61. Partners Leukodystrophy Service At MGH Introduction. alexander's disease is a slowly progressive disease that primarilyaffects children. The adult form of alexander's disease is even more rare. http://fisher.mgh.harvard.edu/leuko/alexander.html

Home Staff Services Leukodystrophy categories Contact us Links X-linked Adrenoleukodystrophy Metachromatic leukodystrophy ... CACH Introduction Alexander's disease is a slowly progressive disease that primarily affects children. First described by Alexander in 1949, it is characterized by the finding of Rosenthal fibers in brain specimens ( Harding 1990 It is genetically determined, by sporadic gain of function mutations in the GFAP gene ( Brenner, Johnson et al. 2001 ). This observation adds Alexander disease to a growing list of intermediate filament diseases which includes Emery-Dreifuss muscular dystrophy (lamin A/C), cardiac and skeletal desmin myopathy (Desmin). To date all cases have been sporadic and more recent mutational analysis has not found mutations in either parent. There have been case reports, not genetically confirmed, of more than one child being affected (Johnson, Personal Communication, United Leukodystrophy Foundation Annual Meeting, 2002). Epidemiology The incidence of more than one affected person in a kindred is rare. Clinical Features: Broad Overview Clinically, it resembles

62. ALEXANDER'S DISEASE Features Listed For alexander'S disease. McKusick 203450. Ataxia; Hydrocephaly/largeventricles, nonspecific; Macrocephaly; Papilloedema. Chromosome(s) http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?52

63. Health Library - Alexander Disease alexander's disease. In most cases, alexander's disease appears to occur randomlyfor unknown reasons (sporadically), with no family history of the disease. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

64. Alexander's Disease alexander's disease,, Print this article, (W. Stewart alexander, 20thcentury, New Zealand pathologist), fibrinoid leukodystrophy, a http://www.amershamhealth.com/medcyclopaedia/Volume VII/Alexanders disease.html

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Alexander's disease, (W. Stewart Alexander, 20th century, New Zealand pathologist), fibrinoid leukodystrophy , a primary white matter disease without specific biochemical abnormalities. Neurological regression, seizures, bulbar signs and macrocrania are the clinical manifestations. MR imaging shows diffuse demyelination, most marked frontally with a coarse appearance of sulci and gyri. For further description, see Alexanders disease HC The Encyclopaedia of Medical Imaging Volume VII Welcome to Medcyclopaedia. This site is open to a public audience, still we want to know a little more about our visitors. Please tick off the boxes that match your profile. Do you live in Europe?

65. Alexander's Disease Professionals only. alexander's disease,, Print this article, (W alexander'sdisease, Fig. 1 a. MR, axial IR image. Macrocephaly, dilated ventricles http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/ALEXANDERS DISEASE.asp

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Alexander's disease, (W. Stewart Alexander, 20th century, English pathologist), rare dysmyelinogenetic leukodystrophy , of sporadic occurrence without a familial incidence. There are three clinical subgroups: infantile, juvenile and adult. In the most common infantile form macrocephaly is the hallmark together with developmental delay, spasticity and seizures. The average duration of the illness is usually about 3 years. The juvenile form is characterized by onset between 7 and 14 years, spasticity, bulbar symptoms and a duration of about 8 years. In the adult the form onset of symptoms is variable as is the clinical manifestation that may have an intermittent course and resemble multiple sclerosis. There is no biochemical test to confirm the diagnosis. The CT and MR appearance ( Fig.1

66. Discussion Forum : By Manas Tungare Replyalexander's disease and PRR, From Holly. Replies to this message Re alexander'sdisease and PRR by Laura; Re alexander's disease and PRR by Laura; http://atready.com/activepages/bb/message.asp?MessageID=56

67. Discussion Forum : By Manas Tungare Discussion Forums at Developmental Concepts. ReplyRe alexander's disease and PRR,From Colleen. I work with a boy who has alexander's disease. He was 2 in July. http://atready.com/activepages/bb/message.asp?MessageID=70

68. Alexander's Disease, A Leukodystrophy We are a support group for people who are dealing or have dealt withAlexander's disease or any other Leukodystrophy. Together we http://groups.msn.com/AlexandersDiseaseaLeukodystrophy

MSN Home My MSN Hotmail Search ... Money Groups Alexander's Disease, a Leukodystrophy AlexandersDiseaseaLeukodystrophy@groups.msn.com Groups Home My Groups Language Help ... Tools SPONSORED SITES: Recommend This Group to a Friend Hi my name is Jackie my husband's name is Patricio. We have a 2 yr old son with Alexander's Disease. We would love to meet others who are dealing with this disease or have dealt with it. Hopefully we will be able to help each other through the difficult times and learn from one another. We would love to share our experience and hear yours. We hope to meet you soon. New Messages View all Hello - I am new Welcome Janet- I'm sorry I hadn't gotten to you sooner. What part of the country are you from. Its sad that we are all so spread out. Thanks to the internet we are ab... Kojitea Hi Kelly KaMeela, Garrett ran into the same problems as Kavon with Tegratol.We were on it for a couple of years and he continued to have "breakthrough" seizures all the time. ... kelly Hi Kelly Hi Kelly, Thanks for responding. I have been checking on Kavon's blood work and his neurologist has been calling Washington and they say they are working on it and it could take up to six m... kameela Hello Noah has many of the same problems - especially with nothing working for high fevers. He is in kindergarten, though, and the school has done much to help him as much as they can. They...

69. Alexander's Disease Leukodystrophy Groups, alexander's disease Leukodystrophy, alexandersdiseaseLeukodystrophy@groups.msn.com, Viewall, Welcome Welcome to alexander's disease Leukodystrophy. http://groups.msn.com/AlexandersDiseaseLeukodystrophy

MSN Home My MSN Hotmail Search ... Money Groups Alexander's Disease Leukodystrophy AlexandersDiseaseLeukodystrophy@groups.msn.com Groups Home My Groups Language Help ... Tools SPONSORED SITES: Recommend This Group to a Friend Welcome to the Leukodystrophy website, New Messages View all Welcome Welcome to Alexander's Disease Leukodystrophy. Whether you are a manager, member, or visitor here, we hope you enjoy this MSN group. MSN Groups Tools Join This Group Recommend This Group Create Your Own Group ... Group Settings Notice: Microsoft has no responsibility for the content featured in this Group. Click here for more info. MSN - More Useful Everyday MSN Home My MSN ... GetNetWise

70. Health Library - Alexander Disease alexander's disease. In most cases, alexander's disease appears to occur randomlyfor unknown reasons (sporadically), with no family history of the disease. http://www.laurushealth.com/library/healthguide/illnessconditions/topic.asp?hwid

71. Metabolic Disorders The other primary white matter disorders include alexander's disease, Canavandisease, Cockayne's syndrome, and PelizaeusMerzbacher's disease. (8). http://spinwarp.ucsd.edu/NeuroWeb/Text/br-500.htm

DEGENERATIVE AND METABOLIC DISORDERS John R. Hesselink, MD, FACR and Richard J. Hicks, MD DEGENERATIVE DISEASES Imaging of degenerative disorders with CT has generally been disappointing, and attempts have been made to apply MR to this area with hopes of demonstrating more specific findings. The key to the MR imaging of many of these disorders may rest in understanding the normal and pathologic distribution of iron in the brain. Iron is visualized as areas of hypointensity on T2-weighted and GRE imagescaused by local field inhomogeneity and magnetic susceptibility effects. Drayer and colleagues noted decreased signal in the globus pallidus, reticular substantia nigra, red nucleus, and dentate nucleus. These areas correlated closely with sites of preferential accumulation of ferric iron on Perls' stains in normal brains post mortem. This iron deposition becomes greater with increasing age, with iron stains first becoming positive at 6 months in the globus pallidum and at 3 to 7 years in the dentate nucleus. With advanced age (approximately the ninth decade), there may be enough iron deposition in the putamen to render it as hypointense as the globus pallidus. Iron may play a role in neurotransmitter metabolism, and several degenerative disorders have been reported to be associated with increased iron deposition in the brain. This has been described in Hallervorden-Spatz disease, Huntington's chorea, Parkinson's disease and multisystem atrophy variants, Alzheimer's disease, and multiple sclerosis.

72. Kennedy Krieger Institute SakkuBai Naidu, MD of the white matter of the brain, Dr. Naidu and colleagues have tested criteriafor in vivo MR imaging diagnosis of alexander's disease, usually eliminating http://www.kennedykrieger.org/kki/kki_staff.jsp?pid=1054

73. EMedicine - Addison Disease : Article By Alexander Brough, MD autoimmune disease II, PGAD II, Schmidt syndrome, addisonian crisis, adrenocorticotrophichormone, ACTH, melanocytestimulating hormone, MSH. Author alexander http://www.emedicine.com/derm/topic761.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Addison Disease Last Updated: August 28, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Addison’s disease, primary adrenal insufficiency, chronic adrenal insufficiency, hypoadrenalism, polyglandular autoimmune diseases, polyglandular autoimmune disease I, PGAD I, polyglandular autoimmune disease II, PGAD II, Schmidt syndrome, addisonian crisis, adrenocorticotrophic hormone, ACTH, melanocyte-stimulating hormone, MSH AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Alexander Brough, MD , Consulting Surgeon, Department of Dermatology, Sewell's Point Clinic Coauthor(s): Elizabeth A Liotta, MD , Assistant Professor, Department of Dermatology, Uniformed Services University of the Health Sciences; Quenby Lea Erickson, DO , Staff Physician, Department of Dermatology, Wilford Hall Medical Center;

74. EMedicine - Addison Disease : Article Excerpt By: Alexander Brough, MD Excerpt from Addison disease. Synonyms, Key Words stimulating hormone,MSH. Please click here to view the full topic text Addison disease. http://www.emedicine.com/derm/byname/addison-disease.htm

(advertisement) Excerpt from Addison Disease Synonyms, Key Words, and Related Terms: Addison’s disease, primary adrenal insufficiency, chronic adrenal insufficiency, hypoadrenalism, polyglandular autoimmune diseases, polyglandular autoimmune disease I, PGAD I, polyglandular autoimmune disease II, PGAD II, Schmidt syndrome, addisonian crisis, adrenocorticotrophic hormone, ACTH, melanocyte-stimulating hormone, MSH Please click here to view the full topic text: Addison Disease Background: In 1855, Thomas Addison first described adrenal insufficiency, which was subsequently named after him. The basis of Addison disease has dramatically changed since its initial description. Originally, the disease usually resulted from an infection of the adrenal gland; the most common infection was tuberculosis, which is still the predominant cause of Addison disease in developing countries. Currently, in developed countries, Addison disease most commonly results from nonspecific autoimmune destruction of the adrenal gland. Pathophysiology: Adrenal insufficiency can manifest as a defect anywhere in the hypothalamic-pituitary-adrenal axis. Primary adrenal insufficiency is a result of destruction of the adrenal cortex. The zona glomerulosa, the outer layer of the adrenal gland, produces aldosterone. Cortisol is produced in both the zona fasciculata and the zona reticularis, the middle and innermost layers of the adrenal gland, respectively. Dehydroepiandrosterone is produced in the zona reticularis.

75. Rare Diseases List - Office Of Rare Diseases disease alexander's disease. Synonyms alexanders leukodystrophy. Megalencephalyin infancy accompanied by progressive spasticity and dementia. http://ord.aspensys.com/diseaseinfo.asp?ID=5774

76. The Myelin Project: Demyelinating Diseases In Brief Refsum's disease, adrenoleukodystrophy, Krabbe's disease, phenylketonuria,Canavan disease, PelizaeusMerzbacher disease and alexander's disease. http://www.myelin.org/diseasesinbrief.htm

HOME Overview Research News ... Scope and Strategies Demyelinating Diseases In Brief Demyelinating diseases are those in which myelin is the primary target. They fall into two main groups: acquired diseases and hereditary neurodegenerative disorders. Acquired Diseases The most common of these is multiple sclerosis (MS), which usually manifests itself between the 20th and 50th years of life. Current estimates are that approximately 2.5 million people worldwide have MS, with between 250,000 and 350,000 cases in the United States, 50,000 cases in Canada, 130,000 cases in Germany, 85,000 cases in the United Kingdom, 75,000 cases in France, 50,000 cases in Italy, and 11,000 cases in Switzerland. An oligodendrocyte (center) is capable of myelinating several axons. This illustration shows how myelin forms wrapped layers around the axon. MS attacks the white matter of the central nervous system (CNS). In its classic manifestation (90% of all cases), it is characterized by alternating relapsing/remitting phases with periods of remission growing shorter over time. Its symptoms include any combination of spastic paraparesis, unsteady gait, diplopia, and incontinence.

77. Demyelinating Diseases - Internet Handbook Of Neurology Cockayne Syndrome eMedicine/Pediatrics. alexander's disease alexander'sdisease A Case Report of a Biopsy Proven Case - Neurology India, 1999; http://www.neuropat.dote.hu/myelin.htm

Internet Handbook of Neurology Compiled by K atalin H Department of Neurology University of Debrecen, Hungary Demyelinating Diseases Chapters: A Collection of High Quality Online Resources for Health Professionals Pathology see Pathology of Infectious Diseases and Disease of Myelin Overview - Washington University Demyelinating Diseases of the Brain - University of California, San Diego Demyelinating Disease - Finch University Chemokine Regulation of Immune-mediated Demyelinating Disease - ILAR Journal, Vol 40(4) 1999 Pathology of Inflammatory Demyelinating Diseases - Mayo Clinic Viral Induced Demyelination - Brain Pathology, January 2001 (PDF) Is There a Role for Human Herpesvirus-6 in the Course of Multiple Sclerosis? - International Journal of MS Care, March Current Immunotherapy for Demyelinating Diseases - Archives of Neurology, May Multiple Sclerosis Overview Multiple Sclerosis - Neurology Associates of Arlington Multiple Sclerosis - Praxis MD Multiple Sclerosis: Current Status and Strategies for the Future - National Academy Press, Multiple Sclerosis: Lectures - University of Utah, Houston (

78. OUP: Methods For Investigating Localized Clustering Of Disease: Alexander Methods for Investigating Localized Clustering of disease. Edited by FE alexander,Department of Public Health Sciences, University of Edinburgh, and P. Boyle http://www.oup.co.uk/isbn/92-832-2135-4

VIEW BASKET Quick Links About OUP Career Opportunities Contacts Need help? oup.com Search the Catalogue Site Index American National Biography Booksellers' Information Service Children's Fiction and Poetry Children's Reference Dictionaries Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks Humanities International Education Unit Journals Law Medicine Music Oxford English Dictionary Reference Rights and Permissions Science School Books Social Sciences World's Classics UK and Europe Book Catalogue Help with online ordering How to order Postage Returns policy ... Table of contents Methods for Investigating Localized Clustering of Disease Edited by F. E. Alexander , Department of Public Health Sciences, University of Edinburgh, and P. Boyle , European Institute of Oncology Publication date: 27 March 1997 International Agency for Research on Cancer 264 pages, colour illustrations, line figures, tables, 240mm x 175mm Series: International Agency for Research on Cancer Scientific Publications Search for titles in the same series Ordering Individual customers order by phone, post, or fax

79. Genesis Health System - Detailed Disease Info - Alexander Technique alexander technique. Definition. San Diego, CA Thunder Bay Press, 1997. Brennan,Richard. The alexander Technique Workbook. Rockport, MA Element Books, 1992. http://www.genesishealth.com/micromedex/detaileddisease/00036730.aspx

Facility Information DeWitt Comm Hosp Genesis Medical Ctr Illini Hospital Genesis Health Grp VNA Alexander technique Definition The Alexander technique is a specific method of adjusting and correcting habitual misaligned body posture in order to relieve muscle tension and allow the body to move with greater ease and efficiency. Purpose This technique teaches simple, efficient physical movements that can improve posture, balance, and coordination. Students learn to regain their natural alignment and balance, thus restoring harmony and enhancing health. It is not used primarily to relieve specific ailments like a backache or a stiff neck, but rather is intended to correct the source of those muscle-related problems. Precautions As one of the least intrusive techniques, the Alexander technique involves virtually no physical manipulation whatsoever and consists primarily of guidance and verbal instructions. It is safe for everyone, including pregnant women. Description Developed in 1904 by Australian actor Frederick Matthias Alexander, the Alexander technique is the result of Alexander's realization that posture can affect one's health and well-being. Having noticed that his breathing and voice were adversely affected by the tense way he held himself on stage, Alexander developed a simple system of balancing his head, neck, and back that not only improved his performance but contributed to his overall general health. By the 1930s, Alexander was not only helping his fellow actors, but had begun a program of training others to teach his method and technique.

80. Helen Miller Alexander alexander, HM and JD Mihail. 2000. Seedling disease in an annual legume consequencesfor seedling mortality, plant size, and population seed production http://www.ku.edu/~eeb/Main/alexande.htm

Helen Miller Alexander Ph.D., Duke University, 1982 Associate Professor Postdoctoral Experience: Department of Plant Pathology, University of Minnesota Phone: (785) 864-3221, Fax: (785) 864-5321 halexander@ku.edu Courses Taught Recently BIOL 152 - Principles of Organismal Biology BIOL 412 - Population Biology BIOL 415 - Field and Laboratory Methods in Ecology BIOL 570 - Introduction to Biostatistics BIOL 630 - Conservation and Wildlife Biology Recent Department and University Service Director, Research Experiences for Undergraduates summer program Executive Committee Member, Kansas Field Station and Ecological Reserves Ambassador to Center for Teaching Excellence Awards and Honors 2000-2001 J. Michael Young Academic Advisor Award Excellence in Teaching Award, 1999 ( from Center for Teaching Excellence: chosen by graduate students in Department of Ecology and Evolutionary Biology) W. T. Kemper Fellowship for Teaching Excellence, 1997. Outstanding Woman Teacher, University of Kansas Commission on the Status of Women, 1991. Research Program Introduction: As a population biologist, I am intrigued both by the factors that affect the size and spactial distribution of populations (population ecology) and by the reasons for changes in the genetic composition of populations (population genetics). Nearly all my research has examined the population biology of plants; plants are often wonderful study organisms because they are easy to census and can be readily manipulated in experiments. I find plant population biology to be both of intrinsic interest and relevant to many applied questions. For example, this discipline is central to understanding why rare species may decline in numbers while invasive, weedy species can have explosive population growth.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 4     61-80 of 91    Back | 1  | 2  | 3  | 4  | 5  | Next 20