web hosting domain names email addresses related sites THE PRION DISEASES A Molecular and Genetic Perspective A dissertation By Robert J. Elbourn The prion diseases: a molecular and genetic perspective Contents Jump Jump Jump Jump ... Jump The number of -helices in PrP c c Jump Studies on transgenic mice to deduce the function of PrP c The overexpression of PrP c Demonstration of the requirement of PrP c for PrP sc Other studies directed at determining the function of PrP c Sc Jump Evidence for the conversion of PrP c into PrP sc Jump Other Possible PrP sc Jump Jump Jump Jump ... Jump Acknowledgements I would like to thank Dr. Ivor Brown and Dr. Glenn Telling for their invaluable support and advice. I would also like to acknowledge Prof. M. Alpers, Prof. J. Collinge, my friends and my family. R.J.Elbourn
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Powered by Ampira Section I: Introduction Aims of the study This study is aimed at looking at the prion diseases from a molecular point of view, taking into account the genetic as well as the transmissible and sporadic aspect of the diseases. It attempts to first fully identify these novel diseases to give an exact idea of what the research is about and why it is taking place. The molecular side starts by looking at the molecular and genetic evidence from the beginning of the discovery of the 'prion' hypothesis. Then, by following a fascinating path of logical deductions and discovery with exciting consequences that were revolutionary for molecular biology and resulted in uncertainties and fierce scientific debates, the properties of the prion diseases are investigated. The report intends to not only critically analyse the 'prion' hypothesis, but to compare it to the viral and bacterial hypotheses as well, ending in identifying the progress that needs to be made in the future, and above all, the major uncertainty of variant CJD. | |
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