61. BioMed Central | Abstract | The Relationship Of The Factor V Leiden Mutation Or The relationship of the factor v leiden mutation or the deletiondeletion polymorphismof the angiotensin converting enzyme to postoperative thromboembolic http://www.biomedcentral.com/1471-2474/2/1/abstract

Welcome guest user home journals A-Z journals by subject advanced search ... Volume 2 Viewing options Abstract Full text PDF Pre-publication history Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Della Valle CJ Issack PS Baitner A Steiger DJ ... Di Cesare PE Key E-mail Corresponding author Research article The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty Craig J Della Valle MD Paul S Issack Avi Baitner David J Steiger Carrie Fang and Paul E Di Cesare Musculoskeletal Research Center, Room 1500 NYU-Hospital for Joint Diseases Department of Orthopaedic Surgery, 301 East 17th Street New York, USA Department of Medicine New York University-Hospital for Joint Diseases 301 East 17th Street New York, USA BMC Musculoskeletal Disorders Abstract Background Although all patients undergoing total joint arthroplasty are subjected to similar risk factors that predispose to thromboembolism, only a subset of patients develop this complication. The objective of this study was to determine whether a specific genetic profile is associated with a higher risk of developing a postoperative thromboembolic complication. Specifically, we examined if the Factor V Leiden (FVL) mutation or the deletion polymorphism of the angiotensin-converting enzyme (ACE) gene increased a patient's risk for postoperative thromboembolic events. The FVL mutation has been associated with an increased risk of idiopathic thromboembolism and the deletion polymorphism of the ACE gene has been associated with increased vascular tone, attenuated fibrinolysis and increased platelet aggregation.

62. Factor V Leiden - MSU Tissue Typing Laboratory factor v leiden. Staff Directory John Gerlach,Ph.D., dipABHI Peggy J. Bull, CHS. http://medtech.cls.msu.edu/ISL/factor5.htm

Factor V Leiden Staff Directory : John Gerlach, Ph.D., dipABHI Peggy J. Bull, CHS

63. Venous Thromboembolism: Factor V Leiden And The Oral Contraceptives Increased Th Venous thromboembolism factor v leiden and the oral contraceptives increasedthe risk. factor v leiden mutation, 35, 6, 9.3 (3.6 to 24.1), 574 (206 to 1830). http://www.eboncall.co.uk/CATs/2242.html

Venous thromboembolism: factor V Leiden and the oral contraceptives increased the risk Clinical bottom line (level 3b) The risk of venous thromboembolism in healthy women aged 15-49 was very small (0.02%). Oral contraceptives independently increased the risk (NNF = 940 for 5 years) Factor V Leiden independently increased the risk (NNF = 570 for 5 years) Vanderbroucke et al: Lancet 1994; 344: 1453-1457 Expires September 2003 The study Case-control study with objective outcomes, adjusted for confounding factors, not validated in an independent set of patients. Setting: anticoagulation clinic, Holland; 1988-93 155 patients (aged mean 35y (range 15y to 49y), first episode of venous thromboembolism Excluded if malignant disease pregnant or peripeurperal recent miscarriage Cases: 155 patients (% , mean age ): cases of first VTE Controls: 155 patients (% , mean age ): friends, relatives or acquaintances matched for age

64. Factor V Leiden And Prothrombin Gene Mutation Questions Subject factor v leiden and Prothrombin Gene Mutation Questions Topic Area ThrombosisForum The Heart Forum Question Posted By BabsD on Wednesday, May 01 http://www.medhelp.org/forums/cardio/messages/33397a.html

Advertisement Heart Forum Sponsor Developed with The American Heart Association, Med Help and Nexcura encourage you to log on to the FREE Heart Profiler and take advantage of this helpful tool. Med Help International A not-for-profit organization Questions in The Heart Forum are being answered by doctors from The Cleveland Clinic Heart Center , consistently ranked the #1 Heart Center in America. Subject: Factor V Leiden and Prothrombin Gene Mutation Questions Topic Area: Thrombosis Forum: The Heart Forum Question Posted By: BabsD on Wednesday, May 01, 2002 I'm a 37 yr old woman who was diagnosed at 31 as having had a silent heart attack, although the doctors don't know when it happened. I was having PVCs(benign), which I mentioned to my Internist during a routine exam. An ekg showed abnormal results, and an echo showed a small area of damage. I next had a thallium stress test, and a heart catheterization showed damage from a moderate heart attack, although I had normal coronary arteries. I had taken the Pill for 5 yrs prior to diagnosis, and my cardiologist is assuming that the MI was caused by a blood clot, possibly related to the pill, although I guess I will never know for sure what caused it. I've had several echos and stress tests since diagnosis, with no change.I have never smoked or taken drugs, drink rarely and am otherwise healthy,although I am 35 lbs overweight. My EF is 50, blood pressure normal, all other tests have come back negative/normal:clotting/coagulation tests,diabetes,lupus, Lyme,excess iron,hepatitis,HIV, lipoprotein a, anti-phosholipid antibody, anti-nuclear antibody tests,etc. I currently take 1 mg folic acid, 81 mg aspirin, 25 mg atenolol, fish oil and a multivitamin. My total cholesterol:186, HDL:43 LDL:130 Trig:68.

65. A To Z Encyclopedia Topic: Factor V Leiden Hematology Program. Unfortunately, at this time, we are not able toprovide information about this condition or procedure. However http://web1.tch.harvard.edu/cfapps/A2ZtopicDisplay.cfm?Topic=Factor V Leiden

66. Gene Variant Discovery Could Save Blood In Surgery A variant form of the gene, called factor v leiden, is present in about five percentof the white population in the United States, making it one of the most http://www.eurekalert.org/pub_releases/2003-02/vumc-gvd021903.php

Public release date: 24-Feb-2003 Contact: Clinton Colmenaers clinton.colmenares@vanderbilt.edu Vanderbilt University Medical Center Gene variant discovery could save blood in surgery Factor V found in bleeders, variant in people who clot Bleeding after cardiac surgery is a major clinical problem, consuming up to 20 percent of the nation’s blood supply. Despite some understanding of the risk factors that contribute to increased blood loss, there is still considerable patient-to-patient variability, said Dr. Brian S. Donahue, assistant professor of Anesthesiology at Vanderbilt University Medical Center. Donahue and colleagues are the first to show that a common genetic variation contributes to a patient’s tendency to suffer bleeding complications. The investigators report Feb. 25 in Circulation that cardiac surgery patients who have a different genetic form of one clotting factor lose less blood and are less likely to receive blood transfusions. The findings herald a new era in medicine, one in which therapies will be customized for individual patients, based in part on the genes they carry. That is the hope anyway, Donahue said. “If we can outline a patient’s specific risk factors for given complications, then we can better tailor our therapeutic approach,” he said. The current study focuses on factor V (“factor five”), one of the proteins essential to normal blood clotting. A variant form of the gene, called factor V Leiden, is present in about five percent of the white population in the United States, making it one of the most common inherited blood coagulation mutations. Individuals with factor V Leiden are at increased risk of forming blood clots, especially deep venous thromboses.

67. UCHSC DNA Diagnostic Laboratory-Factor V Leiden Testing UCHSC DNA Diagnostic Laboratory DNA Analysis for Venous Thrombosis (factor v leidenMutation) General Information The factor v leiden mutation (R560Q) is http://www.uchsc.edu/sm/peds/dnalab/fv.htm

UCHSC DNA Diagnostic Laboratory DNA Analysis for Venous Thrombosis (Factor V Leiden Mutation) General Information: The Factor V Leiden mutation (R560Q) is present in 20-40% of patients with venous thrombosis, 40-65% of adults from families with unexplained thrombophilia, and approximately 95-100% of patients with the phenotype of activated protein C (APC) resistance. The Factor V Leiden mutation is a significant risk factor for venous thrombosis, particularly in the homozygous state or in combination with additional risk factors such as pregnancy, use of oral contraceptives or surgery. Methodology: This test includes preparation of DNA from peripheral blood and PCR based analysis for direct detection of the common Factor V Leiden mutation (R506Q). PCR is performed pursuant to a license agreement with Roche Molecular Systems, Inc. Use: Identification of individuals heterozygous or homozygous for the Factor V Leiden mutation. Indications: Venous thrombosis or history of a thrombotic event, activated protein C resistance by laboratory analysis, presence of another hereditary coagulation disorder (protein C deficiency, protein S or antithrombin III), family history of thrombosis or known Factor V Leiden mutation. V Leiden mutation. Specimen Requirements: Please see Instructions for Shipping and Handling Specimens Turnaround Time: 3-7 days (time required for culture of tissue specimens not included.) Cases are prioritized on an individual basis.

68. Biocompare - Product Matrix - Factor V Leiden Genotyping Primers Search, Home Back factor v leiden Genotyping Primers, Log In / Register,Technology Spotlight. See Disclaimer. factor v leiden Genotyping Primers. http://www.biocompare.com/molbio.asp?catid=3966

69. NEJM -- Coexistence Of Hereditary Homocystinuria And Factor V Leiden -- Effect O Original Article from The New England Journal of Medicine Coexistence ofHereditary Homocystinuria and factor v leiden Effect on Thrombosis. http://content.nejm.org/cgi/content/short/334/12/763

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 334:763-768 March 21, 1996 Number 12 Next Hanna Mandel, M.D., Benjamin Brenner, M.D., Moshe Berant, M.D., Nurith Rosenberg, Ph.D., Naomi Lanir, Ph.D., Cornelis Jakobs, Ph.D., Brian Fowler, Ph.D., and Uri Seligsohn, M.D. Table of Contents Full Text of this article PDF of this article Related Letters to the Editor ... Related Articles in Medline Articles in Medline by Author: Mandel, H. Seligsohn, U. Medline Citation Anticoagulants/Thromboembolism ... Related Chapters at Harrison's Online ABSTRACT Background Venous and arterial thromboembolism occurs in only about one third of patients homozygous for homocystinuria, which suggests that other, contributory factors are necessary for the development of thrombosis in these patients. Factor V Leiden, an R506Q mutation in the gene coding for factor V, is the most common cause of familial thrombosis and could be a potentiating factor. Methods We determined activated partial-thromboplastin times in the presence and absence of activated protein C and tested for the factor V Leiden mutation in 45 members of seven unrelated consanguineous kindreds in which at least 1 member was homozygous for homocystinuria.

70.  Factor V Leiden Mutation  factor v leiden mutation factor v leiden mutation, See molecular genetics individual genetic disorders . Home Back Up . http://www.rcpa.edu.au/pathman/factor_v.htm

Factor V Leiden mutation Factor V Leiden mutation See molecular genetics - individual genetic disorders

71. Prevalence Of Factor V Leiden In A Canadian Blood Donor Population Prevalence of factor v leiden in a Canadian blood donor population. DavidH Outcome measures Presence of factor v leiden. Results Factor http://collection.nlc-bnc.ca/100/201/300/cdn_medical_association/cmaj/vol-155/is

Prevalence of factor V Leiden in a Canadian blood donor population David H. Lee, MD, FRCPC; Penny A. Henderson, ART; Morris A. Blajchman, MD, FRCPC Canadian Medical Association Journal From the Department of Pathology, McMaster University, and the Canadian Red Cross Society Blood Services, Hamilton, Ont. Paper reprints may be obtained from: Dr. Morris A. Blajchman, McMaster University Medical Centre, Rm. HSC 2N34, 1200 Main St. W, Hamilton ON L8N 3Z5 Contents Abstract Introduction Methods Results ... References See also: Editorial: Factor V Leiden: Who should be tested? [ Abstract Objective: To determine the prevalence of factor V Leiden in a Canadian blood donor population. Design: Cross-sectional laboratory study. Setting: Hamilton Centre of the Canadian Red Cross Society. Participants: Volunteer donors who attended Hamilton Centre blood donor clinics over a 4-day period in August 1994; blood samples from 356 people were evaluable. Outcome measures: Presence of factor V Leiden. Results: Factor V Leiden was detected in 19 of the 356 people, for a prevalence rate of 5.3% (95% confidence interval 3.0% to 7.6%). All 19 people were shown to be heterozygous for the mutation. Conclusion: Factor V Leiden is common in the Canadian population. Its prevalence is similar to that reported in other Western countries. These data are relevant in the clinical management of patients at risk for venous thrombosis and those with recurrent thrombotic disorders.

72. FACTOR V LEIDEN AND PROTHROMBIN GENE MUTATION:The Two Most Common Genetic Risk F factor v leiden AND PROTHROMBIN GENE MUTATIONThe Two Most CommonGenetic Risk Factors for Thrombophilia. by Atef Shrit, MD Prior http://www.compunetlab.com/home/publication/0400a.htm

FACTOR V LEIDEN AND PROTHROMBIN GENE MUTATION:The Two Most Common Genetic Risk Factors for Thrombophilia by Atef Shrit, M.D. Prior to 1993, the diagnosis of hereditary thrombophilia could be established in less than 5% of patients under 50 years of age presenting with idiopathic (without identifiable precipitating factors) venous thromboembolism. The major disorders known at that time were deficiencies of antithrombin-III, protein C and protein S. With the discovery that many patients with unexplained venous thrombosis have activated protein C (APC) resistance due to Factor V Leiden mutation or a prothrombin gene mutation, it became possible to define genetic risk factors in many younger patients with idiopathic venous thromboembolism. Activated Protein C Resistance Due To Factor V Mutation (Leiden) Functional assay and DNA testing (Factor V Leiden) for resistance to activated protein C are locally available at CompuNet Clinical Laboratories. Both functional and DNA testing for APC resistance should be included in the evaluation of 1) patients with idiopathic venous thrombosis, 2) women with thrombosis in association with oral contraceptives, hormonal therapy, or pregnancy; and 3) women with recurrent fetal loss. [ Note:

73. Kidney Disease And Factor V Leiden Kidney Disease and factor v leiden. Insurance Does anyone know if thereis any association with Kidney Disease and factor v leiden? I http://www.4burialinsurance.com/wwwboard/messages/68.html

Kidney Disease and Factor V Leiden Insurance Quotes Follow Ups Post Followup 4 Burial Insurance Message Board ... FAQ Posted by Shelly Walt on December 04, 19101 at 20:41:32: Does anyone know if there is any association with Kidney Disease and Factor V Leiden? I don't have a lot of information on either of this issues, but my sister has had multiple miscarriages, has high blood press (130 over 150), has sever swelling on her legs and feet and is only 26 years old. If anyone has any information that might help we would appreciate it. Follow Ups: Re: Kidney Disease and Factor V Leiden Chris Re: Kidney Disease and Factor V Leiden Chris Post a Followup Name: E-Mail: Subject: Re: Kidney Disease and Factor V Leiden Comments: : Does anyone know if there is any association with Kidney Disease and Factor V Leiden? I don't have a lot of information on either of this issues, but my sister has had multiple miscarriages, has high blood press (130 over 150), has sever swelling on her legs and feet and is only 26 years old. If anyone has any information that might help we would appreciate it. Optional Link URL: Link Title: Optional Image URL: Insurance Quotes Follow Ups Post Followup 4 Burial Insurance Message Board ... FAQ

74. Re: Kidney Disease And Factor V Leiden Re Kidney Disease and factor v leiden. In Reply to Kidney Disease and FactorV Leiden posted by Shelly Walt on December 04, 19101 at 204132 http://www.4burialinsurance.com/wwwboard/messages/390.html

Re: Kidney Disease and Factor V Leiden Insurance Quotes Follow Ups Post Followup 4 Burial Insurance Message Board ... FAQ Posted by Chris on November 20, 19102 at 08:22:14: (152.163.188.66) In Reply to: Kidney Disease and Factor V Leiden posted by Shelly Walt on December 04, 19101 at 20:41:32: : Does anyone know if there is any association with Kidney Disease and Factor V Leiden? I don't have a lot of information on either of this issues, but my sister has had multiple miscarriages, has high blood press (130 over 150), has sever swelling on her legs and feet and is only 26 years old. If anyone has any information that might help we would appreciate it. Follow Ups: Post a Followup Name: E-Mail: Subject: Re: Re: Kidney Disease and Factor V Leiden Comments: : : Does anyone know if there is any association with Kidney Disease and Factor V Leiden? I don't have a lot of information on either of this issues, but my sister has had multiple miscarriages, has high blood press (130 over 150), has sever swelling on her legs and feet and is only 26 years old. If anyone has any information that might help we would appreciate it. Optional Link URL: Link Title: Optional Image URL: Insurance Quotes Follow Ups Post Followup 4 Burial Insurance Message Board ... FAQ

75. Factor V Leiden (R506Q) - DNA Analysis factor v leiden, DNA Analysis, R506Q Mutation. factor v leiden R506Q mutationDNA ANALYSIS See also Thrombophilia Panel DNA Analysis. http://imgen.bcm.tmc.edu/medgen/tests/dna/factorvleiden.html

FACTOR V LEIDEN R506Q mutation DNA ANALYSIS See also: Thrombophilia Panel - DNA Analysis Genetic risk factors are involved in the predisposition of individuals to venous thrombosis. These factors include inherited resistance to activated protein C (APC) as well as deficiencies in antithrombin III, protein C and protein S. APC resistance is a major basis for familial thrombosis and is common in the general population (2-5%). APC resistance is frequently associated with factor V Leiden, a point mutation in the factor V gene. Individuals heterozygous for this mutation have an increased risk for venous thrombosis (approximately 5- to 10-fold). Individuals homozygous for this mutation have an even higher risk for venous thrombosis (approximately 50- to 100-fold). Prophylactic anticoagulation therapy should be considered for carrier individuals at risk in situations where venous stasis is likely (i.e. prolonged bed rest after surgery). Analysis for the Factor V Leiden R506Q mutation is offered as a specific DNA test, or as part of a

76. Factor V Leiden What Is It The discovery of factor v leiden was a major advance in thediagnosis of persons predisposed to the development of blood clots. http://www.htcnevada.org/factor V leiden.htm

The Hemophilia and Thrombosis Center of Nevada 2020 W. Palomino Lane Suite 110 Las Vegas, Nevada 89106 since M arch 5, 2003 What Is It The discovery of Factor V Leiden was a major advance in the diagnosis of persons predisposed to the development of blood clots. This is a common inherited abnormality in the Factor V protein which is important in clotting. It is named after the city in the Netherlands that it was first identified in. How Do You Get It Factor V Leiden is the most common inherited blood abnormality that results in the development of blood clots. Because it is inherited, it is important that family members of affected persons be identified and tested. What Should You Do About It Persons who are found to have this abnormality but have not had any history of blood clots should receive preventative measures during times when there is a greater risk of developing blood clots. Because there is an increased risk of the development of blood clots in women with high hormone levels, those using birth control pills, pregnant, or on hormone replacement therapy may be at even greater risk for developing complications. Who Knows If They Have It

77. Venous Thromboembolism: Factor V Leiden Mutation Does Not Increase Risk In Gynec OBGYN.net Banner Ad (468x60) factor v leiden mutation does not increase riskin gynecologic oncology patients. Venous Thromboembolism February 4, 2003 http://www.obgyn.net/newsheadlines/womens_health-Venous_Thromboembolism-20030204

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78. WEB.NL: Welzijn En Gezondheid/Ziektebeelden/Factor V Leiden BEGIN Welzijn en Gezondheid Ziektebeelden factor v leiden. RubriekenZiektebeelden@ (361) new. Links factor v leiden Website http://www.web.nl/gids/Welzijn_en_Gezondheid/Ziektebeelden/Factor_V_Leiden/

HOME Toevoegen Wijzigen Nieuwsbrief ... LOGIN z o e k in de hele gids alleen in deze rubriek g e a v a n c e e r d Arrangementen Humor Dagje uit! ... Ziektebeelden : Factor V Leiden Rubrieken: Ziektebeelden@ new Links: Factor V Leiden Website met informatie over Factor V leiden en soortgelijke stollingsafwijking/problemen (apc resistentie, proteine s/c deficientie, factor II, antitrombine III, homocysteine, cardiolipine, anti fosfolipiden etc). http://www.leefwijzer.nl/factor-V-leiden/ (Toegevoegd: Za Feb 24 2001 Cijfer: 10.00 Stemmen: 3) Stem Opmerking Webgroep factor-v-leiden Webgroep voor mensen met de stollingsafwijking Factor V Leiden, of dergelijke stollingsstoornissen. http://factor-v-leiden-nl.wereld.nl/ (Toegevoegd: Vr Jan 05 2001 Cijfer: 9.33 Stemmen: 3) Stem Opmerking HOME Toevoegen ... LOGIN © 2001- 2003 WEB.NL a CRIO Company

79. Thrombophilia Genetics Br J Haematol 114, 512528. American College of Medical Genetics consensus statementon factor v leiden mutation testing (2000). factor v leiden thrombophilia. http://www.medschl.cam.ac.uk/phgu/info_database/Diseases/Thrombosis/thrombogenet

80. Nature Publishing Group factor v leiden mutation as a predisposing factor for venoocclusive disease followingBMT. However, none of these patients had factor v leiden mutation. http://www.nature.com/cgi-taf/DynaPage.taf?file=/bmt/journal/v25/n10/full/170239

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