61. Amyloidosis MedHist. AHIS. SEARCH BROWSE ABOUT WHAT'S NEW SUBMIT SITE TRAINING SITE MAP,amyloidosis up. Related topics broader, Metabolic Diseases. amyloidosis, http://omni.ac.uk/browse/mesh/detail/C0002726L0002726.html

Amyloidosis [up] Related topics: broader Metabolic Diseases other Acid-Base Imbalance Brain Diseases, Metabolic Diabetes Mellitus Hyperlipidemia ... Amyloidosis One in a series of brief leaflets about leukaemia and related diseases directed at the public. The document covers the causes, signs and symptoms, diagnosis, treatment, and prognosis of amyloidosis (a group of conditions in which an abnormal substance called amyloid is deposited throughout the body). Published on the Web by the Leukaemia Research Fund. Amyloidosis Patient Education Handout [Publication Type] Last modified 28/Mar/2003 [Low Graphics]

62. Amyloidosis -- ECureMe.com amyloidosis, more about amyloidosis, In primary amyloidosis (called AL) theprotein fibrils are made up of the light chain portions of antibodies. http://www.ecureme.com/emyhealth/data/Amyloidosis.asp

March 30, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Amyloidosis more about Amyloidosis Amyloidosis is a condition in which amyloids, i.e., protein fibrils (minute fibers) not normally present in the body, become deposited in one or more sites, damaging the organs where they collect. Virtually any organ in the body may be affected. Symptoms are determined by the location of the buildup, and vary from mild to severe and life threatening. There are two forms of this condition: primary and secondary. In primary amyloidosis (called AL) the protein fibrils are made up of the light chain portions of antibodies. Typical sites of fibril pooling are the heart, lungs, skin, tongue, blood vessels, kidney, liver, and thyroid gland. The cause of this form is not known.

63. It Is Generally Considered That The Amyloidoses Share Common Pathogenic Mechanis These mechanisms may include structural, metabolic, genetic and environmental factorswhich may be common to all forms of amyloidosis, but due to the sporadic http://www.iupui.edu/~amyloid/primary.htm

I Primary Amyloidosis What is Primary Amyloidosis? Primary amyloidosis is a disease caused by the abnormal accumulation of protein molecules in body tissues. These proteins are fragments of immunoglobulin (antibody) molecules which are normally present in the blood to give protection against bacteria and other infectious agents. Normally, antibody molecules are constantly being synthesized by cells of the immune system and then, after a finite life span, degraded so that there is a balance between production and degradation. In this way our active immune system protects our bodies from a constantly changing array of infectious bacteria and viruses. In primary amyloidosis a defect occurs in the immune system. Excessive amounts of certain antibody molecules are produced and fragments of these molecules get deposited in tissues. These tissue deposits, as they enlarge, damage normal tissues and cause the disease that we know as primary amyloidosis. What causes primary amyloidosis? The cause of primary amyloidosis is unknown. Since the amyloid protein comes from immunoglobulin molecules, it is possible that some response of the immune system to an infectious bacteria, virus or other foreign substance may trigger the overproduction of antibody protein. So far this is only speculation, because amyloid has not been known to be associated with any particular infection. Indeed, there are no epidemiological data to suggest that amyloid occurs as result of infection. More is known about how the antibody molecules are deposited in tissue and lead to the disease. It is known that antibody molecules are made only by certain cells in the immune system called plasma cells. It is known that plasma cells can synthesize large amounts of antibody molecules but are usually under regulatory mechanisms that maintain a balance.

64. ORPHANET® : Amyloidosis Translate this page ORPHANET. ORPHANET database access. amyloidosis. Direct accessto details Alias Familial amyloid polyneuropathy. Home Page. http://www.orpha.net/static/GB/amyloidosis.html

ORPHANET database access Amyloidosis Direct access to details Alias : Home Page

65. EMedicine - Amyloidosis, Macular : Article By Sultan Al-khenaizan, MBBS, FRCPC amyloidosis, Macular amyloidosis is a generic term that signifies the abnormalextracellular tissue deposition of one of a family of biochemically unrelated http://www.emedicine.com/derm/topic18.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Metabolic Diseases Amyloidosis, Macular Last Updated: November 1, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: macular amyloidosis AUTHOR INFORMATION Section 1 of 8 Author Information Introduction Clinical Differentials ... Bibliography Author: Sultan Al-khenaizan, MBBS, FRCPC , Consulting Staff, Departments of Dermatology and Internal Medicine, King Fahad National Guard Hospital, Saudi Arabia Editor(s): C Lisa Kauffman, MD , Chief of Dermatology, Associate Professor, Departments of Internal Medicine and Pathology, Georgetown University Medical Center; Richard Vinson, MD , Chief, Department of Dermatology, William Beaumont Medical Center; Warren R Heymann, MD , Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey; Joel M Gelfand, MD

66. EMedicine - Amyloidosis, Overview : Article By Daniel R Jacobson, MD amyloidosis, Overview Amyloid diseases are secondary protein structure diseasesin which insoluble protein fibrils accumulate extracellularly. A amyloidosis. http://www.emedicine.com/med/topic3377.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Rheumatology Amyloidosis, Overview Last Updated: May 28, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: amyloid diseases, primary amyloidosis, secondary amyloidosis, myeloma-associated amyloidosis, familial amyloidosis, localized amyloidosis, senile amyloidosis, senile cardiac amyloidosis, light chain amyloidosis, AL, familial amyloid polyneuropathy, transport protein transthyretin, TTR, ATTR, systemic amyloidosis, A amyloidosis, AA, heavy chain amyloidosis, AH, beta -microglobulin amyloidosis, A b M, familial renal amyloidosis, apolipoprotein AI amyloidosis, AapoAI, fibrinogen amyloidosis, AFib, lysozyme amyloidosis, ALys, apolipoprotein AII amyloidosis, AapoAII, beta protein amyloid, A b , prion protein amyloidosis, APrP, cystatin C amyloidosis, ACys, gelsolin amyloidosis, AGel, atrial natriuretic factor amyloidosis, AANF, keratoepithelin amyloidosis, AKE, lactoferrin amyloidosis, ALac, calcitonin amyloidosis, ACal, islet amyloid polypeptide amyloidosis, AIAPP, prolactin amyloid, Apro, keratin amyloid, Aker AUTHOR INFORMATION Section 1 of 11 Author Information Definition Of Amyloidosis Systemic Amyloidoses Hereditary Renal Amyloidoses ... Bibliography Author: Daniel R Jacobson, MD

67. Amyloidosis amyloidosis. amyloidosis is a progressive, incurable, metabolic disease characterizedby abnormal deposits of protein in one or more organs or body systems. http://www.hendrickhealth.org/healthy/000065.htm

MAIN SEARCH INDEX Amyloidosis Definition Description Causes and symptoms Diagnosis ... Resources Definition Amyloidosis is a progressive, incurable, metabolic disease characterized by abnormal deposits of protein in one or more organs or body systems. Description Amyloid proteins are manufactured by malfunctioning bone marrow. Amyloidosis, which occurs when accumulated amyloid deposits impair normal body function, can cause organ failure or death . It is a rare disease, occurring in about eight of every 1,000,000 people. It affects males and females equally and usually develops after the age of 40. At least 15 types of amyloidosis have been identified. Each one is associated with deposits of a different kind of protein. Types of amyloidosis The major forms of this disease are primary systemic, secondary, and familial or hereditary amyloidosis. There is also another form of amyloidosis associated with Alzheimer's disease Primary systemic amyloidosis usually develops between the ages of 50 and 60. With about 2,000 new cases diagnosed annually, primary systemic amyloidosis is the most common form of this disease in the United States. Also known as light-chain-related amyloidosis, it may also occur in association with multiple myeloma (bone marrow cancer Secondary amyloidosis is a result of chronic infection or inflammatory disease. It is often associated with:

68. Amyloidosis - Bone Marrow Transplant Center - Rush Cancer Institute Learn about amyloidosis, a disorder associated with cancer, and about bone marrowtransplant as a treatment for amyloidosis. amyloidosis. About amyloidosis http://www.bone-marrow-transplant.org/cancer-treatment/amyloidosis.html

Amyloidosis About Amyloidosis Amyloidosis is a group of diseases in which one or more organ systems in the body accumulates deposits of abnormal proteins. Although amyloidosis is not cancer, it is a very serious condition. There are three major types of amyloidosis: primary, secondary and familial. Secondary amyloidosis is caused by a chronic infection or inflammatory disease such as rheumatoid arthritis, familial Mediterranean fever, osteomyelitis or granulomatous ileitis. The deposits in this type of the disease are made up of a protein called the AA protein. Medical or surgical treatment of the underlying chronic infection or inflammatory disease can slow or stop the progression of this type of amyloid. Familial amyloidosis is inherited and is a rare form of the disease that is found in families of nearly every ethnic background. Treatment for Amyloidosis At the Rush Bone Marrow Transplant Center, we recommend treatment with high-dose melphalan as early in the disease course as possible for patients meeting specific criteria. Outpatient bone marrow transplants (OPTion) and immunotransplantation are also options for some patients.

69. Amyloidosis Network International, Inc. amyloidosis Network International, Inc. Contact Information amyloidosis NetworkInternational, Inc. 7118 Cole Creek Drive Houston , TX 770921421. http://www.4woman.gov/nwhic/references/mdreferrals/ani.htm

Search our database by Health Topic or enter your own keywords Amyloidosis Network International, Inc. Contact Information Amyloidosis Network International, Inc. 7118 Cole Creek Drive Houston , TX 77092-1421 Internet Resources http://www.amyloidosis.org/index.html (1-888) AMYLOID Mission Statement The Network's primary function is to link those affected by amyloidosis for further support and to educate the public and professionals so that the disease will be recognized and appropriately treated. Major Focus Areas AUTOIMMUNE DISEASES AND DISORDERS Minor Focus Areas PHYSICIAN REFERRALS Home About Us Contact Us Site Index ... Contact NWHIC or call 1-800-994-WOMAN NWHIC is a service of the U.S. Department of Health and Human Services' Office on Women's Health

70. Amyloidosis eventually causes renal failure. The disease I am referring to isamyloidosis, simply known as kidney failure. There are no tests http://www.chi-kuan-sharpei.com/Amyloidosis.htm

If you are thumbing through the internet looking for a Shar-Pei puppy, I am sure you are very excited. You look at the cute puppy pictures and you want to buy them all. But, before you dash out to pick up your new "couch companion" or "prospective show dog," let me have just a few moments of your time to help you make a wise choice (of both breeder and dog). The Chinese Shar-Pei came to this country with nothing but the wrinkles on it's back. There's no telling exactly where the original "dozen" came from but it was finally a step away from extinction. Within five years of their arrival, the breed mushroomed to nearly 20,000 thanks to people trying to make a fast buck on a "rarity" with no regard for health, temperament, or quality. If it looked like a Shar-Pei and was registered, then it must have been breedable. It didn't matter if it had allergies, skin problems, bad hips, and/or questionable temperament...the attitude was "BREED IT and pocket millions!" As the years went by, the breed clearly became a "medical nightmare." With the profiteers gone, Shar-Pei breeders truly interested in the welfare of the breed picked up the pieces and tried to repair the damage done out of greed and ignorance. It has been a long, uphill battle and progress was being made until the breed was again hit with a devastating illness...an illness that strikes without warning and eventually causes renal failure. The disease I am referring to is AMYLOIDOSIS, simply known as kidney failure.

71. Diagnosis And Therapy Of Systemic Amyloidosis Diagnosis and therapy of systemic amyloidosis. Sakalová, A. 1 Rovenský,J. 2 , Škultétyová, D. 3 , Škultéty, J. 4 , Mistrík http://www.mucos.cz/eng/reuma/dtsa_en.html

Diagnosis and therapy of systemic amyloidosis Sakalová, A. Rovenský, J. , Škultétyová, D. , Škultéty, J. , Mistrík, M. , Šteruská, M. , Hrubiško, M. Slov. Postgrad. Med. Inst. and University Hospital, Bratislava Research Inst. of Rheumatic Dis., Pieš Nat. Inst. of Cardiovascul. Dis., Bratislava Dept. of Surgery, University Hosp., Bratislava Journal of Health Management and Public Health (2000): 5(4), 32 – 43. Abstract: A survey of the pathogenesis, diagnostics and treatment of amyloidosis is presented, illustrated by long-term clinical experience with the treatment of 28 patients with primary amyloidosis, 4 patients with familiar and 12 patients with secondary amyloidosis. To all patients combined treatment by glucocorticoids and cytostatics was administered. For primary amyloidosis methylprednisolone, vincristine, cyclophosphamide, alkeran, chlorethylnitrosourea (VBMCP or MOCCA), and in secondary amyloidosis chlophosphamide, vincristine, prednisone (CVP). In all patients this treatment was combined with DMSO i.v. (5g/100ml saline) for 3-5 days preceding cytostatics. All patients received a combination of proteolytic enzymes (WOBE - MUGOS). In primary amyloidosis the median of survival was 48 months, in secondary amyloidosis 72 months, with response rates 75-80% and clinical remissions median 28 months for AA and 20 months for AL. The authors emphasize the need of early diagnosis and start of combined treatment complemented in recent years successfully with immunomodulatory treatment by hydrolytic enzymes (WOBE - MUGOS).

72. Treatment Of Amyloidosis, Mayo Clinic In Rochester, Minn. Treatment of amyloidosis at Mayo Clinic in Rochester. Amyloid serious. Itmay be disabling or lifethreatening. How is amyloidosis diagnosed? http://www.mayoclinic.org/amyloidosis-rst/

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Amyloidosis Amyloidosis Treatment Disease Characteristics Lifestyle Management Appointments ... Medical Services Treatment of Amyloidosis at Mayo Clinic in Rochester Amyloid (pronounced am'-i-loyd) is an abnormal protein that may be deposited in your body's tissues or organs. This abnormal protein comes from cells in your bone marrow. Amyloidosis (pronounced am-i-loy-do'-sis) results when enough amyloid protein builds up in one or more organs to cause the organ(s) to malfunction. The heart, kidneys, nervous system, and gastrointestinal tract are most often affected. Amyloidosis is a disease of the bone marrow. Your bone marrow makes protective antibodies. Antibodies are proteins that protect you against infection and disease. After they have served their function, these antibodies are broken down and recycled by your body. In amyloidosis, cells in the bone marrow produce antibodies that cannot be broken down. These antibodies then begin to build up in the bloodstream. Ultimately, they leave the bloodstream and can deposit in your tissues as amyloid. Cases of amyloidosis were described 350 years ago. The name "amyloidosis" was first used more than 100 years ago. Only within the past 20 years have physicians understood the specific makeup and structure of amyloid protein. Active research on amyloidosis is under way at Mayo Clinic.

73. NORD - National Organization For Rare Disorders, Inc. amyloidosis. Copyright 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992,1995, 1996, 1997, 1998, 1999, 2001, 2002, 2003 Synonyms of amyloidosis http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Amyloidosis

74. Amyloidosis amyloidosis. amyloidosis Network. 602 Bernard Street. Wassau, WI 54401. HomeHotLines Resources Printed Guide Child Care for the '90's Links. http://www.childhealthinfo.com/amyloidosis.htm

AMYLOIDOSIS Amyloidosis Network 602 Bernard Street Wassau, WI 54401 [Home] [Printed Guide] [Child Care for the '90's] [Links] ... MoreInfo@ChildHealthInfo.com

75. Amyloidosis - Macular - 1 Dept. of Dermatology University of Iowa College of Medicine. amyloidosis- Macular - Left Infrascapular Back. Return to Image Index page. http://tray.dermatology.uiowa.edu/Amyloid-mac001.htm

Dept. of Dermatology - University of Iowa College of Medicine Amyloidosis - Macular - Left Infrascapular Back Return to Image Index page. Return to Image Index page. Return to Dermatology's Home page. September, 1995

76. Amyloidosis amyloidosis is an umbrella term that describes diseases caused by abnormaldeposits in the body of the protein amyloid. amyloidosis. http://www.disability.vic.gov.au/dsonline/dsarticles.nsf/pages/Amyloidosis?opend

77. Return To Medformation Welcome Page Return To Medformation Home amyloidosis is a group of diseases in which amyloid—a proteinlikesubstance—builds up in the organs and tissues. The buildup http://www.medformation.com/mf/CAM.nsf/consconditions/Amyloidosiscc.html

Advanced Search [Pick a topic] Adult Medications Patient Educ. Pediatric Sports Med. Women class clinic doctor hospital job pharmacy support group Which power plant pollutant is not designated as hazardous to human health by the EPA? carbon dioxide carbon monoxide lead nitrogen oxide sulfer oxide We subscribe to the HONcode principles. Verify here Alternative Medicine Indexes: Conditions Herbs Supplements Drugs ... Send to a Friend Amyloidosis Signs and Symptoms What Causes It? Who's Most At Risk? What to Expect at Your Provider's Office ... Supporting Research There are four major types of systemic amyloidosis: Primary amyloidosis (the most common form), typically caused by a buildup of fragments of antibody proteins Hereditary amyloidosis, a genetic form passed down in families Reactive or secondary amyloidosis, which develops along with a chronic inflammatory disease, such as rheumatoid arthritis Beta -microglobulin is a protein that can build up in the blood as a result of kidney failure. This type of amyloidosis occurs in people who have been on dialysis for a long time. Amyloid deposits can affect any organ or tissue. Localized amyloidosis affects more than 90% of people with Type II diabetes mellitus, people with certain cancers of the thyroid or other tumors of the endocrine system, and about 80% of people over age 80. It also affects people with conditions such as Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage, and the disease commonly known as "mad cow disease."

78. Cardiovascular Pathology myocardial fibers. This is characteristic for amyloid. amyloidosis isa cause for infiltrative or restrictive cardiomyopathy. It is http://medlib.med.utah.edu/WebPath/CVHTML/CV072.html

This section of myocardium demonstrates amorphous deposits of pale pink material between myocardial fibers. This is characteristic for amyloid. Amyloidosis is a cause for "infiltrative" or "restrictive" cardiomyopathy. It is a nightmare for anesthesiologists when intractable arrhythmias occur during surgery on such patients.

79. Renal Pathology Here is a chronic renal disease that may actually increase the sizeof the kidney. This is amyloidosis. Pale deposits of amyloid http://medlib.med.utah.edu/WebPath/RENAHTML/RENAL025.html

Here is a chronic renal disease that may actually increase the size of the kidney. This is amyloidosis. Pale deposits of amyloid are present in the cortex, most prominently at the upper center.

80. IMF (UK) - AL Amyloidosis http://www.myeloma.org.uk/frmsets/fsal.htm

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