41. Factor V Leiden Polymorphism (FV:R506Q) factor v leiden Polymorphism (FV R506Q ). Test Overview. Methodologyfactor v leiden Mutation by Polymerase Chain Reaction (PCR). http://pathology.mc.duke.edu/coag/fvlflyer2.html

Factor V Leiden Polymorphism (FV Test Overview Resistance to activated protein C (APC) is a frequently identified abnormality in patients with venous thrombosis. In patients presenting with an initial venous thromboembolic event, as many as 21% have APC resistance. Furthermore, in patients with recurrent venous thrombosis, as many as 60% have APC resistance. APC resistance has also been associated with atypical thromboembolic complications, including portal vein thrombosis and cerebral sinus thrombosis. Exposure to certain environmental risk factors, such as surgery, pregnancy, or oral contraceptives, can further increase the risk for a venous thrombotic event. Although APC resistance is a common finding in patients with venous thrombosis, it is seldom identified as a risk factor for arterial thrombosis. Laboratory screening for APC resistance consists of clotting assays that measure the degree of prolongation of the plasma clotting time upon the addition of APC. In more than 90% of cases, APC resistance is linked to a single polymorphism in the factor V gene. This polymorphism, known as Factor V Leiden (Factor V ), involves a single base pair substitution at position 1691 in the factor V gene, resulting in substitution of the arginine (R) at position 506 by glutamine (Q). This substitution blocks an important APC-cleavage site in factor Va after position 506, thereby resulting in a decreased ability of APC to inactivate the procoagulant factor Va. This single polymorphism results in the observed hypercoagulable state that leads to an increased risk for venous thromboembolism.

42. Factor V Leiden Mutation (FV:Q506) Furthermore, this polymorphism is not infrequently encountered in patients withan additional hypercoagulable state, especially factor v leiden and/or http://pathology.mc.duke.edu/coag/PTGlflyer2.html

Prothrombin (G20210A) Gene Polymorphism (PTG G20210A) Test Overview Prothrombin is the precursor of the serine protease thrombin, a key enzyme in the processes of hemostasis and thrombosis. Decreased levels of prothrombin are associated with an increased risk for hemorrhage, whereas elevated prothrombin levels have been associated with an increased risk for venous thrombosis. Recently a genetic polymorphism located in the 3’-untranslated region of the prothrombin gene has been described. The polymorphism has been associated with increased prothrombin levels as well as an increased risk for venous thrombosis. The polymorphism is due to a single base pair substitution at position 20210 of a guanine (G) for an adenine (A) nucleotide. The mechanism whereby this polymorphism results in increased levels of prothrombin is unknown. The prevalence of this polymorphism ranges from 1% to 3% in Caucasian populations, but is very uncommon in individuals from Asian or African descent. In contrast, several studies have reported that between 5% to 18% of patients with venous thrombosis have this polymorphism. Furthermore, this polymorphism is not infrequently encountered in patients with an additional hypercoagulable state, especially factor V Leiden and/or thermolabile polymorphism in the methylenetetrahydrofolate reductase (MTHFR). Clinical Utility The increased risk of venous thrombosis in patients who are heterzygous for the prothrombin (G20210A) gene polymorphism is 3-fold.

43. Factor V (Leiden) Mutation Analysis The factor v leiden mutation leads to the laboratory finding of APCR and a 7foldincrease in venous thromboembolic events in heterozygous individuals and an 80 http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=TH_Fact

44. FACTOR V LEIDEN factor v leiden. TEST CODEFVLPCR CPT CODE83890,83892,83894,83898SYNONYMS Arg 506Gln mutation in factor V, activated protein http://hsc.virginia.edu/medicine/clinical/pathology/labtests/handbook/fvlpcr.htm

FACTOR V LEIDEN TEST CODE: FVLPCR CPT CODE: SYNONYMS: Arg 506-Gln mutation in factor V, activated protein C (APC) resistance TEST INCLUDES: Genomic DNA isolation, PCR amplification, restriction enzyme digestion and acrylamide gel electrophoresis LABORATORY: Molecular Pathology SPECIMEN: Lavender Top (EDTA), 5 mL MINIMUM VOLUME: 5 mL blood AVAILABILITY: Samples received before 9:00 a.m. on Tuesdays will be included in the weekly run, with results available by Thursday afternoon. TURNAROUND TIME: < 10 days SPECIAL INSTRUCTIONS: REFERENCE RANGE:

45. Inherited Hypercoagulation Disorders: The Factor V Leiden Mutation: Patient Info Inherited Hypercoagulation Disorders The factor v leiden Mutation. Whena wound occurs, several changes take place to minimize blood loss. http://www.telemedicine.arizona.edu/patient_info/benign_disorders/disorders/inhe

Patient Information Resource: Benign Hematologic (Blood) Disorders A collaborative project of the Arizona Telemedicine Program , the Arizona Health Sciences Library and the Arizona Cancer Center See: Inherited Hypercoagulation Disorders: The Factor V Leiden Mutation When a wound occurs, several changes take place to minimize blood loss. First, the blood vessel slows the flow of blood past the wound site. Next, platelets collect at the wound site to form a plug. Finally, fibrin clots form scabs to replace these temporary platelet plugs. heparin or warfarin (Coumadin) or fibrinolytic therapy may be effective. : This web site and its contents are designed for educational purposes only. This web site does not render medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider. Arizona Cancer Center 1515 N. Campbell Ave.

46. Factor V Leiden Investigations factor v leiden mutation. Sample type EDTA blood. Minimum samplevolume 2 x 7.5 ml. Reporting time 2 10 days. Sample labelling http://www.exeterhospitals.co.uk/pathology/exepath/indexf/fvleiden.htm

Factor V Leiden mutation Sample type : EDTA blood Minimum sample volume : 2 x 7.5 ml Reporting time : 2 - 10 days Sample labelling The sample should indicate - Date of birth Hospital number or genetics number Date Signature of the person collecting the specimen Other information 3 to 8 % of Caucasians are heterozygous for FVL Heterozygotes have an eightfold increased risk of thrombosis Homozygotes have an eightyfold increased risk of thrombosis. Department responsible for analysis Molecular Genetics (Laboratory contact Mrs. A. West) Help Index

47. Factor V Leiden Mutation Test Menu factor v leiden Mutation, Test Performed, factor v leiden assay performedby reference laboratory. Results available in five days. Available Stat? http://peir.path.uab.edu/coag/article_56.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Education Test Menu Test Order Form Test Menu Factor V Leiden Mutation Email this article Printer friendly page Primary Name Factor V Leiden mutation Synonym Factor V gene mutation Synonym Leiden gene mutation Contraction FVL Contraction Occasionally confused with factor V activity Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume for APC resistance assay. Do not underfill or overfill. Also collect one (1) lavender-stopper tube (EDTA) whole blood. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. If follow-up factor V Leiden mutation test is indicated, the lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice. Specimen Accepted Daily including weekends Times Available Test Performed Factor V Leiden assay performed by reference laboratory. Results available in five days.

48. Confusing Coagulation Test Names Is it Factor V or factor v leiden? The factor v leiden mutation moleculartest is only performed when the APCR ratio is less than 1.8. http://peir.path.uab.edu/coag/article_187.shtml

Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Education Test Menu Test Order Form Reference Confusing Coagulation Test Names Email this article Printer friendly page Is it Factor V or Factor V Leiden? Factor V is rarely ordered The most common purpose for ordering the factor V activity assay is to help with the differential diagnosis of liver disease. The factor V assay is also ordered to establish the presence of an inherited factor V deficiency. These are very rare and are associated with severe bleeding in infancy. Factor V Leiden is ordered often The factor V Leiden mutation is present in 3-8% of Caucasians and Hispanics and confers a 2- to 8-fold risk of thrombosis (80-fold when homozygous). The factor V Leiden mutation test is usually ordered as part of a thrombophilia profile that includes antithrombin (AT, ATIII), protein C (PC), protein S (PS), factor VIII (for elevated factor VIII), prothrombin G20210A mutation , homocysteine, and lupus anticoagulant (LAC). When the factor V Leiden mutation assay is ordered, the laboratory first performs the activated protein C resistance (APCR) assay, which is an effective screen. The factor V Leiden mutation molecular test is only performed when the APCR ratio is less than 1.8.

49. Liver Information: Budd-Chiari Syndrome Associated With Factor V Leiden Mutation Liver Transplant Program and Center for Liver Disease. BuddChiari Syndrome Associatedwith factor v leiden Mutation A Report of 6 patients. Hoffman R et al. http://www.livertransplant.org/livernewsletter-budd-chiarisyndromeassociatedwith

Budd-Chiari Syndrome Associated with Factor V Leiden Mutation: A Report of 6 patients. Hoffman R et al. Liver Transplantation and Surgery 1999;5:96-100 , (Haifa, Israel) Return to Liver Newsletter Home Page Areas of Expertise Bloodless Surgery Liver Transplantation Live Donor Liver Transplant Liver Surgery Pancreatic Surgery Gallbladder/Bile Duct Surgery Portal Hypertension Surgery Radio Frequency Ablation Endoscopic Retrograde Cholangiopancreatography Pediatric Surgery and Transplant Information for Patients Transplant Patient Guide Long-Term Transplant Care Patient Support Groups Financial Considerations Liver Glossary About the USC University Hospital Features What's New Research and Development Calendar of Events Liver Newsletter Downloads General Information Faculty and Staff Web Links Site Map Contact Us Search this site USC Liver Transplant Program and Center for Liver Disease 1510 San Pablo Street, Suite 430, Los Angeles CA 90033-4612 Phone: (323) 442-5908 Fax: (323) 442-5721 E-mail: uscliver@surgery.hsc.usc.edu

50. Factor V Leiden Mutation Analysis (511154) factor v leiden Mutation Analysis (511154). CPT 83890;83894; 83898 (x2); 83912 Related Information http://www.labcorp.com/datasets/labcorp/html/chapter/mono/mg001200.htm

Factor V Leiden Mutation Analysis (511154) CPT Related Information Factor II (Prothrombin), DNA Analysis Methylenetetrahydrofolate Reductase (MTHFR) Thermolabile Variant, DNA Analysis Thrombotic Risk Profile, DNA Specimen Whole blood Volume 7 mL Minimum Volume 3 mL Container Lavender-stopper (EDTA) tube Storage Instructions Maintain specimen at room temperature. Causes for Rejection Frozen or hemolyzed specimen; quantity not sufficient for analysis Use Detection of Leiden mutation in factor V gene, causing increased risk of thrombosis Limitations This test detects only the factor V R506Q (Leiden) mutation and will help identify those individuals who are at increased risk of thrombosis; however, increased risk of thrombosis can be caused by a variety of genetic and nongenetic factors not screened for by this assay. Methodology Allele-specific polymerase chain reaction (PCR) and gel electrophoresis References Voelkerding KV, "Resistance to Activated Protein C and a Novel Factor V Gene Mutation," Clin Lab Med , 1996, 16(1):169-86 (review).

51. Use Of Selective Factor V Leiden Screening In Pregnancy To Title Use of selective factor v leiden screening in pregnancy to identifycandidates for anticoagulants. Authors Lindqvist, Pelle http://eprints.lub.lu.se/archive/00010671/

52. Arch Surg -- Page Not Found factor v leiden and Morbid Obesity in Fatal Postoperative Pulmonary EmbolismAuthor Information Hagen Blaszyk, MD; Johannes Björnsson, MD http://archsurg.ama-assn.org/issues/v135n12/abs/soa0078.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

53. Esterase Stain, Specific factor v leiden The reliability of the factor v leiden mutation test is believedto exceed 99%. Specificity may be compromised by PCR primer site mutations. http://www.aruplab.com/guides/clt/tests/clt_a210.htm

ARUP's Guide to Clinical Laboratory Testing (CLT) A B C D ... Search Note: Test code links throughout this Guide refer to the corresponding test in the User's Guide. Esterase Stain, Specific Test Number: Methodology: Cytochemical Stain/Microscopic Clinical Significance: The esterase enzyme is found exclusively within the primary granules of late myeloblasts, promyelocytes, and more mature myeloid cells that hydrolyze the substrate naphthol AS-D chloroacetate. The specific esterase stain is often used to determine myeloid lineage in the blasts of acute leukemias. Its reactivity parallels that of myeloperoxidase and Sudan Black B, except that, unlike Sudan Black B, there is no reaction in the granules of monocytes. It is used less often than the other two stains for myeloid lineage, however, because it is regarded as less sensitive and less consistent. See also: Sudan Black B Stain Reference Interval: No reference interval Reference: Beutler E, et al. Williams hematology , 5th ed. 1995; New York: McGraw-Hill Company, L 70-71.

54. E-News 2:19 - Factor V Leiden May 12, 2000 Volume 2, Issue 19, Midwifery Today ENews “Factor VLeiden”, 4) Pregnancy, Clotting, and factor v leiden An Overview. http://www.midwiferytoday.com/enews/enews0219.asp?q=breastfeed*

55. The HeartMDPhD.com Cardiology Web Site (Homozygous Factor V Leiden Case Report) Homozygous factor v leiden Case Report. Username Password Username andpasswords are for restricting access to coauthors of this paper. http://www.heartmdphd.com/leiden.asp

Homozygous Factor V Leiden Case Report Username: Password: Username and passwords are for restricting access to co-authors of this paper. Sign Guestbook View Guestbook Dr. Andrew B. Chung, MD/PhD Atlanta, Georgia (United States of America) 404.699.2780 This Atlanta Cardiology Web Portal was Last Updated on Sunday, March 30, 2003. and Privacy Statements.

56. Arch Dermatol -- Page Not Found The Prevalence of factor v leiden Mutation in Patients With Leg Ulcers and VenousInsufficiency Author Information M. Birgette MaessenVisch, MD; Karly Hamulyak http://archderm.ama-assn.org/issues/v135n1/abs/dst8023.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

57. Arch Dermatol -- Page Not Found factor v leiden Mutation in Postthrombotic and Nonpostthrombotic Venous UlcersAuthor Information Jürg Hafner, MD; Andreas Kühne, MD; Beatrice Schär, PhD http://archderm.ama-assn.org/issues/v137n5/abs/dst0025.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

58. Factor V Leiden Beginpagina — Ziekten en aandoeningen — factor v leiden factor v leidenHelaas kunnen wij u van deze aandoening nog geen beschrijving bieden. http://www.erfocentrum.nl/zena/facto.php

erfelijkheid.nl winkel mail ons nieuwsbrief ... sitemap ZIEKTEN EN AANDOENINGEN ERFELIJKHEID LITERATUUR (PARA)MEDICI Beginpagina ... Ziekten en aandoeningen Factor V Leiden Factor V Leiden Helaas kunnen wij u van deze aandoening nog geen beschrijving bieden. Kijk hieronder voor meer informatie. Meer informatie Factor V Leiden startpagina Lotgenotencontact Oproepen op het prikbord rond Factor V Leiden Info op maat? Bel of mail de Erfolijn... Het Erfocentrum is een onafhankelijke non-profit organisatie gericht op publieksinformatie over erfelijkheid en gezondheid. Het Erfocentrum is een initiatief van de betrokken bij erfelijke en/of aangeboren aandoeningen (VSOP)

59. Hemostasis Reference Laboratory DNA/Factor V Leiden (APC DNA/factor v leiden (APC Resistance) Mutation, Transaction Code325003. CPT Code (Suggested) 83890, 83892, 83894, 83898, 83912. http://www.psbc.org/medical/labs/coagulation/thrombosisdna01.htm

60. Factor V Leiden/Prothrombin Gene PCR Assay The University of Iowa Department of Pathology LABORATORY SERVICES HANDBOOK,factor v leiden/Prothrombin Gene PCR Assay, Order Code PROTPCR. http://www.medicine.uiowa.edu/Path_Handbook/handbook/test764.html

The University of Iowa Department of Pathology LABORATORY SERVICES HANDBOOK Factor V Leiden/Prothrombin Gene PCR Assay Order Code: PROTPCR Molecular Pathology/Diagnostics 6004 BTGH Specimen: Whole Blood CPT Code: See comments Order Form: 0-4 Miscellaneous Requisition Testing Schedule: 0700-2200, 7 days a week, including holidays. Analytic Time: See comments Collection Medium: Sterile container for laboratory use only Minimum: Adults - 10 ml, lavender top tube (EDTA) Children - 5 ml, lavender top tube (EDTA) Reference Range: Normal Comments: Genomic DNA is PCR amplified and the presence of the Factor V Leiden and Prothrombin mutations associated with venous thrombosis are assessed simultaneously by gel electrophoresis. Test run weekly. Expected TAT: 3-9 days. CPT codes used; 83890, 83901 (x2), 83894, 83912 Methodology: PCR Alphabetic main page Updated: 02/08/2003 Note : The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 3     41-60 of 87    Back | 1  | 2  | 3  | 4  | 5  | Next 20