21. Oral Hairy Leukoplakia (OHL) Oral hairy leukoplakia (OHL). How is it diagnosed? Very often, a healthcareprofessional can diagnose OHL simply by looking at the white patch. http://www.aidsmeds.com/OIs/OHL3.htm

Join our confidential mailing list! Enter your email address: LESSONS COOL TOOLS DRUGS FORUMS ... HOME Oral Hairy Leukoplakia (OHL) How is it diagnosed? Very often, a health-care professional can diagnose OHL simply by looking at the white patch. If there is confusion as to whether the white patch is OHL or thrush ( candidiasis ), a simple scrape test can be performed. Using a tongue depressor or a toothbrush, the patch can be lightly scraped. If it appears to come off with scraping, the white patch is probably thrush and not OHL. To be sure that the white patch is OHL, a health-care provider can send a sample of the patch to a lab for analysis. The lab will look for the Epstein-Barr virus (EBV) to confirm a diagnosis of OHL. OHL Index What is it? What are the symptoms of OHL? How is it diagnosed? How is it treated or prevented? Are there any experimental treatments? Printable version of this lesson Search for news stories about this topic Last Revised: 1/14/03

22. Viral Infections: Oral Hairy Leukoplakia Oral hairy leukoplakia. Pathogen Oral hairy leukoplakia (OHL) has been associatedwith EpsteinBarr virus (EBV) and with Human Papilloma Virus (HPV). http://www.hivpositive.com/f-Oi/OppInfections/4-Viral/4-Vir-OralHairy.html

Oral Hairy Leukoplakia Pathogen: Oral hairy leukoplakia (OHL) has been associated with Epstein-Barr virus (EBV) and with Human Papilloma Virus (HPV). The clinical significance of OHL in otherwise healthy, asymptomatic individuals is that it can be an early manifestation of HIV infection. One report (Torres et al.) suggested that the incidence of OHL is significantly higher for males than for females. Sites of Infection: While lesions usually appear on the lateral borders of the tongue but can also appear on the buccal and labial mucosae. The lesions of HL are corrugated or have a shaggy or "hairy" appearance. Diagnosis: By clinical presentation and confirmed by biopsy. Treatment Results: Lozada-Nur et al. treated 10 HL patients with one application of topical podophyllin resin. All patients responded within 4 to 5 days of treatment. Period of clinical remission ranged from 2 to 28 weeks. Investigators have noted that oral high-dose acyclovir (> 3 grams/day) can reduce or eliminate lesions. REFERENCES: Lozada-Nur F et al. Podophyllin resin 25% for treatment of oral hairy leukoplakia: an old treatment for a new lesion. J AIDS 4(5): 543-546, 1991. Torres R et al. Oral lesions in patients with HIV infection enrolled in CPCRA trials. Abstract PBO 165, X Intl Conf AIDS, Japan, 1994.

23. Hairy Tongue Or Hairy Leukoplakia? Hairy Tongue or hairy leukoplakia? My doctor has diagnosed me with fuzzy tonguedisease. What is it, what causes it, and how do I get rid of it? S. http://www.ivillagehealth.com/experts/ent/qas/0,,416906_175551,00.html

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24. Hairy Tongue Or Hairy Leukoplakia? Hairy Tongue or hairy leukoplakia? continued from page 1 So whydoes your tongue look hairy? Keratin. Keratin is one of the http://www.ivillagehealth.com/experts/ent/qas/0,,416906_175551-2,00.html

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25. Hairy Leukoplakia Questions hairy leukoplakia Questions. Answer all the questions appear before the question.Use the boxes within the question instead. hairy leukoplakia http://www.eastman.ucl.ac.uk/cal/hiv/hairyq.htm

Hairy leukoplakia Questions Answer all the questions below by clicking on the down arrow of each question and selecting true / false, then check your answers. NOTE: Do not enter text in the boxes which appear before the question. Use the boxes within the question instead. Hairy leukoplakia:

26. Oral Hairy Leukoplakia Oral hairy leukoplakia. Aetiology. lichen planus. Treatment. determine underlyingcause; clinical review. Prognosis. oral hairy leukoplakia is NOT premalignant. http://www.eastman.ucl.ac.uk/cal/oralmed/97_98/white/hairy.htm

Oral Hairy Leukoplakia Aetiology epithilial hyperplasia induced by local Epstein Barr virus (EBV) infection usually arises in immunocompromised patients: HIV infection iatrogenic immunosuppression bone marrow disease. Incidence common in immunosuppressed states very rare in health Clinical Features asymptomatic adherent white plaque almost exclusively arising on the margins of the tongue and the floor of mouth the surface may be corrugated or filamentous Investigations clinical history and examination biopsy Diagnosis differentiate from other white lesions of the tongue eg. lichen planus. Treatment determine underlying cause clinical review Prognosis oral hairy leukoplakia is NOT premalignant Main Menu White Lesions Salivary Gland Enlargement Gingival Enlargement ... Oral Hyperpigmentation

27. I Have Hairy Leukoplakia But Tested Negative At 17 Weeks. Could I have hairy leukoplakia but tested negative at 17 weeks. The hairy leukoplakialikespots went away in about a week, but my tongue still looks like thrush. http://hivinsite.ucsf.edu/InSite.jsp?doc=3098.0152

28. 1Up Health > Leukoplakia > Causes, Incidence, And Risk Factors Of Leukoplakia (H Comprehesive information on Leukoplakia (hairy leukoplakia, Smoker's keratosis). Alternativenames hairy leukoplakia, Smoker's keratosis. Definition http://www.1uphealth.com/health/leukoplakia_info.html

1Up Health Leukoplakia Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Leukoplakia Information Leukoplakia Causes, Incidence, and Risk Factors Alternative names : Hairy leukoplakia, Smoker's keratosis Definition : A precancerous lesion that develops on the tongue or the inside of the cheek as a response to chronic irritation. Occasionally, leukoplakia patches develop on the female external genitalia. Causes, Incidence, and Risk Factors Leukoplakia is primarily a disorder of the mucous membranes of the mouth, caused by irritation. Lesions usually develop on the tongue, but they may appear on the insides of the cheek. Irritation may result from rough teeth or rough places on dentures, fillings, crown, and so on. It may also result from chronic smoking or other tobacco use (smoker's keratosis). Pipe smoking involves a high risk for development of leukoplakia, as does holding chewing tobacco or snuff in the mouth for a prolonged period of time. Occasionally, leukoplakia patches develop on the female external genital area, but the cause is unknown.

29. 1Up Health > Leukoplakia (Hairy Leukoplakia, Smoker's Keratosis) Information Comprehesive information on Leukoplakia (hairy leukoplakia, Smoker's keratosis). Guide.Alternative names hairy leukoplakia, Smoker's keratosis. Definition http://www.1uphealth.com/health/leukoplakia.html

1Up Health Alternative Medicine Clinical Trials Health News ... Health Topics A-Z Search 1Up Health Leukoplakia Information Guide Alternative names : Hairy leukoplakia, Smoker's keratosis Definition : A precancerous lesion that develops on the tongue or the inside of the cheek as a response to chronic irritation. Occasionally, leukoplakia patches develop on the female external genitalia. Jump to a Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Prevention ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com: AIDS Mouth ulcers Oral cancer More ... More More Topics Chronic Patches Rashes Tobacco use - smoking and smokeless tobacco ... More Search 1Up Health A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

30. San Francisco: Stress And Hairy Leukoplakia Study - AIDS Treatment News AIDS Treatment News. Article San Francisco Stress and hairy leukoplakiaStudy. Date 09/09/88. Issue 064. Persons in the San Francisco http://www.aids.org/immunet/atn.nsf/page/a-064-08

Article: San Francisco: Stress and Hairy Leukoplakia Study Date: Issue: Persons in the San Francisco area who have had hairy leukoplakia and are not currently taking antivirals are wanted for a one-month study at the University of California, San Francisco. The study, conducted by Doctors Tom Coates, Marcus Conant, and Susan Folkman, is non-invasive; participants will fill out questionnaires daily for 28 days. If you are interested in participating and would like more information, call Dr. Folkman, Glenn Strome, or Mike Ward at (415) 476-0981.

31. Bee Propolis For Thrush, Fungus, Or Leukoplakia? - AIDS Treatment News first heard word of mouth reports that propolis, sold in healthfood stores, maybe helpful in treating thrush, fungal infections, and even hairy leukoplakia. http://www.aids.org/immunet/atn.nsf/page/a-037-01

Article: Bee Propolis for Thrush, Fungus, or Leukoplakia? Date: Issue: Author: John S. James Last week we first heard word of mouth reports that propolis, sold in health-food stores, may be helpful in treating thrush, fungal infections, and even hairy leukoplakia. We interviewed two persons with ARC who have used it; both are known personally to this writer. We have not heard of any others with HIV who have used propolis. But the results for these two were dramatic enough to suggest that this treatment might be useful for others. Background on Propolis Propolis, a waxy, resinous substance gathered by bees from buds of trees and used as a cement in the hive, has been scientifically studied as an antifungal, antibacterial, and antiviral treatment in the Soviet Union, Eastern Europe, and China. But U.S. medicine has ignored propolis so completely that the word does not even appear in any of the three major medical dictionaries in common use. Health-food stores have long carried propolis, both in its raw form and in tinctures and capsules. The published work on propolis, mostly from Eastern Europe and the Soviet Union, consists of highly technical laboratory studies, along with largely anecdotal clinical reports, usually of treatment for infections. Apparently there has not been a major effort to prove the effectiveness of propolis with controlled clinical trials, as is done with new drug products from Western pharmaceutical companies. Such trials would be expensive, and it is hard to see a motive for them in countries where physicians and lay persons alike already use the treatment as part of traditional practice. Nor would a U.S. pharmaceutical company be likely to spend the millions of dollars required to gain marketing approval under our system of medicine, for a product already cheaply available through the health-products industry. So propolis simply dropped out of the U.S. medical system. Only the patients might have cared, and they have had no voice for systematic research or advocacy on such matters.

32. Hairy Leukoplakia Information Page Diseases Database hairy leukoplakia Information Page. hairy leukoplakia related topics and differentials, GoHairyleukoplakia specific sites. GoSend hairy leukoplakia http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=5594

33. Oral Hairy Leukoplakia,Tongue Rhett Drugge, MD. http://www.telemedicine.org/glxo0220.htm

Rhett Drugge, M.D. Rhett Drugge, M.D.

34. Oral Hairy Leukoplakia Detection of EpsteinBarr virus (EBV) DNA and antigens in oral mucosa of renal transplantpatients without clinical evidence of oral hairy leukoplakia (OHL). http://www.thedoctorsdoctor.com/diseases/oralhairyleukoplakia.htm

Background This interesting disease is found primarily in patients with a severe immunodeficiency such as in patients with AIDS. It presents with flat to hairy white lesions on the lateral or ventral borders of the tounge. It is asymptomatic and related to a patient's immune status. EPIDEMIOLOGY CHARACTERIZATION INCIDENCE 20% of asymptomatic HIV infected patients Incidence grows as CD4 count decreases Detection of Epstein-Barr virus (EBV) DNA and antigens in oral mucosa of renal transplant patients without clinical evidence of oral hairy leukoplakia (OHL). Ammatuna P, Capone F, Giambelluca D, Pizzo I, D'Alia G, Margiotta V. Department of Hygiene and Microbiology, University of Palermo, Italy. J Oral Pathol Med 1998 Oct;27(9):420-7 Abstract quote The use of the polymerase chain reaction (PCR) to detect the presence of Epstein-Barr virus (EBV) DNA in oral mucosa in the absence of specific lesions gives rise to the problem of identifying the real viral replication sites. Hybridization with the EBV-specific probe was observed in 40/ 89 and 2/13 samples, respectively. Latent antigens (with or without lytic antigens) were detected in only 23 of the 40 samples (collected from eight different transplant patients) that were positive by in situ hybridization. Our data show that EBV is more frequently present in the oral mucosa of immunodeficient patients (where it can efficiently replicate) than in normal subjects.

35. Oral Hairy Leukoplakia (OHL) Slide 1 of 15. http://www.dental.mu.edu/oralpath/spresent/hairyleukoplakia/sld001.htm

36. Oral Hairy Leukoplakia (OHL) Oral hairy leukoplakia (OHL). 3/23/01. Click here to start. Table of Contents.Oral hairy leukoplakia (OHL). Definition. General Considerations. http://www.dental.mu.edu/oralpath/spresent/hairyleukoplakia/

Oral Hairy Leukoplakia (OHL) Click here to start Table of Contents Oral Hairy Leukoplakia (OHL) Definition General Considerations Clinical Descriptionwhen location is lateral border of tongue ... PPT Slide Author: Mary Ann R. Wolf Email: someone@microsoft.com

37. Avera Health - Leukoplakia hairy leukoplakia; Smoker's keratosis. Causes, incidence, and risk factors Hairyleukoplakia may be one of the first signs of infection with the HIV virus. http://www.avera.org/adam/ency/article/001046.htm

Disease Injury Nutrition Poison ... Z Leukoplakia Definition: A precancerous lesion that develops on the tongue or the inside of the cheek as a response to chronic irritation. Occasionally, leukoplakia patches develop on the female external genitalia. Alternative Names: Hairy leukoplakia; Smoker's keratosis Causes, incidence, and risk factors: Leukoplakia is primarily a disorder of the mucous membranes of the mouth, caused by irritation. Lesions usually develop on the tongue, but they may appear on the insides of the cheek. Irritation may result from rough teeth or rough places on dentures, fillings, crown, and so on. It may also result from chronic smoking or other tobacco use (smoker's keratosis). Pipe smoking involves a high risk for development of leukoplakia, as does holding chewing tobacco or snuff in the mouth for a prolonged period of time. Occasionally, leukoplakia patches develop on the female external genital area, but the cause is unknown. Like other mouth ulcers , leukoplakia may become a cancerous lesion. The disorder is most common in the elderly.

38. Oral Manifestations Of AIDS Dr. Heddie O. Sedano, DDS. Back to Classification Relevant References to Oral HairyLeukoplakia (OHL). Go to Top of Page. Oral hairy leukoplakia. Classification. http://www.dent.ucla.edu/pic/members/oralaids/viral/ohl/ohlref.html

Frequent Oral Diseases in HIV Positive and AIDS Patients Dr. Heddie O. Sedano, DDS Back to Classification Relevant References to Oral Hairy Leukoplakia (OHL) Glick and co-workers (1) have demonstrated that the presence of OHL in patients infected with the AIDS virus is a trustable marker for the progression of the HIV infection. Greenspan and co-workers (2) as well as Moniaci and coworkers (3) have shown than 40 to 60% of patients infected with HIV convert to AIDS within 2 to 3 years after the development of OHL. Brandwein et al (7) using standard DNA in situ hybridization (ISH) to detect Epstein Barr virus (EBV) in lingual hairy leukoplakia, found EBV in all 11 specimens that were investigated. EBV was found in the basal and parabasal layers and strongly localized in the upper epithelial layers. Additionally these authors reported that in the same 11 specimes there was no evidence of human papilloma virus (HPV) or cytomegalovirus DNA. The authors concluded that there is no evidence to suggest that HPV is involved in the development of hairy leukoplakia. Miranda and Lozada-Nur (8) as well as other authors (9,10) have reported the presence of lingual hairy leukoplakia in HIV-negative immunosuppressed and in immunocompetent patients. These authors comment on the importance of a thorough examination of the oral tissues in patients who are undergoing immunosuppressive therapy.

39. Hairy Leukoplakia - General Practice Notebook medical information from General Practice Notebook. hairy leukoplakia. Thisis a lesion on the tongue that may be seen in immunocompromised patients. http://www.gpnotebook.co.uk/cache/-1583742947.htm

hairy leukoplakia This is a lesion on the tongue that may be seen in immunocompromised patients. It appears to be the result of a proliferation of Epstein-Barr virus, possibly associated with Papilloma virus in the superficial layers of the squamous epithelium of the tongue. Click here for more information...

40. Health Ency.: Disease: Leukoplakia Alternative names hairy leukoplakia; Smoker's keratosis. Definition hairy leukoplakiamay be one of the first signs of infection with the HIV virus. http://www.austin360.com/shared/health/adam/ency/article/001046.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease L Leukoplakia Overview Symptoms Treatment Prevention Alternative names: Hairy leukoplakia; Smoker's keratosis Definition: A precancerous lesion that develops on the tongue or the inside of the cheek as a response to chronic irritation. Occasionally, leukoplakia patches develop on the female external genitalia. Causes and Risks Leukoplakia is primarily a disorder of the mucous membranes of the mouth, caused by irritation. Lesions usually develop on the tongue, but they may appear on the insides of the cheek. Irritation may result from rough teeth or rough places on dentures, fillings, crown, and so on. It may also result from chronic smoking or other tobacco use (smoker's keratosis). Pipe smoking involves a high risk for development of leukoplakia, as does holding chewing tobacco or snuff in the mouth for a prolonged period of time. Occasionally, leukoplakia patches develop on the female external genital area, but the cause is unknown. Like other mouth ulcers , leukoplakia may become a cancerous lesion.

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