61. Health Care Information Resources Canavan Disease Links canavan disease Links. For resource. canavan disease Canavan Foundationcanavan disease often attacks children in Ashkenazi Jewish families; http://www-hsl.mcmaster.ca/tomflem/canavan.html

The address of this page is: http://hsl.mcmaster.ca/tomflem/canavan.html Canavan Disease Links For more information, see: Genetic conditions , also in the Illness section of this resource. For more information, see: Leukodystrophies , also in the Illness section of this resource. Canavan disease - Canavan Foundation Canavan disease often attacks children in Ashkenazi Jewish families Canavan disease - Canavan Disease from the University of Pittsburgh Department of Human Genetics Canavan disease - Canavan Research Fund Canavan disease - Canavan Disease Canavan disease - Canavan Research Illinois raising awareness, supporting research and networking Please read

62. Canavan's Disease Canavan's Disease. canavan disease; Statement on Carrier Testing for canavan disease;GAUCHER DISEASE FAQ; canavan disease; canavan disease; What is canavan disease? http://www.bdid.com/canavan.htm

HOME Canavan's Disease Canavan Disease Statement on Carrier Testing for Canavan Disease GAUCHER DISEASE FAQ Canavan Disease ... HOME

63. Canavan Disease Valid XHTML 1.0! canavan disease. heading, What is canavan disease ? Canavandisease (CD) is an inherited (genetic) disease. Who gets canavan disease ? http://www.palmslab.com.au/Education/Genetics/canavan.shtml

Canavan Disease What is Canavan disease ? Canavan disease (CD) is an inherited (genetic) disease. It occurs due to a deficiency of the enzyme called Aspartoacylase, since the gene which usually tells the body to produce this enzyme is faulty. Babies are born apparently unaffected. At 2 to 4 months of age, he/she develops poor head control and seizures. Other symptoms are observed before the age of 6 months such as loss of grasping reflex, smiling and increased head circumference. Death usually occurs before 36 months. Who gets Canavan disease ? Genetic diseases are often more common in specific community groups. CD is most common amongst descendants of Central and Eastern European (Ashkenazi) Jews. What causes Canavan disease ? Canavan disease is a disease caused by inheriting a 'double-dose' of a faulty in a gene (called ASPA) which codes for Aspartoacylase. Every person has two copies of this gene in each cell of their body. A person will only be affected by CD if s/he has a mutation in both copies of the ASPA gene. This can only happen if one faulty copy is inherited from each parent. One in every 40 Ashkenazi Jews carries one copy of the faulty gene and one regular copy of the gene. In the general population, however, only about one in 300 people carry a faulty copy of the ASPA gene. Carriers themselves are not affected by the disease.

64. Canavan Disease canavan disease. Canavan Foundation. canavan disease. Canavan Research Foundation dedicated to finding a cure by raising funds for medical research. http://www.ability.org.uk/Canavan_Disease.html

Our Aims Services Stats ... Z Canavan Disease Canavan Foundation Canavan Disease Canavan Research Foundation - dedicated to finding a cure by raising funds for medical research. Canavan Foundation What Every Family Should Know Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

65. CCHS Clinical Digital Library canavan disease Clinical Resources. CliniWeb Homepage (includes links totargeted PubMed MEDLINE searches) canavan disease List of documents. http://cchs-dl.slis.ua.edu/clinical/metabolism/inborn/lipid/leukodystrophies/can

Clinical Resources by Topic: Metabolic Disorders Canavan Disease Clinical Resources Pediatrics Radiology Pathology Genetics ... Miscellaneous Resources See also: Genetic Testing Clinical Resources General Genetic Disorders Clinical Resources General Metabolic Disorders Clinical Resources Canavan Disease Patient/Family Resources MD Consult Reference Books: Table of contents Health Sciences Library subscription INFO All MD Consult Reference Books for Neurology (eMedicine): Table of contents Inherited Metabolic Disorders: Access document CliniWeb: Homepage (includes links to targeted PubMed MEDLINE searches) Canavan Disease: List of documents Pediatrics Resources See also General Pediatrics Resources Behrman: Nelson Textbook of Pediatrics 16th Ed.-2000 (MD Consult): Table of contents Health Sciences Library subscription INFO Chapter 81 - An Approach to Inborn Errors: Access document Neonatal Period: Access document Children after the Neonatal Period Access document Chapter 82 - Defects in Metabolism of Amino Acids: Access document Aspartic Acid (Canavan Disease): Access document Pediatric Database (PEDBASE) List of documents Canavan's Disease: Access document Radiology Resources See also General Radiology Resources CHORUS-Collaborative Hypertext of Radiology: Homepage Musculoskeletal System: List of documents Spongy Degeneration (Canavan Disease): Access document Pathology Resources Cotran: Robbins Pathologic Basis of Disease 6th Ed.-1999 (MD Consult):

66. Qango : Health: Diseases And Conditions: C: Canavan Disease Qango Directory canavan disease all of Qango only this category Options Help.Home Health Diseases and Conditions C canavan disease, Suggest a Site. http://www.qango.com/dir/Health/Diseases_and_Conditions/C/Canavan_Disease/

Chat Forums Free Email Personals Classifieds ... Help Qango Directory Canavan Disease all of Qango only this category Options Help Home Health ... C > Canavan Disease Suggest a Site Health, etc If you would like to suggest a site for this category please click here Home Health Diseases and Conditions ... C > Canavan Disease Suggest a Site Home Suggest a Site Search ... Login

67. The Health Library — Nutritional & Metabolic canavan disease. canavan diseaseNINDS. canavan diseaseUniversity of PittsburghPDF. canavan diseaseNational TaySachs Allied Diseases Association. http://healthlibrary.stanford.edu/resources/internet/bodysystems/nutrition3.html

Diseases and Disorders Use these links to jump directly to your topic of interest: Caffeine Carbohydrates Fats Fiber ... Page 7 Vitamins Vitamin and Mineral Supplements:MEDLINEplus Vitamins:Harvard School of Public Health Vitamins:Aetna InteliHealth Antioxidants:MEDLINEplus ... The Vitamin Sourcebook:netLibrary Vitamin A Vitamin A and Carotenoids:NIH Clinical Center Vitamin A (Retinol):Mayo Clinic Beta Carotene:Mayo Clinic Vitamin A Deficiency:Merck Manual ... Vitamin A : Everything You Need to Know:netLibrary Vitamin B Complex, Biotin Biotin:Aetna InteliHealth Biotin Deficiency and Dependency:Merck Manual Vitamin B Complex, Cobalamin (B12) Vitamin B-12 (Cobalamin):Mayo Clinic Vitamin B12:NIH Clinical Center Vitamin B12 Deficiency, see Blood and Lymphatic Systems, Megaloblastic (Pernicious) Anemia Vitamin B Complex, Folic Acid (B9) Folic Acid:MEDLINEplus Folic Acid/Folate (Vitamin B-9):Mayo Clinic Folate:NIH Clinical Center See also Pregnancy and Childbirth, Nutrition and Pregnancy Vitamin B Complex, Niacin (B3) Niacin (Vitamin B-3):Mayo Clinic Niacin Deficiency:Merck Manual Pellagra:Hendrick Health System Vitamin B Complex, Pantothenic Acid Pantothenic Acid:Aetna InteliHealth Pantothenic Acid Deficiency:Merck Manual Vitamin B Complex, Pyridoxine (B6)

68. Canavan Disease Is In The Family Of Leukodystropies canavan disease is in the family of Leukodystropies. canavan disease isa rare genetic neurological disease. More prevalent in Ashkenazi http://nicholasbreedon.homestead.com/files/Awareness.htm

If you would like to HELP you can make donations to the Nicholas L. Breedon Trust or go to Links on the Home page and pick an organization of your choice. Nicholas L. Breedon Trust First Union Bank 2603 North Hiatus Road Cooper City, Florida 33026 Attn: Bruce Browar We would be happy to answer any questions you may have. You can reach us by E-mail on our Home page. HOME

69. JUF News And Public Affairs Chicago family leads fight against canavan disease. By Children with Canavandisease gradually lose motor and mental ability. Eventually http://www.juf.org/news_public_affairs/article.asp?key=3328

70. Canavan Disease canavan disease. Although canavan disease may occur in any ethnic group, itaffects persons of Eastern European Jewish ancestry more frequently. http://oci.mcw.edu/article/921391101.html

Search: search tips Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Canavan Disease Canavan disease is a rare, inherited, neurological disorder characterized by spongy degeneration of the brain (in which the white matter is replaced by microscopic fluid-filled spaces). Canavan disease is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath of the nerve fibers in the brain. The myelin sheath is the fatty covering surrounding nerve cells that acts as an insulator. Symptoms of Canavan disease, which appear in early infancy and progress rapidly, may include mental retardation, loss of previously acquired motor skills, feeding difficulties, abnormal muscle tone (i.e., floppiness or stiffness), poor head control, and megalocephaly (abnormally enlarged head). Paralysis, blindness, or hearing loss may also occur. Although Canavan disease may occur in any ethnic group, it affects persons of Eastern European Jewish ancestry more frequently. There is no cure for Canavan disease, nor is there a standard course of treatment. Treatment is symptomatic and supportive.

71. ClinicalTrials.gov - Linking Patients To Medical Research Search results for canavan disease ALLFIELDS are shown below. Show all trials,including those no longer recruiting patients. 1 study was found. http://www.clinicaltrials.gov/search/term=Canavan Disease

72. Canavan Disease - General Practice Notebook canavan disease. canavan disease is a severe form of leukodystrophycharacterised by a spongy degeneration of the white matter. It http://www.gpnotebook.co.uk/cache/-919273431.htm

Canavan disease Canavan disease is a severe form of leukodystrophy characterised by a spongy degeneration of the white matter. It is particularly prevalent in Ashkenazi Jews. The underlying defect is one of aspartoacylase deficiency. The clinical presentation is of progressive macrocephaly after a relatively normal first few months, with hypotonia, developmental delay and problems with swallowing becoming worse towards death, usually in the first decade of life. There is no treatment other than supportive measures. Diagnosis is using CT or MRI. Click here for more information...

73. BioExchange - Life Sciences And Biotechnology Resource For E-business Services, Nanogen Licenses Mutations Associated With canavan disease. http://www.bioexchange.com/news/news_page.cfm?id=15364

74. Canavan Disease canavan disease. The highly peculiar look of the head with a nearlyfootball shape to the upper skull, long from front to back makes http://www.pediatric-orthopedics.com/Topics/Muscle_Neuro/Diseases/CANAVAN_DISEAS

Canavan Disease The highly peculiar look of the head with a nearly football shape to the upper skull, long from front to back makes for easy recognition of the advanced cases of Canavan Disease. It is the early presentation usually before 8 weeks old that must differentiated. Hypotonia with decreased visual contact or use, with eyes that jiggle side to side and a rapidly expanding head size lead to neurologic studies. Meanwhile spastic muscle tone begins and progresses very severely. Studies show rapid loss of white matter of the brain. A defect in N-acetyl aspartic acid metabolism (with excess in the urine) is associated with failure of myelin - a lipid that wraps around much of the neural structures so that they can work properly. This disease is relentlessly progresive.

75. Institute For Science, Law And Technology canavan disease Lawsuit. The Greenbergs sought the advice of one specialist afteranother until six months later Jonathan was diagnosed with canavan disease. http://www.kentlaw.edu/islt/canavanupdate.html

INSTITUTE FOR SCIENCE, LAW AND TECHNOLOGY Canavan Disease Lawsuit Background Information on Greenberg v. Miami Children's Hospital, et al. Currrent Status: On July 8, 2002, Judge Gettleman transferred the case to the United States District Court for the Southern District of Florida, Miami Division, and denied Defendants' motion to dismiss. The case is assigned to Judge Federico Moreno, number 02-022244-CIV-MORENO. One of the parents named as a plaintiff in the lawsuit, Dan Greenberg and his wife, live outside of Chicago. Little did the Greenbergs know when their son Jonathan was born in 1981 that they would not only wage a losing battle to save their son's life, but that they would also be subjected to the secretive misappropriation of their son's physical essence: his genetic material. By the age of three months, the Greenbergs began to worry when Jonathan was unable to control his head, make eye contact, or put his hand to his mouth. The Greenbergs sought the advice of one specialist after another until six months later Jonathan was diagnosed with Canavan disease. Similar to Tay-Sachs disease, Canavan disease occurs most frequently in families of Ashkenazi Jewish decent and leads to a degeneration of the brain. The Greenbergs learned that this rare genetic disease had no known cure and that their son would never function past the developmental level of an infant for all of his short life and slowly succumb to the disease's degenerative effects. Children affected with Canavan can smile, look around and hear, but as the illness progresses, they often lose most of their vision and are prone to seizures and infection. They develop difficulty chewing and swallowing and most eventually require tube feeding. Though the children become less responsive over time, they are never totally unresponsive or in a coma. Life expectancy varies, but most do not reach their teen years.

76. Canavan Disease canavan disease. Denitza Blagev, Matthew Golkar, and Joshua Small,.Canavan 2). There are multiple ways of diagnosing canavan disease. http://endeavor.med.nyu.edu/student-org/ama/docs/mgb1999-2000/cd11.htm

77. CANAVAN DISEASE canavan disease. KeriAnne Brady, Jeffrey Cohen, Joy Hao and David Kiken. DiagnosticCriteria for canavan disease. There are several methods for diagnosing CD. http://endeavor.med.nyu.edu/student-org/ama/docs/mgb1999-2000/ab44.htm

78. Leukodystrophy Canavan Foundation Not-for-profit foundation providing informationabout canavan disease, prenatal screening, support, and reasearch. http://www.foundhealth.com/Health/Conditions_and_Diseases/L/Leukodystrophy/

Advertisement Foundhealth.com Search All Terms Any Term Tips Browse foundhealth.com Health calculators Fast Food Database Speakers Bureau How to evaluate sites Submit a site Contact us Home - main directory Top Health Conditions and Diseases L : Leukodystrophy Globoid Cell - Krabbe Alexander disease mini information sheet - From the National Institutes of Health (USA) The Amn-Ald Community Pages - Support site for families dealing with the diseases AMN/ALD (one form of the many Leukodystrophies). Canavan Foundation - Not-for-profit foundation providing information about Canavan disease, prenatal screening, support, and reasearch. Canavan Research Fund - The Canavan Research Fund is a not-for-profit organization dedicated to pioneering research that can treat and eventually cure Canavan and other genetic brain diseases. DrKoop.com - Adrenoleukodystrophy - Information about the causes, symptons, tests available and treatment of this condition. Leukodystrophy - CHORUS document on the different types of Leukodystrophy. A little technical.

79. American College Of Medical Genetics Position Statement on Carrier Testing for canavan disease. American College ofMedical Genetics. Position Statement on Carrier Testing for canavan disease. http://www.acmg.net/Pages/ACMG_Activities/Policy_Statements_Pages/Current/canava

General Information Mission Statement History Membership Application Board of Directors ... Contact Us ACMG Activities Membership Directory Policy Statements Educational Materials 2003 Annual Clinical ... Genetics Meeting Links Genetics in Medicine ACMG Foundation Other Related Sites Members Only Member Log-In Membership Renewal Request for Comments Position Statement on Carrier Testing for Canavan Disease American College of Medical Genetics Position Statement on Carrier Testing for Canavan Disease Canavan Disease is a serious incurable genetic disorder which causes mental retardation and is often fatal in childhood. It is cased by a genetic abnormality which produces a deficiency of the enzyme aspartoacylase and is inherited in an autosomal recessive pattern. Like Tay-Sachs Disease, Canavan Disease occurs at a higher frequency in individuals with Ashkenazi Jewish ancestry, estimated to be 1/40. The screening test to identify individuals who are carriers is a DNA-based test that is performed by only a few specialized laboratories. If both reproductive partners have an Ashkenazi Jewish background, we recommend that carrier testing for Canavan Disease be offered before pregnancy. If only one partner is of Ashkenazi Jewish descent, she/he should be offered carrier testing and the couple should be counseled regarding the limitations and benefits of carrier testing and prenatal diagnosis for this situation.

80. The Contact A Family Directory - CANAVAN DISEASE printer friendly, canavan disease, canavan disease is a rare genetic,degenerative disorder of the nervous system. It is one of a http://www.cafamily.org.uk/Direct/c14.html

printer friendly CANAVAN DISEASE home more about us in your area conditions information ... how you can help search this site Canavan disease is a rare genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies. The term leukodystrophy comes from the Greek words, 'leuko' meaning white and referring to the 'white matter' of the nervous system and 'dystrophy' meaning imperfect growth or development. In Canavan disease, there is widespread degeneration of the white matter in the brain leading to loss of sensory, motor and intellectual function. The white matter of the brain, otherwise known as myelin sheath, is a fatty covering which acts as an insulator around the nerve fibres of the brain. Myelin sheath is made up of a number of different chemicals. Canavan disease is caused by a deficiency in one of these chemicals and this affects the growth of the myelin sheath. Canavan disease is caused by changes (or mutations) in a gene on chromosome 17. There are different types of Canavan disease which include congenital, infantile, and late-onset form. Babies with Canavan disease appear normal in the first few months of life. However, in early infancy they begin to lose previously acquired skills including seeing and hearing. The head becomes progressively enlarged (megalencephaly) as the brain swells and the bones of the skull fail to fuse. Babies lose control of their muscles and the muscles supporting the head become floppy and weak (

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