21. DIABETIC NEUROPATHIES diabetic neuropathies. Clinic Conference March 25 29, 2002. These neuropathiesmay be disabling and even contribute to mortality in diabetic patients. http://www.intmed.mcw.edu/ClinicConf/03-25-02 res Diabetic Neuropathy.htm

Jennifer Zebrack, MD DIABETIC NEUROPATHIES Clinic Conference: March 25 - 29, 2002 Resident Version References: Vinik AI. Diabetic neuropathy: pathogenesis and therapy. American Journal of Medicine. Aug 1999;107(2B):17S-26S. Available on OVID http://ovid.lib.mcw.edu/ Smieja M, et al., for the International Cooperative Group for Clinical Examination Research. Clinical examination for the detection of protective sensation in the feet of diabetic patients. Journal of General Internal Medicine. July 1999;14:418-24. Introduction Diabetic neuropathy is the most frequent symptomatic complication of diabetes and encompasses a wide range of abnormalities affecting both the peripheral and autonomic nervous systems. These neuropathies may be disabling and even contribute to mortality in diabetic patients. Other than improved glucose control, current therapies are primarily palliative and supportive. Peripheral Neuropathy Distal, symmetric polyneuropathy is the most common form of diabetic peripheral neuropathy and usually occurs in a stocking-glove distribution. Patients with peripheral neuropathy are at risk for long-term complications of ulceration, infection, and amputation. All diabetic patients should receive an annual foot exam, including visual inspection, peripheral pulses, and sensation. The Semmes-Weinstein monofilament exam is currently the best screening test to detect clinically significant neuropathy. Patient education regarding foot care and daily monitoring for skin breakdown is essential. Pharmacologic therapies for painful peripheral neuropathy include, but are not limited to, tricyclic antidepressants, antiepileptics, and topical capsaicin.

22. (9[2]:369-391) Diabetic Neuropathies: Features And Mechanisms (92369391) diabetic neuropathies Features and Mechanisms diabetic neuropathiesinclude both focal neuropathies and diffuse polyneuropathy. http://www.brainpathology.com/abstracts/vol9/0902/0902a14.htm

Diabetic Neuropathies: Features and Mechanisms Douglas W. Zochodne This review will summarize some of the clinical, pathological and experimental work applied toward understanding human diabetic neuropathy and will emphasize ideas on pathogenesis. (Download PDF)

23. DIABETIC NEUROPATHIES diabetic neuropathies INDEX 1. INTRODUCTION 2. CLASSIFICATION 3. NATURAL COURSE4. PATHOGENESIS 5. CLINICAL PRESENTATION 6. FOCAL NEUROPATHIES 7. DIFFUSE http://www.diabetesforum.net/cgi-bin/display_engine.pl?category_id=8&content_id=

24. Endotext.com - Diabetes, Diabetic Neuropathies diabetic neuropathies Chapter 28 Aaron Vinik, MD December 18, 2002, DIFFUSE NEUROPATHIES.Proximal motor neuropathies (Diabetic amyotrophy, femoral neuropathy). http://www.endotext.org/diabetes/diabetes28/diabetes28.htm

DIABETIC NEUROPATHIES Chapter 28 - Aaron Vinik, MD December 18, 2002 Contents Contributors Search Introduction Diabetic neuropathy (DN) is the most common and troublesome complication of diabetes mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care(1;2). It is the most common form of neuropathy in the developed countries of the world, accounts for more hospitalizations than all the other diabetic complications combined, and is responsible for 50-75% of non-traumatic amputations (2;3). DN is a set of clinical syndromes that affect distinct regions of the nervous system, singly or combined. It may be silent and go undetected, while exercising its ravages, or it may present with clinical symptoms and signs that although nonspecific and insidious with slow progression but also mimic those seen in many other diseases. It is, therefore, diagnosed by exclusion. Classification DN is not a single entity but a number of different syndromes, ranging from subclinical to clinical manifestations depending on the classes of nerve fibers involved. According to the San Antonio Convention (10), the main groups of neurologic disturbance in diabetes mellitus include: 1) subclinical neuropathy, determined by abnormalities in electrodiagnostic and quantitative sensory testing, 2) diffuse clinical neuropathy with distal symmetric sensorimotor and autonomic syndromes, and 3) focal syndromes.

25. Endotext.com - Diabetes, Diabetic Neuropathies Management of Small Fiber Neuropathies Patients must be instructed on foot carewith All diabetic patients should wear padded socks; Shoes must fit well with http://www.endotext.org/diabetes/diabetes28/diabetes28_2.htm

Go back Diagnosis and differential diagnosis of neuropathy Figure 7. QAFT consists of a series of simple, non-invasive tests for detecting cardiovascular autonomic neuropathy (41;54). These tests are based on detection of heart rate and blood pressure response to a series of maneuvers. Specific tests are used in evaluating disordered regulation of gastrointestinal, genitourinary, pseudomotor function, and peripheral skin blood flow induced by autonomic DN (52). Biopsy of nerve tissue may be helpful for excluding other causes of neuropathy and in the determination of predominant pathologic changes in patients with complex clinical findings as a means of dictating choice of treatment (35;55). Skin biopsy has some clinical advantages in diagnosis of small-fiber neuropathies by quantification of PGP 9.5, when all other measures are negative (20;56). Diabetes as the cause of neuropathy is diagnosed by exclusion of various other causes of neuropathy (28;57). Figure7. A diagnostic algorithm for assessment of neurologic deficit and classification of neuropathic syndrome is given below. NSS; Neurological Symptom Score, NDS; Nerve Disability Score, QST; Quantitative Sensory Test, QAFT; Quantitative Autonomic Function Test, EMG; Electromyography, NCV; Nerve Conduction Velocity

26. Endotext.com - Diabetes, Diabetic Neuropathies http://www.endotext.com/diabetes/diabetes28/diabetesframe28.htm

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27. MEDLINEplus: Diabetic Nerve Problems From the National Institutes of Health diabetic neuropathies The NerveDamage of Diabetes (National Diabetes Information Clearinghouse); http://www.nlm.nih.gov/medlineplus/diabeticnerveproblems.html

Skip navigation Other health topics: A B C D ... List of All Topics Diabetic Nerve Problems Contents of this page: From the NIH Coping Prevention/Screening Research ... Statistics Search MEDLINE for recent research articles on Diabetic Nerve Problems You may also be interested in these MEDLINEplus related pages: Diabetes Diabetic Foot Brain and Nervous System Endocrine System (Hormones) From the National Institutes of Health Diabetic Neuropathies: The Nerve Damage of Diabetes (National Diabetes Information Clearinghouse) Diabetic Neuropathy (National Institute of Neurological Disorders and Stroke) Peripheral Neuropathy (National Institute of Neurological Disorders and Stroke) Clinical Trials ClinicalTrials.gov: Diabetic Neuropathies (National Institutes of Health) Coping Coping with Diabetes Complications (American Diabetes Association) Disease Management Can Neuropathy Be Reversed? What Can One Do to Decrease the Pain? (Joslin Diabetes Center) Diabetic Neuropathy: What You Can Do About It (American Academy of Family Physicians) Take Charge of Your Diabetes: Nerve Damage (Centers for Disease Control and Prevention) Prevention/Screening Diabetes: Preventing Diabetic Complications (American Academy of Family Physicians) Prevent Diabetes Problems: Keep Your Nervous System Healthy (National Diabetes Information Clearinghouse) Also available in: Spanish Research Diabetes Control and Complications Trial (DCCT) (National Diabetes Information Clearinghouse) Specific Conditions/Aspects Autonomic Neuropathy (Mayo Foundation for Medical Education and Research)

28. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Diabetic+Neuropathies http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Diabetic Neuropathies

29. Member Sign In N Engl J Med 1994; 331854860; Vinik AI, et al Epidemiology of diabeticneuropathies. Cost is $37 billion. Sidebar Focal diabetic neuropathies. http://www.medscape.com/viewarticle/426917_print

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

30. Life Extension Magazine October 1996 and excretion of albumin (two measures of free radical activity), and highly significant improvement in the incidence and severity of diabetic neuropathies. http://www.lef.org/magazine/mag96/march96_update4.html

LEF Site Search All categories Protocols Health Conditions Products LE Magazine Medical Abstracts What's Hot FDA Information About LEF LEF News Daily News Life Extension Magazine What's Hot What's New Free Product Directory Click for a FREE copy of our Product Directory LEF Membership What is LEF? Benefits Become a Member Renewals ... Become a Subscriber Our call center has now expanded its hours Monday thru Friday: 8:30am to 12:00am EST 5:30am to 9:00pm PST Saturday hours are: 9:00am to 8:00pm EST 6:00am to 5:00pm PST Sunday hours are: 11:00am to 7:00pm EST 8:00am to 4:00pm PST If you'd like to order by phone or speak to a live person for help, just call toll free: Customer Service Info Privacy Policy We subscribe to the HONcode principles. Verify here LEF Magazine March 1996 Alpha Lipoic Acid For Diabetes, Atherosclerosis And Aging continued from Regeneration Of Other Antioxidants There is considerable evidence that alpha lipoic acid can be used to prevent and treat diabetes, both type I (juvenile diabetes) and type II (mature onset diabetes) and the complications of diabetes. Among the the most serious complications of diabetes is nerve damage, especially in the eye (retinopathy) and heart attacks resulting from atherosclerosis. The two most popular mechanisms of action proposed as the causes of these consequences of diabetes are excessive free radical damage and glycosylation (or glycation), which involves glucose (blood sugar) induced modifications in proteins leading to molecular cross linking of these proteins in the lens of the eye, cell membranes, and in connective tissues such as collagen and elastin.

31. Diabetic Neuropathy A description of this disorder from Medline National Library of Medicine.Category Health Conditions and Diseases diabetic neuropathies......Medline NLM definition of diabetic neuropathies Peripheral, autonomic, andcranial nerve disorders that are associated with DIABETES MELLITUS. http://www.ion.ucl.ac.uk/library/patient/diabetic.htm

Diabetic Neuropathy Medline NLM definition of Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. PubMed Medline search on diabetic neuropathies Diabetic Neuropathy fact sheet: National Institute for Neurological Disorders and Stroke Support Groups

32. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso Conditions and Diseases Neurological Disorders Peripheral NervousSystem diabetic neuropathies . Uncover resources and links http://www.1uphealth.com/links/peripheral-nervous-system-diabetic-neuropathies.h

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Peripheral Nervous System : Diabetic Neuropathies Description See Related Categories Health: Conditions and Diseases: Endocrine Disorders: Pancreas: Diabetes Sites Diabetic Neuropathy A description of this disorder from Medline National Library of Medicine. Dr. Vera Bril - Diabetic Research Studies New research on the most common complication of diabetes. Two articles; Can it be Treated and Treatment with Aldose Reductase Inhibitors. Neuro-Patient Resource Centre Details about diabetic neuropathies, including the types, who gets it, testing and what can be done. NINDS Diabetic Neuropathy Information Page Diabetic neuropathy information sheet compiled by NINDS. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement.

33. Entrez-PubMed Diabetic Nephropathies/epidemiology; diabetic neuropathies/prevention control; diabetic neuropathies/physiopathology; diabetic neuropathies http://www.biomedcentral.com/pubmed/7587918

PubMed Nucleotide Protein Genome ... Books Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books PopSet ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene NCBI Web Site for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Browser Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Domain Links 3D Domain Links Genome Links ProbeSet Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links Show: Sort Author Journal Pub Date Text File Clipboard Order Diabetes Res Clin Pract 1995 May;28(2):103-17 Related Articles, Links Comment in: ACP J Club. 1996 May-Jun;123(3):68 Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M.

34. Entrez-PubMed epidemiology; diabetic neuropathies/physiopathology; diabetic neuropathies/epidemiology;Diabetic Retinopathy/prevention control; http://www.biomedcentral.com/pubmed/7622004

PubMed Nucleotide Protein Genome ... Books Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books PopSet ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene NCBI Web Site for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Browser Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Domain Links 3D Domain Links Genome Links ProbeSet Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links Show: Sort Author Journal Pub Date Text File Clipboard Order Diabetes 1995 Aug;44(8):968-83 Related Articles, Links The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Publication Types: Clinical Trial Controlled Clinical Trial Multicenter Study PMID: 7622004 [PubMed - indexed for MEDLINE] Summary Brief Abstract Citation ASN.1

35. Development Medicine Online Translate this page by admin on 2003/1/28 102639 (15 reads) diabetic neuropathies are the most commonsymmetric sensory and motor neuropathies in the industrialized countries. http://devmedicine.org/xoops/modules/news/index.php?storytopic=30

36. Development Medicine Online Translate this page by admin on 2003/1/28 102639 (16 reads) diabetic neuropathies are the most commonsymmetric sensory and motor neuropathies in the industrialized countries. http://devmedicine.org/xoops/modules/news/article.php?item_id=42

37. Program - Western Veterinary Conference Short sessions will cover diabetic neuropathies, diets for diabetics, andbacterial UTI in cats. 300320 pm diabetic neuropathies Deb Greco. http://www.westernveterinary.org/Search.plx?ID=115

38. Conditions And Diseases: Neurological Disorders: Peripheral Nervous System: Diab Information on Conditions and Diseases, Neurological Disorders, Peripheral NervousSystem, diabetic neuropathies and much more Treasure Coast Health. http://treasurecoasthealth.com/treasurecoasthealth.php/Health/Conditions_and_Dis

Find Doctors on the Treasure Coast Select Specialty Ambulatory Care Anesthesiology Cardiology Dermatology Emergency Medicine Endocrinology Family Practice Gastroenterology Hematology/Oncology Infectious Diseases Internal Medicine Maxillofacial Surgery Neonatology Nephroology Neurology Neurosurgery Obstetrics/Gynecology Ophthalmology Orthopedic Surgery Otolaryngology Pathology Pediatics Physical Medicine Plastic Surgery Podiatry Psychiatry Psychology Pulmonary Radiation Oncology Radiology Rheumatology Surgery Thoracic Surgery Urology Vascular Surgery Select City Sebastian Palm Bay Vero Beach Fort Pierce Okeechobee Port St. Lucie Jensen Beach Stuart Palm City Hobe Sound Loxahatchee MENU Home Doctor Directory Health Resources Women Only ... About Us Conditions and Diseases: Neurological Disorders: Peripheral Nervous System: Diabetic Neuropathies See also: Health: Conditions and Diseases: Endocrine Disorders: Pancreas: Diabetes http://www.nutrisystem.com We have helped millions of people lose weight for more than 30 years. Lose up to 10 lbs. in your first month! Diabetic Neuropathy - A description of this disorder from Medline National Library of Medicine.

39. ClinicalTrials.gov - Linking Patients To Medical Research: Results with Diabetes. Conditions diabetic neuropathies; Diabetes Mellitus,InsulinDependent; Diabetes Mellitus, Non-Insulin-Dependent. http://www.clinicaltrials.gov/search/term=Diabetic Neuropathy

Home Search Browse Resources ... About Search results for Diabetic Neuropathy [ALL-FIELDS] are shown below. Show all trials, including those no longer recruiting patients. 5 studies were found. Recruiting VEGF for Diabetic Neuropathy Condition: Diabetic Neuropathy Recruiting LY333531 Treatment of Peripheral Neuropathy in Patients with Diabetes. Conditions: Diabetic Neuropathies; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Non-Insulin-Dependent Recruiting LY333531 Treatment for Symptomatic Peripheral Neuropathy in Patients with Diabetes. Conditions: Diabetic Neuropathies; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Non-Insulin-Dependent Recruiting LY333531 Treatment for Symptomatic Peripheral Neuropathy in Patients with Diabetes. Conditions: Diabetic Neuropathies; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Non-Insulin-Dependent Recruiting Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers with Regranex or Placebo Condition: Diabetic Foot Ulcers U.S. National Library of Medicine Contact NLM Customer Service National Institutes of Health Freedom of Information Act ... Accessibility

40. Ceanytime: Continuing Education For Healthcare Professionals sharp pains; loss of balance; all of the above. The first step in assessingfor peripheral diabetic neuropathies is generally all the following except http://www.ceanytime.com/pdn/test.htm

Management of Diabetic Complications: A Focus on Peripheral Diabetic Neuropathy Registration, Post-Test, and Program Evaluation This course (ACPE #038-999-00-052-H01) qualifies for 1.0 contact hours (0.10 CEUs) of continuing pharmacy credit, which will be awarded within 4 weeks after submission of a successfully completed program. A passing grade of 70% is required. Any participant who fails the examination may be re-examined one additional time. In order to apply for continuing pharmacy education credit, please complete the post-test and evaluation, answer the questions directly on the post-test form, and submit via e-mail using the “submit” button at the bottom of the post-test. The form can also be printed out, placed in an envelope, and mailed to: Rutgers, The State University of New Jersey College of Pharmacy Continuous Education 160 Frelinghuysen Road Piscataway, NJ 08854-8020 To obtain a certificate of completion for 1 hour of category 1 credit toward the AMA Physician’s Recognition Award, please answer the questions directly on the post-test form, then submit the form via e-mail by using the “submit” button at the bottom of the post-test. The form can also be printed, placed in an envelope, and mailed to: Dannemiller Foundation Attn: Peripheral/00-86 12500 Network Blvd.

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