as determining the timing of sexual maturity. It certain cases, usually due to a micro-tumour, the gland continues to secrete growth hormone for much longer, and in greater quantities, than it should. The affected person will continue to grow upwards, as well as outwards, until secretion is stopped, by medical or surgical intervention. If unchecked, the person will take on the characteristic appearance of one suffering from acromegaly. Acromegaly: when normal growth is complete the ends of the long bones fuse, and the person has reached their final height. If the pituitary starts to produce growth hormone again, the person will experience some upwards growth but, due to the fusion of the long bones, many bones, such as the lower jaw, will grow outwards. This leads to a characteristic appearance of the lower jaw and lips, thickening of the fingers and feet, and enlargement of cartilage structures, such as the nose and adams apple, the latter resulting in a deeper than normal voice. The condition is not hereditary, i.e. is not passed on from parent to child via the genetic material, however, some people believe that a set of conditions, or family tendencies, can be passed on, which may make the child more likely than normal to develop the condition. In one case, a man reported that several members of his family have had several pituitary related problems: - diabetes and cryptorchidism (undescended testes), for instance.

50. Acromegaly acromegaly. Click Here. acromegaly. a condition in which the head, hands, andfeet become enlarged, caused by overactivity of the pituitary gland. http://www.webref.org/biology/a/acromegaly.htm

acromegaly $50 Cell Phone Rebates acromegaly a condition in which the head, hands, and feet become enlarged, caused by overactivity of the pituitary gland Source: Noland, George B. 1983. General Biology, 11th Edition. St. Louis, MO. C. V. Mosby Questia - The Online Library Back Next a- or an- ab- ... acrocentric chromosome acromegaly acrosome active transport ad- adaptation ... Tabularium™ WebRef™ Search WWW Search webref.org Digital River: Get amazing deals on great software! Iverson Software Co., 506 Genesis Ave., Marshall MN 56258-3110 Email WebMaster PRIVACY POLICY This site hosted by EASY CGI Web Hosting

51. Glossary acromegaly Excessive growth caused by overproduction of growth hormoneby the pituitary gland. acromegaly affects mostly middleaged adults. http://www.cushings-help.com/definitions.htm

Today is ...and it's about time there was some support for Cushing's! FAQ Adrenal Crisis? Getting a diagnosis and dealing with tests can be a very trying time. Here are some words you'll want to know. A B C D ... I J K L M N O ... X-Z A Acanthosis nigricans: Asymptomatic, brown to black skin, with a velvety texture. Pedunculated skin tags often are present. The most common sites are the axillae, neck, and groin. If the patient is obese, the eruption may clear with weight loss or correction of the underlying endocrine disorder. Local treatment is not effective. More on Acanthosis nigricans Acromegaly Excessive growth caused by overproduction of growth hormone by the pituitary gland . This is a condition that usually affects middle aged people. It is characterized by gradual, marked enlargement of the bones of the face, jaw and extremities. The excessive growth occurs first in the hands and feet, as soft tissue begins to swell. Apart from these symptoms, the metabolic abnormalities associated with GH Growth Hormone ) that warrant effective GH lowering therapy.

52. Acromegaly Introduction acromegaly is a hormonal disorder that results when thepituitary gland produces excess growth hormone (GH). It most http://www.cushings-help.com/acromegaly.htm

Today is ...and it's about time there was some support for Cushing's! FAQ Adrenal Crisis? Introduction What Causes Acromegaly? ... Other Resources Introduction Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone GH ). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. Overgrowth of bone and cartilage often leads to arthritis. When tissue thickens, it may trap nerves, causing carpal tunnel syndrome, characterized by numbness and weakness of the hands. Other symptoms of acromegaly include thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; abnormalities of the menstrual cycle and sometimes breast discharge in women; and impotence in men. There may be enlargement of body organs, including the liver, spleen, kidneys and heart.

53. Acromegaly -- ECureMe.com acromegaly, more about acromegaly, acromegaly is the excessive productionof growth hormone, which continues to be produced well into adulthood. http://www.ecureme.com/emyhealth/data/Acromegaly.asp

March 30, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Acromegaly more about Acromegaly Gigantism and hyperpituitarism Acromegaly is the excessive production of growth hormone, which continues to be produced well into adulthood. In adults it is involved in regulatory functions in the body, but since the growth plates are closed, excessive levels cause abnormal growth of hands, feet, and internal organs. Since pituitary tumors are the most common cause of this condition, other areas controlled by the pituitary are often affected (such as

54. Acromegaly, Pituitary Dysfunction - Hormonal Disorders acromegaly. What is acromegaly? What Causes acromegaly? acromegaly iscaused by prolonged overproduction of GH by the pituitary gland. http://www.medicalconsumerguide.com/primary_care/hormonal_disorders/acromegaly.h

Primary Care Elective Care Dental Vision ... Pheochromocytoma ACROMEGALY What is Acromegaly? Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features; the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. The most serious health consequences of acromegaly are diabetes mellitus, hypertension, and increased risk of cardiovascular disease. Patients with acromegaly are also at increased risk for polyps of the colon that can develop into cancer.

55. Health Ency.: Disease: Acromegaly acromegaly. hands, feet, and skull. Causes and Risks. acromegaly occursin about 6 out of 100,000 adults. It is caused by abnormal http://www.accessatlanta.com/shared/health/adam/ency/article/000321.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease A Acromegaly Overview Symptoms Treatment Prevention Alternative names: Hyperpituitarism Definition: A chronic metabolic disorder caused by too much growth hormone that results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Causes and Risks Acromegaly occurs in about 6 out of 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located at the base of the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor. Ency. home Disease A Please read this Important notice Also Check Out Subscribe to The Atlanta Journal-Constitution Home Autos Classifieds ... Our Sponsors By using AccessAtlanta.com you accept the terms of our

56. Slide: Acromegaly, Patient Photo acromegaly, patient photo Click picture to enlarge. Close window to returnA patient with acromegaly coarse facial features, big hands. http://www.kumc.edu/instruction/medicine/pathology/ed/ch_21/c21_s18.html

Acromegaly, patient photo Click picture to enlarge. Close window to return A patient with acromegaly: coarse facial features, big hands.

57. ACROMEGALY What is acromegaly? This is a disease caused by the excessive levels ofGrowth Hormone (called GH) in an adult. How common is acromegaly? http://www.dundee.ac.uk/medicine/tayendoweb/acromegaly.htm

University of Dundee ACROMEGALY What is acromegaly? What is the pituitary gland? What is Growth Hormone GH? How common is Acromegaly? ... USEFUL ADDRESS What is acromegaly? This is a disease caused by the excessive levels of Growth Hormone (called GH) in an adult. When it occurs in a child the high levels of GH cause fast growth and is then called Gigantism. It is caused by excessive production of Growth Hormone from an abnormal growth in the pituitary gland. What is the pituitary gland? It is a small pea size gland situated in a hollow bony pouch, at the base of the brain, at the back of the bridge of the nose. It is the master gland of the endocrine system and controls the functions of the other endocrine glands in the body. Pituitary adenoma An abnormal growth of the pituitary gland is called an adenoma . It usually grows very slowly over many years. The pituitary gland sits in a very limited space and surrounded by the very important structures including blood vessels and nerves. Therefore, when an adenoma enlarges it can have a compression effect on the normal pituitary tissue which then fails to work properly. Gradually the expansion of the adenoma can press on surrounding areas causing headache and disturbed vision. What is Growth Hormone GH?

58. Acromegaly acromegaly up. acromegaly / drug therapy, acromegaly, A patientinformation acromegaly / drug therapy. Sandostatin.com, This is an http://omni.ac.uk/browse/mesh/detail/C0001206L0001206.html

Acromegaly [up] Acromegaly / drug therapy Acromegaly A patient information document about acromegaly, a "hormonal disorder that results when the pituitary gland produces excess growth hormone (GH)." It explains the causes, diagnosis and treatment. A list of further reading on the topic is also included. Published by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the US National Institutes of Health. Acromegaly Patient Education Handout [Publication Type] Acromegaly / drug therapy Sandostatin.com This is an international Web site for Sandostatin, and is intended for healthcare professionals outside the US. Sandostatin (octreotide acetate) is used in the treatment of acromegaly and the symptoms associated with gastroenteropancreatic (GEP) neuroendocrine (NE) tumours. The site provides information on the preparation, injection, and dosage of Sandostatin, as well as the causes, symptoms, diagnosis and treatment of acromegaly and GEP NE tumours. Some case studies, journal articles and PowerPoint slides are also available. Produced by Novartis Pharma AG. NB: "The information on this site is not country-specific and may contain information that is outside the approved indications where you practice." Acromegaly / drug therapy Neuroendocrine Tumors / drug therapy Octreotide Pharmaceutical Preparations Last modified 28/Mar/2003 [Low Graphics]

59. Acromegaly osteoarthritis (commonly knees). Pathology acromegaly is caused by prolongedoverproduction of GH by the pituitary gland. The pituitary is http://www.xray2000.f9.co.uk/radpath/a/acromegaly.htm

Acromegaly Definition acromegalia; a disorder marked by progressive enlargement of peripheral parts of the body, especially the head, face, hands, and feet, due to excessive secretion of somatotropin; organomegaly and other metabolic disorders occur, and diabetes mellitus may develop. Radiographic Appearances Skull:, enlarged occipital protuberance prognathism (elongation of mandible) in few cases enlarged paranasal sinuses (esp. frontal): 75% sellar enlargement and erosion osseous enlargement (phalangeal tufts, vertebrae) flared ends of long bones cystic changes in carpals, femoral trochanters osteoporosis spade-like hand calvarial hyperostosis (esp. inner table) vertebrae: posterior scalloping (30%), anterior new bone, loss of disc space premature osteoarthritis (commonly knees) Pathology Pituitary Tumors In over 90 percent of acromegaly patients, the overproduction of GH is caused by a benign tumor of the pituitary gland, called an adenoma. These tumors produce excess GH and, as they expand, compress surrounding brain tissues, such as the optic nerves. This expansion causes the headaches and visual disturbances that are often symptoms of acromegaly. In addition, compression of the surrounding normal pituitary tissue can alter production of other hormones, leading to changes in menstruation and breast discharge in women and impotence in men.

60. Clinical Manifestations Of Acromegaly Clinical manifestations of acromegaly CLINICAL MANIFESTATIONS • Acral overgrowth• Articular overgrowth • Bone density • Cardiovascular disease http://www.uptodate.com/patient_info/topicpages/topics/Pituitar/6039.asp

Following is the full text, Medline abstracts and images of a topic review from UpToDate Some of the regular features found in UpToDate , such as drug information, links to related topics, and a simple but powerful search engine, are not incorporated here. USE OF PROFESSIONAL JUDGMENT Clinical manifestations of acromegaly CLINICAL MANIFESTATIONS Acral overgrowth Articular overgrowth Bone density ... MORTALITY Shlomo Melmed, MD UpToDate performs a continuous review of over 290 journals and other resources. Updates are added as important new information is published. The literature review for UpToDate version 11.1 is current through December 2002; this topic was last changed on August 19, 2002. Acromegaly is the clinical syndrome that results from excessive secretion of growth hormone (GH). Its annual incidence is three to four per million people [ ]. The mean age at diagnosis is 40 to 45 years. Growth hormone excess that occurs before fusion of the epiphyseal growth plates in a child or adolescent is called pituitary gigantism and is discussed separately. The most common cause of acromegaly is a somatotroph (growth hormone-secreting) adenoma of the anterior pituitary. These adenomas account for about one-third of all hormone-secreting pituitary adenomas (

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