61. Gale Encyclopedia Of Medicine: Hemochromatosis hemochromatosis. Author/s Teresa G. Norris. Definition. hemochromatosis is an inheritedblood disorder that causes the body to retain excessive amounts of iron. http://www.findarticles.com/cf_0/g2601/0006/2601000645/p1/article.jhtml?term= He

62. AYC: Hemochromatosis hemochromatosis Basic Information. hemochromatosis is a metabolic disease thatresults in the excessive accumulation of iron in the body tissues and organs. http://alwaysyourchoice.com/ayc/adult/general/Hemochromatosis.php

Adult Medicine General Health Acne Acute Lymphocytic Leukemia ... Information Hemochromatosis Basic Information Hemochromatosis is a metabolic disease that results in the excessive accumulation of iron in the body tissues and organs. Eventually, this over-absorption of iron causes body toxicity and can turn into severe body damage. Without treatment, hemochromatosis can lead to organ failure. This condition is also called “iron overload disease”. It is the most common genetic disorder in the United States. Iron is an essential part of a healthy body’s chemical make-up. A body that is functioning well routinely extracts iron from the diet. The most common sources of iron in the diet are red meat and products that are made from iron-enriched grains. Once the body absorbs iron, it converts the iron into hemoglobin, a molecule in the blood that aids in oxygen transportation. While healthy people typically absorb approximately ten percent of all the iron in the food they eat, a person with hemochromatosis absorbs approximately 20 percent. Because the body cannot release such a large amount of iron, it begins to build up in the body tissues and the organs. The organs that are most affected by this accumulation of iron are the pancreas, heart and liver. As aforementioned, hemochromatosis is a genetic disorder. In fact, it is sometimes called “hereditary hemochromatosis”. This condition is most common among Caucasians of northern European descent. However, other ethnic groups can also be affected. A little under one percent of all United States Caucasians are at risk of developing this disease. At the same time, men are about five times more likely than women to develop hemochromatosis.

63. Hemochromatosis Overview of hemochromatosis (iron overload), a common genetic disease. Peoplewith hereditary hemochromatosis absorb more iron than their body needs. http://www.labtestsonline.org/understanding/conditions/hemochrom.html

TESTS test not listed? ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP ALT Amylase ANA Antibody Tests Apo A Apo B ApoE Genotyping AST Bilirubin Blood Culture Blood Gases BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Risk CBC CEA CF Gene Mutation Chlamydia Chloride Cholesterol CK CK-MB CMP Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C DHEAS Differential EGFR Electrolytes ESR Estrogen Estrogen Receptors Fecal Occult Blood Ferritin Flu Tests FSH Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone hCG HDL Hematocrit Hemoglobin Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody Home Tests Homocysteine HPV H-pylori hs-CRP Insulin Iron Tests LD LDH LDL Lead LH Lipase Lipid Profile Liver Panel Lp(a) Lyme Disease Magnesium Microalbumin Mono Monoclonal Protein Myoglobin Pap Smear Phosphorus Platelets Potassium Prealbumin Progesterone Progest. Receptors Prolactin PSA PT PTH Red Count Renin Rheumatoid Factor Rubella Semen Analysis Serum Iron Sickle Cell Sodium Strep Throat Sweat Chloride Syphilis Tau/Aß42 TB Skin Test Testosterone Ther. Drug Monitoring

64. Advanced Search American Family Physician. Recognition and Management of Hereditary hemochromatosis. Hereditaryhemochromatosis is associated with mutations in the HFE gene. http://www.aafp.org/afp/20020301/853.html

Advanced Search Recognition and Management of Hereditary Hemochromatosis DAVID J. BRANDHAGEN, M.D., VIRGIL F. FAIRBANKS, M.D., and WILLIAM BALDUS, M.D. Mayo Medical School, Rochester, Minnesota Hereditary hemochromatosis is the most common inherited single-gene disorder in people of northern European descent. It is characterized by increased intestinal absorption of iron, with deposition of the iron in multiple organs. Previously, the classic description was combined diabetes mellitus, cutaneous hyperpigmentation and cirrhosis. Increasingly, however, hereditary hemochromatosis is being diagnosed at an earlier, less symptomatic stage. The diagnosis is based on a combination of clinical, laboratory and pathologic findings, including elevated serum transferrin saturation. Life expectancy is usually normal if phlebotomy is initiated before the development of cirrhosis or diabetes mellitus. Hereditary hemochromatosis is associated with mutations in the HFE gene. Between 60 and 93 percent of patients with the disorder are homozygous for a mutation designated C282Y. The

65. SUPPLEMENT: Diagnosis Of Hemochromatosis, Annals 1 Dec 98 Diagnosis of hemochromatosis. If untreated, hemochromatosis can cause serious illnessand early death, but the disease is still substantially underdiagnosed. http://www.acponline.org/journals/annals/01dec98/diaghemo.htm

Annals of Internal Medicine Current Issue Past Issues Library for Internists Subscriptions ... Email this page Annals of Internal Medicine SUPPLEMENT DIAGNOSIS AND MANAGEMENT Diagnosis of Hemochromatosis Annals of Internal Medicine , 1 December 1998. 129:925-931. Lawrie W. Powell, MD; D. Keith George, MD; Sharon M. McDonnell, MD; and Kris V. Kowdley, MD Related Letter If untreated, hemochromatosis can cause serious illness and early death, but the disease is still substantially underdiagnosed. The cornerstone of screening and case detection is the measurement of serum transferrin saturation and the serum ferritin level. Once the diagnosis is suspected, physicians must use serum ferritin levels and hepatic iron stores on liver biopsy specimens to assess patients for the presence of iron overload. Liver biopsy is also used to establish the presence or absence of cirrhosis, which can affect prognosis and management. A DNA-based test for the HFE gene is commercially available, but its place in the diagnosis of hemochromatosis is still being evaluated. Currently, the most useful role for this test is in the detection of hemochromatosis in the family members of patients with a proven case of the disease. It is crucial to diagnose hemochromatosis before hepatic cirrhosis develops because phlebotomy therapy can avert serious chronic disease and can even lead to normal life expectancy. Ann Intern Med.

66. SUPPLEMENT: Hemochromatosis-Associated..., Annals 1 Dec 98 SUPPLEMENT hemochromatosisAssociated Mortality in the United States from 1979to 1992 An Analysis of Multiple-Cause Mortality Data . hemochromatosis. http://www.acponline.org/journals/annals/01dec98/hemomort.htm

Annals of Internal Medicine Current Issue Past Issues Library for Internists Subscriptions ... Email this page Annals of Internal Medicine SUPPLEMENT POPULATION-BASED DATA Hemochromatosis-Associated Mortality in the United States from 1979 to 1992: An Analysis of Multiple-Cause Mortality Data Annals of Internal Medicine , 1 December 1998. 129:946-953. Quanhe Yang, PhD; Sharon M. McDonnell, MD, MPH; Muin J. Khoury, MD, PhD; Joanne Cono, MD, ScM; and R. Gibson Parrish, MD Background: Hemochromatosis, which can lead to serious chronic diseases resulting from iron overload, has an estimated prevalence of 50 to 80 cases per 10 000 persons. However, little population-based information is available on the impact of hemochromatosis on morbidity and mortality. Objective: To evaluate trends over 14 years in deaths and medical conditions associated with hemochromatosis in the United States. Design: We searched Multiple-Cause Mortality Files compiled by the National Center for Health Statistics for the years 1979 to 1992 for all records listing hemochromatosis. We used these data to calculate age-adjusted and age-specific mortality rates, identify medical conditions associated with a known diagnosis of hemochromatosis at death, and calculate proportionate mortality ratios for these medical conditions. Results: The listing of hemochromatosis on death certificates increased 60% from 1979 to 1992. Decedents with hemochromatosis were 23, 13, and 5 times more likely to have liver neoplasms, liver disease, and cardiomyopathy, respectively, than were decedents without hemochromatosis. Conversely, decedents with liver neoplasms, liver disease, and cardiomyopathy were 26, 14, and 5 times more likely, respectively, to have hemochromatosis than were decedents without these conditions. Hemochromatosis was 82 times more likely in persons with the combination of liver neoplasms and diabetes and 43 times more likely in those with the combination of liver disease and diabetes than in those without these conditions.

67. Hemochromatosis - Page 1 Print this page Hereditary hemochromatosis is a manic disorder in which individualsabsorb slightly more iron than normal. This process occurs over decades. http://www.gastromd.com/education/hemochromatosis.html

Home Dr. Jensen Dr. Lozoff General Info ... Print this page Hereditary hemochromatosis is a manic disorder in which individuals absorb slightly more iron than normal. This process occurs over decades. However, tissue damage occurs after significant amounts of iron have been absorbed. In most cases, the individual has absorbed approximately 15-20 grams of iron. It is at this amount of absorbed iron in which patients begin to have tissue damage. Also, it is at this amount of absorbed iron that produces significant organ system damage in individuals. Hereditary hemochromatosis is thought to occur with equal frequency in both sexes. However, since regular blood loss through normal menses occurs in females, the preponderance of cases is in males. This approximates 8-1 male to female ratio. Recently, a test has been developed which detects the cellular or genetic abnormalities responsible for many cases of hemochromatosis. The liver is the first site of iron overload in hereditary hemochromatosis. This is based on absorption of iron by the liver. When food is ingested, it is absorbed in the small intestine. This absorption passes into the veins that then form the portal vein. The portal vein then is directed to the liver. The portal vein then divides into small veins that provide the liver cells with nutrients absorbed from the intestine, thus, the liver is the first site in which iron absorption occurs. Typically, liver function tests are elevated in individuals. As iron absorption continues, and the ability of the liver to store iron is exceeded, the heart, pancreas, joints and bones, skin and the immune system become affected.

68. UPMC Center For Hemochromatosis And Iron Overload Disorders UPMC Center for hemochromatosis and Iron Overload Disorders This work is done throughthe UPMC Center for hemochromatosis, of which the clinic is a part. http://www.upmc.edu/hemochromatosis/

UPMC Center for Hemochromatosis and Iron Overload Disorders About Iron Overload Disorders Information about the disorders and their causes, who is at risk, symptoms, and standard diagnosis and treatment methods Education and Support Descriptions of the classes for patients and professionals who deal with iron overload problems, information about active and forming support groups, and links to other Web sites that present information about hemochromatosis. Staff The professional background of the staff at the UPMC Center for Hemochromatosis and Iron Overload Disorders. Research A summary of the research projects conducted by staff. Contact Us How to make an appointment at the UPMC Center for Hemochromatosis and Iron Overload Disorders, call or e-mail the center and specific staff members, and find the center. Upcoming Special Events Saturday, Sept. 29, 2001 10 a.m. to 1 p.m. Free Hemochromatosis Seminar and Screening Conference Center, 11th Floor, UPMC Presbyterian Free parking and refreshments. Registration required.

69. Hemochromatosis Subscribe now . hemochromatosis. hemochromatosis is a condition in whichthe body accumulates excess amounts of iron. Symptoms of hemochromatosis. http://oci.mcw.edu/article/974757337.html

Search: search tips Email this article Print this article Find related articles: By topic: Arthritis Cardiac/Heart Diabetes By keywords: iron loading iron overload phlebotomy Receive Health Link via email! Subscribe now >> Hemochromatosis Hemochromatosis is a condition in which the body accumulates excess amounts of iron. Serious and sometimes fatal health problems may result from the excess iron that accumulates in the body as a result of this genetic disorder. The excess iron slowly builds to toxic levels in tissues of major organs such as the liver, heart, brain, pancreas, lungs, and synovium (joints). These overburdened organs cease to function properly and eventually become diseased. Hereditary hemochromatosis (HHC) is one of the most common genetic diseases in humans, but it can be undiagnosed or misdiagnosed. Undiagnosed and untreated HHC can develop into diseases such as diabetes, heart trouble, arthritis, cirrhosis of the liver, neurological problems, depression, impotence, infertility, and liver cancer. Iron build up in those with HHC is slow, usually taking years to build to destructive levels. HHC/Iron overload generally manifests in a male's early thirties and is diagnosed in a male's mid to late fifties. For this reason HHC has acquired the mistaken identity of an older male's disease. HHC can be present in females, adolescents and possibly in children.

70. Iron Overload And Hemochromatosis By keywords hemochromatosis. Receive HealthLink via email! Iron Overload andhemochromatosis. July 2002 is hemochromatosis Screening Awareness Month. http://oci.mcw.edu/article/1025279068.html

Search: search tips Email this article Print this article Find related articles: By topic: Genetics Public Health By keywords: hemochromatosis Receive Health Link via email! Subscribe now >> Iron Overload and Hemochromatosis July 2002 is Hemochromatosis Screening Awareness Month. So what exactly does that mean? Hereditary hemochromatosis is one of the most common genetic diseases in humans, but many people have never heard of it. In the United States, as many as one million people have evidence of the disorder, and up to one in every ten people may carry the gene for it. In people who have hemochromatosis, the body accumulates excess amounts of iron. This can result in serious and sometimes fatal health problems. Some diseases associated with hemochromatosis are arthritis, cirrhosis of the liver, diabetes, heart failure and liver cancer. Signs and Symptoms Early symptoms of hemochromatosis are nonspecific and might include fatigue, heart palpitations, joint pain, non-specific stomach pain, impotence and loss of menstrual periods. Even without other symptoms, people with hemochromatosis may have abnormal liver function test results. Symptoms – which reflect the tissue and organ damage that result from the disease – usually appear in middle age, although some people may develop problems earlier. Later disease symptoms include gray or bronze coloration to the skin, liver cirrhosis, liver cancer, diabetes, hypopituitarism, decreased pituitary or gonadal function, heart disease or heart failure, joint disease, chronic abdominal pain, severe fatigue and certain infections.

71. InteliHealth: Liver Digestive, Reviewed by the Faculty of Harvard Medical School hemochromatosis hemochromatosisis most commonly diagnosed in those between ages 40 and 60. http://www.intelihealth.com/IH/ihtIH/WSIHW000/8270/8461/187094.html?d=dmtHealthA

72. Hemochromatosis hemochromatosis information and links to national and international supportgroups, clinics with genetic counselors and geneticists. hemochromatosis. http://www.kumc.edu/gec/support/hemochro.html

Hemochromatosis Iron overload American Hemochromatosis Society, Inc. (AHS) 777 East Atlantic Avenue, Z-363, Delray Beach, Florida U.S.A. 33483-5352 Email: ahs@emi.net Web site: www.americanhs.org Iron Overload Diseases Association, Inc. (IOD) 433 Westwind Drive, N. Palm Beach, FL 33408 Phone: 561.840.8512 - Fax: 561.842.9881 Website: www.ironoverload.org E-mail : iod@ironoverload.org Canadian Hemochromatosis Society 272-7000 Minoru Blvd., Richmond, BC, Canada V6Y 3Z5 Phone: 877.223.4766, toll-free in Canada only, or 604.279.7135 Fax. 604.279.7138 E-mail: office@cdnhemochromatosis.ca Hemochromatosis Foundation, Inc. PO Box 8569, Albany, NY 12208 Phone: 518.489.0972 - Fax: 518.489.0227 Web site: www.hemochromatosis.org Haemochromatosis Society Australia, Inc. 412 Musgrave Road, Coopers Plains, Australia Phone: 07 3345 7583 - Fax: 07 3345 8051 E-mail: margaret@haemochromatosis.org Web site: www.haemochromatosis.org/ Haemochromatosis Society , England Association Hemochromatose , France Hemochromatosis , Belgium Also See: National organizations , information on genetic conditions or birth defects Hemochromatosis Pamphlet , American Liver Foundation Hemochromatosis , Iron Disorders Institute National Digestive Diseases Information Clearinghouse (NDDIC) , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Hemochromatosis case study CDC webcast, May 2000, public health and genetics, view online

73. Hemochromatosis Hematology and Blood Disorders. hemochromatosis. What is hemochromatosis?hemochromatosis What causes hemochromatosis? hemochromatosis http://www.mcghealthcare.org/hematology/hemachro/hemachro.htm

MCG Health System Phone Numbers: (706) 721-CARE 1-800-736-CARE Request an Appointment Online Hematology and Blood Disorders Hemochromatosis What is hemochromatosis? Hemochromatosis, also called iron overload disease, is the most common genetic disorder in the US. It is a metabolic disorder that causes increased absorption of iron, which is deposited in the body tissues and organs. The iron accumulates in the body where it may become toxic and cause damage. What causes hemochromatosis? The carrier frequency is estimated at one in 10 to one in 15, which means that one in 200 to one in 400 persons has hemochromatosis. Although hemochromatosis is an autosomal recessive disorder (which usually means men and women are equally affected), this condition is 10 times more common in men than women. The age of onset is also earlier in males than females. The reasons for these differences are thought to be due to iron loss through menses in females. In other words, females do not build up iron as quickly over time. What are the symptoms of hemochromatosis?

74. Hereditary Hemochromatosis Disease Profile Genetic Disorder Profile hemochromatosis. For more about the MoStGeNe). Other hemochromatosis Resources. hemochromatosis This http://www.ornl.gov/hgmis/posters/chromosome/hh.html

The U.S. Department of Energy Biological and Environmental Research program funds this site. Genetic Disorder Profile: Hemochromatosis For more about the gene that causes hereditary hemochromatosis, see the HFE Gene Profile . The following disease information was adapted from NIH Publication No. 00-4621 Hereditary Hemochromatosis Timeline - Hemochromatosis is first described by Tousseau, who cared for a diabetic patient with cirrhosis of the liver and bronzed skin pigmentation, classic symptoms of HH. - Von Recklinghausen names the disease "hemochromatosis" and identifies an iron-containing pigment in the liver cells of cirrhosis patients. - Sheldon describes the hereditary nature of the disease in his text Haemochromatosis - Stevens reported that a gene for HH may be located on chromosome 6 near the HLA-A locus. Simon concluded that HH demonstrates recessive inheritance. - Feder identifies the hemochromatosis gene and the missense mutations (Cys282Tyr and His63Asp) that cause HH. The hemochromatosis gene was originally HLA-H, but was later changed to HFE.

75. Hemochromatosis Gene The hemochromatosis Gene. Official Gene Symbol HFE. Alternate SymbolHLAH. Name of Gene Product hereditary hemochromatosis protein. http://www.ornl.gov/hgmis/posters/chromosome/hfe.html

The U.S. Department of Energy Biological and Environmental Research program funds this site. The Hemochromatosis Gene Approximate gene location is based on Chromosome 6 map from NCBI Entrez Map Viewer Official Gene Symbol: HFE Alternate Symbol: HLA-H Name of Gene Product: hereditary hemochromatosis protein Locus: 6p21.3 The HFE gene is found in region 21.3 on the short (p) arm of human chromosome 6. Size: The HFE gene's 7 coding regions (exons) are scattered over about 10,000 base pairs of genomic DNA. Exons translated into the HFE protein are interspersed with segments of noncoding DNA (introns). After transcription, introns are spliced out and exons are pieced together to form an mRNA transcript about 2700 bp long. The mRNA is then translated into the 348-amino acid sequence of the hereditary hemochromatosis protein [1,2,3]. Mutations in the HFE gene can result in hereditary hemochromatosis (HH). Protein Function The HFE protein is a transmembrane protein expressed in intestinal and liver cells; it works in conjunction with another small protein called beta-2-microglobulin to regulate iron uptake [4]. Although homologous to other major histocompatibility complex (MHC) class I proteins that present antigens to killer T cells, the HFE protein appears to have no immunological function [5]. The HFE protein is an interesting example of how homology is not always an indicator of protein function.

76. OHSU Health.com - Blood Disorders hemochromatosis. What is hemochromatosis? hemochromatosis, also callediron overload disease, is the most common genetic disorder in the US. http://www.ohsuhealth.com/blood/hemachro.asp?sub=1

77. CLF : Hemochromatosis hemochromatosis What is hemochromatosis? hemochromatosis is an inherited diseasein which the body absorbs too much iron from the diet. http://www.liver.ca/english/liverdisease/hemochromatosis.html

CLF Regional Offices Find a Location BC/Yukon Alberta Saskatchewan Manitoba GTA S.W. Ontario Central Ontario S.E. Ontario Quebec Atlantic Can. HEMOCHROMATOSIS What is Hemochromatosis? Hemochromatosis is an inherited disease in which the body absorbs too much iron from the diet. Hemochromatosis is one of the most common genetic diseases in Canada affecting 1 in 327 Canadians. Normally, only enough iron to meet the body's daily requirements is absorbed; the remainder is usually excreted through the bowels. In hemochromatosis, however, iron continues to be absorbed and stored in different organs and tissues long after body needs are met. The liver is the first organ to store iron and when its storage capacity is exhausted, the iron continues to accumulate in the heart, the pituitary gland and elsewhere in the body. If untreated, damage to the liver, heart, and pancreas may eventually lead to death. What causes hemochromatosis? Hemochromatosis is hereditary. In order to have the disease, a patient must have inherited two defective genes, one from each parent; siblings of an affected individual have a 25 per cent chance of getting this disease. Children are less likely to be affected since the other parent must be a carrier of a hemochromatosis gene. What are the symptoms of hemochromatosis?

78. Hemochromatosis hemochromatosis is an inherited disorder where there is increasein total iron body stores. This leads to deposition of iron in http://www.gentili.net/Hand/hemo.htm

Hemochromatosis is an inherited disorder where there is increase in total iron body stores. This leads to deposition of iron in parenchymal tissues, eventually causing functional impairment. Men are affected far more frequently than in women. Arthritic changes are seen in approximately half of the patients. Distribution: Commonly affected sites of the hands include the metacarpal heads, especially at the 2nd and 3rd metacarpophalangeal joints, and the interphalangeal and carpal joints. . Radiographic Appearance: Osseous eburnation, joint space narowing, well-defined subchondral cysts, medial beak-like osteophytosis at the metacarpal heads, and osteoporosis are all radiographic findings which are frequently seen in this disease process. Chondrocalcinosis is seen in up to fifty percent of the cases, with a direct correlation noted between the amount of chondrocalcinosis and the degree of arthropathy. Differential Diagnosis: Soft tissues findings in the skin and hand help differentiate psoriatic arthritis from findings in hemochromatosis. There is more involvement of the distal joints in the hands with osteoarthritis. It may be difficult to differentiate hemochromatosis from rheumatoid arthritis based on radiographic findings; however, osteophytosis is rarely seen in RA. Greater propensity for the MCP joints with medial beak-like osteophytosis at the metacarpal heads and more widespread involvement of the carpal bones may help to differentiate hemochromatosis from idiopathic CPPD disease.

79. GeneReviews: Hereditary Hemochromatosis Your browser does not support HTML frames so you must view Hereditary hemochromatosisin a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/query?dz=hemochromatosis

80. Diabetes Types, Hemocromatosis hemochromatosis Can Cause Diabetes. by John Walsh, PA, CDE. Signs and Symptoms ofhemochromatosis. fatigue, joint pain, hair loss. diabetes, bronze skin, jaundice. http://www.diabetesnet.com/diabetes_types/hemocromatosis.php

Hemocromatosis Back Next What Type? Type 1 Type 1.5 Type 2 ... Cystic Fibrosis Hemochromatosis Can Cause Diabetes by John Walsh, P.A., C.D.E. Hemochromatosis is an inherited disease that causes excessive amounts of iron to accumulate in the body. Although diabetes can be one of many unwanted side effects of the iron overload, the rate of hemochromatosis is no higher in those with diabetes than those without. Diabetes caused by damage to the pancreas occurs after many years of hemochromatosis. In one French study, diabetes was found in 40% of 115 people at the time their hemochromatosis was diagnosed (Acta Clin Belg 1999 Dec; 54(6): pgs. 334-45). This type of secondary diabetes is often referred to as "bronze diabetes" because it is sometimes accompanied by a bronze color of the skin. Screening for hemochromatosis should be done in people with diabetes who also have liver disease. Hemochromatosis is the most common genetic disease in this country with 13% of the population carrying the gene, and one in every 200 people having it. Those at risk often have a family history of the disease, or a history of heart attacks occurring in family members before the age of 50.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 4     61-80 of 104    Back | 1  | 2  | 3  | 4  | 5  | 6  | Next 20