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         Hairy Leukoplakia:     more detail

81. Notes
39 Greenspan D, Grennspan JS, Goldman H. Oral viral lesion (hairy leukoplakia)associated with acquired immunodeficiency syndrome. MMWR 1985 ; 34 54950.
http://www.pum.umontreal.ca/theses/pilote/charbonneau/these_notes.html
Note(s)
EC-Clearinghouse on Oral Problems related to HIV Infection, WHO Collaborating Centre on Oral Manifestations of the Immunodefieciency Virus. Classification and diagnostic criteria for oral lesions in HIV infection . J Oral Pathol Med 1993 ; 22 : 289-91. Katz MH, Mastrucci MT, Leggott PJ, Westenhouse J, Greenspan JS, Scott GB. Prognostic significance of oral lesions in children with perinatally acquired human immunodeficiency virus infection . Am J Dis Child 1993 ; 147(1) : 45-48. Shiboski C, Hilton JF, Greenspan D, Westenhouse JL, Derish P, Vranizan K, Lifson AR, Canchola A, Katz MH, Cohen JB, Moss AR, Greenspan JS. HIV-Related Oral manifestations in Two Cohorts of Women in San Francisco . J Acquir Immune Defic Syndr 1994 ; 7 : 964-971. Gerbert B, Sumser J, Chamberlin K, Maguire BT, Greenblatt RM, McMaster JR. Dental care experience of HIV-positive patients . JADA 1989 : 119 ; 601-3. Jacobson JJ, Stocking C, Gramelspacher G. Dental care experience of HIV-infected men in Chicago. JADA, 1989 ; 119 : 605-8.

82. Accessibilité Aux Services Buccodentaires Des Personnes Vivant Avec Le VIH-SIDA
Greenspan D, Grennspan JS, Goldman H. Oral viral lesion (hairy leukoplakia) associatedwith acquired immunodeficiency syndrome. MMWR 1985 ; 34 54950. 40.
http://www.pum.umontreal.ca/theses/pilote/charbonneau/these_back.html
Bibliographie
  • 1. EC-Clearinghouse on Oral Problems related to HIV Infection, WHO Collaborating Centre on Oral Manifestations of the Immunodefieciency Virus. Classification and diagnostic criteria for oral lesions in HIV infection . J Oral Pathol Med 1993 ; 22 : 289-91. 2. Katz MH, Mastrucci MT, Leggott PJ, Westenhouse J, Greenspan JS, Scott GB. Prognostic significance of oral lesions in children with perinatally acquired human immunodeficiency virus infection . Am J Dis Child 1993 ; 147(1) : 45-48. 3. Shiboski C, Hilton JF, Greenspan D, Westenhouse JL, Derish P, Vranizan K, Lifson AR, Canchola A, Katz MH, Cohen JB, Moss AR, Greenspan JS. HIV-Related Oral manifestations in Two Cohorts of Women in San Francisco . J Acquir Immune Defic Syndr 1994 ; 7 : 964-971. 4. Gerbert B, Sumser J, Chamberlin K, Maguire BT, Greenblatt RM, McMaster JR. Dental care experience of HIV-positive patients . JADA 1989 : 119 ; 601-3. 5. Jacobson JJ, Stocking C, Gramelspacher G. Dental care experience of HIV-infected men in Chicago. JADA, 1989 ; 119 : 605-8.

83. Acquired Immunodeficiency Syndrome
disease oral candidiasis is the most common opportunistic infection seen in HIVinfectedpatients, followed by a second oral lesion termed hairy leukoplakia.
http://www.nidr.nih.gov/spectrum/NIDCR2/2grasec4.htm
The oral effects of systemic disease are by no means limited only to the periodontium. All of the tissues in the oral cavity are fair game for a variety of insults, either directly from infection, or indirectly as part of the systemic disease process. There is perhaps no better illustration of the involvement of oral tissues in systemic disease than the oral manifestations of AIDS.
Oral Lesions
Since the acquired immune deficiency syndrome was first recognized in the United States in 1981, the mouth has provided a remarkable laboratory for the study of this emerging infectious disease that targets the immune system for destruction. The first clinical reports of this syndrome indicated that lesions in the oral cavity were common and often occurred early in the course of the disease. Oral health scientists initiated not only clinical studies to define the oral signs and symptoms, but also a basic research strategy to understand the molecular virology and immunology of AIDS. Studies of the natural history and epidemiology of HIV/AIDS documented that the fungal disease oral candidiasis is the most common opportunistic infection seen in HIV-infected patients, followed by a second oral lesion termed hairy leukoplakia. A whitish lesion frequently seen on the side of the tongue, hairy leukoplakia is strongly associated with the Epstein-Barr virus and is a reliable predictor of AIDS. A comparison of HIV-positive patients with similar CD4 counts (a measure of the body's immune response) revealed that those with oral candidiasis or hairy leukoplakia tend to develop major opportunistic infections or progress to AIDS more rapidly than patients without these lesions. Also, the odds of developing oral candidiasis increase as the CD4 counts of infection-fighting T cells decrease. In parts of the world where diagnostic blood tests for HIV are not available, the presence of these oral lesions in otherwise asymptomatic adults can be used as an indicator of HIV infection.

84. HIV And Oral Airy Leukoplakia
2 Oral hairy leukoplakia in a HIV-infected woman. Close up. hairy leukoplakia isusually asymptomatic, but large lesions may impair tast and hinder eating.
http://members.xoom.virgilio.it/Aidsimaging/leucovill/leucovill2.htm
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Oral Hairy Leukoplakia Fig. 2 Fig. 2 - Leucoplachia villosa orale in una donna con infezione da HIV. Primo piano.
La leucoplachia villosa orale è in genere asintomatica ma se estesa può causare difficoltà nel mangiare ed alterazioni del gusto. Le lesioni possono rispondere temporaneamente alla terapia con acyclovir o con ganciclovir. Fig. 2 - Oral hairy leukoplakia in a HIV-infected woman. Close up. Hairy leukoplakia is usually asymptomatic, but large lesions may impair tast and hinder eating. Lesions may temporarily respond to acyclovir or ganciclovir. leukoplakia back top page editor ... index

85. HIV And Oral Airy Leukoplakia
Oral hairy leukoplakia. Fig. 1. Fig. 1 Leucoplachia villosa orale in una donnacon infezione da HIV. Fig. 1 - Oral hairy leukoplakia in a HIV-infected woman.
http://members.xoom.virgilio.it/Aidsimaging/leucovill/leucovill1.htm
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Oral Hairy Leukoplakia Fig. 1 Fig. 1 - Leucoplachia villosa orale in una donna con infezione da HIV.
La leucoplachia villosa orale, dovuta al virus di Epstein-Barr, si presenta con lesioni rilevate, biancastre, in genere localizzate sui margini laterali della lingua. La diagnosi si basa sulla non asportabilità delle lesioni con l'abbassalingua, sulla mancata risposta alla terapia antifungina e sull'esame bioptico. Fig. 1 - Oral hairy leukoplakia in a HIV-infected woman. Oral hairy leukoplakia is a raised, white lesion that is usually seen on the lateral margin of the tongue and caused by Epstein-Barr Virus. The diagnosis is established by failure to scrape off the lesion with a tongue blade, failure to respond to antimycotic therapy, and biopsy. l eukoplakia top page next editor ... index

86. Hairy Leukoplakia : Meddie Health Search
options. Home Health Conditions and Diseases Infectious Diseases Viral EpsteinBarr Virus hairy leukoplakia. ITEMS LINKS
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87. Health Content Encyclopedia Article Leukoplakia
Alternate Names. hairy leukoplakia; Smoker's keratosis Definition. hairy leukoplakiamay be one of the first signs of infection with the HIV virus. Symptoms.
http://www.centralbap.com/adamcontent/ency/article/001046.asp

88. Florida State University College Of Medicine Digital Library
Medicine, Ob/Gyn, Psychiatry, and Surgery (eMedicine) Table of contents HairyLeukoplakia Access document; Oral hairy leukoplakia Access document.
http://fsumed-dl.slis.ua.edu/clinical/oral/oral-mucosa/leukoplakia.htm
Clinical Resources by Topic: Oral Disorders
Leukoplakia Clinical Resources
Pediatrics Atlases Radiology Pathology ... Miscellaneous Resources See also:

89. CCHS Clinical Digital Library
Medicine, Ob/Gyn, Psychiatry, and Surgery (eMedicine) Table of contents HairyLeukoplakia Access document; Oral hairy leukoplakia Access document.
http://cchs-dl.slis.ua.edu/clinical/oral/oral-mucosa/leukoplakia.htm
Clinical Resources by Topic: Oral Disorders
Leukoplakia Clinical Resources
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90. Podophyllum Peltatum, Hexandrum, Emodi
White 1997. Ten HIVinfected patients who had bilateral hairy leukoplakiaon the tongue were treated with topical podophyllum resin 25% solution.
http://www.herbmed.org/Herbs/Herb89.htm
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Podophyllum peltatum, hexandrum, emodi
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mayapple, mandrake, Indian apple, wild lemon, duck's foot Evidence for Efficacy (Human Data) Clinical Trials Observational Studies/Case Reports Traditional and Folk Use Warnings Interactions Contraindications Methods of Preparation Contemporary Standardized Methods Folk Methods Formulas/Blends Contemporary Formulas Folk Blends Evidence of Activity Pharmacodynamics Animal Studies Analytical Chemistry Pharmacokinetics (ADME) Other Information Related Links Dynamic Updates Live PubMed Searches History of Records History of Record EVIDENCE FOR EFFICACY (HUMAN DATA) Clinical Trials A double blind randomised study to compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and podophyllin 2.0% sourced from Podophyllum emodii. White 1997 Ten HIV-infected patients who had bilateral hairy leukoplakia on the tongue were treated with topical podophyllum resin 25% solution. A single topical application proved efficacious in producing significant short-term resolution of HIV-related oral hairy leukoplakia.

91. Leukoplakia
Also Known As Oral hairy leukoplakia. Related Resources Opportunistic InfectionsA complete guide to opportunistic infections. Back to Index L Full Glossary.
http://aids.about.com/library/glossary/bldef-leukoplakia.htm
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Leukoplakia Back to Index L Full Glossary Definition: A whitish lesion that appears on the side of the tongue and inside cheeks. The lesion appears raised, with a ribbed or "hairy" surface. Occurs mainly in persons with declining immunity. Also Known As: Oral Hairy Leukoplakia Related Resources: Opportunistic Infections
A complete guide to opportunistic infections
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92. Global Oral Health - CAPP
Combined candidal lesions were evident in 37.8%, hairy leukoplakia in 19.7%and combined gingival/periodontal lesions in 8.5% of patients seen.
http://www.whocollab.od.mah.se/afro/southafrica/data/southafricahiv.html
Selected Country/Section:
South Africa
H UMAN I MMUNODEFICIENCY V IRUS HIV A CQUIRED I MMUNODEFICIENCY S YNDROME AIDS
Demographic and clinical characteristics at baseline of 600 HIV-positive
South Africans (1993-96) Characteristics Patients
Gender
Men
Women
Age (mean) in years Route of transmission
Sexual contact
Blood transfusion Intravenous drug use Unknown Sexual orientation Heterosexual Homosexual Bisexual Ethnicity Black Coloured (persons of mixed descent) White Six hundred adult HIV-infected patients were examined in the greater Cape Town area in 1993-96. Combined candidal lesions were evident in 37.8%, hairy leukoplakia in 19.7% and combined gingival/periodontal lesions in 8.5% of patients seen. Less common lesions were oral ulceration (2.9%) and kaposi's sarcoma (1.5). Source : Arendorf TM. et al. Oral manifestations of HIV infection in 600 South African patients. J Oral Pathol Med 1998; 27: 176-179. More information on the Oral manifestation of HIV/AIDS Prevalence of oral manifestations in 600 HIV-infected patients (many had multiple oral lesions) (1998) Type n Any oral disease Pseudomembranous candidosis Erythematous candidosis Angular cheilitis Combined candidal lesions Oral hairy leukoplakia Linear gingival erythema Necrotising gingivitis Necrotising periodontitis Combined gingival/periodontal lesions Oral ulceration (recurrent and non-recurrent) Kaposi's sarcoma Salivary gland enlargement Melannotic hyperpigmentation Herpes simplex infection

93. EBV
hairy leukoplakia. hairy leukoplakia EBVinduced epithelial hyperplasia causescorregated white lesions that have been termed hairy leukoplakia (HL).
http://www.dentistry.leeds.ac.uk/oralpath/viruses/viral infections/EBV.htm
Epstein Barr Virus Infections Introduction
  • EBV (HHV4) is a gamma-herpesvirus that only naturally occurs in humans. There are no animal reservoirs. EBV was named after Tony Epstein and Yvonne Barr who were the two scientists who first isolated and described the virus in 1964 from lymphoma samples collected by Denis Burkitt. EBV is of direct relevance to the practice of dentistry as:

94. Mucosal & Skin Lesions
Pachyonychia Congenita. White Sponge Nevus. leukoplakia, hairy. Lupus Erythematosus,Skin Graft, Submucous Fibrosis, Hereditary Benign Intraepithelial Dyskeratosis.
http://www.maxillofacialcenter.com/BondBook/mucosa/main.html
Epithelial Lesions
of The Maxillofacial Region
White lacy pattern of lichen planus.
Papillary and Verruciform
Epithelial Masses (Benign)
Note: Diseases with links are those with completed or almost completed sections.
Condyloma
Acuminatum
Focal Epithelial Hyperplasia
Hairy Leukoplakia ...
Keratoacanthoma Leukoplakia, Verruciform Papilloma, Inverted Papilloma,
Cylindrical Cell Papilloma,
Squamous
Peudoepitheliomatous Hyperplasia Verruca Vulgaris Verruciform Xanthoma Top of This Page
Nonpapillary, Nonsloughing
Keratotic Hyperplasias (Benign) Note: Diseases with links are those with completed or almost completed sections.
Actinic Cheilosis
Benign Migratory Glossitis Benign Migratory Stomatitis Keratosis, Chemical ...
Lichen Planus
Nicotine Palatinus Pachyonychia Congenita White Sponge Nevus Leukoplakia, Hairy Lupus Erythematosus Skin Graft Submucous Fibrosis Hereditary Benign Intraepithelial Dyskeratosis Dyskeratosis Congenita Uremic Stomatitis White CoatedTongue Linea Alba Syphilis, Secondary

95. AIDS
hairy leukoplakia of the Mouth Oral hairy leukoplakia is an unusual conditionthat causes small, white, fuzzy patches most often on the tongue.
http://www.aad.org/pamphlets/aidspamp.html
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AIDS The Acquired Immune Deficiency Syndrome (AIDS) is the loss of the body's ability to fight infections due to the infection caused by a virus called Human Immunodeficiency Virus (HIV). Some patients infected with HIV may develop skin conditions, fungal, viral, and other bacterial infections as well as cancer. Since first recognized in 1981, AIDS has been found to be a major health problem all over the world. A person can be infected with HIV for several years before the problems of AIDS occur. The development of the life-threatening complications of AIDS are due to the virus' destruction of white blood cells. These cells are essential in the body's natural immune system. The most common life-threatening infection is a severe and unusual lung infection caused by a common parasite, pneumocystis carinii. This parasite does not cause infections in healthy people. AIDS patients can also develop an unusual cancer known as Kaposi's sarcoma. This cancer begins as one or more painless, flat blotches and bumps, that are pink to purple in color, and are found on the skin or in the mouth. Who is at risk?

96. Katalog - Wirtualna Polska
Serwis Katalog w Wirtualna Polska S.A. pierwszy portal w Polsce.
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Poczta Czat SMS Pomoc Szukaj.wp.pl: -Katalog -Polskie www -¦wiatowe www -Wirtualna Polska -FTP/Pliki -Grupy dyskusyjne -Encyklopedia -Produkty wp.pl Katalog Katalog ¦wiatowy DMOZ ... Viral > Epstein-Barr Virus Fakty o Katalogu Pomoc Regulamin Serwis szukaj ... Ostatnio dodane
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97. Histoplasmosis
Last Updated January 20, 1998
http://www.hivdent.org/slides/histoplasmosis.htm
Histoplasmosis with associated oral hairy leukoplakia (lateral border
of tongue) and pseudomembranous candidiasis (bucal mucosa)
Last Updated January 20, 1998

98. NEJM -- Replication Of Epstein-Barr Virus Within The Epithelial Cells Of Oral "h
We conclude that EBV replicates within the epithelial cells in hairyleukoplakia. This article has been cited by other articles
http://content.nejm.org/cgi/content/abstract/313/25/1564
HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 313:1564-1571 December 19, 1985 Number 25 Next Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion
JS Greenspan, D Greenspan, ET Lennette, DI Abrams, MA Conant, V Petersen, and UK Freese Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Greenspan, J. S. Freese, U. K. Medline Citation Abstract
This article has been cited by other articles:
  • Yoda, K., Sata, T., Kurata, T., Aramaki, H. (2000). Oropharyngotonsillitis Associated With Nonprimary Epstein-Barr Virus Infection. Arch Otolaryngol Head Neck Surg [Abstract] [Full Text]
  • Herrmann, K., Frangou, P., Middeldorp, J., Niedobitek, G. (2002). Epstein-Barr virus replication in tongue epithelial cells. J Gen Virol [Abstract] [Full Text]
  • Lazaro, P., Olalquiaga, J., Bartolome, J., Ortiz-Movilla, N., Rodriguez-Inigo, E., Pardo, M., Lecona, M., Pico, M., Longo, I., Garcia-Morras, P., Carreno, V. (2002). Detection of Hepatitis C Virus RNA and Core Protein in Keratinocytes from Patients with Cutaneous Lichen Planus and Chronic Hepatitis C. J Invest Dermatol [Abstract] [Full Text]
  • Sitki-Green, D., Edwards, R. H., Webster-Cyriaque, J., Raab-Traub, N. (2002). Identification of Epstein-Barr Virus Strain Variants in Hairy Leukoplakia and Peripheral Blood by Use of a Heteroduplex Tracking Assay.

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