Department of Medicine Nephrology Home Research IgA Nephropathy IgA nephropathy is the most common primary kidney disease that can result in kidney failure. We are one of the leaders in research into the molecular mechanisms involved in this condition, focusing on interactions between the IgA molecule and kidney cells. Basic and clinical research topics : Abnormality of IgA molecules in IgAN Interaction between IgA and kidney cells Key investigators : Prof KN Lai, Mr JCK Leung Representative publications Lai KN, Chan LYY, Tang SC, Tsang AWL, Guo H, Tse KC, Yip T, Leung JCK.. Characteristics of Polymeric lambda-IgA Binding to Leukocytes in IgA Nephropathy. J Am Soc Nephrol. 2002:13(9):2309-19. Leung JCK, Tang S, Lam MF, Chan TM, Lai KN. Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy. Kidney Int Leung JCK, Tsang AWL, Chan DTM, Lai KN. Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol. 2000:11(2):241-9. Detection of intracytoplasmic monomeric IgA (mIgA) and polymeric IgA (pIgA) in granulocytes and monocytes after internalization. A predominance of l-IgA uptake was observed. | |
|