81. Inheritance Of Hemophilia Xlinked Inheritance hemophilia. Legend hemophilia is a sex linked traitin humans, inherited in the same way white eye color in Drosophila. http://www.accessexcellence.org/AB/GG/x-linked.html

X-linked Inheritance: Hemophilia Legend: Hemophilia is a sex linked trait in humans, inherited in the same way white eye color in Drosophila. Males are hemizygous, receiving their only X chromosome from their mother. Females are heterozygous, inheriting X chromosomes from both parents. If a female has a defective gene on one of her two X chromosomes, she will be protected from its effects by the normal gene on her second X chromosome. If a male has a mutant X and a normal Y chromosome, he will be affected by a X-linked disease. A son, whose mother has two normal alleles, will not be affected by hemophilia even if the father has the disease and the defective gene. A daughter of the same parents will be a heterozygous carrier. A heterozygous carrier mother and a normal father pass the gene for hemophilia on to possibly one- half of their children. Half the daughters will be carriers and half the sons will be hemophilic. The rest of the siblings will be normal. Daughters, as long as one parent is genotypically normal, can only be carriers. The normal gene on the second X chromosome counteracts the defect and the daughters do not suffer from the trait. If a son receives the defective gene from his mother, he will be hemophilic because the Y chromosome can not counteract the defective gene located on his X chromosome. Graphics Gallery Index About Biotech Index Search Home Questions Email This Link

82. Hemophilia Association Of New Jersey - Hemophilia, Bleeding Disorders The hemophilia Association of New Jersey offers assistance to persons withhemophilia and their families from our office located in East Brunswick. http://www.hanj.org/

You are visitor since 01.01.98. An Website. The Hemophilia Association of New Jersey was founded in August 1971 by 10 concerned families, and offers assistance to persons with hemophilia and their families from our office located in East Brunswick, New Jersey We hope that you find our web site informative as well as comprehensive. Don't forget to periodically check out the "What's New" page to keep up to date on current events that affect the hemophilia community. If you have questions, suggestions or need further information, please feel free to call us or E-mail us All information that appears on the Hemophilia Association of New Jersey website, including links to other websites, is for your general information only. The Hemophilia Association of New Jersey makes no endorsements for or against medical treatments and/or therapies. Please consult your physician, or local treatment center before pursuing any course of treatment. E-mail the Web Master

83. Hematology/Oncology - Hemophilia Hematology/Oncology. hemophilia. hemophilia A (Factor VIII deficiency)and hemophilia B (Factor IX deficiency) are bleeding disorders http://www.mc.vanderbilt.edu/peds/pidl/hemeonc/hemophil.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Hematology/Oncology HEMOPHILIA Hemophilia A (Factor VIII deficiency) and hemophilia B (Factor IX deficiency) are bleeding disorders that are inherited as x- linked recessive traits. Thus, both affect males almost exclusively. The two disorders are clinically indistinguishable but can be easily differentiated by Factor VIII and Factor IX activity assays. In hemophilia A, the Factor VIII procoagulant moiety (Factor VIII:C) is deficient or abnormal, but other components of the Factor VIII/von Willebrand factor system (Von Willebrand's Factor antigen and Ristocetin Cofactor activity) are normal. In general, the severity of bleeding manifestations correlates well with the Factor VIII:C value. Hemophilia B (Christmas disease) is characterized by subnormal Factor IX activity, which may reflect a quantitative or qualitative abnormality in the Factor IX molecule. Both hemophilia A and hemophilia B are heterogeneous conditions with variable degrees of clinical expression. Hemophilia A is far more common, occurring in 1 in 10,000 males in the United States. In contrast, the incidence of hemophilia B is 0.25 in 10,000 males. More than 60% of patients will have a positive family history. Because of the high spontaneous mutation rate for this disease, as many as 1/3 of hemophiliacs have no significant family history.

84. MEDLINEplus: Hemophilia All Topics. hemophilia. Contents of this Children Teenagers. Search MEDLINEfor recent research articles on • hemophilia. You may also http://www.nlm.nih.gov/medlineplus/hemophilia.html

Skip navigation Other health topics: A B C D ... List of All Topics Hemophilia Contents of this page: General/Overviews Coping Pictures/Diagrams Research ... Teenagers Search MEDLINE for recent research articles on Hemophilia You may also be interested in these MEDLINEplus related pages: Bleeding Disorders Blood/Lymphatic System Genetics/Birth Defects General/Overviews Frequently Asked Questions: Hemophilia (World Federation of Hemophilia) Also available in: Spanish Hemophilia (Mayo Foundation for Medical Education and Research) Hemophilia: Facts for Families (World Federation of Hemophilia) Clinical Trials ClinicalTrials.gov: Hemophilia A (National Institutes of Health) Coping Information for Teachers and Childcare Providers (National Hemophilia Foundation) Tips for Travellers (World Federation of Hemophilia) Also available in: Spanish Pictures/Diagrams Hemophilia in Pictures (World Federation of Hemophilia) Also available in: Spanish Research Gene Therapy (National Hemophilia Foundation) Specific Conditions/Aspects Bleeding Disorders: Financial and Insurance Issues (National Hemophilia Foundation) Factor I Deficiency (Afibrinogenemia) (National Hemophilia Foundation) Factor II Deficiency (Prothrombin) (National Hemophilia Foundation) Factor V Deficiency (Mayo Foundation for Medical Education and Research) Factor VII Deficiency (Proconvertin or Stable Factor) (National Hemophilia Foundation) Hemophilia A (Factor VIII Deficiency) (National Hemophilia Foundation) Hemophilia B (Factor IX Deficiency) (National Hemophilia Foundation)

85. MEDLINEplus Medical Encyclopedia: Hemophilia hemophilia. Contents of this page This disease affects mostly males. Diseases inthis category include hemophilia A; hemophilia B; von Willebrand's disease. http://www.nlm.nih.gov/medlineplus/ency/article/000537.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Hemophilia Contents of this page: Illustrations Definition Illustrations Blood clots Definition Return to top A sex-linked hereditary bleeding disorder in which it takes a long time for the blood to clot and abnormal bleeding occurs. This disease affects mostly males. Diseases in this category include: hemophilia A hemophilia B von Willebrand's disease Update Date: 10/4/2001 Updated by: Victoria Kennedy, RN, A.D.A.M. editorial. Health Topics Drug Information Encyclopedia Dictionary ... National Institutes of Health Page last updated: 10 January 2003

86. Hemophilia Treatment Center Harold R. Roberts. Comprehensive hemophilia Diagnostic and TreatmentCenter. Center for Thrombosis and Hemostasis School of Medicine http://www.med.unc.edu/wrkunits/3ctrpgm/thromb/comprehe/

Harold R. Roberts Comprehensive Hemophilia Diagnostic and Treatment Center Center for Thrombosis and Hemostasis School of Medicine 433 Burnett-Womack Building CB #7015 Chapel Hill, NC 27599-7015 Director: Gilbert C. White II, M.D. (919)966-4736; fax: (919)966-8224 email contact: unchtc@med.unc.edu HEMOPHILIA TREATMENT CENTER STAFF This includes a list of all staff members who are associated with treatment and counseling of patients with hemophilia or other bleeding disorders. PHYSICIAN RESOURCES Includes information on the diagnosis, treatment and management of hemophilia A, hemophilia B, and von Willebrand's disease. PATIENT RESOURCES Includes information on "What is hemophilia / von Willebrand's disease?", genetics of hemophilia, home therapy, research studies using new factor products, and HIV/AIDS Clinical Trials. CENTER NEWS OTHER SITES OF INTEREST: Coalition for Hemophilia B Haemophilia Hemophilia and von Willebrand's Disease: Diagnosis, Comprehensive Care, and Assessment. HAMSTeRS: The Hemophilia A Mutation, Structure, Test and Resource Site ... Haemophilia Forum A site for physicians and other health care professionals Hemophilia Home Page Hemophilia of Georgia, Inc. Home Page

87. Gene Therapy For Hemophilia The International Symposium on Gene Therapy for hemophilia September 4 6, 1997, University of North Carolina at Chapel Hill, Chapel Hill, NC. http://www.med.unc.edu/thromb/gene.htm

The International Symposium on Gene Therapy for Hemophilia September 4 - 6, 1997, University of North Carolina at Chapel Hill, Chapel Hill, NC Muscle positive for vector transduction, courtesy of R. J. Samulski and Olivier Danos Presented by the UNC Hemophilia Treatment Center, and the Hemophilia Treatment Centers of Region IV North, the UNC Center for Thrombosis and Hemostasis and the UNC Human Gene Therapy Center. Sponsored by the UNC Office of Continuing Medical Education and Alumni Affairs of the UNC School of Medicine. Organizing Committee: Kenneth M. Brinkhous, M.D. Jeffrey A. Frelinger, Ph.D. Harold R. Roberts, M.D. Richard Jude Samulski, Ph.D. Christopher E. Walsh, M.D., Ph.D. Gilbert C. White II, M.D. David A. Wilcox, Ph.D. Summary, Meeting Agenda and Speakers' Abstracts Poster Abstracts We wish to thank the following companies and organizations for their support and for their contributions of educational grants. Alpha Therapeutic Corporation American Heart Association, Council on Thrombosis American Red Cross Bayer Corporation, Pharmaceutical Division

88. Hemophilia hemophilia resources, support groups, clinics with genetic counselors and geneticists.Image that's a link to Genetics Education Center Support Page hemophilia. http://www.kumc.edu/gec/support/hemophil.html

Hemophilia National Hemophilia Foundation 110 Greene St, Room 303 New York, NY 10012 Phone: (800) 424-2634 or (212) 219-8180 Contact: Cathy Crosby Fax: (212) 966-9247 Web site: www.hemophilia.org World Federation of Hemophilia 1310 Greene Avenue, Suite 500 Montreal, Canada H3Z 2B2 Phone: (514) 933-7944 Fax: (514) 933-8916 E-mail: wfh@wfh.org Web Site: www.wfh.org/ World Federation Links International Resources: Association Française des Hémophiles , France Association for Persons with Hemophilia (Russia) Belgian Haemophilia Society Canadian Hemophilia Society Danmarks Bløderforening , Denmark The German Haemophilia Association The Haemophilia Society , United Kingdom Haemophilia Foundation Australia Icelandic Haemophilia Society Italian Hemophilia Foundation Federazione delle Associazioni Emofilici - ONLUS Netherlands Hemophilia Society Norwegian Haemophilia Society Spanish Hemophilia Federation / Federación Española de Hemofilia South African Haemophilia Foundation ... Swiss Hemophilia Society Other information Hemophilia Page (Bleeding Disorders, Haemophilia)

89. MCG - Comprehensive Hemophilia Treatment Center Specialty section of larger website provides detailed information on hemophilia conditions, describing Category Regional North America United States Georgia Health...... The Medical College of Georgia Comprehensive hemophilia Treatment Center exists toimprove the quality of life for all affected by hemophilia, related bleeding http://www.mcg.edu/centers/Hemo/

90. Northern Alberta Comprehensive Hemophilia Clinic Northern Alberta Comprehensive hemophilia Clinic. Welcome to our HomePage. Members of the Northern Alberta Comprehensive hemophilia Clinic. http://www.ualberta.ca/~britchie/achcn.html

Northern Alberta Comprehensive Hemophilia Clinic Welcome to our Home Page Last update 29 June 1999 The Northern Alberta Comprehensive Hemophilia Clinic has been in existence since 1978. It was formed by the Province of Alberta, under the leadership of the Minister of Health, the Alberta Chapter of the Canadian Hemophilia Society, and their medical consultant, Dr. Garner King. It was charged with the task of providing high quality comprehensive care for people with hemophilia, providing education to families and treaters of hemophilia, and performing research. The clinic has been successful in moving treatment of hemophilia to an outpatient setting, placing control of treatment in the hands of the patients, and providing comprehensive care to people with this disorder. This has resulted in dramatic improvement in efficiencies of care, improved management of hemophilia, improvements in the lifestyle of people with hemophilia, and better relationships between treaters and patients. Comprehensive Clinics are held once a month on the first Monday afternoon of the month in the General Clinics, on the first floor of the Walter McKenzie Center. Comprehensive Clinics are attended by the nurse coordinator, a physiotherapist, a social worker, a representative of the dental clinic, an orthopedic surgeon , and a hematologist. Surveillance clinics are held on intervening Mondays. Members of the Northern Alberta Comprehensive Hemophilia Clinic Wilma McClure RN , Nurse Coordinator Dr. John Akabutu

91. MedWebPlus Subject Hemophilia A free service to help you find health sciences information quickly and easily. hemophilia Web Sites A, , GO, AHF the hemophilia disease management company. http://www.medwebplus.com/subject/Hemophilia

Main About MWP Contribute to MWP Contact Us A service of Flexis, Inc. Welcome to MedWebPlus 2.3! A free service to help you find health sciences information quickly and easily. Hemophilia Broader Terms: All Diseases Hematologic Diseases Related Terms: von Willebrand's Disease Focussed Subsets: Companies Hematology Lists of Internet Resources Societies, Scientific ... von Willebrand's Disease Web Sites: A GO AHF : the hemophilia disease management company A GO BrighamRAD Teaching Case Database Hemophilic Arthropathy by David I Rose, Piran Aliabadi. May 3, 1996 A GO Canadian Hemophilia Society History of Hemophilia A GO A GO Haemophilia : official lournal of World Federation of Hemophilia (tables of contents) A GO Haemophilia Society (published three times a year by the National Center for Biotechnology Information) A GO Hemophilia Home Page maintained by Michael Davon A GO Hemophilia reports (Vol. 4, no. 6, 1998- ) A GO Hemophilia/von Willebrand's Disease by Matt Klimshuk A GO Hemophiliacure Home Page maintained by Paul Vess A GO World Federation of Hemophilia = Fédération Mondiale de L'Hémophilie = Federacion Mundial de Hemofilia Flexis, Inc. Privacy statement Powered by y-Base

92. ::ÃÅÌÎÔÈËÈß Â ÐÎÑÑÈÈ:: The summary for this Russian page contains characters that cannot be correctly displayed in this language/character set. http://www.hemophilia.ru/

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93. TKT Patient Information Hemophilia A hemophilia A It is important for your physician,family, and peers to understand hemophilia A. http://www.tktx.com/patient/hemophilia.htm

Overview Product Pipeline Product Development Executive Officers ... Job Postings Hemophilia A It is important for your physician, family, and peers to understand hemophilia A. Click here to download additional information in PDF format or Click here for additional information For additional information on hemophilia A, you can contact TKT or the organizations to the right. HEMOPHILIA A GENE THERAPY What is Gene Therapy? Gene therapy can be categorized based on two relatively straightforward distinctions. The first is based on where the gene of interest is added to the patient's cell, whether it occurs in vivo (inside the body)or ex vivo (outside the body). The second category is based on how the gene is actually introduced to the cell, whether a viral or non-viral approach. In vivo gene therapies are based on the administration of DNA-based drugs directly to the patient. Ex vivo gene therapies are based on removing a small number of cells from a patient, introducing the gene into a cell and implanting the genetically- engineered cells into the patient. Viral gene therapy approaches use genetically modified viruses to introduce genes into human cells by infection. Non-viral approaches use non-infectious means to introduce the genes into human cells.

94. Hemophilia Research Society The hemophilia Research Society of North America is a fully charted, taxexemptresearch organization whose membership consists of nearly 200 physicians http://www.uth.tmc.edu/xorgs/hrs/

95. This Domain Name Is Booked With Www.net4domains.com http://www.hemophiliaindia.org/

96. Welcome To Hemophilia Resources Of America (HRA): Home hemophilia Resources of America (HRA) is a full service provider of hemophilia coagulationproducts and services for adults and children living with hemophilia http://www.hrahemo.com/

HRA is a full service provider of hemophilia coagulation products and services for adults and children living with hemophilia and von Willebrand disease. A word from our clients: "HRA found that my other home care company was filling the prescription at half the dose. Thank God there was no major problem that resulted from this." "Several head traumas have been prevented due to the protective headgear. If he had not had on the helmet a serious injury would certainly have occurred." "I have always been satisfied with your services, pleasant, professional, courteous, and knowledgeable." "There really is no way to improve something which has been perfected." "It is a pleasure to work with the HRA staff. Every Aspect is Great!" View All Quotes Protect your child as he grows by padding the edges and corners of tables. Contact Us Privacy Statement Web Privacy Statement Search ... Site Map

97. Hemophilia Foundation Of Southern California hemophilia Carrier Testing at Orthopaedic Hospital Blood test for girls and womento see whether more, Important Message from Foundation President. http://www.hemosocal.com/

Women's Issues Ricky Ray Program WON embraces all women in the [more] The Ricky Ray Program Office has established ... [more] Hemophilia Carrier Testing at Orthopaedic Hospital Events schedule Blood test for girls and women to see whether... [more] What is the Foundation? Special Events Our community consists of more than 1,200 men, women and children with hemophilia and other bleeding disorders in the Southern California area. Coming from a variety of ethnic, economic and professional backgrounds, our community works together to help one another solve many shared problems. [more] Sunday, June 30, 2002 - 2002 C.D. LeBlanc Polo Match This was a SENSATIONAL day at will Rodgers Park. The 2002 C.D. LeBlanc trophy cup w ent to .... [more] HemoGames Camp 2002 What a great time we had! Shooting hoops [more] Camp Blood Brothers and Sisters was held August 18 - 24, 2002 The Hemophilia Foundation of Southern California invites all children ages 7-14 with hemophilia and other bleeding disorders to join us for our week-long summer camp [more] Board Of Directors Links to Hemophilia related web sites HFSC Board of Directors OFFICERS [more] The Web can be used for multiple purposes. With respect to hemophilia, the Web is typically...

98. Hemophilia A PubMed the literature LocusLink collection of generelated information OMIM catalogof human genes and disorders Information National hemophilia Foundation a http://www.ncbi.nlm.nih.gov/disease/hemoA.html

99. Hemophilia Library G H. hemophilia. National hemophilia Foundation (NHF) 110 Green Street,Suite 303 New York, NY, USA 10012 (800) 424-2634 Fax (212) 431-0906. http://www.familyvillage.wisc.edu/lib_hemp.htm

100. Hemophilia hemophilia, hemophilia is the most common inherited bleeding disorder. Thereare about 20,000 people in the United States who have hemophilia. http://www.ivillagehealth.com/library/onemed/content/0,7064,241012_245627,00.htm

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