21. Hemophilia.ca http://www.hemophilia.ca/english/

22. Îáùåñòâî áîëüíûõ ãåìîôèëèåé/Association For Persons Wit http://www.blood.ru/hemophilia/

23. AHF Hemophilia Disease Management Company Offers homedelivery of clotting factors and ancillary products for persons with hemophilia and related blood disorders. Explore its education and treatment programs. http://redirect-west.inktomi.com/click?u=http://www.looksmart.com/og/pr%3Dcdd%3B

24. Hemophilia Encyclopedia extensive overviews of key terms and concepts related to hemophilia and itstreatment. Nav Menu Home Patients Families hemophilia Encyclopedia. http://www.hemophiliagalaxy.com/1_PATIENTS/ENCYCLOPEDIA/

Nav Menu: Home A B C ... Y A Albumin Albumin is the most prevalent protein found in blood. It is used as a stabilizer in the manufacturing process of several factor VIII therapies. Albumin is used in the manufacture or formulation of every recombinant factor VIII product currently on the market or under clinical investigation. Antibody A protein produced by blood plasma cells that binds specifically to substances that the body recognizes as foreign. Once bound, the antibody can lead to the destruction or inactivation of the foreign substance. Inhibitors that occur in response to replacement therapies for hemophilia are antibodies to factor VIII Antihemophilic Factor (AHF) Another term for factor VIII , which is one of the clotting factors in the blood needed to form fibrin , which in turn helps stop bleeding. Arthropathy Chronic joint disease (arthritis) caus ed by repeated and uncontrolled bleeding into joints. This is the leading cause of disability in people living with hemophilia. B Bleed (hemorrhage) Bleeding externally or internally. Bruise A black and blue mark under the skin surface that is caused by bleeding under the skin.

25. Welcome To Hemophilia Health Services Bloodstone Magazine Just For Kids Terms. ©Copyright 2002 hemophilia Health Services, Inc. All rights reserved. http://www.hemophiliahealth.com/

Home About Us FactorCare Why HHS Home About Us FactorCare Why HHS ... Terms

26. Www.web-depot.com/hemophilia Similar pages hemophilia of Georgia Home Page This site is dedicated to providing information on the opportunities availablethrough hemophilia of Georgia for Georgia families who have hemophilia, von http://www.web-depot.com/hemophilia

27. Cell Genesys, Inc. Focused on the development and commercialization of cancer vaccines and gene therapies to treat various cancers including leukemia, hemophilia A and B, restenosis after angioplasty and Parkinson's disease. http://www.cellgenesys.com

28. Description of hemophilia. This page is intended for the general public, providinggeneralized information about coagulation. hemophilia Awareness Pages....... http://www.hemophilia.net/descript.htm

29. World Federation Of Hemophilia FAQ Information and safety issues about blood collection, hemophilia, and blood products. http://www.wfh.org/ShowDoc.asp?Rubrique=28&Document=42

30. VersaPharm Pharmaceutical developer and marketer of specialty prescription products to the United States, working to develop and deliver pharmaceuticals primarily for treatment areas of Tuberculosis, hemophilia, and other blood disorders. http://www.versapharm.com/

VersaPharm Incorporated develops and markets specialty prescription products to the United States: Pharmaceuticals for Tuberculosis, Hemophilia, Anthrax, STD, blood disorders and other diseases. By using this website, you agree to be bound by the Terms of Service and Purchase currently in effect. Click here to enter website Terms of Service Mailing Address VersaPharm Incorporated P. O. Box 7509 Marietta, GA 30065-1509 Phone or 770 499-8100 Fax E-mail Info@VersaPharm.com © 2001-3 VersaPharm Incorporated - Website design and maintenance by Photel International If you have problems with this Website, please contact the Webmaster 043 020 011 M Date Last Updated: February 19, 2003

31. Hemophilia: What Is It? hemophilia link, DNA Learning Center Link, Concept 1 Children resembletheir parents. Learn how Mendel worked out inheritance in pea plants. http://www.yourgenesyourhealth.org/ygyh/mason/ygyh.html?syndrome=hemo

32. Your Genes, Your Health Offers a DNA Learning Center's multimedia guide to genetic, inherited disorders Fragile X syndrome, Marfan syndrome, cystic fibrosis and hemophilia are discussed in detail. http://www.yourgenesyourhealth.org

The information within this web site is for educational purposes only, and should not be used as medical advice. A physician should be consulted for any diagnosis and treatment options. Visit the companion site! No list menu at left? Get QuickTime Player (TM) is also required.

33. Tunnel For information in English, please go to this site Swedish hemophilia Society. http://www.xpress.se/fbis/english.html

For information in English, please go to this site: Swedish Hemophilia Society Nepal - our twinning partner This site works best with Internet Explorer. Download Explorer here

34. MEDLINEplus Medical Encyclopedia: Factor V Deficiency Provides brief information about this inherited bleeding disorder, which is similar to hemophilia. Includes causes, symptoms, and prognosis. http://www.nlm.nih.gov/medlineplus/ency/article/000550.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Factor V deficiency Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Blood clot formation Blood clots Alternative names Return to top Parahemophilia; Owren's disease   Definition Return to top Factor V deficiency is an inherited abnormal blood coagulation disorder caused by a deficiency of the plasma protein Factor V.   Causes, incidence, and risk factors Return to top Normal blood coagulation is a complex process involving as many as 20 different plasma proteins , which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form an insoluble protein called fibrin that stops bleeding When certain coagulation factors are deficient or missing, the chain reaction does not take place normally. Factor V deficiency is caused by inheriting a defective Factor V gene. In this disorder, bleeding ranges from mild to severe. The disease is similar to hemophilia , except bleeding into joints is less common. Bleeding can occur almost anywhere in the body, and death from hemorrhage has occurred with this disorder.

35. HEMOPHILIA A hemophilia A. DEFINITION 4. hemophilia with Factor VIIIc Inhibitors. massive dosesof Factor VIIIc concentrate; plasmapheresis with replacement of Factor VIIIc; http://www.icondata.com/health/pedbase/files/HEMOPHIL.HTM

Pediatric Database (PEDBASE) Last Updated: 4/23/94 HEMOPHILIA A DEFINITION: A coagulation disorder characterized by a deficiency in Factor VIIIc resulting in a bleeding diathesis. EPIDEMIOLOGY: incidence: 1/10,000 (80-85% of Hemophilias) age of onset: risk factors: familial - x-linked recessive chrom.#: Xq28 gene: coagulation factor VIIIc PATHOGENESIS: 1. Background Factor VIII is a complex of two components each with different genetic control and biochemical functions: 1. Factor VIIIc - coagulation protein 2. Factor VIIIvW - platelet adhesion protein Factor VIIIc is the final component of the Intrinsic Pathway and in the presence of activated Factor IX, activates Factor X within the Common Pathway Factor VIIIc is complexed with Factor VIIIvW, the latter acting as a carrier protein in Hemophilia A, the plasma levels of Factor VIIIvW are normal female carriers and male fetuses in utero have a Factor VIIIc/Factor VIIIvW ratio less than 1 (normally this ratio is equal to 1) 2. Genetic Defect 1. Severe onset of bleeding in the newborn period Factor VIIIc does not cross the placenta hematomas after injections or circumcision hemarthroses and deep tissue hemorrhages bleeding may be spontaneous clinical evidence of increased bleeding in 90% of these patients by 1 yr of age 2. Moderate

36. Alphanate Online Alphanate Description Antihemophilic Factor - RxList Monographs with links to full prescribing for this Factor VIII replacement used to prevent and control bleeding in patients with hemophilia A....... http://www.rxlist.com/cgi/generic2/hemofilm.htm

Antihemophilic Factor Health News Please, take our 1 second survey! SEASONAL DEPRESSION MENTAL HEALTH ... WEIGHT LOSS DESCRIPTION Antihemophilic Factor (Human) (AHF), Hemofil M, Method M, Monoclonal Purified, is a sterile, nonpyrogenic, dried preparation of antihemophilic factor (Factor VIII, Factor VIII:C, AHF) in concentrated form with a specific activity range of 2 to 15 AHF International Units/mg of total protein. When reconstituted with the appropriate volume of diluent, it contains approximately 12.5 mg/mL Albumin (Human), 1.5 mg/mL polyethylene glycol (3350), 0.055 M histidine and 0.030 M glycine as stabilizing agents. In the absence of the added Albumin (Human), the specific activity is approximately 2,000 AHF International Units/mg of protein. It also contains, per AHF International Unit, not more than 0.1 ng mouse protein, 18 ng organic solvent (tri-n-butyl phosphate) and 50 ng detergent (octoxynol 9). See Clinical PHARMACOLOGY Hemofil M AHF is prepared by the Method M process from pooled human plasma by immunoaffinity chromatography utilizing a murine monoclonal antibody to Factor VIII:C, followed by an

37. HEMOPHILIA C Pediatric Database (PEDBASE); Discipline H O; Last Updated 8/28/93hemophilia C. DEFINITION A coagulation disorder characterized http://www.icondata.com/health/pedbase/files/HEMOPHI3.HTM

Pediatric Database (PEDBASE) Last Updated: 8/28/93 HEMOPHILIA C DEFINITION: A coagulation disorder characterized by a deficiency in Factor XI resulting in a bleeding diathesis. EPIDEMIOLOGY: incidence: rare (2-3% of Hemophilias) age of onset: childhood risk factors: familial - autosomal recessive chrom.#: 4q35 gene: coagulation factor XI Ashkenazi Jews PATHOGENESIS: 1. Background Factor XI is a component of the Intrinsic Pathway and in its activated form (XIa) activates Factor IX 2. Genetic Defect only homozygotes have a bleeding problem no spontaneous bleeding CLINICAL FEATURES: 1. Hematological Manifestations epistaxis hematuria menorrhagia postoperative and post trauma INVESTIGATIONS: 1. Serum prolonged PTT decreased Factor XI homozygotes: 1-10% of normal heterozygotes: 30-65% of normal normal PT, bleeding time, thrombin time, platelet count MANAGEMENT: 1. Supportive avoid trauma and anticoagulants (i.e., ASA) pressure and cold compresses to bleeding sites 2. Replacement Therapy Fresh Frozen Plasma 10-15cc/kg q24h

38. Comprehensive Hemophilia Treatment Center Specialty section of larger website provides detailed information on hemophilia conditions, describing available treatment programs for children and adults, procedures for contact. http://www.mcg.edu/centers/Hemo/index.html

39. Gene Therapy Website The Gene Therapy Program is located in the Department of Medicine and affiliated with the Stanley S. Scott Cancer Center and the Center for Human and Molecular Genetics at Louisiana State University Health Sciences Center at New Orleans. The major aim of the LSUHSC Gene Therapy Program is to develop new therapies for a series of genetic and acquired diseases including Cystic Fibrosis, hemophilia, Krabbes Disease and infectious diseases such as AIDS, TB, and pneumonia. http://www.medschool.lsumc.edu/GeneTherapy/Default.htm

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40. Hemophilia Reports hemophilia Links. MRI Findings in Hemophilic Joints Treated With Radiosynoviorthesis.Anaerobic Power and Muscle Strength in Young Patients With hemophilia A. http://www.mmhc.com/hemo/

mmhc home Hemophilia Links The following are articles in this month's journal.Use our archive to search for previous articles. Volume 7, Number 4 Intraosseous Hematoma in a Newborn as a Presenting Sign of Factor VIII Deficiency MRI Findings in Hemophilic Joints Treated With Radiosynoviorthesis Anaerobic Power and Muscle Strength in Young Patients With Hemophilia A MultiMedia Health Care/Freedom LLC For more information, email info@mmhc.com

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