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Hemiplegic Migraine: more detail

Channelopathy: Cystic Fibrosis, Autosomal Dominant Polycystic Kidney, Brugada Syndrome, Familial Hemiplegic Migraine

41. Progetti
As an ongoing project, we recruit patients with familial hemiplegic migraineand familial migraine. Drug Trial in Familial hemiplegic migraine
http://www.unisi.it/ricerca/ist/cmn/migraine/progetti_si.html
Current Research Projects Clinical and genetic studies of migraine
Project-coordinators: Dr. Stefania Battistini, Dr. Raffaele Rocchi As an ongoing project, we recruit patients with familial hemiplegic migraine and familial migraine. Families suitable for genetic analysis will be selected. Electronic patient database
Project- coordinators : Dr. Stefania Battistini, Tatiana Marsili An electronic database will be created, accessible through Internet, of Familial Hemiplegic Migraine (FHM) and Migraine families with mutations in the P/Q type calcium channel alpha 1 subunit CACNA1A gene aimed at collecting detailed clinical, instrumental and genetic findings of affected family members. Such comprehensive and standardised data collection, among the other partners of the Network, will allow a more efficient and accurate evaluation of genotype-phenotype correlation. Functional Magnetic Resonance
Imaging (fMRI) Study in migraine
Project- coordinators Dr. Stefania Battistini,
Dr. Giampaolo Vatti The pathophysiology of spontaneous migraine aura and headache is poorly understood.We investigate the role of brainstem structure in the mechanisms of generation and maintenance of migraine attack and study the functional changes at cortical and subcortical level during spontaneous and induced (by pattern visual stimulation) attacks by means of functional magnetic resonance imaging (fMRI).

42. Headache Glossary F-H
in duration. hemiplegic migraine. type of migraine causing temporaryparalysis on one side of the body (hemiplegia). Homeopathy. the
http://headaches.about.com/bl-glossary-fh.htm
zfp=-1 About Headaches/Migraine Search in this topic on About on the Web in Products Web Hosting
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Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS Is it Migraine? Tension? What? Coping With Busy Doctors A Different Kind of Diary ... All articles on this topic Stay up-to-date!
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Headache Glossary F Feverfew herb used in the prevention of Migraine. Not regulated by the FDA. Reported to help anecdotally, but there have been no controlled studies to date. G Glaucoma eye disease that can result in blindness if not treated effectively. Sometimes causes headache. H Headache persistant, lasting pain in the head region, as opposed to conditions such as trigeminal neuralgia, which is short in duration. Hemiplegic Migraine type of migraine causing temporary paralysis on one side of the body (hemiplegia) Homeopathy the use of medications in minute dosages in combination with natural substances with the goal of a healthily balanced internal chemistry. In traditional treatment, these dosages would be considered ineffective. Hormone Replacement Therapy use of synthetic hormones, typically estrogen and progesterone during and after menopause or after a hysterectomy.

43. Karyn S. Huntting's Basilar Artery Migraine Page > BAM And Migraine Variants
vascular insufficiency. The other forms of migraine variant are (1) retinal migraine,(2) opthalmoplegic migraine, (3) hemiplegic migraine, (4) facial migraine
http://s-2000.com/bam/bam_variants.html
Home About New Bookstore ... Feedback BAM and Migraine Variants Though BAM is a migraine variant, and therefore technically belongs under the classification of "migraine," a BAM attack can also represent a form of "acute cerebral vascular insufficiency." The other forms of migraine variant are (1) retinal migraine, (2) opthalmoplegic migraine, (3) hemiplegic migraine, (4) facial migraine, and (5) migrainous infarction. Of these, only hemiplegic migraine has been found to be a dominant characteristic in terms of heritability in families. Hemiplegic migraine is also the only form of migraine for which a gene has been located. It is a gene located on chromosome 19 that carries the trait for hemiplegic migraine. Hemiplegia can develop either before or during a migraine. Though Basilar Artery Migraine is certainly a distinct form of migraine variant, BAM patients can exhibit the signs of hemiplegic migraine. The last category of migraine variants listed above, that of migrainous infarction, deserves special note when discussing BAM.

44. Karyn S. Huntting's Basilar Artery Migraine Page > The Physiology Of BAM
More to come here Relationship to Familial hemiplegic migraine. BasilarArtery Migraine may have certain pathophysiologic mechanisms
http://s-2000.com/bam/bam_physiology.html
Home About New Bookstore ... Feedback The Physiology of BAM
Introduction to the Physiology of BAM
The physiology of Basilar Artery Migraine is somewhat unique, and the condition is often difficult to diagnose. Basilar Artery Migraines are a complicated phenomenon involving biochemical, neurogenic, and vascular components. Persons with Basilar Artery Migraine can exhibit symptoms also found in other neurological disorders such as stroke or epilepsy. Patients' reports of Basilar Artery Migraine symptoms, especially in severe cases, can prompt the often arduous process of differential diagnosis to rule out conditions like epilepsy, stroke (cerebral infarct), brain tumor, aneurysm, or other neurological conditions.
What Causes Basilar Artery Migraine
The Direct Causes of BAM BAM is a result of vasospasm (spasm of the artery or vessel) or vasoconstriction (constriction or narrowing of the artery or vessel) in the area of the vertebrobasilar circulation, most likely usually in the basilar artery itself. Spasm or constriction in the basilar artery necessarily affects the circulation of blood in the entire vertebrobasilar region, as the basilar artery itself is key to providing circulation to the posterior areas of the brain. BAM is a migraine variant that involves ischemia (lack of sufficient blood supply) to parts of the brain supplied by the vertebrobasilar circulatory system.

45. CJNS-The Genetic Basis Of Migraine: How Much Do We Know?
Abstract of an article published in the November 1999 issue of the Canadian Journal of Neurological Category Health Conditions and Diseases Migraine Hemiplegic...... Familial hemiplegic migraine (FHM) on the other hand is an autosomal dominant,highly penetrant, though rare form of migraine with strong genetic tendency.
http://www.canjneurolsci.org/26novsuppltoc/genetic.html
Abstract
Close Window
The Genetic Basis of Migraine: How Much Do We Know? Kathy Gardner Abstract: Can. J. Neurol. Sci. 1999; 26: Suppl. 3-S37-S43
For information about this web site e-mail to: journal@cjns.org

46. Æ°«Ðá«ÐªÉiFHMj
(Familial hemiplegic migraine ,FHM). Anew locus for hemiplegic migraine maps to chromosome 1q31.
http://neurol.med.tottori-u.ac.jp/takeshima/ha/HA_MB2.htm

@@iFamilial Hemiplegic Migraine CFHMj
FHMÍÛªÉwïÌªÞ ÅÍOðº¤ÐªÉ(MA)ÌêíÆµÄªÞ³êÄ¢éD
ffîÍGPjOðº¤ÐªÉiMAjÌffîð½·CQjOÆµÄÐáðÜÞªCJµÄàæ¢CRjæ1xßeÒÉÈÆàÐÆèÌ¯lÌìðàÂàÌª¶Ý·éàÌÆKè³êÄ¢éD
ÇóÍÆnÉæè·ªÝçêCáUâ¬]ÞkªÝçêéÆnâ¯¢êñâÓ¯áQðº¤Ænª é±ÆªmçêÄ¢½D FHMÅÍCy¢Oð_@ÉdÄÈìªø«N±³êCsÂtIÈ]ÌáQÉé±Æª éDÜ½]ÇBeð_@ÉìªU³êé±Æàñ³êÄ¨èC´¥ÆµÄ]ÇBeÍð¯é×«Æ³êÄ¢éD 1993NJoutelçÍFHMÌñ¼ÌÆnª1913ÉA½·é±Æð¾ç©Éµ½DÜ½C19p13ÉA½·éÆnÌ³ÒÌåªÉ¬]Þkª©çêé±Æà¾ç©ÆÈÁ½D
CACNA1Aâ`qÌÏÙÊÉæèCFHMÌ¼CEpisodic Ataxia 2iEA2jª¨±éD
Ü½Câ`«¬]¸²ÇiSCA6jÅÍC±Ìâ`qÌCÉ¶Ý·éCAGs[gª20ÈãÉ··éD
Ducrosç ÍCFHM28ÆnÉÂ¢Äâ`qõÆÕ°ÇóÌðÍðsÁ½DCACNA1AÌÏÙðL·éÒÌ89ÉÐáðº¤ÐªÉìª èCñ3ªÌPÌÒÍ¨âJ«ÌÐáðº¤µ¢ÐªÉìðæµÄ¢½D ÞçÌ28ÆnÅÍVçµ©o³ê½5ÂÌÏÙðÜÞ9íÞÌÏÙª Á½ªC±Ì¤¿6íÞÍÐá«ÐªÉÆ¬]ÇóÉÖµÄ¨èC83ªáUÆ¸²ÇðæµÄ¢½D¼Ì3íÞÍC"^"Ðá«ÐªÉipure hemiplegic migrainejÌ´öâ`qÅi±IÈ¬]ÇóÍæ³È¢±Æð©oµ½D
19ÔõFÌÈOÉà1q21-23ÉA½·éÆn C1q31ÉA½·éFHMÆnªñ³êÄ¢éD

47. Whats New In Research 1
A ground breaking discovery the cause of one of the migraines. The cause ofone form of migraine, familial hemiplegic migraine, has been discovered.
http://www.migrainetrust.org/research/resrch1.htm

A ground breaking
discovery
- the cause of one of the migraines
The cause of one form of migraine, familial hemiplegic migraine, has been discovered. It has been found to be a defective gene which encodes for a calcium channel and has been isolated by a group in Holland led by Professor Rene Frants and Dr Michel Ferrari. Professor Peter Goadsby (Headache Group, Institute of Neurology, Queen Square, London UK), a neurologist who is both a Trustee of the Migraine Trust, and is also collaborating on the project, explains the impact of this discovery for both sufferers and researchers. Familial Hemiplegic Migraine (FHM) is a rare form of migraine, inherited through autosomal dominance, which means that half of the children of an affected parent will get the disorder. As FHM is a form of migraine, it manifests itself as headache, with all the typical things that you might see in migraine; nausea, sensitivity to light, sensitivity to sound, sensitivity to movement. However, the aura part of hemiplegic migraine, instead of being flashing lights or spots in the vision or pins and needles down one side of the body, is a hemiplegia or paralysis down on one side of the body, so the arm and the leg do not work properly, and in many cases become completely paralysed.

48. Haploinsufficiency Of ATP1A2 Encoding The Na+/K+ Pump [alpha]2 Subunit Associate
2 pp 192 196 Haploinsufficiency of ATP1A2 encoding the Na + /K + pump 2 subunitassociated with familial hemiplegic migraine type 2 Maurizio De Fusco 1, 6
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v33/n2/abs/ng1081.ht

49. Haploinsufficiency Of ATP1A2 Encoding The Na+/K+ Pump [alpha]2
2003, doi10.1038/ng1081 Haploinsufficiency of ATP1A2 encoding the Na + /K + pump2 subunit associated with familial hemiplegic migraine type 2 Maurizio De
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/vaop/ncurrent/abs/ng

50. Migraine Chapter, Prolonged Aura , B.Todd Troost
yet provided useful information on the pathophysiology of complicated migraine.{7476}hemiplegic migraine occurs both sporadically and as a familial syndrome.
http://imigraine.net/migraine/prolonged.html
MIGRAINE WITH PROLONGED AURA AND MIGRAINOUS INFARCTIONS
In the new classification of migraine, Subtype 1.6 indicates complications of migraine. This would include all of the permanent defects discussed in this section.
Focal symptoms and signs of the aura may persist beyond a headache phase. In the previous classification, this was termed complicated migraine. It is now defined by the IHS classification with two labels with increased specificity. If the aura lasts for longer than one hour but less than one week, the term migraine with prolonged aura is applied. If the signs persist for more than one week or a neuroimaging procedure demonstrates a stroke, a migrainous infarction has occurred. As pointed out previously, mid or later life the aura may not be followed by headache and has been termed migraine accompagnée or migraine associée . Migraine with aura (classic) in early reports was sometimes referred to as "ophthalmic migraine" (to be differentiated from ophthalmoplegic migraine, a subtype of migraine with aura). Migraine with aura is further reviewed under the headings: Cerebral, Ophthalmoplegic, Retinal, Basilar, and Other Varieties.
Cerebral
A variety of cerebral symptoms may occur in migraine with aura, including motor, visual, and other sensory defects. As pointed out previously, if the aura lasts for more than one hour , but less than one week, the term migraine with prolonged aura is applied. However, if the signs persist for more than one week, or a neuroimaging procedure shows a stroke the term used is

51. Migraine Chapter,References, B.Todd Troost
74. Heyck H Varieties of hemiplegic migraine. Heachache 1973;14135 75. WhittyCWM Familial hemiplegic migraine. J Neurol Neurosurg Psych 1953;16172 79.
http://imigraine.net/migraine/refs.html
1. Dalessio DJ: Diagnosing the severe headache. Neurology 1994;(Suppl. 3) 44:6-12.
2. Lipton RB, Stewart WF: Migraine in the United States: epidemiology and health care utilization. Neurology 1993;(Suppl. 3) 43:6-10.
3. Stewart WF, Lipton RB, Celentano DD, et.al. Prevalence of migraine headache in the United States. JAMA 1992;267:64-69.
4. Sacks OW: Migraine, the Evolution of a Common Disorder, Los Angeles, Univ. California Press; 1970:
5. Gowers WR: Subjective visual sensations. Trans Ophthalmol Soc UK 1895;15:1
6. Troost BT, Newton TH: Occipital lobe arteriovenous malformations: Clinical and radiologic features in 26 cases with comments on the differentiation from migraine. Arch Ophthalmol 1975;93:250-256.
7. Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgia, and facial pain. Cephalalgia 1988;(Suppl. 7) 8:1-96.
8. Blau JN: Migraine prodromes separated from the aura: complete migraine. Br Med J 1980;281:658-660.

52. BioSpace News: Migraine
Familial Migraine Mutations Increase Calcium Ion Influx NEW YORK (Reuters Health) Mutations carried by persons with familial hemiplegic migraine (FHM) cause
http://www.biospace.com/news_rxtarget.cfm?RXTargetID=149&SR=31

53. Untitled
To be termed a familial hemiplegic migraine, the sufferer must have symptoms ofhemiparesis or a pins and needles feeling on one side or limb of the body.
http://www.msu.edu/user/espino11/familia.htm
Familial hemiplegic migraines Familial hemiplegic migraines are associated with severe headache pain and a gradual onset of unilateral weakness or heaviness. To be termed a familial hemiplegic migraine, the sufferer must have symptoms of hemiparesis or a pins and needles feeling on one side or limb of the body. This type of migraine could completely resolve in minutes or last several hours, but the hemiparises will last hours or days beyond the headache itself. It is also very typical that the hemiparesis may being evfen before the headache attack. A complicated hemiplegic attack also occurs, where the weakness may last up to two weeks or may never resolve entirely. A familial hemiplegic migraine is ususally inherited from the mother and the affected side of the body in most instances is associated with dysphasia and other cortical symtoms. Becuase of ischaemic changes in the cerebrum and brainstem, deaths due to familial hemiplegic migraines have been recorded. Back to Main Page

54. Untitled
The Migraine Gene. Overview. The familial hemiplegic migraine, FHM, asubtype of migraine with aura, has been mapped to chromosome 19p13.
http://www.msu.edu/user/espino11/genetics.htm

55. Untitled
The Migraine Gene Overview. The familial hemiplegic migraine, FHM, asubtype of migraine with aura, has been mapped to chromosome 19p13.
http://www.cem.msu.edu/~cem181h/projects/97/migrane/genetics.htm
The Migraine Gene Overview The familial hemiplegic migraine, FHM, a subtype of migraine with aura, has been mapped to chromosome 19p13.
Diagram of the gene where chromosome 19p13 is found
Brain-secifif P/Q-type calcium-channel alpha -subunit gene, CACNA1A is identified in the responsible region of 47 exons covering 300 kb. The familial hemiplegic migraine is the result of a missense mutation in the alpha subunit. In the sequencing of all the exons and their corresponding surroundings, a polymorphic variation is revealed, including a (CA) n -repeat and a (CAG) n -repeat in the 3' untranslated region. In the familial hemiplegic migraine, four missense mutations were discovered in conserved functional domains and one of the mutations has occurred in two different unrelated families of hemiplegic migraines. FHM is a rare autosomal dominant subtype migraine with aura and is associated within some families with progressive cerebellar atrophy and ictal hemiparesis. The cerebellar atrophy was found in FHM is linked to the chromosome 19p13. The region that contains chromosome 19p13 FHM locus is also involved with migraines with or without auras. This adds to the hypothesis that FHM is part of the migraine spectrum involving biological mechanisms and similar genetic factors. Mutations In FHM, several synonymous nucleotide substitutions and polymorphisms were identified by their occurrence in lack of cosegregation with the disease and in unaffected controls. The

56. Migraine - Healthywomen.org
hemiplegic migraine Patients with hemiplegic migraine have temporaryparalysis on one side of the body, a condition known as hemiplegia.
http://www.healthywomen.org/content.cfm?L1=3&L2=54.0

57. AMEDEO: The Medical Literature Guide
D, Allder S, Moody A, Martel A. Prolonged hemiplegic migraine associated withunilateral hyperperfusion on perfusion weighted magnetic resonance imaging.
http://www.amedeo.com/medicine/mig/JNEUSURG.HTM
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J Neurol Neurosurg Psychiatry
Abstracts Retrieve all available abstracts of the following 13 articles:
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February 2003 TZOURIO C, Gagniere B, El Amrani M, Bousser MG, Alperovitch A.
Lay versus expert interviewers for the diagnosis of migraine in a large sample of elderly people.
J Neurol Neurosurg Psychiatry 2003; 74: 238-41..
Abstract Related articles SCHON F, Martin RJ, Prevett M, Clough C, Enevoldson TP, Markus HS. "CADASIL coma": an underdiagnosed acute encephalopathy. J Neurol Neurosurg Psychiatry 2003; 74: 249-52.. Abstract Related articles December 2002 DONAGHY M, Chang CL, Poulter N. Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry 2002; 73: 747-50. Abstract Related articles August 2002 LINDAHL AJ, Allder S, Jefferson D, Allder S, Moody A, Martel A. Prolonged hemiplegic migraine associated with unilateral hyperperfusion on perfusion weighted magnetic resonance imaging.

58. AMEDEO: The Medical Literature Guide
YU W, Horowitz SH. Treatment of sporadic hemiplegic migraine with calciumchannelblocker verapamil. Neurology 2003; 60 120-1.. Abstract Related articles.
http://www.amedeo.com/medicine/mig/NEUROL.HTM
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Neurology
Abstracts Retrieve all available abstracts of the following 71 articles:
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February 2003 CUPINI LM, Massa R, Floris R, Manenti G, Martini B, Tessa A et al.
Migraine-like disorder segregating with mtDNA 14484 Leber hereditary optic neuropathy mutation.
Neurology 2003; 60: 717-9..
Abstract Related articles VAN VLIET JA, Bahra A, Martin V, Ramadan N, Aurora SK, Mathew NT et al. Intranasal sumatriptan in cluster headache: Randomized placebo-controlled double-blind study. Neurology 2003; 60: 630-3.. Abstract Related articles THOMSEN LL, Ostergaard E, Olesen J, Russell MB. Evidence for a separate type of migraine with aura: Sporadic hemiplegic migraine. Neurology 2003; 60: 595-601.. Abstract Related articles GOADSBY PJ. Sporadic hemiplegic migraine: Stamp collecting or food for thought? Neurology 2003; 60: 536-7.. LIPTON RB, Scher AI, Steiner TJ, Bigal ME, Kolodner K, Liberman JN et al. Patterns of health care utilization for migraine in England and in the United States.

59. WHAT CAUSES MIGRAINE HEADACHES?
Researchers have located a single genetic mutation responsible for the very rarefamilial hemiplegic migraine, but a number of genes are likely to be involved
http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/97migraine/doc97causes.html
WHAT CAUSES MIGRAINE HEADACHES?
Until recently, the general theory on the migraine process rested solely on the idea that abnormalities of blood vessel (vascular) systems in the head were responsible for migraines. Now, however, experts tend to believe that migraine starts with an underlying central nervous system disorder, which, when triggered by various stimuli, sets off a chain of neurologic and biochemical events, some of which subsequently affect the brain's vascular system. No experimental model fully explains the migraine process.
There is certainly a strong genetic component in migraine with or without auras. Researchers have located a single genetic mutation responsible for the very rare familial hemiplegic migraine, but a number of genes are likely to be involved in the great majority of migraine cases. A number of chemicals, structures, nerve pathways, and other players involved in the process are under investigation.
General Theories to Explain Migraine
Central Nervous Disorder.

60. RECENT LITERATURE
A new CACNA1A gene mutation in acetazolamideresponsive familial hemiplegicmigraine and ataxia. hemiplegic migraine induced by exertion.
http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/97migraine/doc97_lit.html
RECENT LITERATURE
[Please note: By clicking on the titles below you can link directly to Medline abstracts and other articles on the Internet relating to this update. These articles represent only a few of the literature sources used to revise this topic.] [BACK] What Is Headache? Pharmacological and behavioral treatment of pediatric migraine and tension-type headache. Grazzi L, D'Amico D, Leone M, Moschiano F, Bussone G. Ital J Neurol Sci. 1998 Apr;19(2):59-64. Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache? Ebersberger A, Schaible HG, Averbeck B, Richter F. Ann Neurol. 2001 Jan;49(1):7-13. ... Does relaxation treatment have differential effects on migraine and tension-type headache in adolescents? Fichtel A, Larsson B. Headache. 2001 Mar;41(3):290-6.

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Headaches/Migraine

Introduction to the Physiology of BAM

What Causes Basilar Artery Migraine

@@iFamilial Hemiplegic Migraine CFHMj

A ground breaking discovery - the cause of one of the migraines

WHAT CAUSES MIGRAINE HEADACHES?

General Theories to Explain Migraine

RECENT LITERATURE

@@iFamilial Hemiplegic Migraine CFHMj

A ground breaking
discovery
- the cause of one of the migraines