1. ALS Association Information about this nonprofit health organization that is dedicated solely to the fight against amyotrophic lateral sclerosis, Lou Gehrigs Disease. http://www.alsa.org/

Request for Application for Rare Diseases Clinical Research Network Potential Role of Peripherin in Motor Neuron Degeneration Campaign Reaches $10 Million Milestone Axonal Transport Alterations Play a Key Role in Motor Neuron Degeneration ... Help Us Help You The ALS Association National Office: 27001 Agoura Road, Suite 150, Calabasas Hills, CA 91301, Tel: (818) 880-9007 The information contained on this web site may not be published, broadcast or otherwise distributed without the prior written authorization of The ALS Association. ALSA Webmaster

2. NINDS Amyotrophic Lateral Sclerosis Information Page ALS or Lou Gehrig's disease information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/amyotrophiclateralsclerosi

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Amyotrophic Lateral Sclerosis Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Amyotrophic Lateral Sclerosis Information Page Synonym(s): Lou Gehrig's Disease Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Amyotrophic Lateral Sclerosis? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Amyotrophic Lateral Sclerosis? Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a progressive, fatal neurological disease affecting as many as 20,000 Americans with 5,000 new cases occurring in the United States each year. The disorder belongs to a class of disorders known as motor neuron diseases. ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. ALS manifests itself in different ways, depending on which muscles weaken first. Symptoms may include tripping and falling, loss of motor control in hands and arms, difficulty speaking, swallowing and/or breathing, persistent fatigue, and twitching and cramping, sometimes quite severely. ALS strikes in mid-life. Men are about one-and-a-half times more likely to have the disease as women.

3. Amyotrophic Lateral Sclerosis Fact Sheet A fact sheet about symptoms, diagnosis, treatment, and research on ALS, Motor Neuron Disease, or Lou Gehrig's Disease from the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/pubs/als.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Amyotrophic Lateral Sclerosis Fact Sheet Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents What is amyotrophic lateral sclerosis? Who gets ALS? What are the symptoms? How is ALS diagnosed? ... Where can I find more information? What is amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. The disease belongs to a group of disorders known as motor neuron diseases

4. Amyotrophic Lateral Sclerosis Lou Gehrig's Disease - March 15, 1999 amyotrophic lateral sclerosis (ALS), commonly called Lou Gehrig's disease, is a progressive neuromuscular condition http://www.aafp.org/afp/990315ap/1489.html

Advanced Search Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease ANNE D. WALLING, M.D. University of Kansas School of Medicine Wichita, Kansas A myotrophic lateral sclerosis (ALS) was first described in 1869. It is frequently referred to as "Lou Gehrig's disease" in memory of the famous baseball player who died of ALS in 1941. ALS is defined as adult-onset, idiopathic, progressive degeneration of anterior horn cells and upper and lower motor neurons resulting in progressive muscle weakness, wasting and fasciculations. The clinical picture varies, depending on the location and progression of the pathologic changes. Diagnostic criteria of the World Federation of Neurology (the "El Escorial criteria") can help define and classify ALS ( Table 1 Illustrative Case 1 Bulbar Form Relatives of a 61-year-old woman reported that she appeared to have difficulty concentrating during long discussions. Apart from longstanding thyroid and estrogen supplementation, her medical history was unremarkable. Review of systems, a mental status examination and a physical assessment were normal. The patient was a psychologist who usually read several books a week and had an active social life, including competitive bridge and vigorous daily exercise. She had no symptoms of depression, or mental or intellectual difficulties, and denied alcohol or substance abuse. She believed her family's concerns were unwarranted but eventually conceded that her voice "just wore out" during prolonged conversations.

5. World Federation Of Neurology Amyotrophic Lateral Sclerosis Click to go to World Federation of Neurology website World Federationof Neurology amyotrophic lateral sclerosis. MND upcoming meetings http://www.wfnals.org/

World Federation of Neurology Amyotrophic Lateral Sclerosis This web site is sponsored by the World Federation of Neurology Research Group on Motor Neuron Diseases to link researchers and clinicians worldwide with the goal of finding effective treatment and a cure for ALS. What's New Guidelines (posted 09 Mar 2003) - the Association of British Neurologists Clinical Guidelines have been added. Clinics (posted 09 Mar 2003) - King's Motor Neurone Disease (MND) Care and Research Centre now has a website. Some areas of the website are still under construction as the Website Management Committee takes this opportunity to fully review the site's content. However, the old site is largely intact to find those items that have not yet made it to the new site. If our new site is not displaying in a legible manner, you may need to upgrade your browser ( Internet Explorer Opera For Your Information About the WFN Research Group on Motor Neuron Diseases including membership and the journal. This site was generously initiated by the Henry M. Unger Family Foundation

6. ALS Society Of Canada amyotrophic lateral sclerosis, ALS, is also known as MND, or motor neurone disease. With detailed descriptions of the disease and a FAQ. http://www.als.ca/

Recommend This Page Survey/ Your Comments ALS Events Across Canada ... International Alliance of ALS/MND Associations The ALS Society of Canada, a national voluntary organization, is committed to: supporting research towards a cure for ALS supporting ALS Partners in their provision of quality care for persons affected by ALS The ALS Society of Canada endeavors to provide relevant and current information about ALS in an easy to understand format, much of it may be downloaded from this site. click here for the latest ALS headlines click here for related ALS news Voice Box and Flute Sarah Green along with husband Paul and family have shared their story about living with ALS on the CBC on OUTFRONT , the Real Audio recording is available here The Rev'd Chris Vais, who died of ALS in June of this year wrote his final edition of For Words: A Journal of Hope and Healing shortly before his death. His reflections on living with ALS have had a wide audience. With the kind permission of Susan and Clare Vais and the Presbyterian Record, we share it with the wider ALS network in Canada. Other issues of For Words can be found by clicking here , there is also a CBC article located here Catch a glimpse of the Symposium!

7. ALS Survival Guide - Amyotrophic Lateral Sclerosis - Lou Gehrig's Disease amyotrophic lateral sclerosis. Contents of this page http://www.lougehrigsdisease.net/

Offering hope to people with Amyotrophic Lateral Sclerosis [ Home ] What is ALS? ALS News Causes of ALS Vital Stats ... www.alssurvivalguide.com and www.lougehrigsdisease.net ALS can conquer the body but not the mind and the spirit! Stay strong in your hearts dear PALS. This website is dedicated to the loving memory of Douglas Edwin Eshleman, who lost his battle with ALS on Wednesday, November 28, 2001. Thank you for all your thoughts and prayers during this difficult time. The Discuss ALS Forum has been graciously continued by PALS Patrick Madigan. Click here to go to DiscussALS.com What is New? Second Annual Walk to d'feet ALS raises over $216,000. 11-25-01 Doug's last Journal entry. What is ALS? STARTING POINT: Do you want quick answers about ALS? Have you or someone you know been recently diagnosed with ALS?

8. Les Turner ALS Foundation Home Page The nation's largest, independent amyotrophic lateral sclerosis (ALS) organization devoted to raising money for research, patient services and educational materials and to maintaining quality of life for every person with Lou Gehrig's disease. http://www.lesturnerals.org/

Les Turner Amyotrophic Lateral Sclerosis Foundation, Ltd. Donate What is ALS? Research About the Foundation ... Contact us "Hope Through Caring" The Les Turner ALS Foundation is the nation's largest independent publicly supported non-profit organization devoted to the treatment and elimination of amyotrophic lateral sclerosis (ALS), better known as Lou Gehrig's disease. The Foundation supports the ALS community in Chicago and its suburbs and is affiliated with Northwestern University's Feinberg School of Medicine. For more information, please contact us at info@lesturnerals.org Les Turner Foundation 8142 North Lawndale Avenue Skokie, IL 60076-3322 888-ALS-1107 (toll-free) Fax: 847-679-9109 This web site supported through generous grants from: This site last updated on March 28, 2003.

9. Amyotrophic Lateral Sclerosis - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/cache/-268042240.htm

amyotrophic lateral sclerosis This is a form of motor neurone disease (MND). It is the most common form of MND and accounts for 65% to 85% of all cases of MND (1). Amyotrophic lateral sclerosis results from lesions to the corticospinal tract and the anterior horn cells and produces the characteristic feature of tonic atrophy - brisk reflexes and fasciculations. This form of the disease includes Progressive Bulbar Palsy (1). Corticospinal tract degeneration in the absence of significant muscle wasting may be referred to as primary lateral sclerosis. Click here for more information...

10. MEDLINEplus: Amyotrophic Lateral Sclerosis Topics. amyotrophic lateral sclerosis. Contents Statistics. Search MEDLINEfor recent research articles on • amyotrophic lateral sclerosis. You http://www.nlm.nih.gov/medlineplus/amyotrophiclateralsclerosis.html

Skip navigation Other health topics: A B C D ... List of All Topics Amyotrophic Lateral Sclerosis Contents of this page: News From the NIH General/Overviews Coping ... Statistics Search MEDLINE for recent research articles on Amyotrophic Lateral Sclerosis You may also be interested in these MEDLINEplus related pages: Brain and Nervous System Latest News Doubling Up: Researchers Combine a Common Dietary Supplement with an Antibiotic to Treat Lou Gehrig's Disease (01/31/2003, National Institute of Neurological Disorders and Stroke) From the National Institutes of Health Amyotrophic Lateral Sclerosis (ALS) (National Institute of Neurological Disorders and Stroke) Also available in: Spanish General/Overviews Amyotrophic Lateral Sclerosis (Patient Education Institute) - - requires Flash plug-in Also available in: Spanish Amyotrophic Lateral Sclerosis (American Speech-Language-Hearing Association) Facts About Amyotrophic Lateral Sclerosis (ALS) (Muscular Dystrophy Association) Clinical Trials ClinicalTrials.gov: Amyotrophic Lateral Sclerosis (National Institutes of Health) Active Neuromuscular Clinical Trials and Studies Selective Listing (Muscular Dystrophy Association) Coping For Caregivers (ALS Association) Patient Bill of Rights for People Living With ALS (ALS Association) Reasons for Living with ALS (ALS Association) Diagnosis/Symptoms Creatine Kinase Test (Muscular Dystrophy Association) Electromyography and Nerve Conduction Velocities (Muscular Dystrophy Association) Research Amyotrophic Lateral Sclerosis (National Center for Biotechnology Information)

11. Mycoplasma Information on the role of mycoplasma infections within amyotrophic lateral sclerosis. http://www.goulburn.net.au/~shack/mycoplasma.htm

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12. MEDLINEplus Medical Encyclopedia: Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis. amyotrophic lateral sclerosis is causedby progressive loss of motor nerves in the spinal cord and brain. http://www.nlm.nih.gov/medlineplus/ency/article/000688.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Amyotrophic lateral sclerosis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top Lou Gehrig's disease; ALS Definition Return to top A disease of the motor nerve cells in the brain and spinal cord, causing progressive loss of motor control. Causes, incidence, and risk factors Return to top Amyotrophic Lateral Sclerosis is caused by progressive loss of motor nerves in the spinal cord and brain. In about 10% of cases, ALS is caused by a genetic defect. In other cases, the cause of the nerve deterioration is unknown. ALS affects approximately 1 out of 100,000 people. Except for having a family member affected with the hereditary form of the disease, there are no known risk factors. Symptoms Return to top Symptoms usually do not develop until until after age 50. Progressive loss of muscle strength and coordination eventually interfere with the ability to perform routine activities, such as going up steps, getting out of a chair, or swallowing. Occasionally, breathing or swallowing muscles may be the first to be affected. As the disease progresses, more muscle groups are affected and patients become progressively incapacitated. There is no effect on the ability to think or reason.

13. Winning Over Lou Gehrig's Disease A man uses Cayce's remedies to reverse the debilitation brought by amyotrophic lateral sclerosis (ALS). http://members.tripod.com/~dudley_delany/index-102.html

Get Five DVDs for $.49 each. Join now. Tell me when this page is updated WINNING OVER LOU GEHRIG'S DISEASE By A. Robert Smith In 1991, David Atkinson was told by his doctor that he had amyotrophic lateral sclerosis (ALS) and there was nothing that could be done to overcome it. A star football player, pole vaulter, and boxer in his youth, a businessman with five children from two marriages, he has led the vigorous life of an entrepreneur, including operating his own shrimp boat and his own furniture manufacturing firm. Atkinson was accustomed to succeeding, and he challenged his unpromising medical prognosis. But nothing worked until his daughter introduced him to the Edgar Cayce holistic healing remedies. The results have been amazingly successful. He was interviewed at his home in Salisbury, North Carolina, on August 14, 1994, by Venture Inward editor A. Robert Smith. (Smith) How did it begin? (Atkinson) In the spring of 1991, my wife Wendy and I had decided to move from Wilmington, North Carolina to Florida. About a week before we were to go, I started having difficulty with my neckthe muscles were giving way. I noticed it when I was cutting the grass. My head flopped down on my chest. I went inside and rested for a while, but when I went out in the heat it happened again. And it got worse. I was starting to have trouble swallowing, and eating, and chewing. I decided to see a doctor before we left for Florida. Of course, we didn't consider that it was anything serious. After a series of tests, examinations, and biopsies, I was diagnosed with motor neuron disease, which is the European term for amyotrophic lateral sclerosis, ALS, or Lou Gehrig's disease. The doctor gave us some literature to read, and we were really devastated when we found out what it was all about. The medical literature explained that

14. Welcome To TriOne Held in Alameda in the San Francisco Bay area in August. TriOne is a nonprofit triathlon with all proceeds directly benefiting ALS (amyotrophic lateral sclerosis) research. ALS is more commonly known as Lou Gehrigs Disease. http://www.trione.org/

15. WWW.ALS-MA.ORG Statewide amyotrophic lateral sclerosis group; information on disease, services, and newsletter. http://www.als-ma.org/

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16. Boulianne Lab. The Hospital For Sick Children. Toronto, Ontario, Canada. My laboratory has been using genetic techniques available in Drosophila to study the development and the function of the nervous system. We have developed models of aging and human neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimers Disease (AD). From the University of Toronto (Canada). http://www.utoronto.ca/gboullab/

Program in Developmental Biology Hospital for Sick Children Gabrielle Boulianne Staff Alumni Research ... Links University of Toronto Mail comments, questions and suggestions to jamie.hughes@utoronto.ca Last updated January 6, 2003 Hospital for Sick Children

17. Amyotrophic Lateral Sclerosis (ALS) (aka Lou Gehrig's Disease) | MDA Muscular Dystrophy Association the largest contributor to ALS research and support.Category Health Conditions and Diseases......amyotrophic lateral sclerosis (ALS) (Also known as Lou Gehrig's Disease)Click for Materials En Español and MDAchats. Bookmark this page! http://www.mdausa.org/disease/als.html

Amyotrophic Lateral Sclerosis (ALS) (Also known as Lou Gehrig's Disease) Click for and MDAchats Bookmark this page! It's your source for information and news about ALS and will be updated regularly. Quick Definition: Adulthood. Generalized weakness and muscle wasting with cramps and muscle twitches common. ALS first affects legs, arms and/or throat muscles. Usually progresses rapidly with 3 to 5 year average survival. Autosomal dominant, autosomal recessive. Find Your Local MDA Do you need to find MDA in your city? Enter your Zip code here for where to turn for clinics and medical services; support groups; summer camp; local events and volunteer and fund-raising opportunities close to home. For more articles and references, please use the search feature Basic References Special ALS Materials FAQ's and Simply Stated Articles ... News Releases Basic References Facts About ALS "Ask the Experts" Responses about ALS: Diagnosis, Symptoms and Treatments Diseases Related or Often Confused With ALS General Neuromuscular Questions Genetics and Neuromuscular Diseases ... General Interest Publications Special ALS Materials ‘How the MDA Clinic can make a difference’ ALS Fall Conference with Dr. Bradley - Part 1

18. Edgar Cayce's Treatment For Amyotrophic Lateral Sclerosis A brief introduction to his approach to treating amyotrophic lateral sclerosis. Includes several testimonials and a link to a Cayce forum. http://members.tripod.com/~dudley_delany/index-10.html

Get Five DVDs for $.49 each. Join now. Tell me when this page is updated EDGAR CAYCE'S TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS Greetings! This website is about amyotrophic lateral sclerosis (ALS). However, as an important preliminary, let me first tell you about my experience with multiple sclerosis (MS). I am a retired chiropractor, massage therapist, and registered nurse. I developed multiple sclerosis during the summer of 1991. Some of my symptoms included numbness, blurred vision, difficulty swallowing, tremors, muscle spasms, depression, fatigue, failing memory, slurred speech, and bladder dysfunction. In the fall of 1991, I began using an alternative treatment for MS suggested by the late Edgar Cayce, a mild-mannered photographer who lived between 1877 and 1945, and who is today widely regarded as the father of modern holistic medicine. At the age of twenty-one, Cayce developed the amazing ability to enter into a self-induced hypnotic trance in which he could successfully diagnose and prescribe effective treatments (often drawing from diverse health disciplines) for all manner of human illsincluding MS. Over 14,000 of his trance discourses (which came to be known as "readings") were transcribed verbatim and are currently available for inspection and study at the Association for Research and Enlightenment (A.R.E.) in Virginia Beach, Virginia.

19. (ALS-TDF) ALS Therapy Development Foundation Dedicated to finding therapies for amyotrophic lateral sclerosis. Contains descriptions of the disease and the foundation. http://www.als-tdf.org/

Provide Site Feedback December Drug Update Research Digest FAQ ... ALS THERAPY DEVELOPMENT FOUNDATION AND ROBERT PACKARD CENTER FOR ALS RESEARCH RECEIVE FUNDING FOR COLLABORATIVE RESEARCH The ALS Therapy Development Foundation (ALS-TDF) today announced a grant from the ALS Marathon Team to fund collaborative projects with the Robert Packard Center for ALS Research at Johns Hopkins University. The grant funds joint research and pre-clinical projects between the two organizations to accelerate the development of new treatments for Lou Gehrig's disease (ALS)... [READ THE FULL PRESS RELEASE] ALS THERAPY DEVELOPMENT FOUNDATION AWARDS GRANT TO IMPROVE CLINICAL TRIAL MANAGEMENT IN ALS The ALS Therapy Development Foundation (ALS-TDF) announced that it has awarded a grant to the Neurology Clinical Trials Unit at the Massachusetts General Hospital (MGH) to advance clinical trial design in Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease)... [READ THE FULL PRESS RELEASE] Treatment Investigation Update: Umbilical Cord/Placental Cell Infusion (Cord Blood) As the ALS-TDF research team works to facilitate and support a clinical trial of umbilical cord/placental cell infusion in ALS, we have been monitoring the experience of ALS patients treated with infusions of human umbilical cord/placenta blood cells at two locations in the US...

20. Facts About ALS | MDA Publications New 4/02 Facts About amyotrophic lateral sclerosis (ALS) MuscularDystrophy Association. WHAT IS amyotrophic lateral sclerosis? ALS http://www.mdausa.org/publications/fa-als.html

New 4/02 Facts About Amyotrophic Lateral Sclerosis (ALS) Muscular Dystrophy Association Introduction What is Amyotrophic Lateral Sclerosis? What Happens to Someone With ALS? What Happens to the Nervous System in ALS? ... MDA Is Here to Help You Dear Friends : When I learned in 1994 that I had amyotrophic lateral sclerosis, my world changed. I was in my early 50s, had a good career with the U.S. Small Business Administration, and was a husband and father. Suddenly, I faced a serious disease that would affect every aspect of my life. Glenn Harwood I decided my best weapon in this battle would be attitude. I've met every challenge ALS has presented with an approach that's unbeatable: I can do it, I will do it. With that conviction, I have a full and rewarding life with the help of a power wheelchair, a voice synthesizer and lots of e-mail. I've continued working, traveling and learning. I have wonderful allies in this fight: a fantastic family, including my wife, Fran, our two children and two beautiful grandchildren, who give me all the help I need and great joy and purpose. My faith in God never fails me, and helps me keep going with hope. I've also honed my sense of humor. I carry a page of jokes with me at all times and regularly e-mail friends across the country with "My Sunday Bulletin," a compendium of jokes I collect from my e-mail friends. My motto is "Can't Walk or Talk But Can Always Laugh."

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