81. Alpha-1-antitrypsin Deficiency alpha1-antitrypsin deficiency,, Print this article, alpha-1-antitrypsindeficiency, Fig. 1 Ú-1-antitrypsin deficiency in a young woman. http://www.amershamhealth.com/medcyclopaedia/Volume V 1/ALPHA 1 ANTITRYPSIN DEFI

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Alpha-1-antitrypsin deficiency, well established as a factor playing a major role in the development of chronic obstructive pulmonary disease (COPD). a -1-antitrypsin is a protein that blocks the destructive action of neutrophil elastase on lung elastin fibres. Imbalance of lung proteases and antiproteases probably plays a role in the development of emphysema . Individuals with a homozygous deficiency who also smoke have a greatly increased risk of developing severe panlobular emphysema before the age of 35. Such a homozygous deficiency accounts for less than 1% of COPD. Bronchiectasis , particularly in the lower lobes, is encountered in a few patients with a -1-antitrypsin deficiency ( Fig.1

82. Alpha One Foundation Information about the organization, research, and news as well as alpha 1antitrypsin deficiency.Category Health Conditions and Diseases...... http://www.alphaone.org/

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83. SupportPath.com: Alpha 1 - Antitrypsin Deficiency SupportPath.com, Alpha 1 antitrypsin deficiency. Also called A1AD. NoneListed. Clinical Trials Research on Alpha 1 - antitrypsin deficiency http://www.supportpath.com/sl_a/alpha_1_antitrypsin_deficiency.htm

Alpha 1 - Antitrypsin Deficiency Also called: Other topics of interest on SupportPath.com: Emphysema Liver Disease About Us Add-A-Link ... here Online Communities / Message Boards... Alpha-1 Support UK Website: http://www.alpha1.org.uk/ Description: Internet based group which provides support for UK families who have members with the condition Alpha-1 Antitrypsin Deficiency. Date Added: 01/10/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... Alpha Liver E-List Email address: alpha-liver-subscribe@yahoogroups.com Description: Email support list for people and families affected by Alpha-1 Antitrypsin Deficiency Liver Disease. Date Added: 03/16/2002 National / International Organizations... UNITED STATES Alpha 1 Association Website: http://www.alpha1.org/ Description: Was formed "To improve, through support, education, and research the quality of life of those affected by alpha-1-antitrypsin deficiency".

84. Alpha 1-Antitrypsin Deficiency alpha 1antitrypsin deficiency. Image URL Alpha 1 anti trypsin deficiency, ImageURL Alpha 1 anti-trypsin deficiency, Image URL Alpha 1 anti-trypsin deficiency, http://www.brisbio.ac.uk/ROADS/subject-listing/alpha1antitrypsindeficiency.html

A collection of medical, dental and veterinary images for use in teaching. Home About the Archive FAQ Terms and Conditions ... Help alpha 1-Antitrypsin Deficiency Alpha 1 anti trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency Alpha 1 anti-trypsin deficiency

85. NEJM Replacement Therapy For Alpha 1-antitrypsin Deficiency Original Article from The New England Journal of Medicine Replacementtherapy for alpha 1antitrypsin deficiency associated with emphysema. http://content.nejm.org/cgi/content/short/316/17/1055

86. NEJM Heterozygous MZ Alpha 1-antitrypsin Deficiency In Adults Original Article from The New England Journal of Medicine Heterozygous MZalpha 1antitrypsin deficiency in adults with chronic active hepatitis and http://content.nejm.org/cgi/content/short/304/10/557

87. Member Sign In protein. Adapted with permission from Carrell RW, Lomas DA, Sidhar S,et al Alpha 1 antitrypsin deficiency. A conformational disease. http://www.medscape.com/viewarticle/408728_3

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88. Member Sign In Abstract. In the setting of asthma, early emphysema due to alpha 1 antitrypsindeficiency (alpha 1 -ATD) is an unusual and frequently missed diagnosis. http://www.medscape.com/viewarticle/408728

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89. Irish Medical Journal page, IMJ Home. Alpha 1antitrypsin deficiency Author Rooney C, McElvaneyNG, Taggert C, Coakley R, O'Neill SJ. Alpha 2-antitrypsin http://www.imj.ie/news_detail.php?nNewsId=2048&nVolId=70

90. Alpha1-Antitrypsin (A1AT) Deficiency Alpha 1antitrypsin deficiency-a model for conformational diseases. N Engl J Med. Thecellular basis for liver injury in alpha 1-antitrypsin deficiency. http://www.clevelandclinicmeded.com/diseasemanagement/gastro/alpha1/alpha1.htm

Published August 13, 2002 Anthony S. Tavill, MD Department of Gastroenterology and Hepatology Print Chapter The Cleveland Clinic Foundation There are many inherited metabolic diseases that may have a pathologic impact on the liver. In many cases the liver component of these diseases is only an epiphenomenon of a more generalized systemic disorder. Examples of such epiphenomena are glycogen and lipid storage diseases in which hepatomegaly is a manifestation of the underlying metabolic defect although the liver is not necessarily the major target organ. However, there are three genetically determined diseases in which the liver may be the principal target organ, with manifestations of acute, subacute, or chronic disease that may become evident in early or later life. These are hereditary hemochromatosis (HH) , a major disorder of iron overload; Wilson's disease , a genetic disorder of copper overload; and alpha

91. Aetna: Prolastin (Alpha 1 - Antitrypsin Inhibitor) Therapy Policy. Aetna covers alpha 1antitrypsin inhibitor therapy for selected patientswith emphysema due to alpha 1-antitrypsin deficiency when ALL of the following http://www.aetna.com/cpb/data/CPBA0145.html

Home Coverage Policy Bulletins Medical Coverage Policy Bulletins Number: 0145 Subject: Prolastin (Alpha 1 - antitrypsin Inhibitor) Therapy Important Note http://cms.hhs.gov/manuals/pub06pdf/pub06pdf.asp Policy Aetna covers alpha 1-antitrypsin inhibitor therapy for selected patients with emphysema due to alpha 1-antitrypsin deficiency when ALL of the following criteria are met: Patient is a non-smoker; and Patient has PiZZ, PiZ(null) or Pi(null,null) phenotype (homozygous) alpha 1-antitrypsin deficiency; and Patient has progressive emphysema with a documented rate of decline in FEV1. Once initiated, therapy will usually be continued for the remainder of the patient's life. Recipients of alpha 1-antitrypsin inhibitor therapy should be immunized against hepatitis B. It is also recommended that this medication not be used in patients with immunoglobulin antibody IgA deficiency who are known to have antibodies against IgA (anti-IgA antibody). These patients may experience severe reactions, including anaphylaxis to IgA, which may be present in human alpha 1-antitrypsin inhibitor. Note: This coverage may be subject to precertification review in plans that include precertification requirements. Initial approval will be given for a six-month period upon evaluation of written documentation of pulmonary function tests (PFT) results. Dosing is limited to 60 mg/kg of patient body weight, administered intravenously every week. Prior to the re-approval for continued use at six-month intervals, written documentation of repeat PFT results is required to evaluate the maintenance or improvement of baseline function.

92. ALPHA 1-ANTITRYPSIN DEFICIENCY ALPHA 1antitrypsin deficiency - A specific enzyme (alpha 1 antitrypsinase) thatwhen absent genetically can result in panacinar emphysema (lung disease) and http://www.medhelp.org/glossary2/new/GLS_0242.HTM

ALPHA 1-ANTITRYPSIN DEFICIENCY - A specific enzyme (alpha 1 antitrypsinase) that when absent genetically can result in panacinar emphysema (lung disease) and liver disease. The incidence is approximate 1 in 10,000 people. There is no specific treatment for this condition other than supportive care for the liver and lung complications . Medications such as alpha-1proteinase inhibitor is given regularly to these patients. Med Help Home Search Ask the Doctor Patient Network The medical glossary has been made possible by a generous donation from:

93. :: Liver Diseases - Alpha -1 Antitrypsin (AAT) Deficiency :: Alpha 1 antitrypsin (AAT) deficiency One of the most common inheriteddisorders among caucasians. Incidence is 1 per 2-7000 population. http://www.liverindia.com/alpha.htm

Types of Liver Diseases Alcoholic Liver Diseases Autoimmune Hepatitis Budd Chiari Syndrome Chronic Hepatitis ... Wilson's Disease Alpha -1 Antitrypsin (AAT) deficiency One of the most common inherited disorders among caucasians. Incidence is 1 per 2-7000 population. The phenotypic variations in AAT gene is expressed as the Protease inhibitor (Pi) alphabetical nomenclature. The Pizz variant most often characterizes the ATT deficiency state. Among Pizz infants with jaundice 25% will experience cirrhosis within the first decade of life, 25% will show persistent liver enzyme elevation progressing to cirrhosis in the second decade, 25% will resolve the biochemical change completely and show only mild fibrosis on biopsy. The liver injury in all these cases is probably attributed to release of proteases. Liver transplantation normalizes serum ATT levels and hence none of the transplanted patients develop lung injury and emphysema. SiteMap Login Contact Us Feed Back ... Advertise Link M.S.(Gen),FRCS(UK),M.D.(UK) and Fellow In Abdominal Transplantation(USA) Sr. Consultant Surgeon and Head of Liver Transplantation (Indraprastha Apollo Hospital).

94. Home Page in the UK. The original site was for sufferers of the condition Alpha1Antitrypsin deficiency and their families. After having http://www.alpha1.org.uk/

Supported Sites Contact Webmaster About this site Support For You! is a voluntary private web site set up to provide support for people with chronic illness, and their families, based in the UK. The original site was for sufferers of the condition Alpha-1 Antitrypsin Deficiency and their families. After having launched the original site it became obvious that there was a demand for a site that covered a wide range of chronic conditions. This site has been developed with the following objectives: To provide a central resource UK residents with chronic illness. To develop and host web sites for those groups unable to provide their own resources. To provide an ability for people with a condition to communicate with others with the same condition. To link into other groups who already have their own web based resources. Currently supported groups Alpha-1 Support UK is a group for supporting the condition Alpha-1 Antitrypsin Deficiency.

95. Welcome To The New Website Of The Alpha-1 Canadian Registry Welcome to the new website of the alpha1 Canadian Registry. Bienvenue auRegistrar alpha-1 Antitrypsine Canadien. You are visitor number 3541. http://www.alpha1canadianregistry.com/

Welcome to the new website of the Alpha-1 Canadian Registry We are a member of the Alpha-1 International Registry Bienvenue au Registrar Alpha-1 Antitrypsine Canadien You are visitor number: 3791

96. Alpha Link - AlphaLink - Alphalink.org Information and resources for alpha link alphalink alpha link alpha link builda web site build web site create a web site create web site directory email http://www.alphalink.org/

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