41. 1Up Health > Primary Amyloidosis > Causes, Incidence, And Risk Factors Of Primar Comprehesive information on Primary amyloidosis (Amyloid primary). Primaryamyloidosis Causes, Incidence, and Risk Factors. Alternative names http://www.1uphealth.com/health/primary_amyloidosis_info.html

1Up Health Primary amyloidosis Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Primary amyloidosis Information Primary amyloidosis Causes, Incidence, and Risk Factors Alternative names : Amyloid - primary Definition : A disorder in which insoluble protein fibers are deposited in tissues and organs, impairing their function. Causes, Incidence, and Risk Factors The cause of primary amyloidosis is unknown, but the condition is related to abnormal production of immunoglobulins by plasma cells (a type of immune cell). Symptoms are related to the organs affected by the deposits, which can include the following: tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Cardiomyopathy (decreased heart function), renal failure (kidney failure), carpal tunnel syndrome (painful swelling of nerves in the wrist), malabsorption (inadequate absorption of nutrients from the intestinal tract), gastrointestinal reflux, and other conditions can result. The deposits infiltrate the affected organs, causing them to lose resilience and become stiff, which decreases their ability to function. Secondary amyloidosis can be caused by infection, inflammatory diseases, and sometimes cancer. Risk factors have not been identified. Primary amyloidosis is rare, occurring only in 1 out of 100,000 people.

42. 1Up Health > Cardiac Amyloidosis > Causes, Incidence, And Risk Factors Of Cardia Comprehesive information on Cardiac amyloidosis (amyloidosis cardiac, Primarycardiac amyloidosis - AL type, Restrictive cardiomyopathy - amyloidosis http://www.1uphealth.com/health/cardiac_amyloidosis_info.html

1Up Health Cardiac amyloidosis Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Cardiac amyloidosis Information Cardiac amyloidosis Causes, Incidence, and Risk Factors Alternative names : Amyloidosis - cardiac, Primary cardiac amyloidosis - AL type, Restrictive cardiomyopathy - amyloidosis, secondary cardiac amyloidosis - AA type, Stiff heart syndrome Definition : Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein in the heart tissue, resulting in decreased heart function. Causes, Incidence, and Risk Factors Amyloidosis refers to buildup of a fibril called amyloid in tissues anywhere in the body. Fibrils are proteins produced in excess that are deposited in different organs and slowly replace normal tissue. Different types of amyloidosis are caused by different types of proteins, such as "AL" and "AA." In cardiac amyloidosis there may be associated conduction disturbances (changes in the way the cardiac electrical impulse is transmitted through the heart). Cardiac amyloidosis usually occurs during primary amyloidosis (called AL type amyloidosis). Primary amyloidosis usually accompanies multiple myeloma, a blood disorder in which too much of a certain type of protein is produced. This excess protein is deposited in the heart and in other organs such as the kidney. Deteriorating kidney function also occurs.

43. InteliHealth: Amyloidosis listed and crossreferenced in an AZ format. amyloidosis. Health A toZ, Reviewed by the Faculty of Harvard Medical School amyloidosis http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9444.html

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44. Amyloidosis amyloidosis,, Print this article, amyloidosis may be primary, familial, agerelated,or associated with haemodialysis or a number of diseases. http://www.amershamhealth.com/medcyclopaedia/Volume III 1/amyloidosis.html

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Amyloidosis, deposition of amyloid within various tissues. Amyloidosis may be primary, familial, age-related, or associated with haemodialysis or a number of diseases. In the primary form, mesenchymal structures, such as the heart, muscle, tongue, synovial membrane and perivascular connective tissues are most frequently involved. A similar form occurs in patients with plasma cell myeloma . In the secondary form, amyloid deposition shows predilection for the liver, spleen, kidneys and adrenals. Associated disorders include rheumatoid arthritis, sepsis, neoplasm, inflammatory disorders, familial Mediterranean fever, Crohn's disease and cystic fibrosis. The heredofamilial amyloidoses include neuropathies, nephropathies, cardiomyopathies, and miscellaneous types. Deposition of amyloid in cardiac tissues results in decompensation with dyspnoea, oedema and pleural effusion. In addition, macroglossia may develop and lead to dysphagia and dysarthria. Other features of amyloidosis are hypertension, lymphadenopathy, weight loss, purpura, scleroderma-like skin changes and joint pain. For a further description, see

45. Amyloidosis Professionals only. amyloidosis,, Print this article, a protein accumulation.amyloidosis may be primary (idiopathic) or secondary. Secondary http://www.amershamhealth.com/medcyclopaedia/Volume IV 2/AMYLOIDOSIS.asp

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Amyloidosis, a collective term for a group of diseases that are characterized by the widespread extracellular deposition of insoluble amyloid protein. The process is usually systemic, but localized forms are recognized. Clinical manifestations are protean, and result from organ dysfunction secondary to amyloid protein accumulation. Amyloidosis may be primary (idiopathic) or secondary. Secondary causes include myeloma , solid malignancies, and chronic inflammatory conditions such as rheumatoid arthritis and tuberculosis . In primary nonfamilial, amyloidosis and amyloidosis secondary to myeloma, the deposited protein is derived from immunoglobulin light chains. In nonmyelomatous secondary amyloidosis, the protein is derived from amyloid A protein, an acute phase reaction protein. Renal cell cancer is the commonest solid organ malignancy associated with secondary amyloidosis. Approximately 3% of patients with renal cell carcinoma have autopsy evidence of systemic amyloidosis, and this can occur in the absence of metastases. CT findings in amyloidosis are extremely variable and diverse. The usual sites of involvement in primary amyloidosis are kidneys, heart, lungs, gastrointestinal tract and skin, while the usual sites in secondary amyloidosis are kidneys, liver, spleen and adrenal glands.

46. MedWebPlus Subject Amyloidosis Welcome to MedWebPlus 2.3! A free service to help you find health sciencesinformation quickly and easily. amyloidosis Broader Terms http://www.medwebplus.com/subject/Amyloidosis

47. MedWebPlus Subject Diseases And Conditions Metabolic Diseases MedWebPlus A service of Flexis, Inc. ADVERTISEMENT click here - ADVERTISEMENT- click here - ADVERTISEMENT advertisement ADVERTISEMENT http://www.medwebplus.com/subject/Diseases_and_Conditions/Metabolic_Diseases/Amy

48. FAMY - Patient Assosiation For Familial Amyloidosis Polyneuropathy FAMY Patient assosiation for Familial amyloidosis Polyneuropathy.Information about the disease. http//www.netscape.com. http://www-pp.hogia.net/famy/english/

49. Amyloidosis amyloidosis is a group of diseases in which amyloid—a proteinlikesubstance—builds up in the organs and tissues. The buildup http://www.healthandage.com/html/res/com/ConsConditions/Amyloidosiscc.html

Table of Contents Conditions Amyloidosis Signs and Symptoms What Causes It? Who's Most At Risk? What to Expect at Your Provider's Office ... Supporting Research There are four major types of systemic amyloidosis: Primary amyloidosis (the most common form), typically caused by a buildup of fragments of antibody proteins Hereditary amyloidosis, a genetic form passed down in families Reactive or secondary amyloidosis, which develops along with a chronic inflammatory disease, such as rheumatoid arthritis Beta -microglobulin is a protein that can build up in the blood as a result of kidney failure. This type of amyloidosis occurs in people who have been on dialysis for a long time. Amyloid deposits can affect any organ or tissue. Localized amyloidosis affects more than 90% of people with Type II diabetes mellitus, people with certain cancers of the thyroid or other tumors of the endocrine system, and about 80% of people over age 80. It also affects people with conditions such as Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage, and the disease commonly known as "mad cow disease." Signs and Symptoms The signs and symptoms depend on the location and size of the amyloid deposits.

50. UCL Centre For Amyloidosis And Acute Phase Proteins Welcome to The Centre for amyloidosis and Acute Phase Proteins The Centre conductsworld leading research in all aspects of the pentraxin family of plasma http://www.ucl.ac.uk/medicine/amyloidosis/

UCL Medicine Welcome to The Centre for Amyloidosis and Acute Phase Proteins The Centre conducts world leading research in all aspects of the pentraxin family of plasma proteins, and in amyloidosis, ranging from structural biology, through molecular, genetic, biochemical, physiological and pathological studies, to clinical diagnostics, patient management and new drug discovery. There are extensive collaborative links with scientists, clinicians and industry in many of these areas. The goal is to elucidate fundamental normal and pathobiological mechanisms in order to improve diagnosis, management and outcome of disease. Apart from all aspects of amyloidosis, for which the NHS National Centre is located in this Department, there are particular interests in coronary heart disease and atherothrombosis generally, and in inflammatory and autoimmune diseases. Centre Director: Professor Mark Pepys FRS Professor Philip Hawkins Dr Helen Lachmann Dr Glenys Tennent Beth Jones PA to Professor Pepys Department of Medicine (Royal Free Campus) Royal Free and University College Medical School Rowland Hill Street LONDON UK P hone: Fax: Email:

51. National Amyloidosis Centre NATIONAL amyloidosis CENTRE Department of Medicine, Royal Free University CollegeMedical School, Royal Free Hospital, Rowland Hill Street, LONDON, NW3 2PF http://www.ucl.ac.uk/medicine/amyloidosis/nac/

UCL Medicine CAAPP NATIONAL AMYLOIDOSIS CENTRE Department of Medicine, Royal Free Hospital, Rowland Hill Street, LONDON, NW3 2PF , UK Director/Consultant: Professor Philip N Hawkins Tel: Consultant: Professor Mark B Pepys Tel: Lecturer: Dr Helen J Lachmann Tel: Clinical Service Manager: Mr Gary Brown Tel: Nurse Practitioner: Ms Sheril Madhoo Tel: Secretary: Ms Jackie McLeod Tel: General Office: Ms Sherla Morris Tel: Fax: Email: p.n.hawkins@rfc.ucl.ac.uk Diagnosis, quantification and monitoring of amyloidosis with whole body SAP scintigraphy. Histological review and immunohistochemistry to determine amyloid fibril type. Characterisation and exclusion of hereditary amyloidosis and familial Mediterranean fever, DNA testing and genetic counselling. Recommendations for treatment which range from chemotherapy to organ transplantation.

52. KLUWER Academic Publishers | Amyloidosis Books » amyloidosis. amyloidosis. edited by J. Marrink MH van Rijswijk. MartinusNijhoff Publishing, Boston Hardbound, ISBN 089838-844-9 October 1986, 396 pp. http://www.wkap.nl/prod/b/0-89838-844-9

Title Authors Affiliation ISBN ISSN advanced search search tips Books Amyloidosis Amyloidosis edited by J. Marrink M.H. van Rijswijk Martinus Nijhoff Publishing, Boston Hardbound, ISBN 0-89838-844-9 October 1986, 396 pp. Out of Print Home Help section About Us Contact Us ... Search

53. KLUWER Academic Publishers | Amyloid And Amyloidosis 1990 Books » Amyloid and amyloidosis 1990. Amyloid and amyloidosis 1990. Protein AA/SAAand secondary amyloidosis; AL protein and light chain related amyloidosis; http://www.wkap.nl/prod/b/0-7923-1089-6

Title Authors Affiliation ISBN ISSN advanced search search tips Books Amyloid and Amyloidosis 1990 Amyloid and Amyloidosis 1990 Add to cart Proceedings of the VIth International Symposium on Amyloidosis, held in Oslo, Norway, 5-8 August 1990. edited by Jacob B. Natvig Gunnar Husby Anne Husebekk Knut Sletten Per Westermark This volume covers the whole field of amyloidosis and amyloid-proteins from molecular aspects to clinical symptoms and treatment. It is therefore a clinically-oriented book focusing on the latest developments in the infiltration of organs by amyloid deposits: Protein AA/SAA and secondary amyloidosis AL protein and light chain related amyloidosis Amyloid enhancing factor (AEF), amyloid P component and proteoglycans in amyloidosis Amyloid proteins related to polypeptide hormones Patho-fibrillogenesis and amyloid proteins Transthyretin related amyloid and hereditary amyloidosis Amyloid in Alzheimer's disease Diagnostics, clinical and therapeutic aspects Special session on bioassays and standardization of amyloid proteins and precursors Contents Review(s) The book is well indexed and presents an excellent opportunity to gain a grasp of the current state of knowledge in the subject

54. Lipids Online Slides: Amyloidosis, High-density Lipoprotein Cholesterol LCAT) Slide Tray. slides in tray 0 Add Search Results to Tray. SearchSlides. Index of Slide Contents. search amyloidosis results 2. 1 http://www.lipidsonline.org/slides/slide01.cfm?q=amyloidosis

55. Amyloidosis amyloidosis, amyloidosis is a group of diseases in which amyloid—aproteinlike substance—builds up in the organs and tissues. http://www.ivillagehealth.com/library/onemed/content/0,7064,241012_245556,00.htm

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56. Arthritis Research Campaign | AA Amyloidosis Table 1. Classification of amyloidosis. Amyloid Protein, Protein Precursor,Clinical. AA, SAA, Reactive (secondary). PATHOGENESIS OF REACTIVE amyloidosis. http://www.arc.org.uk/about_arth/med_reports/series3/tr/6408/6408.htm

scotland + n. ireland north wales + midlands east + southeast ... south + southwest Patricia Woo FRCP PhD Professor of Paediatric Rheumatology Department of Molecular Pathology University College London Medical School The Windeyer Building 46 Cleveland Street London W1P 6DB Table 1. Classification of amyloidosis Amyloid Protein Protein Precursor Clinical AA SAA Reactive (secondary). Familial Mediterranean fever. Familial amyloid nephropathy with urticaria and deafness (Muckle-Wells' syndrome). AL Immunoglobulin light chains Idiopathic (primary), myeloma or macroglobulinaemia-associated. ATTR Transthyretin (prealbumin) Familial amyloid polyneuropathy, Portuguese type; familial amyloid cardiomyopathy, Danish type. Familial amyloid polyneuropathy, Iowa type; Hereditary non-neuro pathic systemic amyloidosis (Ostertag-type). AGel Gelsolin Familial amyloidosis, Finnish type.

57. HealthlinkUSA Amyloidosis Links of medical and health related topics. FindWhat. Click here for page1 of amyloidosis information from the HealthlinkUSA directory. http://www.healthlinkusa.com/13ent.htm

58. Multiple Myeloma, Amyloidosis amyloidosis related to plasma cell dyscrasia is not curable. The roleof chemotherpay, and cytokine therapy is discussed. amyloidosis. http://www.clevelandclinic.org/myeloma/amyloidosis.htm

AMYLOIDOSIS Definition Amyloid is a protein-polysaccharide complex substance having starch-like characteristics. Amyloidosis occurs when this substance is deposited into organs or tissues. Cause Amyloidosis is thought to result from many factors. The cause is unknown. PREVALENCE AND INCIDENCE OF AMYLOIDOSIS Amyloidosis is a rare disease. About two-thirds of patients with amyloidosis have primary (where no specific cause or disease is related to the abnormal protein deposits), less than 5% have secondary (associated with another chronic disease, often in multiple myeloma), less than 5% familial (inherited) and less than 5% have senile (occurring secondary to old age) amyloidosis. In patients with primary amyloidosis, 95% are over the age of 40 and 66% are men. Weakness or fatigue Weight loss Heart damage (congestive heart failure) shortness of breath swelling of the feet and legs chest pains irregular heart rhythm lightheadedness (due to lowering of blood pressure during sudden position changes) Abnormal sensations of the arms, feet, or legs

59. Amyloidosis Studies, And Research Back Home Up Next. The following are the Research Protocols for amyloidosis. Questionsrelated to amyloidosis. Questions, Suggestions or to Enquire about a trial http://www.clevelandclinic.org/myeloma/amstudy.html

The following are the Research Protocols for Amyloidosis Phase II Trial of Doxil, Vincristine and Decadron (DVD) in Amyloidosis. Phase II Trial Evaluating the Role of High Dose Decadron, and a- interferon for maintenance. Questions related to Amyloidosis Questions, Suggestions or to Enquire about a trial Cleveland Clinic Home Contact Us Privacy Statement © Cleveland Clinic 2003

60. ThirdAge - Adam - Primary Amyloidosis Primary amyloidosis. Definition A function. Secondary amyloidosis can becaused by infection, inflammatory diseases, and sometimes cancer. http://www.thirdage.com/health/adam/ency/article/000533.htm

document.write(''); document.write(''); document.write('<'); document.write('/SCRIPT>'); document.write(''); document.write(''); document.write('<'); document.write('/A>'); document.write('<'); document.write('/NOSCRIPT>'); document.write('<'); document.write('/IFRAME>'); Activities Computers Family Tree Health ... Prevention Primary amyloidosis Definition: A disorder in which insoluble protein fibers are deposited in tissues and organs, impairing their function. Alternative Names: Amyloid - primary Causes, incidence, and risk factors: The cause of primary amyloidosis is unknown, but the condition is related to abnormal production of immunoglobulins by plasma cells (a type of immune cell). Symptoms are related to the organs affected by the deposits, which can include the following: tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Cardiomyopathy (decreased heart function), renal failure (kidney failure), carpal tunnel syndrome (painful swelling of nerves in the wrist), malabsorption (inadequate absorption of nutrients from the intestinal tract), gastrointestinal reflux, and other conditions can result. The deposits infiltrate the affected organs, causing them to lose resilience and become stiff, which decreases their ability to function. Secondary amyloidosis can be caused by infection, inflammatory diseases, and sometimes cancer.

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