61. On Target - Weekly Journal, Issue July 15, 2001 5. GENETICS back to top. Familial hemiplegic migraine. Familial hemiplegicmigraine is an autosomal dominant disorder characterized http://www.targethealth.com/07152001.htm

(Complimentary Newsletter from Target Health Inc.) Home Qualifications On Target Staff ... Publications July 15, 2001 Contents: I. WHAT'S NEW New Addition To Our Staff II. HISTORY OF MEDICINE James Parkinson - Child Advocate III. SUMMER SAFETY TIPS How to Avoid Stomach Distress IV. ETHICS IN CLINICAL RESEARCH Johns Hopkins Receives a 483 After a Death in a Clinical Trial V. GENETICS Familial Hemiplegic Migraine VI. NEUROLOGY Relapsing–Remitting Multiple Sclerosis (MS) VII. MICROBIOLOGY Drug Resistance and Duration and Intensity of Treatment VII. FDA Clinical Trials of Serious or Life-Threatening Conditions TARGET HEALTH I. WHAT'S NEW back to top New Addition To Our Staff TARGET HEALTH is pleased to announce the appointment of Mr. Joonhyuk Choi as Data Analyst/Programmer to our growing Target e*CRF ™ development team. Mr. Choi holds a degree in Electrical and Computer Engineering and will answer directly to our Chief Technology Officer, Joon You. Other members of the Target e*CRF ™ team include Yong Joong Kim, Laura Suciu, and Kevin Kim. We know that we have the best and most user-friendly Internet-based data collection, retrieval and project management system in the Industry. For more information contact julesmitchel@targethealth.com

62. Publications cerebral edema and fatal coma after minor head traumrole of the CACNA1A calciumchannel subunit gene and relationship with familial hemiplegic migraine. http://www.humgen.nl/lab-frants/migraine/Publications.htm

Dutch Migraine Genetic Research Group (DMGRG) Key publications before 1999 Lesnik Oberstein SA, van den Boom R, van Buchem MA, van Houwelingen HC, Bakker E, Vollebregt E, Ferrari MD, Breuning MH, Haan J. Cerebral microbleeds in CADASIL. Neurology. 2001 Sep 25;57(6):1066-70. Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J, van den Maagdenberg AM, Jen J, Baloh RW, Barilla-LaBarca ML, Saccone NL, Atkinson JP, Ferrari MD, Freimer NB, Frants RR. Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. Am J Hum Genet. 2001 Aug;69(2):447-53. Diener HC, Tfelt-Hansen P, de Beukelaar F, Ferrari MD, Olesen J, Dahlof C, Mathew N. The efficacy and safety of sc Alniditan vs. sc Sumatriptan in the acute treatment of migraina randomized, double-blind, placebo-controlled trial. Cephalalgia. 2001 Jul;21(6):672-9. Kors EE, Terwindt GM, Vermeulen FL, Fitzsimons RB, Jardine PE, Heywood P, Love S, van den Maagdenberg AM, Haan J, Frants RR, Ferrari MD. Delayed cerebral edema and fatal coma after minor head traumrole of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine.

63. Projects Several large multigeneration families with various phenotypes (includingfamilial hemiplegic migraine) are currently studied by linkage analysis. http://www.humgen.nl/lab-frants/migraine/Projects.htm

Dutch Migraine Genetic Research Group (DMGRG) Genetic characterization of new migraine genes in multi-generation families Several large multi-generation families with various phenotypes (including familial hemiplegic migraine) are currently studied by linkage analysis. Using positional cloning strategies the causative genes will be discovered. In these cases, candidate genes are searched for mutations. Project-leaders: Prof. Dr. R. R. Frants, Dr. M. D. Ferrari, Dr. A. M. J. M. van den Maagdenberg PhD students involved: Drs E.E. Kors, Drs K.R.J. Vanmolkot, Drs J.J. Hottenga Search for new migraine genes using non-parametric linkage analysis A large genetic study has been initiated in the genetic isolate of Costa Rica, to discover a gene for migraine with aura (severe early onset). Some 150 patients have been recruited from the Central Valley for this study already. Project-leaders: Prof. Dr. R. R. Frants, Dr. M. D. Ferrari, Dr. A. M. J. M. van den Maagdenberg PhD students involved: Drs E.E. Kors, Drs K.R.J. Vanmolkot, Drs J.J. Hottenga

64. Baylor Neurology Case Of The Month presentation suggested a TIA, embolic stroke, or complex partial seizure with apostictal paralysis (though one might also consider a hemiplegic migraine). http://www.bcm.tmc.edu/neurol/challeng/pat27/summary.html

Patient #27 Summary and Discussion Chalmer McClure, M.D., Ph.D. Neurology Resident Diagnosis: Ischemic stroke secondary to postinfectious focal varicella vasculitis Patient #27 presented with the sudden onset of transient inability to talk accompanied by left-sided weakness. These episodes lasted only 30 to 60 seconds and subsequently resolved (with the exception of the last episode, which left a sustained deficit). The distribution of involvement (face, arm and leg) suggests a subcortical process, though the inability to talk suggests cortical involvement. However, the finding of left-sided weakness associated with a true aphasia would be very unusual unless the person in question was left-handed and the lesion/process involved subcortical as well as cortical structures (in other words, a large stroke). Speech arrest can be seen with sudden neurological deficits in several areas including non-dominant subcortical regions, but the speech arrest is usually transient as in this case. The child's initial clinical presentation suggested a TIA, embolic stroke, or complex partial seizure with a post-ictal paralysis (though one might also consider a hemiplegic migraine). Stroke in the young is often the result of an underlying metabolic abnormality or overwhelming intercurrent illness. Focal seizures may result from structural abnormalities, stroke, or a parasitic infection such as neurocysticercosis, among others. As the child's illness progressed, and results of the laboratory studies and radiographic images became available, the differential diagnosis was narrowed.

65. Calcium Channels Critical Targets Of Toxicants And Diseases - DERT Critical Targ Certain rare diseases including LambertEaton Myasthenic Syndrome (LEMS), hereditaryataxias and Familial hemiplegic migraine may also be the result of altered http://www.niehs.nih.gov/dert/cachnmtg.htm

Meetings Past Meetings Calcium Channels Critical Targets of Toxicants and Diseases December 6-8, 1999 Doubletree Guest Suites Durham, NC Aims and Scope Voltage-gated calcium channels control numerous critical cellular functions in neuronal and non-neuronal cells. They are targets of numerous therapeutic agents, ethyl alcohol, arthropod and mollusk toxins and some environmentally relevant toxic metals. Certain rare diseases including Lambert-Eaton Myasthenic Syndrome (LEMS), hereditary ataxias and Familial Hemiplegic Migraine may also be the result of altered calcium channel function. Therefore, it is important to define and identify what is currently known about voltage-gated calcium channels, the role they play in certain rare disorders, and the role that xenobiotics play in their dysfunction. This workshop will bring together neurobiologists, neurotoxicologists and neurologists to explore the state of the science/medicine in this field with the ultimate goal of identifying research gaps, both basic and clinical. Speakers and Topics Monday, December 6

66. Migraine Gene Discovered The Netherlands have discovered an abnormally structured gene in people sufferingfrom a rare inherited form of migraine called familial hemiplegic migraine. http://www.pslgroup.com/dg/d712.htm

67. Migraine:c hemiplegic migraine occurs both sporadically and as a familial syndrome.This entity is defined as vascular headache featured http://www.wfubmc.edu/neurology/migraine/migc.html

MIGRAINE WITH PROLONGED AURA AND MIGRAINOUS INFARCTIONS In the new classification of migraine, Subtype 1.6 indicates complications of migraine. This would include all of the permanent defects discussed in this section. Focal symptoms and signs of the aura may persist beyond a headache phase. In the previous classification, this was termed complicated migraine. It is now defined by the IHS classification with two labels with increased specificity. If the aura lasts for longer than one hour but less than one week, the term migraine with prolonged aura is applied. If the signs persist for more than one week or a neuroimaging procedure demonstrates a stroke, a migrainous infarction has occurred. As pointed out previously, mid or later life the aura may not be followed by headache and has been termed or . Migraine with aura (classic) in early reports was sometimes referred to as "ophthalmic migraine" (to be differentiated from ophthalmoplegic migraine, a subtype of migraine with aura). Migraine with aura is further reviewed under the headings: Cerebral, Ophthalmoplegic, Retinal, Basilar, and Other Varieties. Cerebral A variety of cerebral symptoms may occur in migraine with aura, including motor, visual, and other sensory defects. As pointed out previously, if the aura lasts for more than one hour , but less than one week, the term migraine with prolonged aura is applied. However, if the signs persist for more than one week, or a neuroimaging procedure shows a stroke the term used is

68. The Migraine Action Association Homepage 2) hemiplegic migraine We are looking into a new drug treatment forhemiplegic migraine/ migraine with prolonged aura. You must http://www.migraine.org.uk/latestnews.htm

LATEST NEWS Headaches in Parliament Phil Hope, MP for Corby, Northants, last week drew the attention of parliament to the plight of severe headache sufferers in a debate on the National Service Framework for Long Term Medical Conditions with a particular focus on neurological conditions. Mr Hope expressed concern that although primary headache disorders, including migraine, are the most common neurological conditions in the UK there has, as yet, been no confirmation that they will be included in this NSF. Mr Hope is an occasional migraine sufferer and the headquarters of the Migraine Action Association, the national patient support group for headache sufferers, is in his constituency. He is the chairman of the All Party Parliamentary Group on Primary Headache Disorders. He emphasised that migraine is very different and much more debilitating than an ordinary headache and can have a substantial impact on the quality of life of sufferers. Despite its prevalence, affecting 15% of people in the UK, the physical, emotional, social and economic burdens are poorly acknowledged. He called for better education and a reallocation of resources to ensure improved care for sufferers at primary care level. Failure to deliver this can result in sufferers developing other medical conditions such as depression and referrals to already over stretched hospital neurology departments. For the government, Mr David Lamey , Parliamentary Under-Secretary of State for Health, confirmed that this NSF will focus on working age adults, will address issues common to all neurological conditions and that conditions such as headache will be considered. This NSF is scheduled for publication in 2004 with a 10 year implementation programme commencing in 2005.

69. Migrain Jenisjenis migrain yang lain. hemiplegic migraine– rasa lemah sebelah badan. Geneyang berkaitan dengan familial hemiplegic migraine ini boleh dikenalpasti. http://www.anispharmacy.com/migraine.htm

sini Migrain Migrain juga dikenali sebagai hemikrania, perkataan Greek yang membawa maksud sebelah tengkorak. Ia juga dikenali sebagai vascular headache. Sakit kepala yang berlaku berulang, berdenyut-denyut selalunya terjadi sebelah kepala sahaja. Ada juga yang bermula di sebelah kepala sahaja dan kemudiannya melarat kedua-dua belah kepala. Dalam kes yang teruk, migrain menyebabkan pening (nausea), muntah, cirit-birit, pengekalan cecair badan (retention of fluid) dan sensitif kepada bunyi dan cahaya. Jenis-jenis migrain yang utama. 1 - Classic migraine Lebih kurang 10% hingga 15% pesakit migrain mengalami migrain jenis ini. 10 hingga 30 minit sebelum berlakunya migrain, tanda-tanda awal (warning) berlaku. Tanda-tanda ini dikenali sebagai aura atau prodrome dan ia berlaku selama 5 - 15 minit. Tanda-tanda aura ini adalah seperti berikut: terlihat cahaya terang (bright spots), garisan zigzag (zigzag lines), penglihatan berganda (double vision), buta sementara (temporary blindness), kebas (numbness), kepala terasa berpusing (dizziness), pening (drowsiness), sukar bercakap (slurred speech) dan keliru (confusion). Selepas tanda-tanda ini hilang, migrain mula menyerang. Aura dikatakan disebabkan oleh saluran darah yang menghantar darah ke otak dan tisu sekelilingnya mengecil sementara, jadi menghad penghantaran darah ke bahagian tersebut. Ini menyebabkan gangguan pada saraf rasa dan pengawalan motor. Bagaimanapun ada juga yang mengatakan bahawa aura bermula di sistem saraf – satu fenomena yang dikenali sebagai “spreading depression of the cortex”. Ada kajian yang menunjukkan bahawa pengaliran darah hanya bertambah beberapa jam selepas aura terjadi dan sakit kepala bermula.

70. Directory :: Look.com Hemiplegic (7) Sites. American Council for Headache Education HemiplegicMigraine Page List of symptoms associated with hemiplegic migraine. http://www.look.com/searchroute/directorysearch.asp?p=595830

71. Human Genome News, October-December 1996; 8(2) CACNL1A4 region is homologous to a human chromosome 19 region previously implicatedin episodic ataxia type 2 and familial hemiplegic migraine (an inherited http://www.ornl.gov/hgmis/publicat/hgn/v8n2/07migra.html

go to current issue Archive Edition Sponsored by the U.S. Department of Energy Human Genome Program Human Genome News, October-December 1996; 8(2) Gene Watch DOE Clone Resources Spur Disease-Gene Discoveries Migraine Two research groups report results suggesting a common genetic cause for migraine and epilepsy and the availability of an animal model that may be useful for further studies. Both groups used the chromosome 19 physical map and selected clones supplied by the Human Genome Center at Lawrence Livermore National Laboratory (LLNL). Researchers led by Lisa Stubbs at Oak Ridge National Laboratory (ORNL) reported the isolation, mapping, and expression analysis of the chromosome 8 gene found in the mutant "tottering" mice studied extensively as models for human epilepsy and cerebeller ataxia. The mouse region is homologous to a human chromosome 19 region previously implicated in episodic ataxia type 2 and familial hemiplegic migraine (an inherited form of migraine). Now the ORNL studies indicate that mutations in the human gene are indeed the causative factor in both disorders. Tottering mutants may thus represent mouse models of both diseases, according to the authors of the

72. Human Genome News, January 1998; 9(1-2) A subset of migraines, called hemiplegic migraine, is often precededby an aura. hemiplegic migraine has also been associated with http://www.ornl.gov/hgmis/publicat/hgn/v9n1/01carran.html

go to current issue Archive Edition Sponsored by the U.S. Department of Energy Human Genome Program Human Genome News, January 1998; 9:(1-2) Genome Resources Help Scientists Explore Life-Environment Interactions Most current tests for human exposure to environmental mutagens are only indicators of genetic damage and cannot predict adverse outcomes for individuals. In the following article, Anthony V. Carrano [Lawrence Livermore National Laboratory (LLNL)] explains that the future of genetic toxicology and mutation research lies in studying genes and individual genetic variation to reveal risk factors that make some people more susceptible to disease. The basic topic addressed by scientists who explore these issues, he notes, is the nature and consequence of genetic change or variation, with the ultimate purpose of predicting or preventing disease. This article is excerpted from a talk by Carrano at the Human Genome Project session at the 1997 Society of Toxicology meeting in Cincinnati, Ohio. Other speakers were J. Craig Venter (The Institute for Genomic Research), Henry Wagner (Johns Hopkins University), and Richard Woychik (now at Case Western Reserve University). The first 6 years of the Human Genome Project are behind us, and now resources can be applied to functional genomic studies, the genomics of the future. Functional genomics will be facilitated by completing the entire human genome sequence as soon as possible and, along the way, sequencing a significant portion of the mouse and other model-organism genomes. We want to determine all transcript structures and gene-expression patterns in the human genome; ultimately, we want to understand the phenotypes resulting from mutations in every one of the open reading frames. Many groups have begun working in this area even before the genome project is completed, and much work reported at recent genome meetings is pointed toward functional genomics.

73. NYHEADACHEDOCTOR.COM, A Leading Internet Source Providing The Lastest Informatio or vomiting. Rare variants of childhood migraine include the basilarmigraine syndrome and hemiplegic migraine. The basilar migraine http://www.nyheadachedoctor.com/expert/child.asp

How do I know if I have... A Migraine Headache Tension-type Headaches Cluster Headaches Sinus Headaches A Brain Tumor Although it is not uncommon for children to suffer from headaches, all too often a child's headache complaints are dismissed by parents and pediatricians. This is especially true when an adult in the family also suffers from headache. In these situations there is a tendency to assume that the child is imitating a family member or is just seeking attention. In families where there are no headache sufferers, the child's headache is often attributed to school phobia, stress, or malingering. Migraine is quite common during the childhood years. More than 8 million children and adolescents suffer from migraine resulting in greater than one million lost school days each year. Childhood migraine differs from adult migraine in a number of ways: Prior to puberty boys get migraine as often as girls; after puberty girls suffer from migraine more frequently

74. Welcome To My Guestbook THEY SAID I HAD A hemiplegic migraine, WHICH CAUSED THE PARALISIS ON THE LEFTSIDE. 2001HAD A hemiplegic migraine WHICH CAUSED ME TO BE HOSPITALIZED. http://www.userbook.com/cgi/gbook.cgi?gb=2318&page=46

75. Dorlands Medical Dictionary complicated migraine, migrainous infarction. familial hemiplegic migraine, a raretype of hemiplegic migraine that is passed on as an autosomal dominant trait. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

76. Migrainerubriek - Hoofdbrekens En Kopzorgen Na lezing van het proefschrift The molecular basis of familial hemiplegic migrainevan de Leidse moleculair bioloog Roel A. Ophoff zou je geneigd zijn de vraag http://people.zeelandnet.nl/vdwindt/migraine/domino.htm

Over Migraine Domino-theorie bij migraine Voorwaarde voor de uitscheiding van serotonine is de instroom van calcium in de hersencellen. Calcium-ionen gaan de hersencel binnen via een kanaal. Als dat kanaaltje door veranderingen van het gen defect is, kan migraine ontstaan, met name die met auraverschijnselen, d.w.z. met stoornissen in het zien en de spraak. De vraag is of bepaalde genen of veranderingen in bepaalde genen mee over-erven. Het antwoord is: ja. Bepaalde genen zijn erfelijk bij een bepaalde aandoening, in dit geval familiaire hemiplegische migraine. De kans dat een vader of moeder met migraine zonen of dochters krijgen die ook migraine krijgen, is duidelijk verhoogd. Maar erfelijkheid (dus aanleg) verklaart niet alles. Ook de omgeving speelt -voor ieder individu verschillend- een rol bij migraine. Denk maar aan voeding, overgevoeligheid voor licht en geluid, stress, enz. Ophoff concludeert dat de genetische component slechts gedeeltelijk bijdraagt aan de oorzaak van migraine. Nader onderzoek (o.a. bij transgene muizen bij wie met het gen is gemanipuleerd) moet helpen het mysterieuze domino-effect van migraine te ontrafelen. En misschien kunnen deze genetische mechanismen ook de oorzaken van andere aandoeningen verklaren. Ophoff: "Vervolgstudie heeft bovendien aangetoond dat dit gen ook een rol moet spelen in de etiologie* van de gewone vormen van migraine." (*etiologie = de leer der ziekte-oorzaken). Dick de Scally uit: Hoofdzaken nr 1 1998 R.A. Ophoff : The molecular basis of familial hemiplegic migraine, Migraine as a Ca2+ channel disorder. Leiden, 1997. ISBN 9090107894.

77. Spinocerebellar Ataxia A mutation in this gene is also associated with familial hemiplegic migraine, aswell as in SCA6 (see following), but is not involved in the familial variant http://www.tchain.com/otoneurology/disorders/central/cerebellar/sca.htm

Cerebellar Degenerations Timothy C. Hain, MD Return to Education Index Last update: Feb 20, 2000 The main goal of this page is to serve as a repository for recent information about inherited cerebellar degenerations. It is not comprehensive, but we hope that it might be of some use to individuals searching for information about these rare conditions on the web. We highly recommend also using the OMIM database , which can be accessed on the web. A large number of the genetic ataxias can be tested for using contemporary methodology. An example of a lab that does this is Athena Most of the information here concerns inherited conditions, as there is considerable new data derived from researchers using a nearly complete map of the human genome (your tax dollar is doing some good !), and improvements in the technology of molecular biology. It seems quite feasible that within the next decade, we may be able to determine the gene that is damaged in most inherited cerebellar degenerations. As these data become known, it may also be possible to target specific therapies, probably over the next 2 decades. In other words, stay tuned, but we aren't there yet. There are numerous non-genetic causes of cerebellar disease.

78. Migraine Associated Vertigo (Baloh et al, 1996). Familial hemiplegic migraine has been linkedto mutations in the calcium channel gene (Ophoff et al, 1996). http://www.tchain.com/otoneurology/disorders/central/mav.html

Migraine Associated Vertigo (MAV) Please use the following link: http://www.dizziness-and-balance.com/disorders/central/migraine/mav.html

79. WebGuest - Open Directory : Health : Conditions And Diseases : Neurological Diso Sites American Council for Headache Education hemiplegic migrainePage List of symptoms associated with hemiplegic migraine. http://directory.webguest.com/index.cgi/Health/Conditions_and_Diseases/Neurologi

Browse thru 1000's of books about health, mind and body: About Us Privacy Statement Acceptable Use Policy Legal Notices ... Contact Us the entire directory only in Migraine/Hemiplegic Top Health Conditions and Diseases Neurological Disorders ... Migraine : Hemiplegic Sites: American Council for Headache Education Hemiplegic Migraine Page - List of symptoms associated with hemiplegic migraine. The Genetic Basis of Migraine: How Much Do We Know? - Abstract of an article published in the November 1999 issue of the Canadian Journal of Neurological Sciences. Hemiplegic Migraine Induced by Exertion - Summary of a case report published in the September 2000 issue of Archives of Neurology. JAMA Migraine Information Center - Involvement of a Ca2+ Channel Gene in Familial Hemiplegic Migraine and Migraine With and Without Aura - Abstract of research published in the September 1997 issue of Headache. Migraine Gene Discovered - Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. National Headache Foundation - Brief description of the condition.

80. BioSpace News: Migraine a small case series suggest that the calciumchannel blocker verapamil, given eitherorally or IV, is an effective treatment for sporadic hemiplegic migraine. http://links.biospace.com/news_rxtarget.cfm?RxTargetID=149

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