1. Baylor Neurology Case Of The Month A summary and general discussion about Isaacs' syndrome.Category Health Conditions and Diseases isaacs syndrome...... Diagnosis 1) Isaacs' Syndrome 2) Syncope The patient was then dischargedand was to be followed in clinic. A Review of Isaacs' Syndrome. http://www.bcm.tmc.edu/neurol/challeng/pat2/summary.html

Summary and Discussion Amit Verma, M.B.B.S. Chief Resident, Department of Neurology Diagnosis: The patient was admitted to the hospital and received 6 courses of plasma exchange. He was subsequently started on oral prednisone and cyclophosphamide and during his hospital stay noticed a marked improvement in the myokymia and muscle strength. The myotonia improved as well. The patient was then discharged and was to be followed in clinic. A Review of Isaacs' Syndrome Epidemiology The condition is extremely rare and has therefore never been studied in a controlled fashion. A recent review of all reported cases by Jamieson and Katiriji in 1994 suggests an equal incidence in both sexes. The disease appears to present earlier in life with most patients being less than 40 years of age at the time of symptom onset. A study of 3 families by Ashizawa et al in 1983 suggested a dominant mode of inheritance in the familial form of the disease. Etiology and Pathogenesis The etiology of the disease remains unclear. Isaacs in 1961 was the first person to localize the disorder to the peripheral nerves. Pharmacological localization of the generator of the myokymia seems to confirm the initial observations of Isaacs. More exact localization has been less fruitful. The electrical activity appears to originate from multiple sites in the axon. There is some evidence to suggest the role of autoimmunity and, specifically, antibodies against the potassium channel in motor nerve terminals. The potential importance of circulating antibodies is supported by the fact that plasma exchange is effective in treatment of some patients with this disease. A recent case has been reported in which a patient met criteria for both Isaacs' syndrome and CIDP, another potential autoimmune disease.

2. HONselect - Isaacs Syndrome Translate this page English isaacs syndrome, - Myokymia, Continuous - Neuromyotonia - Pseudomyotonia- Acquired Neuromyotonia - Continuous Muscle Activity Syndrome - Gamstorp http://www.hon.ch/HONselect/RareDiseases/C05.651.392.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Isaacs Syndrome - Myokymia, Continuous - Neuromyotonia - Pseudomyotonia - Acquired Neuromyotonia - Continuous Muscle Activity Syndrome - Gamstorp-Wohlfart Syndrome Français: ISAACS, SYNDROME Deutsch: Isaacs-Syndrom - Myokomie, anhaltende - Neuromyotonie - Pseudomyotonie - Isaacs-Mertens-Syndrom Español: SINDROME DE ISAACS - MIOCIMIA CONTINUA - NEUROMIOTONIA - SEUDOMIOTONIA - PSEUDOMIOTONIA Português: SINDROME DE ISAACS - MIOQUIMIA CONTINUA - NEUROMIOTONIA - PSEUDOMIOTONIA HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: Yes Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C05.651.392.html Last modified: Thu Jul 25 2002

3. Isaacs Syndrome - Benign Fasiculations ranked one of the best hospitals in America. Subject isaacs syndrome benign fasiculations. Topic Area Neuromuscular http://www.medhelp.org/forums/neuro/archive/4267.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: isaacs syndrome - benign fasiculations Topic Area: Neuromuscular Forum: The Neurology and Neurosurgery Forum Question Posted By: Rita on Sunday, March 29, 1998 My husband was diagnosed with benign fasiculation then later Isaac's Syndrome. So far he has tried Klonopin, Quinine, Tegretol, Dilantin, etc. None seem to help except the Klonopin which takes the edge off of the nervousness and tingling he has. It does not help the muscle jerks at all. He has had this for 11 years and is in otherwise good health. These muscle jerks started in the legs and have now progressed to all parts of the body. There is no wasting of the muscles. Is there any help out there other than what we've found. We are desperate for an answer. After a while it tends to weigh on you physically and especially emotionally. Thanks for any help. The standard treatment of Isaac's syndrome is phenytoin and carbamazepine and valproate are used as a second line agents, it would appear however that your

4. ?ISAACS SYNDROME? I have a dear friend who has been diagnosed. with isaacs syndrome. He has been suffering for 3 years now http://neuro-www.mgh.harvard.edu/neurowebforum/NeuromuscularArticles/ISAACSSYNDR

?ISAACS SYNDROME? This article submitted by artemis on 8/24/96. Author's Email: artemis005@aol.com Please help. I have a dear friend who has been diagnosed with Isaacs Syndrome. He has been suffering for 3 years now and has tried every conceivable treatment available with no relief. He is asking me to reach out to others in this situation. I have read many of the postings here at the Webforum; the people here are certainly very knowledgable concerning this and other ailments. Specifically, it would be interesting to hear about any special diets etc. which people have tried, and also, how do you think you contracted and/or developed this disorder? My friend's neurologist believes it was initiated by a chemical used in dental work he had previous to the onset of Isaacs. Please also advise as to pertinent journal articles and the like. There seems to be very little out there. And, finally, are there any support groups for this. If not, we would like to start onemaybe via the internet. If there are any folks with isaacs in the New England area please email me . Thanks for your help! Good luck to everyone.

5. Information About Isaacs' Syndrome isaacs syndrome is excessive and spontaneous activity of a nerve fiber. http://www.medhelp.org/perl6/neuro/archive/6335.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Information about Isaacs' Syndrome Topic Area: Neurology - General Forum: The Neurology and Neurosurgery Forum Question Posted By: Ellie on Saturday, July 04, 1998 I would like to know what the early symptoms of Isaacs' are. Are bulbar symptoms a common complaint? How does this disease progress and what are the common treatmeants and drugs? What tests are used to diagnose? Thank you in advance. Isaacs Syndrome is excessive and spontaneous activity of a nerve fiber. Twiching, spasms, and rippling of muscles (Myokyemia) are evident, the latter being the main clinical sign. There is also delayed relaxation after muscle contraction. Generalized muscle stiffness is also a symptom. Complaints of muscle aches are common, but severe muscle pains is not common. Any muscle group may be affected. Stiffness and slowness of movement may eventually make walking difficult, in extreme cases all voluntary activity is blocked. EMG may help in the diagnosis (show myokymia). The syndrome arises in childhood or adult life either in association with an peripheral neuropathy or an inherited coordination problem that may respond to acetazolamide, or remit spontaneously. Treatment with dilantin or tegretol may abolisth continuous muscle activity. Plasma exchange may help if intractible. If you are interested in getting an evaluation at CCF, call 1-800-CCF-CARE. Good Luck.

6. Isaacs Syndrome Articles, Support Groups, And Resources isaacs syndrome articles, support groups, and resources for patientsfrom Med Help International (www.medhelp.org). isaacs syndrome. http://www.medhelp.org/HealthTopics/Isaacs_Syndrome.html

[Health Topics A-Z] A B C D ... Z Isaacs Syndrome Ask The Doctor Forums isaacs syndrome - benign fasiculations (Neurology and Neurosurgery Forum) [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 3/30/2003

7. A Case Of Isaacs' Syndrome Medicine A case of isaacs syndrome with Trousseau s phenomenon wacstudied electrophysiologically and histologically. The needle http://www.amc.seoul.kr/~salee/a_isaacs.htm

A Case of Isaacs' Syndrome Joong Koo Kang, MD., Sang-Ahm Lee, MD., Kwang Kuk Kim, MD., Myoung Chong Lee, MD. Department of Neurology, University of Ulsan College of Medicine Gheeyoung Choe Department of Pathology, University of Ulsan College of Medicine A case of Isaacs syndrome with Trousseau s phenomenon wac studied electrophysiologically and histologically. The needle electromyography showed typical neuromyotonic discharges of spontaneous recurrent high-frequency(150-300Hz) bursts of motor unit activity with 0.5-3 second of duration and typical waning pattern This discharge was not suppressed by brachial plexus block Motor and sensory nerve conduction velocities were either s!ightly below or in the lower range of normal. In repetitive nerve stimulation test a decremental response to low rate stimulation was noted in abductor digiti quinti muscle. On sural nerve biopsy, there was a decrease in the number of myelinated nerve fibers showing both axonal and myelin degeneration The clinical and electrophysiologic abnormalities improved considerably after treatment with phenytoin. J Korean Neurol Assoc 1993;11:592-598.

8. Searchalot Directory For Isaacs Syndrome Related Web Sites. Baylor Neurology Case of the Month A summary andgeneral discussion about Isaacs' syndrome. Readers Digest Health http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders

Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases Neurological Disorders ... Muscle Diseases : Isaacs Syndrome Related Web Sites Baylor Neurology Case of the Month - A summary and general discussion about Isaacs' syndrome. Readers Digest Health - A description of Isaacs' syndrome, its alternate names and resources. NORD - A general discussion, the synonyms and further resources for Isaacs' syndrome. Related Categories Health: Conditions and Diseases: Musculoskeletal Disorders Health: Conditions and Diseases: Neurological Disorders: Peripheral Nervous System Health: Conditions and Diseases: Rare Disorders All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo!

9. Searchalot Directory For Musculoskeletal Disorders Feet (24); Fractures (23); isaacs syndrome (3); Melorheostosis (3).Nail Patella Syndrome (9); Neuromuscular Diseases (128); Ollier Disease http://www.searchalot.com/Top/Health/ConditionsandDiseases/MusculoskeletalDisord

Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases : Musculoskeletal Disorders Aarskog Syndrome Amputee Arthritis Back and Spine ... Tendonitis Related Web Sites Eosinophilic Granuloma Hub - Links to information and resources. Dynomed.com - Patient Encyclopedia - Common orthopaedic conditions are explained in this searchable encyclopedia. Wellness Train - Spiritual program of self help for individuals suffering from pain. Shin Splints - An article about the causes, symptoms, treatment and corrective measures by Edward M. Staub, M.D. Common Shoulder Injuries - Covers disorders of Tendinitis, Rotator Cuff Tear, Impingement Syndrome, dislocation and shoulder separation.

10. 1Up Health > Health Links Directory > Conditions And Diseases: Musculoskeletal D Cleidocranial Dysplasia (6) Congenital Anomalies (161) Connective Tissue (286) Costochondritis(5) Feet (24) Fractures (23) isaacs syndrome (3) Melorheostosis http://www.1uphealth.com/links/conditions-and-diseases-musculoskeletal-disorders

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Conditions and Diseases : Musculoskeletal Disorders Description Categories Aarskog Syndrome Amputee Arthritis Back and Spine ... Tendonitis See Related Categories Health: Child Health: Conditions and Diseases: Musculoskeletal Disorders Health: Medicine: Medical Specialties: Rheumatology Health: Medicine: Medical Specialties: Sports Medicine Health: Medicine: Surgery: Orthopedics ... Shopping: Health: Orthopedic Sites Accurheum.com Dedicated to the accurate diagnosis and treatment of rheumatic diseases, live chat with healthcare professionals, up to date rheumatology news, links to information and a message board. AskMe Orthopedics Experts volunteer to answer questions related to orthopedics. Bone, Muscle and Joint CBSHealthWatch by Medscape, offers health management tools and information for beginner and advanced readers, as well as what your doctor reads. Common Knee Injuries A brief look at sprains, cartilage tears, knee cap: "Chondromalacia", anterior cruciate ligament tears and Osgood-Schlatter's. Written by Edward M. Staub, M.D.

11. GoGuides.Org Directory | Isaacs Syndrome Home Health Fitness Disabilities Disorders Conditions Diseases Nervous System Disorders Neuromuscular Diseases isaacs syndrome http://www.goguides.org/index.php/viewCat/13375

Home Nervous System Disorders Neuromuscular Diseases Isaacs Syndrome ... URL Submission Status Sponsored Link: Sponsored Link: Advertise Here Isaacs Syndrome: Number of Matches: 3 Baylor College of Medicine: Patient # 2 - Find a case study and report on a 39 year old male diagnosed with isaacs syndrome. URL: http://www.bcm.tmc.edu/neurol/challeng/pat2/summary.html eMedicine: Myokymia - Presented is a clinical report authored by Suying Song, MD. URL: http://www.emedicine.com/neuro/topic235.htm NORD: Isaacs' Syndrome - Find the synonyms, a general discussion and further resources. URL: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Isaacs'%20Syndrome < Previous Pages: Next >> Guide needed for this topic. Apply to edit this category Link To GoGuides Advertising ... GoGuide Profiles © 2003 GoGuides.Org. Registration Pending

12. GoGuides.Org Directory | Isaacs Syndrome Add URL to isaacs syndrome. Add informational sites your site. You choseisaacs syndrome. Is this the best category for your site? Yes http://www.goguides.org/index.php/add/13375

Home Nervous System Disorders Neuromuscular Diseases Isaacs Syndrome Add URL to : Isaacs Syndrome Add informational sites about isaacs syndrome; A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions. Step 1.) Verify the category you chose is the most appropriate for your site. You chose: Isaacs Syndrome Is this the best category for your site? Yes/No If the answer is no, please find the most appropriate category for your submission. Sites submitted incorrectly will not be included in the GoGuides directory. Step 2.) Determine your mode of site submission from the options below: GoGuides.Org Express Submission GoGuides.Org Standard Submission 2 Business Day Review or Standard Submission Best choice for users needing sites listed quickly. Expedited review of site for inclusion.Only 2 US Business Days! Guaranteed review of your site within only two business days. Only a one time $39.99 fee Get listed Fast!

13. Directory :: Look.com isaacs syndrome (3) See Also. Sites. Baylor Neurology Case of the MonthA summary and general discussion about Isaacs' syndrome. NORD http://www.look.com/searchroute/directorysearch.asp?p=594580

14. Directory :: Look.com Cleidocranial Dysplasia (6) Congenital Anomalies (162) Connective Tissue (296) Costochondritis(4) Feet (24) Fractures (23) isaacs syndrome (3) Melorheostosis http://www.look.com/searchroute/directorysearch.asp?p=339150

15. Mioti: Medical Condition not available. NORD Isaacs' Syndrome....... Condition isaacs syndrome. isaacs syndrome. Washington UniversitySchool of Medicine. http://www.mioti.com/cat/condition/condition.asp?Cat=IsaacsSyndrome

16. Mioti: Medical Condition Irritable Bowel Syndrome, • Irritable Colon. • Isaacs Merten Syndrome,• isaacs syndrome. • Islet Cell Cancer, • Ivemark Syndrome. General Topics. http://www.mioti.com/cat/condition/results.asp?Alpha=I

17. WebGuest - Open Directory : Health : Conditions And Diseases : I Intrauterine Dwarfism@ (5); Iritis@ (27); Irritable Bowel Syndrome@ (70);isaacs syndrome@ (3). Last update 1102 PT, Monday, July 8, 2002 http://directory.webguest.com/index.cgi/Health/Conditions_and_Diseases/I/

Browse thru 1000's of books about health, mind and body: About Us Privacy Statement Acceptable Use Policy Legal Notices ... Contact Us the entire directory only in Conditions_and_Diseases/I Top Health Conditions and Diseases : I A B C D ... Isaacs Syndrome Last update: 11:02 PT, Monday, July 8, 2002 Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor

18. Isaacs Syndrome Website Results :: Linkspider UK isaacs syndrome Websites from the Linkspider UK. isaacs syndrome Directory.Complete Results for isaacs syndrome Related Topics. http://www.linkspider.co.uk/Health/ConditionsandDiseases/NeurologicalDisorders/M

Isaacs Syndrome Websites from Linkspider UK Keyword: Isaacs Syndrome Linkspider UK Directory Isaacs Syndrome Search for Directory Tree: Top Health Conditions and Diseases Neurological Disorders ... Muscle Diseases : Isaacs Syndrome (3) Add URL Advertise Here! Personalize Amazon ... Weather See Also: Health: Conditions and Diseases: Musculoskeletal Disorders Health: Conditions and Diseases: Neurological Disorders: Peripheral Nervous System Health: Conditions and Diseases: Rare Disorders Baylor Neurology Case of the Month - A summary and general discussion about Isaacs' syndrome. Readers Digest Health - A description of Isaacs' syndrome, its alternate names and resources. NORD - A general discussion, the synonyms and further resources for Isaacs' syndrome.

19. Musculoskeletal Disorders Website Results :: Linkspider UK Costochondritis (4); Feet (24); Fractures@ (23); isaacs syndrome@ (3); Melorheostosis@(3). Nail Patella Syndrome@ (9); Neuromuscular Diseases@ (128 http://www.linkspider.co.uk/Health/ConditionsandDiseases/MusculoskeletalDisorder

Musculoskeletal Disorders Websites from Linkspider UK Keyword: Musculoskeletal Disorders Linkspider UK Directory Musculoskeletal Disorders Search for Directory Tree: Top Health Conditions and Diseases : Musculoskeletal Disorders (964) Add URL Advertise Here! Personalize Amazon ... Tendonitis See Also: Health: Child Health: Conditions and Diseases: Musculoskeletal Disorders Health: Medicine: Medical Specialties: Rheumatology Health: Medicine: Medical Specialties: Sports Medicine Health: Medicine: Surgery: Orthopedics ... Eosinophilic Granuloma Hub - Links to information and resources. Dynomed.com - Patient Encyclopedia - Common orthopaedic conditions are explained in this searchable encyclopedia. Wellness Train - Spiritual program of self help for individuals suffering from pain. Shin Splints - An article about the causes, symptoms, treatment and corrective measures by Edward M. Staub, M.D. Common Shoulder Injuries - Covers disorders of Tendinitis, Rotator Cuff Tear, Impingement Syndrome, dislocation and shoulder separation. Common Knee Injuries - A brief look at sprains, cartilage tears, knee cap: "Chondromalacia", anterior cruciate ligament tears and Osgood-Schlatter's. Written by Edward M. Staub, M.D.

20. Continuous Muscle Fiber Activity ISAACS, Journal Of Neurology, Neurosurgery And DL, SatyaMurti, S., Davis, L. and Drachman, DB, isaacs syndrome with laryngeal involvementan unusual presentation of myokymia, Neurology, 29 1612-5, 1979. http://www.remarkablemedicine.com/Clinical/clinicaluses/neuromuscular/musclefibe

Your browser does not support script Special Offer Free Book Click here for more Continuous Muscle Fiber Activity Isaacs Journal of Neurology, Neurosurgery and Psychiatry describes the syndrome of continuous muscle fiber activity in two patients, marked by progressive muscle stiffness increased by voluntary muscle contractions and accompanied by fasciculation and weakness. Electromyography recorded a state of constant rapid dysrhythmic discharge of independent muscle fibers. The author defined the state as myotonic afterdischarge and likened it to post-tetanic afterdischarge. Neither patient showed response to numerous medications including quinidine, procainamide, cortisone, and atropine. Treatment with PHT (100 mg q.i.d.) resulted in dramatic improvement in symptoms and electromyographic changes both at rest and on voluntary effort. In a five-year follow-up, the author reported that both patients were still well and had lost their abnormal stiffness. He noted that on the occasions when PHT had been stopped, the symptoms returned. 176. Isaacs, H., A syndrome of continuous muscle-fibre activity.

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