81. Is Essential Tremor A Neurodegenerative Disease? IS essential tremor A NEURODEGENERATIVE DISEASE? DENVER —essential tremormay be as much as 20 times more common than Parkinson’s disease. http://www.neurologyreviews.com/jun02/nr_jun02_tremor.html

Home Address Change Archives Return to table of contents I S E SSENTIAL T REMOR A N EURODEGENERATIVE D ISEASE? ON THE VERGE OF A PATHOPHYSIOLOGIC BREAKTHROUGH? Dr. Louis and colleagues used a scanning technique, 1H magnetic resonance spectroscopic imaging, to measure levels of intracellular metabolites such as N -acetylaspartate (NAA), total choline, and total creatine (tCR) in several brain regions in patients with essential tremor. Because NAA is a marker of neuronal viability, the researchers believed that any reductions observed in this particular metabolite would indicate neuronal damage or death. Only 15 postmortem studies in essential tremor have been published to date, and these have not consistently demonstrated degeneration of a specific cell population. Variable reductions in Purkinje cells in the cerebellar cortex have been observed in a few autopsy studies. Overall, this has been an understudied area of neurologic science, said Dr. Louis. Essential tremor affects people of all age-groups, although its prevalence increases substantially with age. In some cases, it runs in families in an autosomal dominant fashion; in other instances, there is no familial predisposition, suggesting that the causes are likely to be environmental factors. Hands, head, and voice are most often affected, and the symptoms often begin as mild tremors that become more severe and disabling over time.

82. NS Essential Tremor Essential and Intention Tremor. More than a million Americans sufferfrom essential tremor and 500,000 have Parkinson's Disease. http://www.hjd.org/hospitals/hjd/html/body_ns_essential_tremor_.html

Movement Disorders Chronic Pain Other Disabling Conditions Essential and Intention Tremor More than a million Americans suffer from Essential Tremor and 500,000 have Parkinson's Disease. The first new treatment approach in 30 years for disabling tremor due to Essential Tremor and tremor associated with Parkinson's disease is now available at NYU Medical Center. Recently approved by the U.S. Food and Drug Administration (FDA), the Tremor Control therapy uses an implanted pacemaker-like device to deliver mild, electrical stimulation to block the brain signals that cause tremor. Tremor - the disabling, involuntary rhythmic shaking of the limbs or other parts of the body, is the only symptom of Essential Tremor and one of four major symptoms of Parkinson's disease. "NYU Medical Center is pleased to be able to offer the benefits of Tremor Control Therapy to patients," said Dr. Patrick Kelly, Professor and Chairman, Department of Neurosurgery. "Tremor is a condition that severely impacts a patient's quality of life as well as their ability to function in life. Mistakenly, many sufferers continue to live with tremor because they assume that it is part of the normal aging process or that nothing can be done." Essential Tremor is the most common neurological movement disorder in this country. The condition afflicts at least a million Americans, usually age 45 or older. Parkinson's disease is a progressive and degenerative neurological disease that affects approximately 500,000 people in the United States. Tremor worsens from mild to disabling at a variable rate, depending on the individual. Currently, thousands of people throughout Europe, Canada and Australia have the system implanted to control their tremor.

83. Drug Controls Essential Tremor Drug Controls essential tremor About 5 million Americans have essential tremor,a condition characterized by shaking hands, legs, head and a quavering voice. http://www.applesforhealth.com/esstremor1.html

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84. Essential Tremor essential tremor. Tremor, or uncontrollable trauma. However, many people withtremor have what is called idiopathic or essential tremor. In these http://www.psychology.psych.ndsu.nodak.edu/mccourt/website/htdocs/HomePage/Psy48

85. Lexi-Comp Product Info DEESSTRPC0085Essential Tremor Patient Title essential tremor Patient Chart. Price $14.95. essential tremorPatient Chart. Size 20 x 28 Laminated Wall Poster. http://store.lexi.com/lexistore/marketing/prodinfo/de/DEESSTRPC0085/index.jsp

86. Neurological Disorder Hepburn's shaky hands and voice resemble the tremor associated with Parkinson's diseasebut stem from an even more common movement disorder—essential tremor. http://cpmcnet.columbia.edu/news/in-vivo/Vol2_Iss02_jan29_03/

Neurological Disorder Cancer Pathways Cancer Research Biology in the Basement ... POV Though it's up to 20 times more common than Parkinson's, essential tremor is more mysterious. No cellular defect has been linked to the disease, which affects up to 6 percent of the population, and its environmental and genetic roots remain obscure. New research from Dr. Elan D. Louis, assistant professor of neurology, and his colleagues may lead to answers on both fronts. They recently identified a brain region where cells may be dying in tremor patients and an environmental toxin that may trigger the disease. The research was published in the Nov. 15 Neuroscience Letters and the Dec. 24 Neurology. Though essential tremor sometimes becomes so disabling that patients are unable to work or feed themselves, the disease does not shorten the patient's life and is less studied than other neurological diseases. Only 15 postmortem brains of essential tremor patients have been examined in the last 100 years. Some of these postmortem exams suggested that cells in the cerebellar cortex—the "little brain" near the brainstem that helps control movement—shrink or disappear in people with the disease. To get a better picture of possible cellular deterioration, Dr. Louis and Dr. Dikoma Shungu, associate professor of clinical radiology (physics), used a relatively new brain scanning technique to look for signs of degeneration in living patients. The method, proton magnetic resonance spectroscopic imaging, or MRSI, measures the concentration of chemicals inside neurons, giving researchers a more detailed view of cell activity than that provided by other types of brain imaging. Dr. Louis looked primarily at the level of N-acetyl-aspartate (NAA) in the brain because a low level is believed to indicate damaged or dying neurons.

87. Essential Tremor Information Page Diseases Database essential tremor Information Page. 3 synonyms or equivalents were found. Essentialtremor aka/or Hereditary essential tremor aka/or Benign essential tremor http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=1324

88. Member Sign In What's new concerning treatments for essential tremor? LongTerm Safety and Efficacyof Unilateral Deep Brain Stimulation of the Thalamus in essential tremor. http://www.medscape.com/viewarticle/431461

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89. Health Library - Benign Essential Tremor Benign essential tremor. Synonyms Disorder years. Benign essential tremoris generally considered a slowly progressive disorder. Disease http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

90. ESSENTIAL TREMOR essential tremor. DEFINITION 1. Background. also called Benign essential tremor,Heredofamilial Tremor, and Familial (Essential) Tremor. 2. Pathogenesis. http://www.icondata.com/health/pedbase/files/ESSENTIA.HTM

Pediatric Database (PEDBASE) Discipline: CNS Last Updated: 10/06/97 ESSENTIAL TREMOR DEFINITION: A slowly progressive symmetric tremor affecting the arms and hands. EPIDEMIOLOGY: incidence: ? age of onset: usually between 40-50 years of age but can begin in infancy or childhood risk factors: familial - autosomal dominant chrom.#: ? gene: ? M = F Sweden PATHOGENESIS: 1. Background also called Benign Essential Tremor, Heredofamilial Tremor, and Familial (Essential) Tremor 2. Pathogenesis etiology unknown CLINICAL FEATURES: 1. Neurological Manifestations 1. Tremor has a frequency of 4-9 Hz and is symmetric usually limited to the arms and hands but may eventually involve the facial muscles, tongue, head, and neck worse when arms and hands are placed in certain positions (i.e., antigravity) diminishes at rest and disappears with sleep enhanced by fatigue and stress alcohol may attenuate may be slowly progressive 2. Complications 20% of patients eventually develop rigidity dysarthria with significant involvement of the head and neck INVESTIGATIONS: all investigations are normal MANAGEMENT: 1. Medical

91. Essential Tremor... essential tremor. ABSTRACT. essential tremor (ET), is the most common disturbanceof the disorders of movement and affects close to 5% of people over 40 years. http://www.imbiomed.com.mx/Neuro/NCv2n2/english/Znc72-04.html

Otero SE, Arriada MN Temblor esencial Arch Neurocien (Mex) Essential tremor ABSTRACT Essential tremor (ET), is the most common disturbance of the disorders of movement and affects close to 5% of people over 40 years. ET is considered to be a genetically transmitted disorder in an autosomal dominant form with anticipatory phenomenon, although sporadic forms have also been described. Because ET has traditionally been handled as a monosymptomatic and benign disorder, it is diagnosed very infrequently, thus depriving the affected person from the benefits of a timely therapy. Recent studies have shown that 15% of patients with ET retire early due to the tremors, while up to 5% of the affected patients are so handicapped by the disorder that they greatly depend on their family members for help with their daily activities. The tremor's relation with other movement disorders, such as Parkinson's disease and dystonia is controversial, currently accepting the fact that only a small percentage of patients with essential tremor will develop these complications, because the research that signaled tremors as an important condition for dystonia and Parkinson did not have the proper clinical criteria. Treatment for ET is based on the degree of affectation. A long term therapy is recommended only to those patients in whom tremors notoriously affect their daily routines. Propranolol and primidone are the most commonly prescribed medications. Stereotactic surgery has been successfully used in patients who suffer disabling tremors and do not respond to medication. In this review, the diagnosis, treatment criteria and the relation of ET with other disorders of movement are highlighted.

92. Essential Tremors - Neurologychannel essential tremor is associated with purposeful movement (eg, holdinga glass to drink, shaving, writing, buttoning a shirt). It http://www.neurologychannel.com/tremor/index.shtml

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement TREMOR Overview Risk Factors Diagnosis Treatment CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Dementia Encephalitis Epilepsy Essential Tremor ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES Clinical Trials Links Videos ABOUT US Healthcommunities.com Pressroom Testimonial Overview Tremor is involuntary trembling in part of the body. Essential tremor is associated with purposeful movement (e.g., holding a glass to drink, shaving, writing, buttoning a shirt). It occurs most often in the hands and head and also may affect the arms, voice box (larynx), trunk, and legs. Essential tremor is caused by abnormalities in areas of the brain that control movement and does not occur as the result of disease (e.g., Parkinson’s disease). It usually does not result in serious complications. Incidence and Prevalence Essential tremor affects approximately 5 million people in the United States. Incidence is highest in people over the age of 60.

93. Beeson Scholar Functional Correlates Of essential tremor. Coauthor(s) Livia BarnesMPH,1 Steven M. Albert MS PhD,1,2 Howard Andrews PhD3 BACKGROUND http://www.beeson.org/output/researchpage.cfm?Beeson_ID=34

94. CJNS-Clinical And Electromyographic Examinations Of Patients With Essential Trem Abstract, Close Window Clinical and Electromyographic Examinations ofPatients with essential tremor Ivan Milanov. Abstract Background http://www.canjneurolsci.org/27febtoc/clinical.html

Abstract Close Window Clinical and Electromyographic Examinations of Patients with Essential Tremor Ivan Milanov Abstract: Background: It is believed that no clinical differences exist among essential, familial and senile tremor, or between the tremor with synchronous or alternating electromyographic activity. The aim of this study was to evaluate the clinical and electromyographic findings in a large group of patients with different types of essential tremor. Methods: Two hundred and twenty patients with sporadic, familial or senile variants of essential tremor were examined. According to the electromyographic activity recorded from the antagonistic muscles, the patients were subdivided into a group with synchronous (SYN) and a group with alternating (ALT) activity. The historical aspects of the disease were noted, and a detailed neurological examination was performed. Results: A widespread tremor involving upper and lower limbs and 3-4 different anatomical regions was typical for familial tremor. It also had higher amplitude than the sporadic and senile tremor. ALT tremor had a higher amplitude and longer burst duration than SYN and more often involved lower limbs. Rest tremor was common in the ALT group. Overall, ALT tremor was more common than previously supposed.

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