61. Mayo Clinic - Mayo Clinic Study Shows One In Four Have Precursor To Heart Failur Mayo Clinic in Rochester. Wednesday, January 08, 2003. Mayo Clinic Study Shows Onein Four have Precursor to heart failure. This is diastolic heart failure.”. http://www.mayoclinic.org/news2003-rst/1591.html

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic in Rochester Wednesday, January 08, 2003 Mayo Clinic Study Shows One in Four have Precursor to Heart Failure Mortality eight to 10 times higher in patients with heart-filling dysfunction ROCHESTER, Minn. More than one-fourth of adults over age 45 have abnormalities in the way their heart fills with blood and are at significantly increased risk for premature death, according to results of a study of 2,042 randomly selected residents of Olmsted County, Minn. The study is published in the Jan. 8 issue of the Journal of the American Medical Association (JAMA). Individuals with diastolic dysfunction, or problems with the heart’s filling with blood between beats, were eight to 10 times more likely to die within five years than those with normal filling. According to the study’s lead author, the findings point to the need for better understanding of diastolic heart failure and how it can be prevented. “Many people think of heart failure as being due to a large, weakly pumping heart,” says Margaret Redfield, M.D., director of the Mayo Clinic Heart Failure Clinic. “This is called systolic heart failure, when the ejection fraction the portion of the blood in the left ventricle pushed out to the body with each beat is less than 50 percent. But this study shows that for nearly half of heart failure patients, pumping function is normal, but the heart is stiff or does not relax and therefore cannot fill with blood properly. This is diastolic heart failure.”

62. HeartPoint: Congestive Heart Failure Explains what heart failure is, symptoms, what to watch for, evaluation, prognosis, medication other Category Health Conditions and Diseases Heart Disease Failure......CONGESTIVE heart failure. heart failure at one time was an almostuntreatable disorder. Times have changed. Today, there are many http://www.heartpoint.com/congheartfailure.html

C O N G E S T I V E H E A R T F A I L U R E Heart failure at one time was an almost untreatable disorder. Times have changed. Today, there are many important and effective measures that can be utilized to improve the symptoms, and the survival, of patients with congestive heart failure. Perhaps more than in other conditions, it is important to understand what is going on, and for the patient to participate in the care of this condition. It is very common, affecting over 2 million people in the United States including one in 10 people over the age of 75, and is the leading cause of hospital admissions for patients in the Medicare population. It is increasing in frequency as our population ages and as we find better ways to help people survive initial heart attacks they now can survive to experience CHF. It may be worthwhile to learn or review about [ How the Heart Works ] now or at some point in your reading of this section. ©COPY;1997 HeartPoint Updated June 1998 Commentary Food You Will Love HeartPoint Gallery In The News ... Home

63. Pet Columns Discusses CHF in dogs. http://www.cvm.uiuc.edu/ceps/petcolumns/chf.html

Veterinary Teaching Hospital CARE Grief Helpline Wildlife Medical Clinic Admission to Veterinary School Birds Cats Dogs Equine General Livestock Reptiles Wildlife Search for these words: Find articles: Containing all these words Containing any of these words CEPS / 2938 VMBSB 2001 S Lincoln Ave / Urbana, Illinois 61802-6199 / Phone: 217/333-2907 The Pet Columns site provides authoritative general information for animal owners. Please consult your local veterinarian with your questions about specific care for your animal. Your comments about the site are welcome, but we cannot dispense medical advice via the Internet.

64. Heart Failure - Congestive Heart Failure (CHF) Heart Attack. heart failure. Peripheral Vascular Disease. The Condition, The Treatment,The Solution, heart failure is a common and serious medical condition. http://www.guidant.com/condition/heartfailure/

Condition Compass Overview Abdominal Aortic Aneurysm Arrhythmias Coronary Artery Disease ... comments Heart failure is a common and serious medical condition. Despite its misleading name, in heart failure the heart doesn't suddenly stop working... more Early diagnosis and treatment of heart failure are very important. Heart failure cannot be cured, but many treatment options exist... more Heart failure can cause problems with the timing or coordination of the heart's contractions. Implantable devices are available to help restore proper timing... more Terms and Conditions

65. Well Advice Information utilizing lifestyle and nutrition therapies and prescriptions as an alternative to conventional medicine. Some diseases covered are atherosclerosis, heart failure, cholesterol and high blood pressure. http://www.welladvice.bigstep.com/generic.html;$sessionid$4PZOTTIAAAEGBWGIHUVHBM

66. Hospital Joins National Heart Failure Registry Program Hospital Joins National heart failure Registry Program. STONY BROOK,NY, February 11, 2003 — To help focus public attention during http://commcgi.cc.stonybrook.edu/artman/publish/article_364.shtml

Stony Brook News Contact Media Relations Stony Brook in the News Events ... News Categories Search Entire Site General University News Arts/Humanities Engineering/Science Health Sciences/Hospital Marine Sciences Stony Brook in the News Advanced Search Health Sciences/Hospital Press Release Contact: Iva Kocijan FAX: 631.632.6313 Stony Brook University, SUNY 144 Admin Stony Brook, NY 11794-0605 Hospital Joins National Heart Failure Registry Program STONY BROOK, NY, February 11, 2003 — To help focus public attention during February (Heart Month), Stony Brook University Hospital is participating in the ADHERE (Acute Decompensated Heart Failure National Registry) program. ADHERE is a nationwide registry that has been established to collect and analyze demographic data and treatment in patients hospitalized with the diagnosis of congestive heart failure (CHF). Tens of thousands of patients from more than 200 hospitals across the country will be entered into the database during the next few years. It already has more than 30,000 patients enrolled from 200 U.S. hospitals. “The information collected will enable us to follow treatment trends within our hospital, institute measures to ensure quality of care and aid in the appropriate allocation of health care resources, overall improving care of patients with CHF,”says Krishnamurthy Suresh, MD, chief of the Heart Failure Program at Stony Brook University Hospital.

67. Advanced Search Preventing Congestive heart failure. JAY N. COHN an ACE inhibitor. EarlyIntervention in Patients at Risk for Coronary heart failure. http://www.aafp.org/afp/980415ap/cohn.html

Advanced Search Articles Departments Patient Information Preventing Congestive Heart Failure JAY N. COHN, M.D., University of Minnesota Medical School, Minneapolis, Minnesota The morbidity, mortality and health care costs associated with congestive heart failure make prevention a more attractive public health strategy than treatment. Aggressive management of etiologic factors, including hypertension, coronary artery disease, valvular disease and excessive alcohol intake, can prevent the left ventricular remodeling and dysfunction that lead to heart failure. Early intervention with angiotensin converting enzyme inhibitors in patients with chronic left ventricular dysfunction can prevent, as well as treat, the syndrome. Several intervention strategies in patients with acute myocardial infarction can slow or prevent the left ventricular remodeling process that antedates congestive heart failure. The primary care physician must be alert to the need for aggressive intervention to reduce the burden of heart failure syndrome on the patient and on society. C ongestive heart failure is a complex clinical syndrome characterized by exertional dyspnea, fatigue and, often, peripheral edema resulting from left ventricular dysfunction. Although the extent of the abnormal function of the left ventricle can be quantitated, it is more difficult to measure the severity of symptoms; furthermore, the specific mechanism underlying the symptoms remains poorly understood. Since neurohormonal systems are often stimulated in the heart failure syndrome, activation of the sympathetic nervous system and the renin angiotensin system is often implicated in sodium retention, edema formation and some other symptoms of heart failure.

68. The Cardiac Center Brigham And Women's Hospital A list of treatment alternatives available to patients with cardiomyopathy/heart failure. A list of services, information for patients and second opinions are topics discussed. http://www.bwheart.org/services_cardiomyopathy.html

Cardiac Center News History Search An institution recognized worldwide for its expertise and contributions to the field of cardiology and cardiac surgery. Additional Resources: BWH Division of Cardiac Surgery Brigham and Women's Hospital Extranet

69. Pacemaker Therapy Halves Heart Failure Deaths Using specialized pacemakers to recharge the weakened hearts of heart failure patientscan halve the death rate from the disease and reduce hospitalizations by http://www.eurekalert.org/pub_releases/2003-02/jhmi-pth021003.php

Public release date: 11-Feb-2003 Contact: John Lazarou jlazaro1@jhmi.edu Johns Hopkins Medical Institutions Pacemaker therapy halves heart failure deaths Also cuts hospitalizations Using specialized pacemakers to recharge the weakened hearts of heart failure patients can halve the death rate from the disease and reduce hospitalizations by nearly a third, a Johns Hopkins study has found. Results of the study, which analyzed clinical trials of pacemaker therapy for heart failure involving a total of 1,634 patients, are published in the Feb. 12 issue of The Journal of the American Medical Association. "The devices range in cost from $20,000 to $50,000," says lead author David J. Bradley, M.D., Ph.D., a cardiology fellow. "These specialized pacemakers have been known to improve the quality of life for heart failure patients, but whether they also save lives had been unclear." Heart failure accounts for more than 700,000 hospitalizations among Medicare beneficiaries every year, Bradley says. In the year 2000, hospitalization charges amounted to $14 billion. Half of deaths among these patients are caused by progressive cardiac dysfunction, which pacemakers help correct by stimulating the heart muscle to contract, pumping blood to the body. Heart failure, which affects nearly 5 million people in the United States, is a condition in which the heart can't pump enough blood to the body's other organs. This can result from assorted problems including heart attack, high blood pressure or heart valve disease. The "failing" heart keeps working but not as efficiently as it should. People with heart failure can't exert themselves because they become short of breath and tired.

70. California Pacific Medical Center _ Heart Failure And Transplant Program Programs for endstage cardiac disease, artificial hearts and heart transplant. http://www.cpmc.org/heart

Advanced Medical Care Heart Failure/ Transplant For Patients For Physicians ... Contact Us We focus on providing experienced, multi-disciplinary care that is individualized for each patient personal care that involves the patient, family members and the referring physician. What a heart program needs to be... Excellent Results Total Patient Care Cardiac Disease Management About Our Sutter Health Network ... Home

71. Sleep Breathing Disorder May Be A Cause, Rather Than Just An Effect, Of Heart Fa An interruption in normal breathing patterns during sleep which is often seen inheart failure patients may contribute to heart failure rather than just being http://www.eurekalert.org/pub_releases/2003-02/mc-sbd020703.php

Public release date: 10-Feb-2003 Contact: Lee Aase newsbureau@mayo.edu Mayo Clinic Sleep breathing disorder may be a cause, rather than just an effect, of heart failure ROCHESTER, Minn. An interruption in normal breathing patterns during sleep which is often seen in heart failure patients may contribute to heart failure rather than just being a result, according to findings of a Mayo Clinic collaborative study published this week in Circulation: Journal of the American Heart Association. "The goal of medicine is to not just treat symptoms of illness, but to find underlying causes," says Virend Somers, M.D. Ph.D., a Mayo Clinic cardiologist and one of the study's authors. "In this instance we are now finding that central sleep apnea, which has been previously understood as a symptom of heart failure, may contribute to the development of heart failure in people at risk." Heart failure is the most common cause of hospitalization in people over age 65, and people who reach age 40 have a 1-in-5 chance of eventually developing heart failure. Symptoms include fatigue, shortness of breath and swelling in the legs and abdomen. Sleep apnea is an interruption of airflow for 10 seconds or more during sleep, which can cause significantly lower oxygen levels in the bloodstream. Patients with severe apnea have 30 or more of these episodes per hour, while those with mild apnea stop breathing at least 15 times. In obstructive sleep apnea (OSA) the chest and abdomen move normally, but a blocked airway prevents the patient from breathing. Central sleep apnea (CSA) differs in that the patient's airway is not obstructed, but the body's breathing reflex is periodically interrupted so there is no chest and abdomen movement.

72. CHFpatients.com - Coreg And Beta-blockers For Heart Failure Information for patients with congestive heart failure. http://www.chfpatients.com/coreg.htm

Heartbytes New CHF Drugs IV Drugs Surgeries Updated March 19, 2003 Coreg is used to treat CHF, as long as the patient does not already have too-low blood pressure or asthma. The usual target dose depends on your weight. If you weigh 187 pounds or less, it will probably be 25mg twice a day. If you weigh more then 187 pounds, it will probably be 50mg twice a day, if you tolerate that dose. You should start at 3.125mg once or twice a day, and work your way up. The generic name is carvedilol with brand names in different countries like Coreg, Dilitrend, Dimitone, and Kredex. Why take a beta-blocker? Your weakened heart is wearing itself out, trying to make up for its weak pumping action by pumping more times per minute. Beta-blockers slow your heart down, which slows down this wearing-out process. Coreg also blocks alpha receptors in artery walls. This dilates (expands) your arteries, lowering the resistance your heart must pump against - your blood pressure. So Coreg slows your heart down and eases the resistance it has to work against. What else does it do? Well, it can reduce certain heart arrhythmias, including PVCs . Beta-blockers also reduce the frequency of migraine headaches, if you get them.

73. CANPAP (Canadian Positive Airway Pressure) The CANPAP trial is a multicentre Canadian randomized clinical trial for the treatment of patients with congestive heart failure and central sleep apnea. http://www.canpap.org/

Home Site Map Multi-centre Can adian Trial of Continuous P ositive A irway P ressure For The Treatment of Congestive Heart Failure and Central Sleep Apnea (CANPAP) CANPAP is a multi-centred randomized trial designed to explore a new non-pharmacologic therapy (Continuous Positive Airway Pressure - CPAP) for patients with Congestive Heart Failure and Central Sleep Apnea. The CANPAP trial is currently recruiting in many large metropolitan cities in Canada. The trial began in January 1999 at six clinical sites in Canada. An additional four sites have since joined the trial. The clinical sites participating in the CANPAP trial are as follows: National CANPAP site Toronto (Site A) , Ontario - Toronto General Hospital/University Health Network, Mount Sinai Hospital and the Samuel Lunenfeld Research Institute Co-Investigation sites Toronto (Site B) , Ontario - St. Michael's Hospital Vancouver , British Columbia - Vancouver Hospital Calgary , Alberta - Foothills Hospital London , Ontario - London Health Sciences Centre Montreal , Quebec - Royal Victoria Hospital Quebec City , Quebec - Hopital Laval Edmonton , Alberta - Misericordia Community Hospital/Caritas Health Group Halifax , Nova Scotia - Queen Elizabeth II Health Sciences Centre Winnipeg , Manitoba - Health Sciences Centre To explore if you may qualify for this study, please answer the following questions:

74. Myogen Develops therapeutic drugs to treat heart failure using expertise in molecular cardiology and a human heart tissue bank. Located in the United States. http://www.myogen.com/

Quick Search Corporate Overview -Myogen's Vision -Myogen's People Product Pipeline -Cardiovascular Disease -Ambrisentan -Enoximone -Perfan IV Discovery Research -Cardiac Signaling Pathways -Fetal Gene Program -Heart Tissue Bank -Cardiogenomics -Press Releases -Events -Links -Resources Career Opportunities -Open Jobs -Colorado Lifestyle -Contact HR Investor Relations Contact Us -Driving Directions -Site Map MYOGEN AWARDED SBIR GRANT FROM NATIONAL INSTITUTES OF HEALTH MYOGEN APPOINTS JERRY T. JACKSON TO ITS BOARD OF DIRECTORS Myogen is a biopharmaceutical company focused on the discovery, development and commercialization of therapeutic drugs for the treatment of cardiovascular diseases. Our advanced understanding of the molecular biology and clinical medicine of cardiovascular disease provides us the capability to discover novel therapies that address segments of the cardiovascular patient population that are not adequately treated by existing therapies. Contact Us Driving Directions Site Map

75. News@UofT -- Researchers Get To The Heart Of Heart Failure -- June 19, 2002 Researchers get to the heart of heart failure ACE 1 contributes toheart failure while ACE 2 protects against it by Janet Wong. June http://www.newsandevents.utoronto.ca/bin3/020619a.asp

Contact Us U of T Magazine National Report Edge ... U of T Home Researchers get to the heart of heart failure ACE 1 contributes to heart failure while ACE 2 protects against it by Janet Wong June 19, 2002 Researchers at the University of Toronto and the University Health Network have identified two genes that play critical roles in heart function - one that contributes to heart failure and one that protects against it. "This finding is really amazing because it opens up new avenues for the treatment of cardiovascular diseases and heart failure," says Professor Josef Penninger of U of T's medical biophysics and immunology departments and lead author of a study in the June 20 issue of Nature . He and colleague Dr. Peter Backx , a physiology and medicine The researchers initially began the study by looking for genes that controlled heart development in flies. Intrigued by finding that the fly's ACE 2 gene is essential in the development of fly hearts, they broadened the study and look for the role of ACE 2 in rats that develop hypertension and cardiovascular disease.

76. Passage Yehudi Menuhin, 82 His debut at 7 electrified a San Francisco audience and by the age of 11, Menuhin and his violin had reached the boards of Carnegie Hall, performing with the New York Philharmonic under the baton of legendary German conductor Fritz Busch. Menuhin was a giant of the 20th century classical music world who performed with and later conducted virtually all of the great orchestras. He died of heart failure in Berlin, three days after canceling a concert appearance. Wired News http://www.wired.com/news/news/story/18427.html

77. News@UofT -- Scientists Identify Same Gene In Mice, Humans Leading To Heart Fail 27, 2003 A rare genetic mutation that causes heart failure and premature deathin people in their teens and 20s acts through the same mechanisms found in http://www.newsandevents.utoronto.ca/bin4/030227a.asp

Contact Us U of T Magazine National Report Edge ... U of T Home Scientists identify same gene in mice, humans leading to heart failure Clear link between a genetic mutation of a protein and the disruption of calcium regulation in the heart by Janet Wong Feb. 27, 2003 A rare genetic mutation that causes heart failure and premature death in people in their teens and 20s acts through the same mechanisms found in lab mice, reports an international team of scientists including two from U of T. "We've shown a clear link between the genetic mutation of a protein called phospholamban and the disruption of calcium regulation in the heart," says Dr. David MacLennan , U of T professor in the Banting and Best Department of Medical Research and one of the senior authors in a Feb. 28 paper in Scienc e . "Scientists at U of T and elsewhere have learned how this process functioned in mice but this is the first time we've seen the same mechanism in people."

78. Passive Smoking And The Risk Of Coronary Heart Disease A metaanalysis of epidemiologic Studies published in the New England Journal of Medicine indicates secondhand smoke causes heart attack, atherosclerosis or hardening of the arteries, congestive heart failure and other cardiovascular problems. http://216.185.112.5/presenter.jhtml?identifier=3172

79. BioMed Central | Abstract | Management Of Congestive Heart Failure: A Gender Gap Key Email. Research article, Management of congestive heart failurea gender gap may still exist. Observations from a contemporary http://www.biomedcentral.com/1471-2261/3/1/abstract

Welcome guest user home journals A-Z journals by subject advanced search ... Volume 3 Viewing options Abstract Full text PDF Pre-publication history Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Burstein JM Yan R Weller I Abramson BL Key E-mail Corresponding author Research article Management of congestive heart failure: a gender gap may still exist. Observations from a contemporary cohort Jason M Burstein Raymond Yan Iris Weller and Beth L Abramson University of Toronto, Ontario, Canada McMaster University, Ontario, Canada Public Health Sciences, University of Toronto, Ontario, Canada St. Michael's Hospital, Toronto, Ontario, Canada BMC Cardiovascular Disorders Abstract Background Unlike other cardiovascular diseases the incidence and prevalence of congestive heart failure (CHF) continues to increase. While gender differences in coronary artery disease have been well described, to date, there has been a relative paucity of similar data in patients with CHF. We conducted a pilot study to evaluate the profile and management of patients with CHF at a tertiary care centre to determine if a gender difference exists. Methods A chart review was performed at a tertiary care centre on consecutive patients admitted with a primary diagnosis of CHF between June 1997 and 1998. Co-morbidity, diagnostic investigations, and management of CHF were recorded. Comparisons between male and female patients were conducted.

80. Congestive Heart Failure Canadian site looking at prevention and treatment as well as evaluation of this disease. http://www.santepub-mtl.qc.ca/Medecin/coeur/heart.html

While the number of hospitalizations for myocardial infarction (heart attack) has been falling by 1% a year, hospitalizations for heart failure have risen by 21% in Montréal since 1990. In-hospital mortality stands at 12%, the average length of hospital stay is 14 days, and re-admissions are frequent. The most frequent causes of relapse are improper observance of treatment, poorly controlled hypertension, other heart problems, and infections. How can we talk about prevention? Simply by examining the causes, i.e. ischaemic heart disease, high blood pressure, cardiomyopathies, diabetes, and valvulopathies. Since the first two conditions are the most frequently associated, we believe that there is a link between strategies for preventing ischaemic heart disease and the prevention of heart failure. Continuum of Heart Failure Prevention Evaluation of Heart Failure Treatment of heart failure according to the type of ventricular dysfunction No resources for patient Information is updated regularly Update : July 7, 1999

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