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         Holmes-adie Syndrome:     more detail

21. Health Library - Adie Syndrome
Synonyms. Adie's Pupil; Adie's Syndrome; Adie's Tonic Pupil; holmesadie syndrome;Papillotonic Psuedotabes; Tonic Pupil Syndrome. Disorder Subdivisions. None.
http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

22. Mioti: Medical Condition
not available. NORD Adie Syndrome. Information...... Mioti. Condition Adie Syndrome. Neuromuscular holmesadie syndrome.
http://www.mioti.com/cat/condition/condition.asp?Cat=AdieSyndrome

23. Descripteur - Adie Syndrome
Diseases Adie Syndrome MESH Nervous System Diseases Autonomic Nervous SystemDiseases Adie Syndrome SYNDROME ADIE holmesadie syndrome Adie's Syndrome
http://alexpub.hospvd.ch/Thesaurus.htm&numrec=051915580919730
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    MESH : Eye Diseases: Pupil Disorders: Tonic Pupil: Adie Syndrome
    MESH
    : Pathological Conditions, Signs and Symptoms: Signs and Symptoms: Neurologic Manifestations: Pupil Disorders: Tonic Pupil: Adie Syndrome
    MESH
    : Nervous System Diseases: Neurologic Manifestations: Pupil Disorders: Tonic Pupil: Adie Syndrome
    MESH
    : Nervous System Diseases: Cranial Nerve Diseases: Oculomotor Nerve Diseases: Adie Syndrome MESH : Eye Diseases: Ocular Motility Disorders: Oculomotor Nerve Diseases: Adie Syndrome MESH : Nervous System Diseases: Cranial Nerve Diseases: Ocular Motility Disorders: Oculomotor Nerve Diseases: Adie Syndrome MESH : Nervous System Diseases: Central Nervous System Diseases: Ocular Motility Disorders: Oculomotor Nerve Diseases: Adie Syndrome MESH : Nervous System Diseases: Autonomic Nervous System Diseases: Adie Syndrome SYNDROME ADIE Holmes-Adie Syndrome Adie's Syndrome Holmes Adie Syndrome Syndrome, Adie

24. Tonic Pupil Back To Previous Level Adie
See Related Articles Chronic cough in the holmesadie syndrome associationin five cases with autonomic dysfunction. J Neurol Neurosurg Psychiatry.
http://mitglied.lycos.de/adiesyndrom/usalinks.htm
Adie Pupil
Adie's tonic pupil Holme-Adie pupil A physical finding of a dilated
pupil that reacts poorly to light but better to accomodation
http://www.bme.jhu.edu/labs/chb/glossary/adiepup.html

www.bme.jhu.edu
Tonic Pupil Back to previous level Adie's Syndrome Horner's
Syndrome Harvard U.:Painful Horner's syndrome secondary to i
http://www.ohsu.edu/cliniweb/C11/C11.710.800.html

CLINICAL PROTOCOL FOR A PATIENT HAVING A SEIZURE
CLINICAL PROTOCOL FOR A PATIENT HAVING A SEIZURE PURPOSE:
To classify seizure type (partial, generalized, hysterical) by
http://www.ttuhsc.edu/pages/neuro/ttep/protocol.htm
www.ttuhsc.edu http://www.nlm.nih.gov/mesh/mtrees/C11.txt Category C11. Eye Diseases Asthenopia Conjunctival Diseases Conjunctival Neoplasms Conjunctiv http://www.nlm.nih.gov/mesh/mtrees/C11.txt www.nlm.nih.gov Ophthoguide.com Ophthalmology Search Engine and Ophthal Conferences Bookmark this page for your Future Medlin http://www.ophthoguide.com/ophtho/index2.html www.ophthoguide.com http://www.cmea.com/medline/291.html Physicians' SilverPlatter MEDLINE SilverPlatter Information, Inc.

25. Casereport
Pavesi G, Macaluso GM, Medici D, Ventura P, Lusvardi M, Gemignani F, etal. On the cause of tendon areflexia in the holmesadie syndrome.
http://mitglied.lycos.de/adiesyndrom/casereport.htm
Original (www.medscape.com) From
Journal of the American Board of Family Practice
Adie Syndrome: A Case Report
Authors: T. Micheal Sherrill, MD, David J. Lutz,
Private Family Practice, Raleigh, NC.
[J Ain Board Fam Pract 10(6):439-440, 1997. American Board of Family Practice] Introduction
In 1932 Adie [1] described a syndrome in which unilateral accommodation and pupillary contraction were abnormal. lt typically was observed in young women with no history or evidence of syphilis and involved a unilateral dilated pupil that was unresponsive to light. He noted that deep tendon reflexes were absent or markedly diminished in these patients. He concluded that it was "a benign disorder sui generis". We report a recent case of Adie syndrome. Case Report
A 37-year-old woman came to the office with right pupil dilatation. lt was noticed by a nurse for the first time earlier that morning and had not been present previously according to the patient's report. The patient's only visual complaint was mild photophobia in sunlight. She also had complaints of sinus congestion, headaches, and intermittent mucopurulent rhinorrhea believed to be due to an exacerbation of seasonal allergies. She denied fever, extremity weakness, paresthesias, or a history of sexually transmitted diseases. The patient had a remote history (more than 10 years ago) of an episode of left arm and facial weakness, which resolved. On a physical examination she had anisocoria with a 5-mm right pupil and a 3-mm left pupil. Pupillary light response was absent on the right and decreased accommodation was present. Extraocular movements were intact bilaterally. Findings on a fundal examination were normal, and her blood pressure was 128/84 mmHg. No other abnormalities were noted. Magnetic resonance imaging (MRI) was ordered and findings were normal except for sinusitis.

26. Autonomic Differential Diagnosis
holmesadie syndrome Hereditary form l Autosomal dominant; Acquiredform Most common in young women; Children Often with history
http://www.neuro.wustl.edu/neuromuscular/autonomic.html

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AUTONOMIC DISEASE SYNDROMES

27. Alphabetical Contents
Hirayama's syndrome Hirschsprung's HIV HLA Disease associations HMGCoA ReductaseInhibitors HMSN HMSN-Russe (HMSNR) holmes-adie syndrome Holmes Ataxia
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28. Dorlands Medical Dictionary
holmesadie syndrome (holmes-adie syndrome) (homacrmz-a¢de) GM Holmes; WilliamJohn Adie, Australian neurologist in England, 1886–1935 Adie's syndrome.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

29. LDBullseye
holmesadie syndrome and Lyme disease The Lancet, Volume 357, Number 9258,10 March 2001 Correspondence holmes-adie syndrome and Lyme disease.
http://www.geocities.com/ldbullseye/vol112.html
BULL'S-EYE
- Targeting Lyme Disease -
Excerpts from Vol. 11.2, April, 2001
Brookhaven Scientists Determine Key Lyme Disease Protein Structure UPTON, NY—A research team working at the U.S. Department of Energy's Brookhaven National Laboratory has determined the three-dimensional structure of a key protein on the bacterium that causes Lyme disease. Called OspC, the protein is derived from two strains of the Lyme disease bacterium. This research may lead to a second-generation vaccine that would be more effective than the current one. The current vaccine is based on another Lyme disease protein, known as OspA, which was previously deciphered at Brookhaven. Both OspA and OspC are outer surface proteins of Borrelia burgdoferi, the bacterium that causes Lyme disease. Researchers from Brookhaven Lab, Stony Brook University's School of Medicine, the University of Rochester Medical Center and Rutgers University will report their findings on the structure of OspC in the March 1, 2001 edition of The EMBO Journal. Spread by the bite of an infected deer tick, Lyme disease is the most common vector-borne disease in the U.S. Between 1982 and 1996, more than 99,000 cases were reported in the nation. Early symptoms of the disease include a bull's-eye rash and flu-like symptoms. If the disease is not promptly treated with antibiotics, more serious symptoms, including joint and neurological complications, may develop.

30. Autonomic Differential Diagnosis
Ocular Horner's syndrome Miosis; Mild ptosis; Facial vasodilation reduced sweating;holmesadie syndrome Autosomal dominant Dilated, myotonic pupil; Areflexia.
http://www.geocities.com/HotSprings/Spa/3960/autonomic.html
AUTONOMIC DISORDERS
Diseases or syndromes
Amyloidosis
Catecholamines
Congenital

Diabetes Mellitus
Hereditary

Immune

Infections

Localized dysfunction
...
Urinary

DISEASE SYNDROMES Systemic diseases
  • Diabetes Mellitus Amyloidosis Porphyria Infections Chronic renal or hepatic disease: Usually subclinical
Immune disorders System Degenerations

31. Revista De Neurología
Translate this page Adie. holmes-adie syndrome. Clinical case A. Carlos Rodríguez Barrionuevo,Antonio Herrero Hernández, Lurdes Vázquez Martín.
http://www.neurologia.com/ind.asp?Vol=27&Num=160

32. GoGuides.Org Directory | H
Human @ (3); Hip Dysplasia, Congenital @ (3); Histoplasmosis @ (3);holmesadie syndrome @ (3); Hyperhidrosis @ (3); Hyperkinetic Syndrome
http://www.goguides.org/index.php/viewCat/12089

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33. Www.nlm.nih.gov/pubs/gyours/gyja94.txt
which is helpful in defining some of the causes of Harlequin syndrome and its relationshipto similar disorders such as holmesadie syndrome, RossÕ syndrome
http://www.nlm.nih.gov/pubs/gyours/gyja94.txt

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Disk (11) Herpes (102) Hidradenitis Suppurativa (5) Hirsutism (7) Histoplasmosis(8) Hives (15) Hodgkin's Disease (13) holmesadie syndrome (5) Homocystinuria
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  • 37. Emneuro4
    0.1%). holmes-adie syndrome if diminished deep tendon reflex and orhtostatichypotension also present. 6. Horner’s syndrome. -miosis
    http://mail.ml.usoms.poznan.pl/eyemanual/emneuro4.htm
    Department of Ophthalmology and Visual Sciences
    UIC Online Eye Manual / Neuro-ophthalmology IV. Pupillary disorders
    A. Pupillary light reflex pathway
    B. Afferent pupillary defect

    C. Anisocoria

    D. Light-near dissociation
    A. Pupillary light reflex pathway B. Afferent pupillary defect -elicited by swinging flashlight test -normal pupillary response is constriction followed by slight redilation -abnormal response is decreased or absent constriction with redilation or redilation that is larger than when light is swung to other eye. -indicator of optic nerve disease which causes light to appear dimmer in the affected eye than in the opposite eye. -also seen in extensive retinal disease (eg. large RD), brunescent cataract, and some amblyopes (up to 0.6 log unit density defect) C. Anisocoria Definition - unequal pupillary size 1. Physiologic -most common cause of anisocoria -pupillary size difference less than 1 mm and varies from day to day -more common in elderly patients 2. Third nerve palsy -anisocoria (mydriasis) associated with ptosis and ocular motility disturbance seen in intracranial aneurysms (ICA/Post. comm. a.) -isolated anisocoria may be seen with uncal herniation or basal meningitis -anisocoria during eye movement seen in aberrent regeneration of CN III 3. Traumatic/surgical

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    40. Baylor Neurology Case Of The Month
    holmesadie syndrome, or tonic pupil with generalized loss of tendon reflexes,may be associated in some cases with clinical signs of sensory or autonomic
    http://www.bcm.tmc.edu/neurol/challeng/pat39/summary.html
    Patient #39
    Summary and Discussion
    Dennis R. Mosier, MD, PhD
    Diagnosis: Motoneuron disease
    with Coexistent demyelinating disease (possible multiple sclerosis) Discussion:

    Coexistence of motoneuron disease and suspected demyelinating lesions has a limited, but interesting, differential diagnosis. Radiation injury can produce MRI T2 signal changes suggestive of demyelination, focal lower motoneuron degeneration, and upper motoneuron signs below the level of the injury, but would not be consistent with the clinical history and presentation of this patient. Several hereditary syndromes have been described with combinations of late-onset paraparesis, optic atrophy, and amyotrophy, but none well fitting the apparently sporadic and rapidly progressive bulbar disease encountered in this patient. Prion diseases , including Creutzfeldt-Jakob disease, may present with amyotrophy and bulbar dysfunction (reviewed in Worrall et al., 2000), as well as oligoclonal bands on CSF studies, but anatomic findings typically reflect spongiform changes rather than demyelination. Furthermore, cases of prion-related amyotrophy have nearly always occurred in a clinical context suggesting prion disease (e.g., advancing dementia), which was not observed in this patient. Motoneuron disease and lesions suggesting CNS demyelination have been reported in HIV disease as well as HTLV-1 associated myelopathy ; the role of opportunistic infections is not always clear in reports of the former.

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