1. EMedicine - POEM Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH Key Words, and Related Terms crowfukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell http://www.emedicine.com/derm/byname/poem-syndrome.htm

(advertisement) Excerpt from POEM Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEM Syndrome Background: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it is known in Japan) syndrome by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 systems involved. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. Polyneuropathy: The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

2. EMedicine - POEM Syndrome : Article By Wingfield Rehmus, MD, MPH Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. http://www.emedicine.com/derm/topic771.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine POEM Syndrome Last Updated: June 14, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Wingfield Rehmus, MD, MPH , Staff Physician, Department of Dermatology, Stanford University Medical Center Coauthor(s): Alexa Boer Kimball, MD, MPH , Director of Clinical Trials, Assistant Professor, Department of Dermatology, Stanford University School of Medicine Wingfield Rehmus, MD, MPH, is a member of the following medical societies: American Academy of Dermatology Editor(s): Neil Shear, MD , Professor and Chief of Dermatology, Professor of Medicine, Pediatrics and Pharmacology, University of Toronto Medical School; Head of Dermatology, Sunnybrook Women's College Health Sciences Center, Canada;

3. POEMS_SupportGroup Other names for the disease is crowfukase syndrome or Takatsuki syndrome http://www.poems-sg.netfirms.com/

This site is hosted by Netfirms Web Hosting POEMS Syndrome Support Group P olyneuropathy O rganomegaly, E ndocrinopathy, M onoclonal gammopathy, and S kin changes Syndrome Home What is POEMS Personal Account Effects of Disease Tips for Caregivers ... Stem Cell Transplant Last Updated: 14 Sep 2002 Email Add: POEMS Syndrome P olyneuropathy O rganomegaly, E ndocrinopathy, M onoclonal gammopathy, and S kin changes Syndrome POEMS syndrome is a rare disease that affects many systems in a patient. Other names for the disease is Crow-Fukase syndrome or Takatsuki syndrome Significance of Support Group Importance of Positive Thinking in Recovery

4. Birth Disorder Information Directory - CO-CZ List of Sites. Crow Fukase Syndrome (PEP Syndrome, POEMS Syndrome, Shimpo's Syndrome,Takatsuki's Syndrome) crowfukase syndrome. Cryptophthalmos-Syndactyly http://www.bdid.com/defectco.htm

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5. Alzhheimer crowfukase syndrome a case associated with vasospastic angina. Theskin changes in the Crow-Fukase (POEMS) syndrome. A case report. http://tuftsneurology.org/webres/poems.htm

POEMS Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.

6. ORPHANET® : POEMS Syndrome Base de données sur les maladies rares et les médicaments orphelins POEMS syndrome. Direct access to details. Alias crowfukase syndrome http://orphanet.infobiogen.fr/static/GB/poems.html

ORPHANET database access POEMS syndrome Direct access to details Alias : Home Page

7. Tufts University Neurology crowfukase syndrome a case associated with vasospastic angina (Medline) Acta Neurol(Napoli) 1994 Aug;16(4)170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu http://tuftsneurology.org/training/references/links/poems.html

Case Presentations Guestbook In-Service Training Exam PDA Tips ... Search Medline Links Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome (Medline) Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 (Medline) Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? (Medline) Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines (Medline) Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina (Medline) Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report

8. Alzhheimer Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. http://www.tuftsneurology.org/webres/poems.htm

POEMS Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.

9. Service Page - Pathologie Information DISEASE POEMS syndrome, Synonym(s) crowfukase syndrome, Sign(s)of the disease (23), Other website(s) (2), Outpatient clinic(s). http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905

10. Tufts University Neurology crowfukase syndrome a case associated with vasospastic angina http://www.tuftsneurology.org/training/references/links/poems.html

Case Presentations Guestbook In-Service Training Exam PDA Tips ... Search Medline Links Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome (Medline) Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 (Medline) Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? (Medline) Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines (Medline) Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina (Medline) Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report

11. IM Abstract 39-12 Case 13 the serum, and the levels of IL1ß, IL-6, TNF-a, and thiamine, which were thoughtin past reports to be mediators of PH in crow-fukase syndrome, were normal. http://www.naika.or.jp/im/im39/ab39_12/c391213.html

VEGF Is Causative for Pulmonary Hypertension in a Patient with Crow-Fukase (POEMS) Syndrome Hideki Niimi, Kimiyoshi Arimura, Manabu Jonosono, Teruto Hashiguchi, Masaharu Kawabata, Mitsuhiro Osame and Isao Kitajima* From the Third Department of Internal Medicine, Kagoshima University, Kagoshima and *the Department of Clinical Laboratory Medicine, Kagoshima University, Kagoshima We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1ƒÀ, IL-6, TNF-ƒ¿, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome. (Internal Medicine 39: 1101-1104, 2000) ÅIXV“ú2001/10/4@E-mail : naika@naika.or.jp

12. IM Abstract 41-8 Case 3 crowfukase syndrome Associated with High-Output Heart Failure Tsutomu Araki, TetsuoKonno, Ryuichiro Soma, Akikatsu Nakashima, Hiroaki Takimoto, Yohei Tofuku http://www.naika.or.jp/im/im41/ab41_8/c410803.html

Crow-Fukase Syndrome Associated with High-Output Heart Failure Tsutomu Araki, Tetsuo Konno, Ryuichiro Soma, Akikatsu Nakashima, Hiroaki Takimoto, Yohei Tofuku and Masami Shimizu* From the Department of Internal Medicine, Saiseikai Kanazawa Hospital, Kanazawa and *Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome. ÅIXV“ú2002/12/20@E-mail : naika@naika.or.jp

13. Health Library - POEMS Syndrome covered by this report. Synonyms. crowfukase syndrome; PEP Syndrome;Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

14. COLLEGE DE FRANCE Translate this page 27) 1919-1923. Hitoshi S. (1995), ‘crow-fukase syndrome’ (Japanese),Nippon Rinsho, 53 (3) 747-751. Eidner T., Oelzner P http://www.ifrance.com/ihpst/AFLcollege2001/AFL2903.htm

15. Lymph_node Hyaline vascular type ? plasma cell type plasma cell () ? (+) crow-fukase syndrome (?). http://www2d.biglobe.ne.jp/~aquila/medical/p9/m29.html

@ƒŠƒ“ƒpß ƒŠƒ“ƒp‹ ‚Ì•ª‰» @1)@B×–E 2)@T×–E ƒŠƒ“ƒpß‚Ì”½‰ž«•Ï‰» ... @@  @Lymphocyte predominance, nodular —A“üƒŠƒ“ƒpŠÇ •Ó‰“º marginal sinus @:@MƒÓ‚ª‘¶Ý Post capillary venule, PCV @:@ŒŒŠÇ‚©‚çlymphocyte‚ªƒŠƒ“ƒpß‚Ɉڍs‚·‚é ”çŽ¿ cortex àh–E ã󒆐S germinal center (-)@:@ˆêŽŸàh–E@¨@“ñŽŸàh–E@:@GC(+) @@@@‘å‚«‚ȍזE@¨@–¾‚é‚­Œ©‚¦‚é @@@@B cell‚ª•ª‰»‘B Tingible body MƒÓ Follicular dendric cell (APC)@¨@B cell‚ɍRŒ´’ñŽ¦ mantle zone @@@@B cell + memory cell @@@@¬‚³‚ȍזE@¨@ˆ‚­Œ©‚¦‚é –T”玿 para-cortex T zone T cell —AoƒŠƒ“ƒpŠÇ ƒŠƒ“ƒp‹ ‚Ì•ª‰» @1)@B×–E @@Š²×–E stem cell @@B cell GC @:@RŒ´ŽhŒƒ‚É‚æ‚萬n small cleaved large cleaved small non-cleaved large non-cleaved Immunoblast plasma cell 2)@T×–E @@Š²×–E stem cell @@T cell@©@ Interdigitating cell (APC) T zone ƒŠƒ“ƒpß‚Ì”½‰ž«•Ï‰» Follicular hyperplasia @:@GC‚𔺂¤àh–E‚Ì‘¶AŽî‘å @@@a)@ @@@@SLE, Sjogren, Still @@@@’†S•”‚Éàh–EŒ`¬ @@@@M-zone(+) @@@@plasma cell‚Ìàh–EŠO‘¶ @@@b)@ Bacterial infection @@@c)@ Castleman's disease @@@@cŠuƒŠƒ“ƒpß‹‘åŽîᎠangio-follicular hyperplasia @@@@@àh–E“à‚ɐN“ü‚µ‚½ŒŒŠÇ•Ç‚̏Ɏq‰» hyalization @@@@@Hyaline vascular type@Ì@plasma cell type@:@àh–EŠÔ‚Éplasma cell Z Crow-Fukase syndrome (‚ŒŽ•a) @@@d)@ Crow-Fukase syndrome (‚ŒŽ•aj POEMS synd.

16. NORD - National Organization For Rare Disorders, Inc. POEMS Syndrome. To purchase fulltext report ($7.50) View Cart/Checkout. Copyright1991, 2000, 2002 Synonyms of POEMS Syndrome crow-fukase syndrome; PEP Syndrome; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom

17. Member Sign In Hospital, Chicago, Ill. Introduction. POEMS syndrome, also knownas the crowfukase syndrome, was first reported in 1956. 1 It http://www.medscape.com/viewarticle/409056

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18. Member Sign In Introduction. POEMS syndrome, also known as the crowfukase syndrome, was firstreported in 1956. The crow-fukase syndrome a study of 102 cases in Japan. http://www.medscape.com/viewarticle/409056_print

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19. C CriglerNajjar Syndrome; @ Crohn's Disease; @ crow-fukase syndrome;@ Cryptosporidiosis; @ Cubital Tunnel Syndrome; @ Cushing's Syndrome; http://www.ad.com/Health/Conditions_and_Diseases/C/

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20. Untitled VEGF was greatly increased in serum (1,850 pg/ml), which has been foundto be increased exclusively in patients with crowfukase syndrome. http://www.med.tohoku.ac.jp/study_room/50/ITOYAMA/abst/004.html

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