61. NIGMS -- News & Events: Bacterial Slime Clogs Cystic Fibrosis Lungs A research brief on how bacteria that thrive in the thick mucus clogging thelungs and intestines of people with cystic fibrosis encase themselves in a http://www.nigms.nih.gov/news/releases/brief_greenberg.html

skip navigation NIGMS Home What's New Site Map ... Search NIGMS for: Text size: A A A Research Funding ... E-mail this link Bacterial Slime Clogs Cystic Fibrosis Lungs by Alisa Zapp Machalek April 2, 2002 Cystic fibrosis (CF) is one of the most common fatal genetic diseases in the United States. Approximately 30,000 Americans have the disease and an estimated 8 million are carriers of it. Thick, sticky mucus clogs the lungs and intestines of those with CF, causing malnutrition, frequent lung infections, breathing difficulty, and eventually permanent lung damage. Bacteria, especially Pseudomonas aeruginosa, thrive in this thick mucus, causing persistent infection. Most people with CF die from respiratory failure caused by these infectionsoften around the age of 30. Once these bacteria gain a foothold in CF lungs, they are invincible even to long-term antibiotic treatment. Scientists led by Dr. E. Peter Greenberg of the University of Iowa College of Medicine revealed why. The researchers showed that the bacteria encase themselves in a protective slime called a biofilm. Partial to wet surfaces, biofilms are responsible for everything from dental plaque and bathtub soap scum to bacterial colonies that corrode the bottom of ships. Within gluey pockets in the biofilm, colonies of bacteria flourish, nourished by a network of water-filled channels and shielded from the effects of antibiotics. Dr. Greenberg and his coworkers developed a sensitive lab test that detects biofilms in CF lungs, based on telltale molecules produced by the structures.

62. Blazing A Genetic Trail Research on mutant genes and hereditary diseases. Includes family studies, the Human Genome Project, how to conquer hereditary diseases like cystic fibrosis, key to basic genetics and a glossary. http://www.hhmi.org/genetictrail/

The full text and illustrations of the original print version of Blazing a Genetic Trail are available for download as an Adobe Acrobat PDF file (8MB). Download Adobe Acrobat Reader. Updated Spring 2002

63. Consensus Statement Overview: Genetic Testing For Cystic Fibrosis Related to this Consensus Conference. Genetic Testing for cystic fibrosisApril 1416, 1997 Vol. 15, No. 4. Genetic testing for CF http://consensus.nih.gov/cons/106/106_intro.htm

Related Conference Materials (PDF file, 1.2 MB) NLM Bibliography News Release CME Online List of Publications Related to this Consensus Conference Genetic Testing for Cystic Fibrosis April 14-16, 1997 Vol. 15, No. 4 Read full NIH Consensus Statement Download full NIH Consensus Statement (PDF file, 352K) NOTE: NIH Consensus Statements are prepared by a nonadvocate, non-Federal panel of experts, based on (1) presentations by investigators working in areas relevant to the consensus questions during a 2-day public session; (2) questions and statements from conference attendees during open discussion periods that are part of the public session; and (3) closed deliberations by the panel during the remainder of the second day and morning of the third. This statement is an independent report of the panel and is not a policy statement of the NIH or the Federal Government. The statement reflects the panelís assessment of medical knowledge available at the time the statement was written. Thus, it provides a "snapshot in time" of the state of knowledge on the conference topic. When reading the statement, keep in mind that new knowledge is inevitably accumulating through medical research.

64. Cystic Fibrosis - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/MedwebPage.cfm?ID=919601157

65. NIH Consensus Statements: 106. Genetic Testing For Cystic Fibrosis State of Knowledge Regarding Natural History, Epidemiology, GenotypePhenotypeCorrelations, Treatment, and Genetic Testing of cystic fibrosis in Various http://consensus.nih.gov/cons/106/106_statement.htm

106. Genetic Testing for Cystic Fibrosis National Institutes of Health Consensus Development Conference Statement Apr 14-16, 1997 This statement was originally published as: Genetic Testing for Cystic Fibrosis. 1997 April 14-16;15(4);1-37. For making bibliographic reference to consensus statement no. 106 in the electronic form displayed here, it is recommended that the following format be used: Genetic Testing for Cystic Fibrosis. NIH Consens Statement Online 1997 Apr 14-16 [cited year, month, day];15(4): 1-37. NIH Consensus Statements are prepared by a nonadvocate, non-Federal panel of experts, based on (1) presentations by investigators working in areas relevant to the consensus questions during a 2-day public session; (2) questions and statements from conference attendees during open discussion periods that are part of the public session; and (3) closed deliberations by the panel during the remainder of the second day and morning of the third. This statement is an independent report of the panel and is not a policy statement of the NIH or the Federal Government. The statement reflects the panelís assessment of medical knowledge available at the time the statement was written. Thus, it provides a "snapshot in time" of the state of knowledge on the conference topic. When reading the statement, keep in mind that new knowledge is inevitably accumulating through medical research.

66. Lost Lake Breath Of Life Run - Home Page Race to benefit cystic fibrosis. http://www.lostlakerun.org/

questions, comments or suggestions 12th Annual Lost Lake Breath of Life Run THE RESULTS ARE IN! Click Here to jump to the results for 2002 Click HERE to View pictures from 2002 2003 - Race Directors' Message: Enjoy a day of viewing the most beautiful countryside on the Kenai Peninsula. Challenge yourself for thousands of children and young adults that suffer from Cystic Fibrosis. All proceeds and donations from the 12th annual Lost Lake Breath of Life Run will be sent to the Cystic Fibrosis Foundation to help fund research to find a cure. Applications will be available to download after June 1, 2003. Entry fee for 2003 will be $150.00 and must be postmarked before July 1, 2003 for this reduced rate. The entry fee can be collected donations, so ask your friends to help - it's all tax deductible. Come enjoy the last run of the season for a great cause - You'll feel great! Challenge yourself! Alaska's only cross-country race to benefit Cystic Fibrosis. Breathtaking View of Resurrection Bay 16 Miles of Cross-Country Terrain Peak Elevation Gain of 2,100 Feet

67. CDC - Infection By Ralstonia Species In Cystic Fibrosis Patients: Identification Infection by Ralstonia Species in cystic fibrosis Patients Identification of R.pickettii and R. mannitolilytica by Polymerase Chain Reaction. cystic fibrosis. http://www.cdc.gov/ncidod/eid/vol8no7/01-0472.htm

Past Issue Vol. 8, No. 7 July 2002 EID Home Ahead of Print Past Issues EID Search ... Comments Download Article PDF Help Feedback Research Infection by Ralstonia Species in Cystic Fibrosis Patients: Identification of R. pickettii and R. mannitolilytica by Polymerase Chain Reaction Tom Coenye,* Peter Vandamme,† and John J. LiPuma*  *University of Michigan Medical School, Ann Arbor, Michigan, USA; and †Ghent University, Ghent, Belgium The frequency of respiratory tract infections caused by Ralstonia species in persons with cystic fibrosis (CF) and the role of these species in CF pulmonary disease are not well documented. In part, this lack of documentation may be attributed to the difficulty in accurately identifying Ralstonia species; R. mannitolilytica and R. pickettii in particular may be misidentified as other closely related species, particularly those of the Burkholderia cepacia complex.  We used polyphasic analyses to identify 42 Ralstonia isolates from sputum cultures from 38 CF patients. Several isolates that could not be identified to the species level may belong to novel

68. National Cystic Fibrosis Awareness This committee exists to serve as an instrument for advancing the public's awareness of the genetic disease, cystic fibrosis. Site includes mission statement and message board. http://www.cfawareness.org/

69. Department Of Paediatrics Cystic Fibrosis cystic fibrosis. Table of Contents. Introduction. cystic fibrosis occursin about 1 in 2,500 births in Victoria. All patients are seen http://www.med.monash.edu.au/paediatrics/resources/cf.html

Cystic Fibrosis Table of Contents Introduction Inpatient Management Children with Possible CF Treatment of Exacerbations of Chest Infection On Discharge Meconium Ileus Equivalent Introduction Cystic fibrosis occurs in about 1 in 2,500 births in Victoria. All patients are seen at the Royal Children's Hospital at the time of diagnosis, which is usually in the first year of life. Some patients living in the south-east of the city or eastern Victoria are cared for jointly by the department of Thoracic Medicine at the RCH and the Department of Paediatric Respiratory Medicine, MMC. The prognosis has improved very considerably over the last 20 years and most patients now reach adulthood. In the ward the resident medical staff will see patients who have acute flare-ups of chest infection and those with severe lung disease. The 50% of patients who have little chest trouble are rarely admitted to the ward, so staff are likely to have a biased view of the condition. The development of a very positive attitude by the parents from the time of diagnosis seems to be very important in the prognosis. The handling of the family at the time of diagnosis is carefully planned. If they are given a gloomy outlook, this can be hard to change.

70. Proteome Systems Limited - Proteomics Technology And Discovery. Specializes in interpretation of 2dimensional gels, for discovery programs in the areas of cystic fibrosis, cancer, infectious disease and aging. US and Japanese contacts with headquarters in Sydney, Australia. http://www.proteomesystems.com/

Click here for more information on ProteomIQ introduction Welcome to Proteome Systems. Proteome Systems is dedicated to the development of proteomics technology, to the discovery of biomarkers and drug targets, and to proteomic bioinformatics. Proteome Systems is focused on developing integrated proteomic technologies that speed discovery. We are committed to innovation, collaboration and high throughput analysis. Proteome Systems - the future of life sciences. special feature Sydney, Australia – March 25, 2003 - Proteome Systems and VRI BioMedical Limited (ASX: VRI) have finalised a binding Master Development Agreement on development of point-of-care diagnostics. The first joint product under this agreement involves the development of a simple, quantitative test for assessing the immune system of elite athletes. This program will involve partnering with sporting bodies, including The Australian Institute of Sport , to evaluate the ... more current news about us 20/03/03 The Sydney Morning Herald: LabWatch Since 1986, Dr Liz Harry of the school of Molecular and Microbial Biosciences at the University of Sydney has been studying how bacterial cells multip ...

71. Cystic Fibrosis cystic fibrosis Research Mucociliary Clearance For cystic fibrosis CollaboratorsC. William Davis, Garrett Matthews (Cell and Molecular Physiology). http://www.cs.unc.edu/Research/nano/cismm/cystic/

Main Page Biomedical Research Tools Research About Us ... Internal See Related: Posters Talks Publications Biomedical Research Cystic Fibrosis Fibrin and Blood Clotting Gene Therapy and Viruses DNA Cell Division ... Nanoscale Science Research Group Home Cystic Fibrosis Research Mucociliary Clearance For Cystic Fibrosis Collaborators: C. William Davis, Garrett Matthews (Cell and Molecular Physiology) This collaboration is using the 3D Force Microscope and nanoManipulator core projects. Garrett Matthews was a Physics graduate student working on the Adenovirus studies. After graduation, he began working in Davis' lab on the mucociliary clearance project. His cross-disciplinary training within the Resource has made this possible. Overview: The mucociliary clearance system is the first line of defense against inhaled particulates, aerosols, and pathogens in the airways of the lung. These materials are adsorbed out of the air stream onto the mucus gel contained within the airway surface liquid (ASL) coating the ciliated epithelium that lines the airways. The particulate-laden mucus is transported continuously by cilia, beating in a mucus-free periciliary liquid (PCL), to the glottis where it is expelled from the airways and swallowed. This collaboration is applying the new capabilities afforded by nanometer-resolution 3D force microscope to two unsolved biophysical problems in mucociliary clearance: the behavior and fate of periciliary liquid during mucus transport, and the effects of volume-depletion on the viscoelastic properties of mucus.

72. Cystic Fibrosis Information And Resources Non profit web site which provides free information to professionals involved with the treatment of cystic fibrosis. An open access (PUBLIC) section is also available to both patients and family http://www.cysticfibrosismedicine.com

Best viewed with Internet Explorer ver 5.5 or above at a resolution of 800x600 This site needs Javascripting and Cookies turned on for optimum browsing articles

73. Breathing Room: The Art Of Living With Cystic Fibrosis Guidance about the art of living with cystic fibrosis.Category Health Conditions and Diseases cystic fibrosis......Breathing Room facilitates candid and open communication between adults with CysticFibrosis, supports the development of a community of adults with CF and http://www.thebreathingroom.org/

Home News and Info Looking Glass Caregiver Stories ... Contact Join our newsletter list! Enter your email address: Breathing Room facilitates candid and open communication between adults with Cystic Fibrosis, supports the development of a community of adults with CF and provides education and insight for families, caregivers, and medical professionals who impact our lives. Technology by Reception Announcement Breathing Room's Annual Reception will take place on April 27 in Palo Alto, California. Please see the announcement for more information. We look forward to seeing you! About The Breathing Room Get Involved! Special Thanks Make a Donation Through the Looking Glass An ongoing multimedia project showcasing the emotional journey traveled by adults living with this genetic disease. Image index Featured Image Vrksasana "Magnificent tree reaching upward toward the sky" ... Featured story A Place Where They are Still Alive by Joe Lindic I was even concerned about sharing that very sacred part of my life Go there Story index Poetry index News and information ... Contact us

74. We'll Find A Cure // This Time Around Supports fans with cystic fibrosis. Lyrics, fun, links and campaigns. http://www.fallenstars.com/hmh/

Java Applet list of Hanson fans with cystic fibrosis Please take a moment to let it load. No applet? Click here Best viewed with Microsoft Internet Explorer. To my cousin Rae-Anne, my best friend Felicity and everyone touched by CF, this page is for you. FastCounter by LinkExchange HTP Magazine. House Of Hope Central i will come to you track nine

75. Cystic Fibrosis Disease Information On Symptoms, Treatment And Causes Concise factsheet on causes, symptoms and treatment of cystic fibrosis, this factsheet can also be Category Health Conditions and Diseases cystic fibrosis......BUPA health information factsheet cystic fibrosis (CF) is an inherited diseasethat affects the lungs and causes chest infections cystic fibrosis. http://hcd2.bupa.co.uk/fact_sheets/Mosby_factsheets/Cystic_fibrosis.html

search A-Z of health health news healthy living medicines ... A-Z of health Cystic fibrosis Published by BUPA's Health Information Team January, 2003 Download this factsheet Cystic fibrosis (CF) is an inherited condition. It can have many symptoms, affecting different parts of the body, particularly the lungs and digestive system. CF is the most common inherited disease in white people, affecting about 1 in every 2,500 children born. It is much more rare in people of African or Asian descent. Diagnosis of CF About one in five babies with CF are diagnosed at birth, when their gut becomes blocked by extra thick meconium (the black tar-like bowel contents that all babies pass soon after birth). This condition may need surgery. Just over half of people with CF are diagnosed as babies because they are not growing or putting on weight as they should. This is because the pancreas is not producing chemicals (enzymes) which pass into the gut as food leaves the stomach. Without these enzymes, the fat in food cannot be properly digested. In children who are affected, the fat passes straight through the gut. The child does not benefit from the energy from the fat. Since the stools contain an excess of fat, they are oily and very smelly. Other symptoms CF is a "multi-system" disease, meaning that it affects many body organs. However, most of the symptoms are to do with the lungs and the gut.

76. Welcome To Cystic Fibrosis Western Australia Includes a calendar of events, information for people with CF who travel to Australia from other countrie Category Health Conditions and Diseases cystic fibrosis......cystic fibrosis Western Australia provides care and support, services andinformation for people with CF. cystic fibrosis Western Australia, http://www.cysticfibrosiswa.org/

Donations What is CF? Our Mission Our Philosophy Proposed Changes ... to our Constitution Cystic Fibrosis Western Australia Cystic Fibrosis WA website is sponsored in memory of David Goldberg 65 Roses? Model West Quest 2003 Bequests Great Strides! Coming Events StarSearch 2003! Links StarSearch 2003 details now available! L.J. Hooker Supporting Cystic Fibrosis Australia All queries to info@cysticfibrosiswa.org Download our

77. Boogerwoods Halloween haunted house/trail in which all proceeds are donated for the cure of cystic fibrosis. http://www.boogerwoods.com/

26 th Anniversary BOOGER BUSTIN IS A TUFF JOB DATES Oct. 25 - 26 - 30 - 31 This Site Has Won The The Internet's Premiere Halloween Publication Comments From Past Visitors THE ULTIMATE HALLOWEEN ENTERTAINMENT IN NORTH CAROLINA..............................THE ULTIMATE HALLOWEEN ENTERTAINMENT IN NORTH CAROLINA

78. Cystic Fibrosis Medical A-Z Directory Biomedical directory with listings of hospitals, charities, research, and information by topic and location. http://www.cellscience.com/CFmain.html

Cystic Fibrosis Search Now: rating for web sites is intended to serve only as an indication of the design quality, clarity, presentation and style of the URL, and is in no way intended as a judgement of the quality of services or information provided. To have a site listed is itself an indication that the site is of general interest - (Guide: NR Not rated, strong, good, excellent)

79. Céline Dion - The Journey So Far - Céline Supports Celine Dion lost her niece to CF and has supported the cause since.Category Health Conditions and Diseases Personal Pages...... She is the National Celebrity Patron for the Canadian cystic fibrosis Foundation,and supports the TJ Martell Foundation and the Diana Princess of Wales http://www.celinedion.com/english/journey_celinesupports.html

The Journey So Far Awards Photo Gallery T.J. Martell Foundation and the Diana Princess of Wales Memorial Fund. Canadian Cystic Fibrosis Foundation (CCFF) , and appears courtesy of CCFF. Quebec Cystic Fibrosis Association (QCFA) Canadian Cystic Fibrosis Foundation 2221 Yonge Street, Suite 601, Toronto, Ontario M4S 2B4, (416) 485-9149 What's Goin' On Music The Journey So Far Rendez-vous ... Home

80. Cystic Fibrosis Foundation ... Adding Tomorrows Every Day Salutes Cochran for her support of the cystic fibrosis Foundation. (April 2001) http://www.cff.org/specialpeople04.htm

About the Cystic Fibrosis Foundation News Publications ... Special Event Prizes Sorry, the page you were looking for could not be found.

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