21. Smallpox Vaccination – Adverse Reactions: Erythema Multiforme: Frequency erythema multiforme Frequency Susceptible Populations. erythema multiforme(EM) Cases per 1,000,000 Primary Vaccinations(*). Age (yrs). http://www.bt.cdc.gov/training/smallpoxvaccine/reactions/ery_multi_frequency.htm

of document.write(totalImages) Zoom View All Click on image to enlarge A variety of rashes occur in a large number of vaccinees 1-2 weeks after vaccination. Erythema Multiforme (EM) Cases per 1,000,000 Primary Vaccinations(*) Age (yrs) 1968 National Survey(†) 1968 10-State Survey(§) N/A N/A N/A Totals 1 yr N/A Numbers rounded to the nearest tenth, total number of vaccinations estimated in both studies. Observations missing age were distributed according to the existing age distribution for EM. EM case rates not reported in this study. Case sources include: Physician reporting via survey in 10 states with active case information follow-up and chart review for post-vaccinial encephalitis and vaccinia necrosum reports. Recent Studies Recent studies indicate that 5.6-14.3 percent of adult vaccinees develop rashes at sites other than the vaccination.

22. Erythema Multiforme Target Rash erythema multiforme is an allergic reaction with many different causes. Somepeople only have erythema multiforme in the mouth. http://www.skinsite.com/info_erythema_multiforme.htm

Erythema Multiforme I. Definition: Erythema multiforme is an allergic reaction with many different causes. It can affect people of all ages and is often more severe in children and young adults. Erythema multiforme often starts as a red rash on the palms, soles, and back of the hands. It can spread to the trunk, face, and mouth in severe cases. Some people only have erythema multiforme in the mouth. As the skin lesions age they often look like small targets with purple to dusky centers surrounded by red rings. The condition can be associated with fever, muscle aches, and not feeling well. II. Causes: There are many causes of erythema multiforme. These include allergic reactions to viral, bacterial, and fungal infections; sensitivity to food or drugs; immunizations; or sometimes it occurs in association with other disorders. The most common causes of erythema multiforme are Mycoplasma pneumonia, cold sores, herpes of the genitals, and as a reaction to medication (sulfa drugs). Erythema multiforme is not contagious.

23. Erythema Multiforme erythema multiforme is part of a spectrum of diseases beginning with a selflimitedrash of the skin and mucous membranes which may progress to a disseminated http://www.thedoctorsdoctor.com/diseases/erythema_multiforme.htm

Background Erythema multiforme is part of a spectrum of diseases beginning with a self-limited rash of the skin and mucous membranes which may progress to a disseminated blistering and sometimes fatal disorder known as Stevens-Johnson syndrome (SJS). Older classification systems divided the disease into erythema multiforme minor and major. The major variant is associated with fever, systemic symptoms, and severe oral lesions. These severe cases were sometimes termed SJS and were usually associated with drugs while the minor form was associated with herpes and other infections. At the extreme end is toxic epidermal necrolysis (TEN) which is the most advanced form of Stevens-Johnson syndrome and erythema multiforme. One clinical distinction uses the diagnosis of TEN if greater than 30% of the total body surface area is involved by blisters and peeling and SJS when mucosal lesions are present and the blisters involve less than 30% of the total body surface area. Working Classification System Bullous erythema multiforme Recurrent erythema multiforme Persistent erythema multiforme Stevens-Johnson syndrome Overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (epidermal detachment between 10-30%) Toxic epidermal necrolysis with spots (widespread purpuric macules or target lesions) Toxic epidermal necrolysis without spots The recurrent form has been associated herpes simplex virus infection. The persistent form has been associated with underlying malignancies and Epstein-Barr virus.

24. Lupus Erythematosus And Erythema Multiforme:ANSWER described a syndrome characterized by lupus erythematosus with erythema multiformelikelesions,speckled antinuclear antibodies, anti-SjT antibodies and http://dermatology.cdlib.org/DOJvol3num2/cases/mendonca2.html

DIAGNOSIS: Rowell's Syndrome Discussion In 1963 Rowell et al. described a syndrome characterized by lupus erythematosus with erythema multiforme-like lesions,speckled antinuclear antibodies, anti-SjT antibodies and rheumatoid factor.(1) Anti- SjT is now thought to be identical with anti-La (SS-B). Rowell originally reported this syndrome in DLE(1) but it also occurs in SLE.(2) Perniotic lesions frequently occur.(3) Figure 7 Figure 7: Annular erythematous purpuric plaques on the arm. This case fulfills all the criteria described initially by Rowell et al. and by subsequent reports.(4-7) Although a positive rheumatoid factor has also been shown in many (but not all) cases reported thus far, this test was not obtained for our patient. This report does differ from previous descriptions of Rowell's syndrome in that the first biopsy was interpreted as erythema multiforme.(8) However, the second biopsy was consistent with lupus erythematosus. Some authors feel that Rowell syndrome may simply be coincidental occurrence of lupus erythematosus and erythema multiforme.(9)

25. Lupus Erythematosus And Erythema Multiforme-like Lesions: Unknown Lupus erythematosus and erythema multiformelike lesions. The pathologyinterpretation of the initial biopsy was erythema multiforme. http://dermatology.cdlib.org/DOJvol3num2/cases/mendonca1.html

Lupus erythematosus and erythema multiforme-like lesions. Rui Mendonca MD Dermatology Online Journal 3(2): 4 Case Report A 68 year old female presented in February 1996 with a skin eruption of 10 weeks duration. She initially had sores and bleeding of the lips, and later on developed lesions on the arms, upper chest thighs and legs. Her past medical history included a cerebrovascular accident, hypertension, and an aortic aneurysm. At the time of presentation, her medications included furosemide, digoxin, warfarin, isoptin, potassium, captopril and spironolactone. (The last two had been introduced 3 months prior.) Physical examination revealed crusted erosions on the lips and annular erythematous plaques on the chest, arms, thighs and legs. The buccal mucosa was not involved. Histopathology of a plaque from the right arm revealed a largely necrotic epidermis with a subepidermal vesicle. Necrotic keratinocytes were present at the dermo-epidermal junction and throughout the epidermis. The upper dermis was edematous and extravasated erythocyes were present and extend into the papillary dermis. The pathology interpretation of

26. Erythema Multiforme -- ECureMe.com erythema multiforme, more about erythema multiforme, Abnormal, This isa rash that appears suddenly. more about erythema multiforme, .. http://www.ecureme.com/emyhealth/data/Erythema_Multiforme.asp

March 30, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Erythema Multiforme more about Erythema Multiforme Abnormal This is a rash that appears suddenly. It usually is symmetrical (i.e., if it is on one arm, it is also on the other). A very severe form is called Stevens-Johnson syndrome and can be life-threatening. Stevens-Johnson syndrome usually involves prominent blistering of the mouth and eyes. Appearance (multiple types): Red, raised, large lesions

27. Erythema Multiforme erythema multiforme. erythema multiforme (a multishaped red rash)is characterized by target-like lesions, which often look for http://www.drhull.com/EncyMaster/E/erythema_multiforme.html

Help for sleepless parents Encyclopedia Index E erythema multiforme Search erythema multiforme Erythema multiforme (a multi-shaped red rash) is characterized by target-like lesions, urticaria (hives), it is not itchy. Erythema multiforme is often a recurrent, postinfectious process, frequently associated with herpes simplex virus and mycoplasma infections. It is a self-limited condition, and rarely causes any major problems. Erythema multiforme is often confused with giant urticaria, another harmless condition, or Stevens-Johnson syndrome, which can be quite serious.

28. Postgraduate Medicine: Taking Aim At Erythema Multiforme Taking aim at erythema multiforme. In this article, Dr Katta summarizesthe latest information on erythema multiforme and its management. http://www.postgradmed.com/issues/2000/01_00/katta.htm

Taking aim at erythema multiforme How to spot target lesions and less typical presentations Rajani Katta, MD VOL 107 / NO 1 / JANUARY 2000 / POSTGRADUATE MEDICINE CME learning objectives To review the typical clinical findings of erythema multiforme To examine the evidence supporting herpes simplex virus infection as an inciting factor in erythema multiforme To learn treatment methods for erythema multiforme Preview : The first attack of erythema multiforme can be alarming to the victim, who is often an otherwise-healthy young adult. In a typical episode, a symmetric pattern of round, red lesions suddenly appears, frequently on the extremities, and erosions develop in the mouth. Fortunately, the condition is self-limited. Unfortunately, it is usually recurrent, possibly because of the ongoing, subclinical presence of herpes simplex virus. In this article, Dr Katta summarizes the latest information on erythema multiforme and its management. Katta R. Taking aim at erythema multiforme: how to spot target lesions and less typical presentations. Postgrad Med 2000;107(1):87-90 T he incidence of erythema multiforme is unknown, but the condition is relatively common. It occurs worldwide, in both men and women, and in people of any age (although most patients are under 40) (1).

29. Erythema Multiforme . erythema multiforme has been sonamed because of the large degree of variety in its clinical presentation.......erythema multiforme. Dan Lewis. http://fohweb.uws.edu.au/podiatry/erythema.htm

Erythema multiforme Dan Lewis Description Erythema multiforme minor: EM minor as the name suggests is the less severe of the two types and accounts for 80% of EM cases (Elias, Fritsch, 1993). It is characterised by symetrical, round, red or target shaped lesions which occur on the extremities. In severe cases vesicles and bullous lesions may be present both on the skin and mucous membranes (Arnold, Odom, James, 1990). Stevens Johnson syndrome: In Stevens Johnson syndrome (SJS) the degree of vascular damage is greater than in EM minor. The lesions produced are large hemorrhagic bullae on an erythematous base which predominantly affect the mucous membranes and occasionaly the internal organs (Vivier, 1986). Incidence and Epidemiology Clinical Presentation Erythema multiforme minor. While there is variety in the lesions that EM minor produces the rash is usually monomorphous in each patient and thus they will tend to display one of the following; Target lesions are symetrical, acral distributions occuring most often on the palms and the soles. The initial lesion is dull red, flat macule, which expands slightly to a maximum of 2cm over 24 hours. While the periphery remains erythmatous the center clears, becoming cyanotic or purpuric and forming the characteristic target or iris pattern. The lesions last for 1 to 2 weeks and then recede leaving residual hyperpigmentation. The target lesion is not always complete and polycyclic or arcuate lesions may predominate.

30. 1Up Health > Erythema Multiforme > Causes, Incidence, And Risk Factors Of Erythe Comprehesive information on erythema multiforme (Lyell's syndrome,StevensJohnson syndrome, Toxic epidermal necrolysis). Covers http://www.1uphealth.com/health/erythema_multiforme_info.html

1Up Health Erythema multiforme Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Erythema multiforme Information Erythema multiforme Causes, Incidence, and Risk Factors Alternative names : Lyell's syndrome, Stevens-Johnson syndrome, Toxic epidermal necrolysis Definition : Erythema multiforme is a skin disorder resulting from an allergic reaction Causes, Incidence, and Risk Factors Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Approximately 90% of erythema multiforme cases are associated with herpes simplex or Mycoplasma infections. The disorder occurs primarily in children and young adults. Erythema multiforme may present with a classic skin lesion with or without systemic (whole body) symptoms. In Stevens-Johnson syndrome, the systemic symptoms are severe and the lesions are extensive, involving multiple body areas (especially the mucous membranes). Toxic epidermal necrolysis (TEN syndrome, or Lyell's syndrome) involves multiple large

31. Online Dermatology Image Library Dermatlas Dermatology thrush,erythema multiforme,erythema multiforme,dermatologyimage,Stevens-Johnson syndrome, minor images. Match ALL words Match ANY word. http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=34

32. Online Dermatology Image Library ARM erythema multiforme © 200102, Johns Hopkins University Schoolof Medicine Dermatlas, Image Name em_2_010205, File Type jpg. http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=98

33. Arch Intern Med -- Page Not Found Arch Intern Med. 162;843, April 8, 2002, Is erythema multiforme AssociatedWith Bupropion Use?, Francesco Drago; Alfredo Rebora. http://archinte.ama-assn.org/issues/v162n7/ffull/ilt0408-2.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

34. Erythema Multiforme & Vaccination erythema multiforme vaccination Package insert (Hep B) Griffith RD, et al.erythema multiforme following diphtheria and tetanus toxoid vaccination. http://www.whale.to/vaccines/erythema.html

Package insert (Hep B) Griffith RD, et al. Erythema multiforme following diphtheria and tetanus toxoid vaccination. J Am Acad Dermatol. 1988 Oct;19(4):758-9. No abstract available.PMID: 2972761; UI: 89034970. Leung AK, et al. Erythema multiforme following diphtheria-pertussis-tetanus vaccination. Kobe J Med Sci. 1987 Aug;33(4):121-4. No abstract available.PMID: 3501037; UI: 88092135.PMID: 3501037; UI: 88092135. Leung AK. Erythema multiforme following DPT vaccination. J R Soc Med. 1984 Dec;77(12):1066-7. No abstract available.PMID: 6334749; UI: 85082926. [See Related Articles] Freeman T. Erythema multiforme in children taking amoxicillin after vaccination. Can Med Assoc J. 1982 Nov 1;127(9):818, 820. No abstract available.PMID: 7139496; UI: 83050429. [See Related Articles] Dogliotti M. Erythema multiforme an unusual reaction to BCG vaccination. S Afr Med J. 1980 Mar 1;57(9):332-4. PMID: 7355353; UI: 80124467. [See Related Articles] Scott EG, et al. Erythema multiforme complicating smallpox vaccination. J Miss State Med Assoc. 1969 Feb;10(2):41-2. No abstract available.PMID: 5763298; UI: 69091434. [See Related Articles] Home Vaccination Diseases ... Vaccine damage

35. Erythema Multiforme erythema multiforme. Definition erythema multiforme is a skin disorderresulting from an allergic reaction. Alternative Names http://www.pennhealth.com/ency/article/000851.htm

Disease Injury Nutrition Poison ... Prevention Erythema multiforme Definition: Erythema multiforme is a skin disorder resulting from an allergic reaction Alternative Names: Lyell's syndrome; Stevens-Johnson syndrome; Toxic epidermal necrolysis Causes, incidence, and risk factors: Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Approximately 90% of erythema multiforme cases are associated with herpes simplex or Mycoplasma infections. The disorder occurs primarily in children and young adults. Erythema multiforme may present with a classic skin lesion with or without systemic (whole body) symptoms. In Stevens-Johnson syndrome, the systemic symptoms are severe and the lesions are extensive, involving multiple body areas (especially the mucous membranes). Toxic epidermal necrolysis (TEN syndrome, or Lyell's syndrome) involves multiple large blisters bullae ) that coalesce, followed by sloughing of all or most of the skin and mucous membranes.

36. Dermatology - Erythema Multiforme erythema multiforme What is erythema multiforme? other infectious diseases;certain vaccines. What are the symptoms of erythema multiforme? http://www.sw.org/clinical_content/adult/derm/emulit.htm

Erythema Multiforme What is erythema multiforme? Erythema multiforme is a skin disorder characterized by symmetrical, red, raised skin areas all over the body. These patches often look like "targets" (dark circles with purple-grey centers). The skin condition may be chronic and usually lasts for two to four weeks each time. Most often, this disorder is caused by the herpes simplex virus. Other causes may include the following: an interaction with a certain medication other infectious diseases certain vaccines What are the symptoms of erythema multiforme? The following are the most common symptoms of erythema multiforme. However, each individual may experience symptoms differently symptoms may include: sudden, red patches and blisters, usually on the palms of hands, soles of feet, and face flat, round red "targets" (dark circles with purple-grey centers) itching cold sores fatigue joint pains fever The symptoms of erythema multiforme may resemble other skin conditions. Always consult your physician for a diagnosis. Treatment for erythema multiforme: Specific treatment for erythema multiforme will be determined by your physician based on: your age, overall health, and medical history

37. Diseases And Conditions -- Discovery Health -- Erythema Multiforme erythema multiforme is a skin reaction that results in red, targetshapedpatches on the skin. image) erythema multiforme. Erythema http://health.discovery.com/diseasesandcond/encyclopedia/104.html

erythema multiforme By Lynn West, MD Images (click to view larger image) Erythema multiforme is a skin reaction that results in red, target-shaped patches on the skin. What is going on in the body? Erythema multiforme is an hypersensitivity reaction commonly caused by an infection or a medication. The person's body responds to an organism or chemical with an exaggerated allergic response. Erythema multiforme can be minor or more severe. The more severe form is also known as Stevens-Johnson syndrome. Severe reactions can involve the skin, lungs, kidneys, eyes, and other areas. Rarely, in severe cases, death may occur. What are the signs and symptoms of the condition? Signs and symptoms of erythema multiforme include the following: reddish-purple, target-shaped patches on the skin, especially the palms and soles hive-like, raised swollen areas on the skin that do not clear up like true hives open, tender areas of the surfaces of the mouth, eyes, and genitals general discomfort fatigue fever Severe cases may cause skin peeling and serious eye inflammation, among other signs and symptoms. What are the causes and risks of the condition?

38. Erythema Multiforme: Case Report And Discussion erythema multiforme Case Report and Discussion. Lisa M obtained.The child's condition was diagnosed as erythema multiforme. His http://www.familypractice.com/journal/1998/v11.n01/1101.09/art-1101.09.htm

Erythema Multiforme: Case Report and Discussion Lisa M. Kroonen, MD , Family Medicine Residency Program, Kaiser Fontana, Fontana, CA [J Am Board Fam Pract 11(1):63-65, 1998. © 1998 American Board of Family Practice] Introduction Erythema multiforme may be placed on a disease continuum that includes Stevens-Johnson syndrome and toxic epidermal necrolysis. It was first described in 1866 by Hebra as a skin disease with symmetrically distributed red papules, evolving within several days to form annular or iris-like shapes or blisters. The term multiforme described this evolution of primary lesions into different forms. In 1922 Stevens and Johnson described a febrile illness with stomatitis, purulent conjunctivitis, and skin lesions similar to those of erythema multiforme, which has become known as Stevens-Johnson syndrome or erythema multiforme major. Toxic epidermal necrolysis, with severe exfoliation of the skin and mucous membranes and a high rate of mortality, is considered by many sources to be at the most severe extreme of this disease spectrum. Case Report An 18-month-old boy was brought to the emergency department with worsening generalized body rash. There was no complaint of fever, lack of oral intake, itchiness, or ocular involvement. One week earlier he had been seen for presumed otitis media and given a prescription for amoxicillin. Five to 6 days after starting the medication, he began to develop an erythematous rash that began on his arms and legs. Two days later the rash was evident on his palms and soles, as well as truncal area. Initially the rash was specifically described as beginning as small areas of redness, which within days became raised and enlarged and then developed surrounding lighter layers and central areas of paleness.

39. Erythema Multiforme erythema multiforme. event. erythema multiforme has an abrupt onsetand typically resolves without scarring in 26 weeks. Systemic http://www.maxillofacialcenter.com/BondBook/mucosa/em.html

Erythema Multiforme Quick Summary Introduction References Photos ... Prognosis Recently ruptured blister of the buccal mucosa. Quick Review for Patients Erythema multiforme is an unusual allergic reaction which results in red rashes, blisters and ulcers of the mouth membranes and the skin, either together or separately. Some cases are very severe and may be fatal, but most persons have a much more mild, self-limiting form of the disease. Recurring examples do occur, especially when recurring herpes virus infection (fever blisters on the lip) is the triggering event. Erythema multiforme has an abrupt onset and typically resolves without scarring in 2-6 weeks. Systemic or topical corticosteroids are usually effective. Top of This Page Introduction Note: click on underlined words for more detail or photos. Erythema multiforme is an acute, self-limiting, blistering and ulcerative allergic response of the skin and mucous membranes. Some authorities separate the disease into minor and major (Stevens-Johnson syndrome) subtypes, and an extreme subtype referred to as toxic epidermal necrolysis (Lyell's disease), first described in 1956. Most cases are minor, but death has resulted from severe involvement. Infection appears to be the triggering event in at least half of the cases, usually with Herpes simplex virus or Mycoplasma pneumoniae. Medications, especially sulfonamides, and foods may also initiate an attack, and those associated with medications tend to be among the most severe cases.

40. Example Site - E Erythema Multiforme Keywords A B C D E F H I K L M P R S T U Z G j n o Q V W X Y. ErythemaMultiforme erythema multiforme See StevensJohnson Syndrome. http://www.totalskincare.com/library/totalskincare_e_erythema-multiforme.html

Keywords: A B C D E F G H I ... Y-Z Erythema Multiforme Erythema Multiforme See Stevens-Johnson Syndrome. Ecthyma Eczema Egg powder Elder flowers ... Erysipelas Erythema Multiforme Erythrasma Essential oil Ethocyn Ethyl Alcohol ... Eyelid Surgery

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