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         Cerebral Gigantism:     more detail

21. Service Page - Pathologie Information
DISEASE cerebral gigantism jaw cysts, Synonym(s) Cramer niederdellmann syndrome,Sign(s) of the disease (32), Outpatient clinic(s). Dysmorphology clinic.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2081

22. SOTOS SYNDROME: A CASE REPORT:14(5)
Sotos syndrome (cerebral gigantism) is a rare form of accelerated growth in uteroand in the first three to four years of life, after which it proceeds at a
http://www.kfshrc.edu.sa/annals/146/cr9400.html
November 1994
SOTOS SYNDROME: A CASE REPORT
Mohammed Alhumaidi, MD Address reprint requests and correspondence to Dr. Alhumaidi: Assistant Professor, College of Medicine, King Saud University, Abha Branch, P.O. Box 641, Abha, Saudi Arabia. Accepted for publication 2 May 1994. A four-year-old Saudi male was seen in the Endocrine Clinic of Asir Central Hospital because of a voracious appetite and excessive gain in weight. On examination, he had the typical phenotypic features of Sotos syndrome which included accelerated growth with height and weight more than three standard deviations (SD) above the mean. He had coarse facial features, prominent forehead, macrocephaly, large ears, hypertelorism and aplethoric face. He was frequently aggressive with advanced bone age of five years and magnetic resonance imaging (MRI) of the brain indicated widening of the lateral ventricles. He had no features to suggest other forms of overgrowth such as Marfan syndrome, McCune-Albright syndrome or homocystinuria. Endocrine causes of excessive weight gain due to pituitary or adrenal hyperfunction have been ruled out by biochemical tests, computed tomography (CT), and MRI. We document the first case report of Sotos syndrome from Saudi Arabia.

23. NINDS Soto's Syndrome Information Page
Contact us . Content for this page. NINDS Soto's Syndrome InformationPage. Synonym(s) cerebral gigantism. Reviewed 0701-2001. Get
http://accessible.ninds.nih.gov/health_and_medical/disorders/sotos.htm
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    NINDS Soto's Syndrome Information Page
    Synonym(s): Cerebral Gigantism Reviewed 07-01-2001 Get Web page suited for printing
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    Table of Contents (click to jump to sections)
    What is Soto's Syndrome?

    Is there any treatment?

    What is the prognosis?

    What research is being done?
    ...
    Organizations

    What is Soto's Syndrome?
    Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. The disorder may be accompanied by mild mental retardation, delayed motor, cognitive, and social development, hypotonia (low muscle tone), and speech impairments. Children with Soto's syndrome tend to be large at birth and are often taller, heavier, and have larger heads (macrocrania) than is normal for their age. Symptoms of the disorder, which vary among individuals, include a disportionately large and long head with a slightly protrusive forehead, large hands and feet, hypertelorism (an abnormally increased distance between the eyes), and downslanting eyes. Clumsiness, an awkward gait, and unusual aggressiveness or irritability may also occur. Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported.

    24. NINDS - Neurological Disorder Information
    Syndrome 9 Central Pain Syndrome 10 Cephalic Disorders 11 Cerebral Aneurysm 12 CerebralArteriosclerosis 13 Cerebral Atrophy 14 cerebral gigantism 15 Cerebral
    http://accessible.ninds.nih.gov/health_and_medical/disorder_index.htm
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    25. Cer – Chl
    identifier=10000056. cerebral gigantism. http//www.health.gov/NHIC/NHICScripts/AlphaKey.cfm?Alpha=.cerebral gigantism. http//www
    http://www.healthmednet.com/Cer - Chl.htm
    Cer – Chl cercarial dermatitis (swimmer’s itch, schistosomiasis) http://www.cdc.gov/ncidod/diseases/index.htm Cerebellar Agenesis Cerebellar Agenesis http://www.laurushealth.com/library/healthguide/illnessconditions/pagebuilder.asp?URL=Default.htm Cerebellar Astrocytoma http://cancernet.nci.nih.gov/clinpdq/pif.html CEREBELLAR ASTROCYTOMA http://www.icondata.com/health/pedbase/pedlynx.htm Cerebellar Ataxia http://health.excite.com/ cerebellar ataxia http://webmd.lycos.com/adam/asset/adam_disease_articles/a_to_z/c Cerebellar Ataxia http://www.hon.ch/cgi-bin/HONselect?browse+C10.228.700 Cerebellar Ataxia Cerebellar Ataxia http://www.webcrawler.com/health/diseases_and_conditions/conditions_a_z/conditions_c Cerebellar Ataxia Cerebellar Ataxia http://www.NIH.gov/health/InformationIndex/HealthIndex/Pubincov.htm Cerebellar degeneration http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9339.html?k=menux408x9939xALZ Cerebellar Degeneration, Subacute Cerebellar Degeneration, Subacute http://www.laurushealth.com/library/healthguide/illnessconditions/pagebuilder.asp?URL=Default.htm Cerebellar Diseases@ http://dmoz.org/Health/Conditions_and_Diseases/

    26. Neonatology On The Web: Macrencephaly
    Much sporadic cases include macrencephaly with chromosomal disorder (XXYKlinefelter'ssyndrome). cerebral gigantism, Beckwith's Syndrome, and Achondroplasia.
    http://www.neonatology.org/syllabus/macrencephaly.html
    Neo Home New Clinical Computers ... Links
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    Macrencephaly
    Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, California.
    Anatomical Abnormality
    The designation macrencephaly signifies a large brain and is a feature of heterogenous group of disorders that have not been well defined. Nevertheless, there are several entities in which the brain is generally well formed but is usually large.
    • Familial, isolated macrencephaly
      • Autosomal dominant
      • Autosomal recessive
    • Sporadic, isolated macrencephaly
    • Cerebral gigantism
    • Beckwith's syndrome
    • Achondroplasia
    • Neurocutaneous syndromes
      • Multiple hemangiomatosis
      • Pseudopapilledema
      • Asymmetrical hypertrophy +/- scoliosis (Klippel-Trenaunay-Weber)
      • Lipomas, lymphangiomas
      • Asymmetrical hypertrophy, +/- scoliosis, telangiectatic lesions, flame nevus of face (cutis marmorata telangiectatica congenita)
      • Neurofibromatosis
    • Unilateral macrencephaly
    Timing and Clinical Aspects
    Although neuronal proliferation in the cerebrum is an event that occurs pricipally during the second to fourth months of gestation, it is possible that this time period is prolonged in disorders of excessive proliferation. Alternatitively, the abnormal proliferation may occur at the appropriate time during development but at an excessive rate. The clinical syndrome in the several types of macrencephaly varies from no apparent neurological defecit (e.g., autosomal dominant, isolated macrencephaly) to severe recalcitrant seizures and mental retardation (e.g., unilateral macrencephaly, autosomal recessive, isolated macrencephaly). In other types of disorder, extraneural features may dominate the clinical picture (e.g., Beckwith's syndrome, and certain neurocutaneous syndromes). Note that although macrocephaly i.e., large head, accompanies these disorders, many other causes of macrocephaly in the newborn must be distinguished, e.g., hydrocephalus, large brain secondary to such disorders as Alexander's or Canavan's leukodystrophies, subdural hematoma, and large skull as in certain congenital hemolytic anemias or cranioskeletal dysplasia.

    27. Birth Disorder Information Directory - N
    See Granulomatous Disease, Chronic, Autosomal Cytochromeb-PositiveForm, Type II. Nevo Syndrome (cerebral gigantism, Nevo Type)
    http://www.bdid.com/defectn.htm

    HOME
    N
    N-Acetylglutamate Synthetase Deficiency N5-Methylhomocysteine Transferase Deficiency NADH-CoQ Reductase

    28. Soto('s) Syndrome
    HOME Soto('s) Syndrome (cerebral gigantism). SOTO; sotos; Soto Syndrome; Soto's Syndromeinformation sheet; cerebral gigantism; Sotos Syndrome Support Association;
    http://www.bdid.com/soto.htm

    HOME
    Soto('s) Syndrome (Cerebral Gigantism)

    HOME

    29. Bilateral Kinematic And Kinetic Data Of ...
    Translate this page Auteur/Author, Dodge, Philip R. Titre/Title, Developmental Medicine and ChildNeurology. Article, cerebral gigantism. Identification, 25 1983 Pages 248-52.
    http://www.cidg.com/~marienf/k/i/n/m017383.htm
    # Article : A0031793 Cote/Call Number Auteur/Author
  • White, Hank
  • VandenBrink, Keith
  • Augsburger, Sam, and others Titre/Title Journal of Prosthetics and Orthotics (JPO) Article Bilateral kinematic and kinetic data of two prosthetic designs : A case study. Identification No 4 12 2000 Pages: 120-24 Descripteurs/Descriptors
  • Adolescent
  • Demande par
    courrier
    Client (nom, adresse...):
    Type de demande: PEB Photocp (frais) Commentaires:
  • 30. Www.csh.dk/sjaeldne_handicap/sotos_syndrom/alt_sotos_syndrom.txt
    Dodge, PR cerebral gigantism. Livingood, AB Borengasser, MA cerebral gigantismin Infancy Implications for Psychological and Social Development.
    http://www.csh.dk/sjaeldne_handicap/sotos_syndrom/alt_sotos_syndrom.txt

    31. FAIVRE L
    GOSSET P., ROMANA S., MUNNICH A., VEKEMANS M., CORMIER DAIRE V. Apparent sotos syndrome(cerebral gigantism) in a child with trisomy 20p11.2p12.1 mosaicism.
    http://www.necker.fr/irnem/Unites 2000/histo.htm
    FAIVRE L., PRIEUR A.M., LE MERRER M., HAYEM F., PENET C., WOO P., HOFER M., DAGONEAU N., SERMET I., MUNNICH A., CORMIER-DAIRE V.
    Clinical variability and genetic homogeneity of the camptodactyly-arthropathy-coxa vara-pericarditis syndrome.
    Amer. J. Med. Genet.,
    (Services cités :
    The camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is an autosomal recessive condition characterized by the association of congenital or early onset camptodactyly and noninflammatory arthropathy with synovial hyperplasia, Progressive coxa vara deformity and/or noninflammatory pericardial or pleural effusions have been observed in some patients, Recently, the disease gene has been assigned to human chromosome region 1q25-q31, and truncating mutations have been identified in the megakaryocyte stimulating factor gene, Studying 12 patients from 8 unrelated families, we emphasized hip and spine involvement, particularly in the course of the disease as shown in a 58-year-old patient. Despite clinical variability, linkage studies support genetic homogeneity of the disease. [References: 25] FAIVRE L., VIOT G., PRIEUR M., TURLEAU C., GOSSET P., ROMANA S., MUNNICH A., VEKEMANS M., CORMIER DAIRE V.

    32. A Write Shop, Editing & Publishing Company.
    $9.95. cerebral gigantism. Sotos Syndrome. A chapter is included with thelatest information on Sotos Syndrome, also known as cerebral gigantism.
    http://www.awriteshop.com/sotossyndrome.htm
    Sandy's Story Available in E-Book format only. Download Acrobat Reader E-Book Information Cerebral Gigantism Sotos Syndrome Learn how a young mother struggles to get the appropriate medical, educational and social needs for her child in the late 60’s and early 70’s. Discover how she contends with family, friends and strangers for acceptance of her disabled daughter. Find out how Sandy’s untimely death was due to malpractice because she was disabled. Experience how Sandy’s life and death teaches her mother of the need for reform in the medical, educational and social fields in dealing with disabled children and their families. Realize how Sandy’s mother vows, after her daughter’s death, to spend the remainder of her life improving the lives of disabled individuals.

    33. Searchalot Directory For C
    Agenesis (5); Cerebral Abscess (4); Cerebral Edema (4); cerebral gigantism(4); Cerebral Palsy (165); Cerebrocostomandibular Syndrome
    http://www.searchalot.com/Top/Health/ConditionsandDiseases/C/
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    34. Searchalot Directory For Soto's Syndrome
    and professionals. Soto's Syndrome Also known as cerebral gigantism,an information sheet compiled by NINDS. MCW Healthlink - An
    http://www.searchalot.com/Top/Health/ConditionsandDiseases/GeneticDisorders/Soto
    Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases Genetic Disorders : Soto's Syndrome Related Web Sites
    • Sotos Syndrome Support Association - Online community for education of professionals and families and to exchange ideas, gather research, and help one another cope. Quarterly newsletters, reference library, annual meetings, and conferences are available to members and professionals.
    • Soto's Syndrome - Also known as cerebral gigantism, an information sheet compiled by NINDS.
    • MCW Healthlink - An article about soto's syndrome with an explanation of what it is, the features, symptoms and the prognosis.
    • About com Guide Laura L. Jelliffe, Ph.D.

    35. Gigantism
    Other forms of excessive growth include cerebral gigantism, elephantoid hypertrophyof an entire limb or finger in neurofibromatosis, local soft tissue and
    http://www.amershamhealth.com/medcyclopaedia/Volume III 1/GIGANTISM.asp
    Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase.
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    *For Medical Professionals only, registration required Gigantism, abnormal size and stature attributable to excessive growth, such as that occurring in the immature skeleton in hyperpituitarism . When the growth plates have not yet closed, direct hormonal stimulation of endochondral bone formation takes place, leading to proportional increase of bones in both length and width. The overgrowth of bones from hypersecretion of growth hormone that occurs after the growth plates have fused is termed acromegaly ; this abnormality affects predominantly the hands, feet and lower jaw. Other forms of excessive growth include cerebral gigantism, elephantoid hypertrophy of an entire limb or finger in neurofibromatosis , local soft tissue and bone gigantism in Klippel Trenaunay Weber syndrome macrodystrophia lipomatosa and lipoatrophic diabetes . The radiographic differential diagnosis of localized gigantism includes both congenital and acquired causes. The latter include dactylitis secondary to infection, trauma, infarction

    36. Dorlands Medical Dictionary
    cerebral gigantism, gigantism in the absence of increased levels of growth hormone,attributed to a cerebral defect; infants are large, and accelerated growth
    http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

    37. Member Sign In
    Among these are cerebral gigantism, acromegaly, and McCuneAlbrightsyndrome. Pathway defects causing cerebral gigantism and its
    http://www.medscape.com/viewarticle/410889_15
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    38. List Of Illnesses - Friends' Health Connection
    Internal) Cataplexy Cataracts Celiac Sprue Cellucystitis Cerebellar DegenerationCerebral Aneurysm Cerebral Cavernous Angioma cerebral gigantism Cerebral Palsy
    http://www.friendshealthconnection.org/illnesses.shtml
    List of Illnesses Below is a list of the health problems for which we currently have members. New members join daily. Please feel free to fill out a membership application even if your health problem is not listed. As new members join with your health problem we will connect you. A B C D ... W X Y Z A
    Abdominal Adhesions
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    Abherrant Regeneration
    Accident survivors
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    Acid Reflux
    Acne Rosacea
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    Adenocarcinoma Addisons Disease Agoraphobia Adrenal Dysfunction Agnogenic Myeloid Metaplasia AIDS Alcoholism (recovering) Allergic Broncho Pulmonary Aspergillosis Allergies (General) Allergies (Bee) Allergies (Food) Allergies (to chemicals) Allergies (to mold) Alloimmunthrombocytopenia Alopecia Areata Alzheimer's Amputations Amyotrophic Lateral Sclerosis (ALS) Anaphylaxis Anemia Anemia (Hemolytic) Anemia (Pernicious) Angina Angiodema Angogenic Metaplasia Ankylosing Spondylitis (see also Arthritis) Anorectal Problems Anorexia Antiphospholipid Antibody Syndrome Anxiety Aorta Pulmonary Window Aortic Valve Replacement Aphasia Apnea (Sleep) Archnoiditis Arnold-Chiari Malformation Arteriovenous Malformation (AVM) Arteritis (Giant Cell Temple) Artheroclerosis Arthralgia Arthritis Arthritis (Adult Onset) Arthritis (Degenerative) Arthritis (Juvenile Rheumatoid) Arthritis (Non-Rheumatoid Inflammatory) Arthritis (Osteo) Arthritis (Zero-negative) Arthrogrypossis Asperger's Syndrome Aspergillosis Asthma Asthmatic Bronchitis Astigmatism

    39. The DRM WebWatcher: Sotos Syndrome
    For information about Sotos syndrome, check these sites. cerebral gigantismTechnical information from Online Mendelian Inheritance in Man (OMIM).
    http://www.disabilityresources.org/SOTOS.html
    Home Subjects States Librarians ... Contact Us The DRM WebWatcher Sotos Syndrome Updated 3/19/2000 A B C D ... About/Hint/Link
    Sotos syndrome is a rare genetic disorder characterized by excessive growth prior to and after birth. Children affected by Sotos syndrome may exhibit characteristic facial differences and developmental delays. For information about Sotos syndrome, check these sites.
    Cerebral Gigantism
    Technical information from Online Mendelian Inheritance in Man (OMIM).
    Soto Syndrome
    Brief clinical information from Pediatric Database.
    Sotos Syndrome
    An overview and additional sources of information from the National Organization for Rare Disorders.
    Sotos Syndrome Support Association
    The web site of this nonprofit organization includes FAQs, support, and links.
    Related subjects:
    Developmental Disabilities
    Facial Differences
    Growth Disorders
    Rare Disorders ...
    Resources in your state
    (c) 1997-2000 Disability Resources, inc.

    40. YOUNG ONSET NEUROLOGICAL DISEASE ASSOCIATION Br YONDA For Short
    Central Pain Syndrome, Cephalic Disorders , Cerebral Aneurysm, Cerebral Arteriosclerosis,Cerebral Atrophy, cerebral gigantism, Cerebral Palsy , CharcotMarie
    http://www.geocities.com/yondaohio/01.html
    YONDA for short
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    We also have Publicaciones en español. Remember to include you mailing address. A ADHD, AIDS - Neurological Manifestations, Acquired Epileptiform Aphasia, Acute Disseminated Encephalomyelitis, Adrenoleukodystrophy, Agenesis of the Corpus Callosum, Agnosia, Aicardi Syndrome, Alexander Disease, Alpers' Disease, Alternating Hemiplegia, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Anencephaly, Aneurysm, Angelman Syndrome, Angiomatosis, Anoxia or Hypoxia, Aphasia, Apraxia , Arachnoid Cysts, Arachnoiditis, Arnold-Chiari Malformation, Arteriovenous Malformation, Asperger Syndrome, Ataxia Telangiectasia, Attention Deficit-Hyperactivity Disorder, Autism, Autonomic Dysfunction B Back Pain, Batten Disease, Behcet's Disease, Bell's Palsy, Benign Essential Blepharospasm, Benign Focal Amyotrophy, Benign Intracranial Hypertension, Binswanger's Disease, Blepharospasm, Bloch-Sulzberger Syndrome, Brachial Plexus Birth Injuries, Brachial Plexus Injuries, Bradbury-Eggleston Syndrome, Brain Aneurysm, Brain Injury, Brain and Spinal Tumors, Brown-Sequard Syndrome C Canavan Disease, Carpal Tunnel Syndrome, Causalgia, Cavernomas, Cavernous Angioma, Cavernous Malformation, Central Cervical Cord Syndrome, Central Cord Syndrome, Central Pain Syndrome, Cephalic Disorders , Cerebral Aneurysm, Cerebral Arteriosclerosis, Cerebral Atrophy, Cerebral Gigantism, Cerebral Palsy , Charcot-Marie-Tooth Disorder, Chiari Malformation, Chorea, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Chronic Orthostatic Intolerance, Chronic Pain, Coffin Lowry Syndrome, Coma, including Persistent Vegetative State, Complex Regional Pain Syndrome, Congenital Facial Diplegia, Congenital Vascular Cavernous Malformations, Corticobasal Degeneration, Cranial Arteritis, Craniosynostosis, Creutzfeldt-Jakob Disease, Cumulative Trauma Disorders, Cushing's Syndrome, Cytomegalic Inclusion Body Disease (CIBD), Cytomegalovirus Infection

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