1. MEDLINEplus Medical Encyclopedia: Hereditary Angioedema A definition of hereditary angioedema along with a look at the causes, incidence and risk factors.Category Health Conditions and Diseases hereditary angioedema......hereditary angioedema. Also, see angioedema. Causes, incidence, and riskfactors Return to top. hereditary angioedema is an inherited disorder. http://www.nlm.nih.gov/medlineplus/ency/article/001456.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Hereditary angioedema Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Prevention Illustrations Antibodies Definition Return to top Hereditary angioedema is an inherited abnormality of the immune system that causes swelling , particularly of the face, and abdominal cramping. Also, see angioedema Causes, incidence, and risk factors Return to top Hereditary angioedema is an inherited disorder. It is caused by the absence of a protein called C1 inhibitor (or a defect in this protein), which in turn effects blood vessels. People with hereditary angioedema can develop rapid swelling of the hands, feet, limbs, face, intestinal tract, or airway (larynx or trachea). Unlike an allergic reaction , there is usually no itching or hives . Swelling of the gut can cause intestinal cramping. If swelling closes the airway, it can be fatal. Attacks of swelling can become more severe in late childhood and adolescence. A family history is usually noted, at times only reported to descendants as an unexpected, sudden, and premature death of a parent, aunt/uncle, or grandparent.

2. EMedicine - Angioedema, Hereditary : Article By Warren R Heymann, MD An in dept look at hereditary angioedema beginning with an introduction, clinical features, differentials, work up, treatment, medication and follow up. http://www.emedicine.com/derm/topic24.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Allergy And Immunology Angioedema, Hereditary Last Updated: November 1, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: hereditary angioedema AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Warren R Heymann, MD , Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey Warren R Heymann, MD, is a member of the following medical societies: American Academy of Dermatology American Society of Dermatopathology , and Society for Investigative Dermatology Editor(s): Robert A Schwartz, MD, MPH , Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School; Michael J Wells, MD , Staff Physician, Department of Dermatology, Texas Tech University Health Sciences Center;

3. Hereditary Angioedema Support Group A non profit Organization dedicated to those families that are touched by a rare blood disease known Category Health Conditions and Diseases hereditary angioedema......hereditary angioedema Support Group http://www.hereditaryangioedema.com/

4. Hereditary Angioedema (HAE) - United Kingdom Report September / October 1999 hereditary angioedema (HAE) United Kingdom Report (Our thanks to the PiA/UK for their kind permission to reprint this article) hereditary angioedema (HAE) is a complement deficiency, a rare disorder where those affected have a deficiency of a http://www.pidsnz.co.nz/news/1999/sepoct/hae.htm

September / October 1999 Newsletter Hereditary Angioedema (HAE) - United Kingdom Report (Our thanks to the PiA/UK for their kind permission to reprint this article) Ann Price, who knows all about HAE, having had a family history of the disorder, has done a lot of work recently in preparation for setting up a national network for people with HAE. She sends us this report. People with HAE commonly have the disorder for many years before the correct diagnosis is made. We are now in the process of setting up, under the umbrella of the PiA, an HAE Network. The network will offer support for people with HAE and help them access effective medical treatment. This condition can be very frightening and isolating before a diagnosis is made, but there are now effective treatments available which can transform the picture for those of us with HAE. Hereditary Angiodema (HAE) PiA/UK Member Ann Blake describes a set of circumstances leading up to her diagnosis that hopefully are not too typical, but we suspect they probably are! "I have a very rare condition: Hereditary Angioedema. This was finally diagnosed in November 1994 by accident, after 14 years of misdiagnosis!!

5. Hereditary Angioedema hereditary angioedema Support Group hereditary angioedema (HAE) is a rare but serious disorder. http://hereditaryangioedema.com/

6. Hereditary Angioedema Angioedema Hereditario. Dyax Launches Automated Call Center to FacilitateUS Enrollment in its Phase II Trial of DX88 for hereditary angioedema. http://www.hereditaryangioedema.com/right.htm

Links, Chat, Mailing List, Registration and Donation Form, HAE Table, Support and Friendship, Lista de correo en español C1-Inhibitor Deficiency Disorder Angioedema Hereditario Dyax Launches Automated Call Center to Facilitate U.S. Enrollment in its Phase II Trial of DX-88 for Hereditary Angioedema How Do I Contact Dyax About The Trial? Click Here Our Strategic Partner - The Immune Deficiency Foundation HAE Poll When having an HAE attack, Where is the swelling mostly likely to occur? Feet Face Airway Stomach/Abdomen Hands Both Feet and Hands Genitals Current Results The HAE Association's Newsletter Support Our Organization - Purchase The HAE Bear St. Louis HAE Conference Video Now Available Video Ordering Information HAE Association Now Accepting Members And Donations Hereditary Angioedema (HAE) is a rare but serious disorder. Patients with HAE have episodes of swelling of the hands, feet, trunk, face, gut and airways. In addition, patients with HAE may have recurrent attacks of nausea, vomiting, and abdominal pain. Swelling of the airways can be deadly if not treated and controlled properly. Attacks may occur without any cause. However, anxiety, stress, or minor trauma such as dental procedures, can trigger episodes. The frequency and severity of attacks are unpredictable. Patients with HAE must be closely monitored by a physician who understands this disorder. Click on the link "Understanding The Different Types Of Angioedema" for a detailed table describing the many forms of angioedema.

7. Health Ency. Disease Hereditary Angioedema Causes and Risks. hereditary angioedema is an inherited disorder. http://www.icflorida.com/shared/health/adam/ency/article/001456.html

8. Canadian Hereditary Angioedema Society http://www.haecanada.com/

9. Health And Medical Information: Diseases And Conditions, Medical Dictionary, Pro A brief article about hereditary angioedema. http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=3721

10. Canadian Hereditary Angioedema Society Home Page The Canadian hereditary angioedema Society A NonProfit CharitableOrganization. Mission Statement. The Canadian Hereditary http://www.haecanada.com/emaster.php?PageName=emain

11. Rd.com: hereditary angioedema, a general discussion, alternate names and resources. http://www.rd.com/common/nav/index.jhtml?articleId=8612968

12. MEDLINEplus Medical Encyclopedia: Angioedema surface. There seems to be a hereditary tendency toward the developmentof both angioedema and hives (see hereditary angioedema). http://www.nlm.nih.gov/medlineplus/ency/article/000846.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Angioedema Contents of this page: Alternative names Definition Causes, incidence, and risk factors Symptoms ... Prevention Alternative names Angioneurotic edema; Swelling - eyes Definition Return to top The development of large welts below the surface of the skin, especially around the eyes and lips. The welts may also affect the hands, feet, and throat. The condition is associated with allergies and histamine release. Causes, incidence, and risk factors Return to top Angioedema is a swelling similar to urticaria hives ), but the swelling is beneath the skin rather than on the surface. There seems to be a hereditary tendency toward the development of both angioedema and hives (see hereditary angioedema ). Angioedema is associated with the release of histamine and other chemicals into the bloodstream, which is part of the allergic response Common allergens include: medications foods (such as berries, shellfish , fish, nuts, eggs, milk, and others) pollen animal dander ( scales of shed skin) insect bites exposure to water, sunlight, cold or heat

13. HAE Danmark - Hereditary Angioedema hvor man kan hente et hav af informationer om HAE (hereditary angioedema). Se under "mere information" for at finde en http://www.hae.dk/

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14. EMedicine - Angioedema : Article By Maurice Reid, MD Synonyms and related keywords angioneurotic edema, oedema, laryngeal edema,hereditary angioedema, HAE, acquired angioedema, AAE, allergic reactions http://www.emedicine.com/med/topic135.htm

document.write(''); (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Allergy And Immunology Angioedema Last Updated: August 1, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: angioneurotic edema, oedema, laryngeal edema, hereditary angioedema, HAE, acquired angioedema, AAE, allergic reactions, hereditary angioneurotic edema, airway obstruction, swelling AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Maurice Reid, MD , Staff Physician, Department of Emergency Medicine, University of Maryland Medical System Coauthor(s): Brian Euerle, MD , Program Director, Assistant Professor, Department of Surgery, Division of Emergency Medicine, University of Maryland Medical School; Mary Bollinger, DO , Director of Allergy, Assistant Professor, Department of Pediatrics, Division of Pediatric Pulmonology and Allergy, University of Maryland School of Medicine Maurice Reid, MD, is a member of the following medical societies:

15. Angioedema, Unusual Presentations Unusual Presentations of hereditary angioedema and Acquired Angioedema. Introduction.hereditary angioedema has been known to exist for over a century. http://www.medical-library.org/journals/derm/angioede.htm

Current Clinical Strategies Publishing Home Table of Contents January, 1999Volume 324, Number 14, pp 891-1047 Unusual Presentations of Hereditary Angioedema and Acquired Angioedema Thomas J. Tsou, MD, FACEP Director of Pediatric Emergency Medicine King-Drew /University of California, Los Angeles Medical Center Los Angeles, California Mark D. Dixon, MD Assistant Program Director, Emergency Medicine Department King-Drew/University of California, Los Angeles Medical Center Los Angeles, California Bolanile Akinwole, MD Assistant Professor, Emergency Medicine Department King-Drew/University of California, Los Angeles Medical Center Los Angeles, California Mahmoud Nouh, MD Assistant Professor, Emergency Medicine Department King-Drew/University of California, Los Angeles Medical Center Los Angeles, California Eugene Hardin, MD, FACEP Chairman, Emergency Medicine Department King-Drew/University of California, Los Angeles Medical Center Los Angeles, California From the Department of Emergency Medicine King-Drew/UCLA Medical Center, Los Angeles, California

16. Genzyme Research: Hereditary Angioedema Pathogenesis. Characterised by recurrent and mucosal swelling, including potentiallylifethreatening angioedema in the narrow passages of the larynx. http://www.genzyme.com.au/practitioners/hereditary_angioedema.htm

- Introduction Etiology Pathogenesis Clinical Description Symptoms ... Management, Hereditary Angioedema Genetic Disease Profile Introduction In the classic complement pathway of the humoral immune response Etiology Caused by functional deficiency of C1-esterase inhibitor. Loss of regulatory control results in over expression of the complement-mediated inflammatory response. Top of Page Pathogenesis Characterised by recurrent and mucosal swelling, including potentially life-threatening angioedema in the narrow passages of the larynx. Top of Page Clinical Description May present during early childhood. Episodic inflammatory attacks with localised tissue swelling, often around eyes and lips. Swelling may include hands, feet, and throat. Top of Page Symptoms Sudden weals (welts) - Often around eyes and mouth. - Red and itching. - Welts will blanch and swell if irritated. Abdominal cramping. Difficulty breathing. Chemosis. Top of Page Genetics Autosomal recessive. Panethnic.

17. Hereditary Angioedema And Lupus Erythematosus hereditary angioedema and Lupus Erythematosus Theresa Pacheco MD 1Dermatology Online Journal 7(1)24B. 1.Department of Dermatology http://dermatology.cdlib.org/DOJvol7num1/medderm/abstracts/pacheco.html

DOJ Contents English Portuguese Hereditary Angioedema and Lupus Erythematosus Theresa Pacheco MD Dermatology Online Journal 7(1):24B 1.Department of Dermatology, University of Colorado Health Sciences Center The association between hereditary angioedema and lupus erythematosus in a family with twin boys was reported in the medical literature in 1974. Subsequent reports have confirmed this association. The daughter of one of the twins from the original report has hereditary angioedema and systemic lupus erythematosus (SLE). We present her case and discuss the affected family.

18. New Prevention, Treatment For Hereditary Angioedema Attacks, September 1996 New Prevention, Treatment for hereditary angioedema Attacks. Infusionsof an immune system protein known as C1 inhibitor can safely http://www.niaid.nih.gov/publications/dateline/0996/page8.htm

New Prevention, Treatment for Hereditary Angioedema Attacks Infusions of an immune system protein known as C1 inhibitor can safely prevent and reduce acute swelling caused by hereditary angioedema (HAE), according to an NIAID study. HAE is caused by a defect in the gene that encodes the C1 inhibitor protein, an important regulator of a group of immune system enzymes known collectively as complement. Affected individuals produce either insufficient or dysfunctional C1 inhibitor. The resulting disregulation of complement in these individuals leads to episodes of swelling, typically in the extremities, face, larynx, and abdomen. Patients with severe HAE have at least one attack per month, with symptoms lasting from one to four days. Attacks affecting the abdomen often cause nausea, vomiting, and severe pain, while those involving the larynx and other upper airway structures can lead to asphyxiation, a potentially fatal complication. "We wanted to show that C1 inhibitor prepared this way would be safe and efficacious, particularly in patients for whom other therapies were not effective," says Dr. Frank, who now chairs the Department of Pediatrics at Duke University Medical Center. The researchers tested the heat-sterilized C1 inhibitor in placebo-controlled prevention and treatment studies. For the prevention study, they gave multiple infusions of either C1 inhibitor or placebo over a 17-day period to HAE patients whose symptoms could not be controlled with standard therapy. Three weeks later, the patients received the alternate treatment over a second 17-day period. Swelling attacks were significantly less frequent and less severe during treatment with C1 inhibitor than with placebo. In addition, no patients experienced swelling of the larynx while receiving C1 inhibitor. Four of the six patients had swelling in this area while receiving placebo.

19. 1Up Health > Hereditary Angioedema > Causes, Incidence, And Risk Factors Of Here Comprehesive information on hereditary angioedema . 1Up Health Diseases Conditions hereditary angioedema Causes, Incidence, and Risk Factors. http://www.1uphealth.com/health/hereditary_angioedema_info.html

1Up Health Hereditary angioedema Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Hereditary angioedema Information Hereditary angioedema Causes, Incidence, and Risk Factors Definition : Hereditary angioedema is an inherited abnormality of the immune system that causes swelling , particularly of the face, and abdominal cramping. Also, see angioedema Causes, Incidence, and Risk Factors Hereditary angioedema is an inherited disorder. It is caused by the absence of a protein called C1 inhibitor (or a defect in this protein), which in turn effects blood vessels. People with hereditary angioedema can develop rapid swelling of the hands, feet, limbs, face, intestinal tract, or airway (larynx or trachea). Unlike an allergic reaction , there is usually no itching or hives . Swelling of the gut can cause intestinal cramping. If swelling closes the airway, it can be fatal. Attacks of swelling can become more severe in late childhood and adolescence. A family history is usually noted, at times only reported to descendants as an unexpected, sudden, and premature death of a parent, aunt/uncle, or grandparent. Previous Next Jump to Another Section of this Guide Definition Causes, Incidence, and Risk Factors

20. 1Up Health > Hereditary Angioedema Information Comprehesive information on hereditary angioedema . Covers info and more.1Up Health Diseases Conditions hereditary angioedema. http://www.1uphealth.com/health/hereditary_angioedema.html

1Up Health Alternative Medicine Clinical Trials Health News ... Health Topics A-Z Search 1Up Health Hereditary angioedema Information Guide Definition : Hereditary angioedema is an inherited abnormality of the immune system that causes swelling , particularly of the face, and abdominal cramping. Also, see angioedema Jump to a Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Prevention ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com: Angioedema Hives More C1 inhibiting factor ... More More Topics Allergic reactions Breathing difficulty Itching Swelling ... More Search 1Up Health A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

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