21. La Imagen Del Mes Translate this page A manifestation of extrapontine myelinolysis confirmed by magnetic resonanceimaging. MR imaging of pontine and extrapontine myelinolysis. http://www.rochelink.roche.com.ar/pub/rnarg/med/revista1/imagen.htm

22. ¸ÃÃÁÈÒʵÃìàǪÊÒà »Õ·Õè 2 Central Pontine and extrapontine myelinolysis A study of 3 cases inRamathibodi hospital. Pornpatr Likittanasombut, MD* Disya Ratanakorn http://www.med.tu.ac.th/Journal/journal22_01.html

Central Pontine and Extrapontine Myelinolysis : A study of 3 cases in Ramathibodi hospital Pornpatr Likittanasombut, M.D.* Disya Ratanakorn, M.D.** *Department of Medicine, Faculty of Medicine, Thammasat University **Department of Neurology, Ramathibodi Hospital Mahidol University Abstract Central pontine áÅÐ exrapontine myelinolysis (CPM,EPM) à»ç¹â¤·Õ辺à¡Ô´¢Öé¹µÒÁËÅѧ¡Òá¡éä¢ÀÒÇÐâ«à´ÕÂÁµèÓã¹àÅ×Í´ ¼Ùéà¢Õ¹ µÇ¨·Ò§ MRI ¾º¼Ùé»èǨӹǹ·Ñé§ÊÔé¹ 3 Ò à»ç¹¼ÙéË­Ô§ 2 Ò áÅмÙéªÒ 1 Ò ÁÕÍÒÂصÑé§áµè 20-62 »Õ ¾ºÀÒÇÐCPMáÅÐEPM ã¹¼Ùé»èÇÂ2 Ò áÅÐEPM 1 Ò ¼Ùé»èÇ·ءÒÂÁÕÍÒ¡Ò«ÖÁŧËÅѧá¡éä¢ÀÒÇÐâ«à´ÕÂÁµèÓ ¼Ùé»èÇ 1Ò ÁվĵԡÁà»ÅÕè¹á»Å§ áÅÐÍÕ¡ÒÂÁÕÍÒ¡Ò parkinsonism áÅÐdystonia ¼Å MRI¾º¼Ô´»¡µÔã¹¼Ùé»èÇ·ءÒ áÅмÙé»èÇ·ءÒÂÁÕ»ÐÇѵԡÒá¡éä¢ÀÒÇÐâ«à´ÕÂÁµèÓã¹àÅ×Í´àçÇ â´Âà©ÅÕè 15.25 mEq/l/24hr (10-19 mEq/l/24hr ) ¨Ò¡¡ÒµÔ´µÒÁ¼Ùé»èǾºÇèÒ¼Ùé»èÇÂàÊÕªÕÇÔµ·Ñé§ 3 Ò 㹡һéͧ¡Ñ¹ÀÒÇйÕé ¼Ùéà¢Õ¹á¹Ð¹Ó¡Òá¡éä¢ÀÒÇÐâ«à´ÕÂÁµèÓã¹àÅ×Í´ ã¹ÍÑµÒ µèÓ¡ÇèÒ 10 mEq/l/24hr

23. SpringerLink: Neuroradiology - Abstract Volume 41 Issue 2 (1999) Pp 144-146 paediatric neuroradiology Cerebral bleeding, infarcts, and persumedextrapontine myelinolysis in hypernatraemic dehydration. IA http://link.springer-ny.com/link/service/journals/00234/bibs/9041002/90410144.ht

Neuroradiology ISSN: 0028-3940 (printed version) ISSN: 1432-1920 (electronic version) Table of Contents Abstract Volume 41 Issue 2 (1999) pp 144-146 paediatric neuroradiology : Cerebral bleeding, infarcts, and persumed extrapontine myelinolysis in hypernatraemic dehydration I. A. AlOrainy (1), A. M. O'Gorman (1), M. K. Decell (2) (1) Department of Medical Imaging, The Montreal Children's Hospital, 2300 Tupper Street, Montreal, Quebec H3H 1P3, Canada e-mail: ialora@PO-Box.mcgill.ca Tel.: + 1-5 14-9 34-44 00 ext. 22 59 Fax: + 1-5 14-9 34-43 47 (2) Pediatric Critical Care Division, The Montreal Children's Hospital, Quebec, Canada Received: 30 December 1997 Accepted: 6 May 1998 Abstract The neuroimaging findings in an infant with hypernatremic dehydration are presented. Brain parenchymal haemorrhage and extensive multiple infarcts were present in the acute stage. Follow-up CT showed bilateral, symmetrical changes presumed to indicate extrapontine myelinolysis in the thalamus and globus pallidus. MRI confirmed sparing of the pons. Only three previous cases of neuroimaging abnormalities due to hypernatraemia have been described in the radiological literature. Key words Article in PDF format (225 KB) Online publication: February 5, 1999

24. Abstract A total of 35 paediatric cases of pontine and/or extrapontine myelinolysis are reportedand, to our knowledge, CPM secondary to CMV hepatitis in an infant has http://link.springer-ny.com/link/service/journals/00247/contents/02/00722/s00247

Case Report Central pontine myelinolysis secondary to cytomegalovirus hepatitis in a 10-month-old child N. Cagla Tarhan , Ali Firat , Arzu Otken , A. Muhtesem Agildere and Fulya Demirceken Fevzi Cakmak Cad. 10. Sok. No:45, 06490 Bahcelievler, Ankara, Turkey Sami Ulus Children's Hospital, Department of Paediatrics, Ankara, Turkey Abstract. We present a 10-month-old child with central pontine myelinolysis (CPM) secondary to chronic active hepatitis due to cytomegalovirus (CMV) infection. A total of 35 paediatric cases of pontine and/or extrapontine myelinolysis are reported and, to our knowledge, CPM secondary to CMV hepatitis in an infant has not been previously reported. The MRI findings are highlighted. Keywords. Central pontine myelinolysis - CMV - MRI - Infant E-mail: caglat@baskent-ank.edu.tr E-mail: itarhan@isbank.net.tr Phone: +90-312-2126868 Fax: +90-312-223-7333

25. MRI Findings In Osmotic Myelinolysis - A Study Of Six Patients syndrome and has characteristic CT and MR features in the central pons (centralpontine myelinolysis) and in other locations (extrapontine myelinolysis). http://www.srs.org.sg/html/day 2/scientific 1/myelin.html

MRI Findings in Osmotic Myelinolysis - A Study of Six Patients GC Chua, YY Sitoh* Department of Diagnostic Radiology Tan Tock Seng Hospital, Singapore *Department of Neuroradiology National Neuroscience Institute, Singapore Reprint (PDF) Version of this Article OBJECTIVES Osmotic myelinolysis is a distinctive clinical syndrome and has characteristic CT and MR features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis). This study was undertaken to determine the MR appearance of these lesions in T1 weighted, T2 weighted and diffusion weighted sequences. MATERIALS AND METHODS We describe six patients who presented with deranged serum sodium levels and subsequently developed osmotic myelinolysis. CT scan and MRI scan were performed at various time interval prior and after onset of clinical signs of osmotic myelinolysis. RESULTS Low T1 and high T2 signal intensities were seen in the various sites of white matter in the cerebrum as well as the pons. Patchy enhancement of the lesions were noted. Diffusion-weighted images (DWI) were acquired for all cases, which consistently demonstrated hyperintensity in these lesions. The mechanism for the MR appearance is discussed. This has never been reported in the literature.

26. Searchalot Directory For E Erythema Multiforme (3); Erythromelalgia (4); Esophageal Diseases (47);Essential Tremor (3); extrapontine myelinolysis (3); Eye Cancer (17). http://www.searchalot.com/Top/Health/ConditionsandDiseases/E/

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27. NEJM -- Osmotic Demyelination Syndrome Following Correction Of Hyponatremia Hyatrogenic extrapontine myelinolysis in Central Diabetes Insipidus Are Cyclosporineand 1Desamino-8-D-Arginine Vasopressin Harmful in Association?. http://content.nejm.org/cgi/content/abstract/314/24/1535

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 314:1535-1542 June 12, 1986 Number 24 Next Osmotic demyelination syndrome following correction of hyponatremia RH Sterns, JE Riggs, and SS Schochet Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Sterns, R. H. Schochet, S. S. Medline Citation Abstract This article has been cited by other articles: Sugimoto, T, Murata, T, Omori, M, Wada, Y (2003). Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. J. Neurol. Neurosurg. Psychiatry [Abstract] [Full Text] Saeed, B O, Beaumont, D, Handley, G H, Weaver, J U (2002). Severe hyponatraemia: investigation and management in a district general hospital. J Clin Pathol [Abstract] [Full Text] Polster, T, Hoppe, M, Ebner, A (2001). Transient lesion in the splenium of the corpus callosum: three further cases in epileptic patients and a pathophysiological hypothesis. J. Neurol. Neurosurg. Psychiatry

28. JKMS Vol 13, No. 1 Abstract. Fulltext. 1998 Feb;13(1)99-102. A case of central pontine andextrapontine myelinolysis with early hypermetabolism on 18FDG-PET scan. http://jkms.kams.or.kr/1998/abstract/99a.html

Abstract Full-text 1998 Feb;13(1):99-102 A case of central pontine and extrapontine myelinolysis with early hypermetabolism on 18FDG-PET scan. Roh JK, Nam H, Lee MC Department of Neurology, Seoul National University Hospital, Korea. We report a 63 year-old woman who developed central pontine and extrapontine myelinolysis after rapid correction of hyponatremia. Lesions on brain MRI showed hypermetabolism on 18FDG-PET scan in the early stage of the disease and became hypometabolic on the follow-up scan. We suggest that active microglia and astrocytes are the main cause of the increased glucose metabolism.

29. JKMS Vol 13, No. 1 A case of central pontine and extrapontine myelinolysis with early hypermetabolismon 18FDGPET scan. Roh JK, Nam H, Lee MC Abstract Full-text (PDF). http://jkms.kams.or.kr/1998/199802.html

Molecular bases of coronary heart disease in Koreans. Kim JQ, Song J, Park YB, Hong SH Abstract Full-text (PDF) pages 1-15 Identification of insulin-like growth factor (IGF)-I and IGF-binding protein in chylous ascites. Lee DY Abstract Full-text (PDF) pages 17-20 Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma. Park HS, Hwang SC, Nahm DH, Yim HE Abstract Full-text (PDF) pages 21-26 A study of the viral etiology of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Huh J, Chi HS, Kim SS, Gong G Abstract Full-text (PDF) pages 27-30 Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea. Kim JE, Huh J, Cho K, Kim CW Abstract Full-text (PDF) pages 31-38 Arthritic manifestations of inflammatory bowel disease. Suh CH, Lee CH, Lee J, Song CH, Lee CW, Kim WH, Lee SK Abstract Full-text (PDF) pages 39-43 Increased serum levels of mutant p53 proteins in patients with colorectal cancer. Shim KS, Kim KH, Park BW, Lee SY, Choi JH, Han WS, Park EB

30. The Neurology Research Program documented proof that the rapid correction of this condition causes a specificneurologic illness known as central pontine and extrapontine myelinolysis. http://www.medstarresearch.org/research_studies/neurology/neurology.htm

The Neurology Research Program Investigations of hyponatremia are ongoing and include studies of brain imaging. Currently, magnetic resonance imaging (MRI) studies of the brain during hyponatremia and after correction provide valuable information about the imaging appearance of this disease, its mechanism of action, and the potential mitigation of its effects. Planned for the near future are studies that may explore various treatments of hyponatremia. Select another research area Back to top Home About MRI ... Employee Website Page updated Submit comments and suggestions to the webmaster www.corbisimages.com : We make every reasonable attempt to keep our information as accurate as possible, but unintentional errors and changes may occur. Information is subject to change without notice. We do not assume responsibility for any errors, or for the use or misuse of any information on this web site. The entire risk as to the use of these web pages is assumed by the User.

31. IM Abstract 39-11 Case 11 Slowly Progressive Dystonia Following Central Pontine and extrapontine myelinolysisYukie Yoshida, Jun Akanuma, Sanae Tochikubo, Akihiko Hoshi, Yutaka Matsuura http://www.naika.or.jp/im/im39/ab39_11/c391111.html

Slowly Progressive Dystonia Following Central Pontine and Extrapontine Myelinolysis Yukie Yoshida, Jun Akanuma, Sanae Tochikubo, Akihiko Hoshi, Yutaka Matsuura, Mari Homma and Teiji Yamamoto From the Department of Neurology, Fukushima Medical University, Fukushima A 28-year-old woman was hospitalized with dysarthria and oro-mandibular and upper limb dystonia. Approximately 8 years prior to the current admission, the woman became severely hyponatremic due to traumatic subarachnoid hemorrhage-related SIADH. Brain MRIs showed a signal increase in the central pons, thalamus and striatum on T2 weighted images compatible with central pontine and extrapontine myelinolysis. From a few months after that event, dystonia progressed slowly over the subsequent 8 years. We speculate that the particular damage chiefly to the myelin structures by myelinolytic process may have caused an extremely slow plastic reorganization of the neural structures, giving rise to progressive dystonia. (Internal Medicine 39: 956-960, 2000) ÅIXV“ú2001/10/4@E-mail : naika@naika.or.jp

32. Intenal Medicine Contents Vol.39 No.11 Immunohistochemical Studies, Slowly Progressive Dystonia Following CentralPontine and extrapontine myelinolysis, Bilirubin Adsorption http://www.naika.or.jp/im/im39/im39-11.html

Management of Septic Patients without the Consultation Services of Infectious Disease Specialists @AIKAWA N Expression of c-kit in Gastrointestinal Stromal Tumors @SHINOMURA Y Does Brain Damage (Hepatic Encephalopathy) Improve without Any Complication and Sequellae after Liver Transplantation? @ICHIDA T Thrombin and Antithrombin in Binswanger's Disease @UCHIYAMA S Infected Aneurysms @OHTA T The Effects of Long-acting Nitrates on 5-year Cardiac Events of Patients with Coronary Thrombolytic Therapy for Acute Myocardial Infarction Psychobehavioral and Immunological Characteristics of HTLV-1 Carriers and Non-Carriers with Persistently Low Natural Killer Cell Activity Cerebral Blood Flow and Cessation of Cigarette Smoking in Healthy Volunteers Nationwide Survey of the Annual Prevalence of Viral and Other Neurological Infections in Japanese Inpatients Current Practice of Management of Bacteremic Sepsis: A Study in a Tertiary Care Teaching Hospital in Japan Mixed Carcinoid-Adenocarcinoma of the Liver Gastrointestinal Stromal Tumors of the Small Intestine That Expressed c-kit Protein Malignant Peritoneal Mesothelioma Associated with Deep Vein Thrombosis Following Radiotherapy for Seminoma of the Testis Reversibility of Serum NH Level in a Case of Sudden Onset and Rapidly Progressive Case of Type 2 Citrullinemia Congenital Hepatic Fibrosis with Fatal Cholestatic Liver Damage Esophageal Perforation Associated with Profound Shock Successfully Managed with Hemodynamic Assistance Using Percutaneous Cardiopulmonary Support

33. Annals Of Internal Medicine: Letters 2000;1327114. PMID 0010787364 Annals Abstract PubMed 2. Menger H,Jorg J. Outcome of central pontine and extrapontine myelinolysis (n = 44). http://www.annals.org/issues/v133n12/full/200012190-00023.html

19 December 2000 Volume 133 Number 12 LETTERS Noncardiogenic Pulmonary Edema in Marathon Runners Letters on Pages Letter 1 to the Editor: Ayus and colleagues' report of hyponatremic encephalopathy with noncardiogenic pulmonary edema in marathon runners demonstrates the life-threatening potential of this syndrome and its treatment. The authors' use of intravenous hypertonic sodium chloride (514 mmol/L) resulted in an increase in plasma sodium levels (10 mmol/L in 12 hours) to twice the maximal rate recommended as optimal to avoid osmotic demyelination or central pontine myelinolysis (9 mmol/L per 24 hours) . Was there evidence of this lesion at autopsy in the runner with the lowest sodium level (117 mmol/L) who developed brain stem herniation during treatment? Exercise-related hypovolemic hyponatremia, as shown by low pulmonary wedge pressures in this study, might be more appropriately treated with intravenous isotonic sodium chloride (308 mmol/L) to enhance extracellular fluid volume while more gradually correcting plasma tonicity in the high-risk setting of rapid-onset osmotic dysequilibrium . Better understanding of this rare syndrome and potential complications during treatment may lead to safer outcomes and preventive strategies. Arthur J. Siegel, MD

34. HONG KONG COLLEGE OF RADIOLOGISTS bilateral basal ganglia and thalami. DIAGNOSIS Osmotic Myelinolysis(central pontine myelinolysis extrapontine myelinolysis). http://www.hkcr.org/CaseOfMonth/mar01/feb01a.html

CASE OF THE MONTH ANSWER FOR FEB Figure 1 Figure 3 Figure 2 Figure 3 There are also T2 hyperintense lesions in the bilateral basal ganglia and thalami. DIAGNOSIS : HISTORY PREVIOUS MTHS HOME CURRENT MTH ... Click on thumbnail for full-sized image

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37. UCSF - Neuroradiology Interesting Case: December, 2001 extrapontine myelinolysis (requires an appropriate clinical context; oftenassociated with central pontine myelinolysis). Discussion. Background. http://www.neurorad.ucsf.edu/previouscases/12012001.html

Excerpted from: Thieme Publishing's "Teaching Atlas of Brain Imaging" UCSF Attendings Nancy J. Fischbein MD William Dillon MD , and A. James Barkovich MD 167 cases, over 1000 figures at $139.00. Interesting Cases Clinical Presentation Six months prior to presentation, this 13 year old girl developed fatigue and weight loss. She then presented with a generalized seizure and lapsed into coma for three days. Upon awakening, she was disoriented and inappropriate. An MR scan was obtained. Fig A Fig B Fig C Fig D Pearls Reversibility of T2-prolonging lesions has been documented, suggesting that they represent areas of edema and possibly microinfarction. The so-called lupus anticoagulant (an antiphospholipid antibody) has a high association with cerebrovascular accidents and venous sinus thrombosis. Pitfalls No specific imaging finding is diagnostic of neuropsychiatric lupus. Imaging findings do not necessarily correlate with severity of clinical manifestations. Radiologic Findings An axial proton density-weighted image (Fig. A ) and a coronal FLAIR image (Fig.

38. Untitled Document Læger 1988; 150 17725. 5. Karp BI, Laureno R. Pontine and extrapontine myelinolysisa neurologic disorder following rapid correction of hyponatremia. http://www.dadlnet.dk/ufl/ufl9930/v_p/28395.htm

KASUISTIK Sygehistorie Der var sufficient respiration, BT var 280/150 mmHg, og der var normale pupiller med sparsom lysreaktion. Der blev ved modtagelsen givet Stesolid-suppositorium 10 mg 2 uden effekt efterfulgt af injektion med diazepam 10 mg Fig. 1 Fig. 1. Diskussion D P-Na Fig. 2 Fig. 2. Summary Seizures in a patient with polydipsia and severe hyponatraemia. A case of a 40-year-old psychiatric patient is reported. Primarily, he was thought to have epileptic seizures, but demonstrated acute symptoms of severe hyponatraemia, plasma sodium was 106 mmol/l. Treatment was initiated with hypertonic saline until regression of symptoms, followed by slow correction of serum sodium to subnormal level. The patients outcome was good. This treatment is discussed focusing on the importance of an immediate onset, despite that the cause of hyponatraemia may be unknown. Reprints: Et standardiseret skema til beregning af salt- og vandbalancen kan rekvireres hos forfatteren, evt. som WP- eller QuattroPro-fil via e-post.

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40. CURRENT ISSUE 5024(PDF full text file). · extrapontine myelinolysis in a Patientwith Systemic Lupus Erythematosus A Case Report. MC Liou, KH http://fma.mc.ntu.edu.tw/JFMA/Contents_of_The_Latest_Issue/Issue_2002/101_toc/10

July Volume 101 No 7 Please down load and install the Acrobat Reader 4.0 before viewing the following papers Original Articles ¡P Complementary Role of F-Fluorodeoxyglucose Positron Emission Tomography and I Scan in the Follow-up of Post-therapy Differentiated Thyroid Cancer. C.H. Hsu, R.S. Liu, C.H. Wu, S.M. Chen, L.S. Shih............................ (PDF full text file) ¡P Clinical Characteristics and Management of Acute Suppurative Thyroiditis in Children. P. Chang, W.Y. Tsai, P.I. Lee, P.H. Hsiao, L.M. Huang, J.S. Lee, S.f. Peng, Y.W. Li..................................................................... (PDF full text file) ¡P Speech and Swallowing Function after Reconstruction with a Radial Forearm Free Flap or a Pectoralis Major Flap for Tongue Cancer. W.F. Su, S.G. Chen, H. Sheng (PDF full text file) ¡P Comparing the Efficacy and Safety of Atorvastatin and Simvastatin in Asians with Elevated Low-Density Lipoprotein-Cholesterol-A Multinational, Multicenter, Double-Blin Study. C.C. Wu, R. Sy, V. tanphaichitr, A.T.T. Hin, S. Suyono

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