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         Isaacs Syndrome:     more detail
  1. Overcoming Metabolic Syndrome by Scott Isaacs, Fred Vagnini, 2005-11-01
  2. Modern Management of Premenstrual Syndrome by Samuel Smith, 1993-04
  3. Your Daughter Has Been Diagnosed With Rett Syndrome by Kim Isaac Greenblatt, 2006-01-01
  4. Diseases of the Salivary Glands: Including Dry Mouth and Sjogren's Syndrome Diagnosis and Treatment by Isaäc van der Waal, 1997-01-15
  5. The Burning Mouth Syndrome by Isaac Van Der Waal, 1990-06
  6. Emergency department response to SARS, Taiwan.(RESEARCH): An article from: Emerging Infectious Diseases by Wei-Kung Chen, Hong-Dar Isaac Wu, et all 2005-07-01

41. I In Health > Conditions And Diseases
Intrauterine Dwarfism@ (5); Iritis@ (27); Irritable Bowel Syndrome@(70); isaacs syndrome@ (3). S. earch. Find I on Help build the
http://ilectric.com/browse/web/Health/Conditions_and_Diseases/I/
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42. ClinicalTrials.gov - Linking Patients To Medical Research: Browse: I
recruiting). 41. Iron Overload (2 studies recruiting). 42. isaacs syndrome(1 study recruiting). 43. Ischemia (46 studies recruiting). 44.
http://www.clinicaltrials.gov/ct/gui/screen/BrowseAny?recruiting=true&path=/brow

43. ClinicalTrials.gov - Linking Patients To Medical Research: Browse: I
47. Iritis (3 studies). 48. Iron Metabolism Disorders (9 studies). 49. Iron Overload(9 studies). 50. isaacs syndrome (1 study). 51. Ischemia (365 studies). 52.
http://www.clinicaltrials.gov/ct/gui/screen/BrowseAny?recruiting=false&path=/bro

44. Word Lists
Skeletal; Hypopituitarism. Inappropriate ADH Syndrome; Intestinal Polyps;isaacs syndrome. Jaundice, Chronic Idiopathic. Kallmann Syndrome;
http://www.ma-ts.com/mt/rare_diseases.htm
Rare Diseases source Health On The Net Foundation

45. Search 2 Uff
INTESTINE LYMPHANGIECTASIA, RI0080, 579.8, isaacs syndrome, RN1490, 333.90, G71.1,121020. ISTIOCITOSI X, RCG150, 277.8, IVEMARK SYNDROME, RN0740, 759.0, 759.0,208530.
http://malattierare.pediatria.unipd.it/cerca_ing/cerca_2_uff.asp?parola=i

46. Acquired Neuromyotonia (codes) Continuous Muscle Fiber Activity (
Name isaacs syndrome Synonyms, MuscleNerve. 2001 Jun; 24(6) 834-8 Otsuka,-R;Arimura,-K; Osame,-M Isaacs' syndrome Ryoikibetsu-Shokogun-Shirizu.
http://malattierare.pediatria.unipd.it/pubblicaMR/mr_dx_ing.asp?mr=185

47. Special Interest Groups Of The Physiological Society ...Ion Channel
Neuromyotonia (isaacs syndrome) In Neuromyotonia (NMT) patients present with continuousand spontaneous muscle activity, generated in the peripheral motor
http://www.physoc.org/SIG/Channels/LV29.html
HOME JOURNALS MEETINGS NEWS/EVENTS ... JOBS Special Interest Groups
Ion Channels
Updated: 12th May 1999
webmaster@physoc.org
Autoimmunity and ion channels at the neuromuscular junction
New work is revealing that autoantibodies which attack the neuromuscular junction can affect different ion channels in different ways. Bethan Lang and Angela Vincent discuss these findings and their potential relevance to other areas of medicine.
M yasthenia gravis (MG) is an autoimmune disease in which antibodies to nicotinic acetylcholine receptors (AChR) cause loss of function and muscle weakness. The antibodies mainly act via complement-mediated lysis and increased AChR degradation. However, recent studies suggest that antibodies can affect ion channel functions in different ways; for instance, in some patients with myasthenia gravis, antibodies do not bind directly to the AChR, but appear to reduce AChR function via perturbing signalling pathways. Moreover, maternal antibodies that specifically inhibit the function of fetal AChR can lead to fetal paralysis and severe developmental abnormalities, even when the mother is asymptomatic.
By contrast, in Lambert-Eaton myasthenic syndrome (LEMS), antibodies mainly cause down-regulation of voltage-gated calcium channels, and new data shows that these antibodies bind to the

48. Rare Disease Support EGroup Community
I I Cell Disease Ichthyosis Ichthyosis, CHILD Interstitial Cystitisisaacs syndrome Isovaleric Acidemia Ivemark Syndrome. RETURN HOME.
http://www.angelfire.com/on2/egroups/I
I I Cell Disease
Ichthyosis

Ichthyosis, CHILD

Interstitial Cystitis
...
RETURN HOME

49. Neuroimmunology Group, Mayo Clinic In Rochester, Minn.
neurological disorders Myasthenia gravis; Stiffman syndrome; Neuromyotonia(isaacs syndrome); Morvan's syndrome. Neurosarcoidosis. Staff.
http://www.mayoclinic.org/neurology-rst/neuroimmunology.html
search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Specialties Neurology Neurology Overview Special Interest Groups Diseases/Treatments Appointments ... All Medical Specialties - Rochester
Division of Neuroimmunology
Disorders of the immune system may have significant effects on the nervous system. Neuroimmunologists diagnose and treat neurological disorders caused by inflammation or autoimmunity in the nervous system. The Division of Neuroimmunology includes 16 staff neurologists with diverse subspecialty interests ranging from paraneoplastic disorders to sarcoidosis.
Conditions and Symptoms
  • Paraneoplastic neurological disorders
    • Limbic Encephalitis Cerebellar degeneration Paraneoplastic sensory neuropathy Paraneoplastic gastrointestinal dysmotility Opsoclonus myoclonus Lambert-Eaton syndrome
    Autoimmune neurological disorders
    • Myasthenia gravis Stiffman syndrome Neuromyotonia (Isaacs syndrome) Morvan's syndrome
    Neurosarcoidosis
Staff
Rochester Jacksonville

50. Neuromuscular Disease Group, Mayo Clinic In Rochester, Minn.
LambertEaton syndrome; Botulism; Neuromyotonia (isaacs syndrome); Cramp-fasciculationsyndrome; Fasciculations. Peripheral neuropathy; Motor neuron diseases (ALS).
http://www.mayoclinic.org/neurology-rst/neuromuscgroup.html
search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Specialties Neurology Neurology Overview Special Interest Groups Diseases/Treatments Appointments ... All Medical Specialties - Rochester
Neuromuscular Disease Group
Neuromuscular disorders affect the function of muscles due to problems with the peripheral nervous system (muscles and nerves) rather than the brain and spinal cord. The most common symptom of these disorders is weakness. Neurologists in our group provide comprehensive evaluation of these disorders, electrodiagnostic studies (EMG) and muscle or nerve biopsy as needed. Our group is also active in laboratory and clinical research to improve the diagnosis and treatment of patients with these disorders.
Conditions and Symptoms
  • Muscle disorders
    • Polymyositis Dematomyositis Inclusion-body myositis Congential myopathy Mitochondrial myopathy Elevated creatine kinase (CK) Muscular dystrophy Myotonic dystrophy
    Neuromuscular junction disorders
    • Myasthenia gravis Congenital Myasthenic syndrome Lambert-Eaton syndrome Botulism Neuromyotonia (Isaacs syndrome) Cramp-fasciculation syndrome Fasciculations
    Peripheral neuropathy Motor neuron diseases (ALS)
Staff

51. Rare Disorders Information Sites
Huntington's@; Hydrocephalus@; Incontinentia Pigmenti@; isaacs syndrome@;Jacobsen Syndrome; Joubert Syndrome@; Kearns Sayre Syndrome@; Kernicterus
http://www.medicalorg.com/ConditionsandDiseases/RareDisorders/
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(Not sure of spelling? Use first letters and * such as abc* or abcd* or abcde*) Match:.. All Any
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Search Words: Top Health Conditions and Diseases : Rare Disorders

See Also:
  • Health: Conditions and Diseases: Genetic Disorders National Organization for Rare Disorders, Inc. - Information about NORD, its programs, special events and the variety of services offered. Includes a rare disease, organization and orphan drug database. Diseases are listed alphabetically for easy searching. Cherubs - A non-profit support group for the families and medical care providers of children and adults born with Congenital Diaphragmatic Hernia. Office of Rare Diseases - Information on more than 6000 rare diseases, including current research, publications from scientific and medical journals, completed research, ongoing studies, and patient support groups. International Rare Disease Support Network - A community providing more than a 1000 different links to support groups for the people of all nations. Human Growth Foundation - Information about growth-related disorders through education, research, and advocacy. Member driven organization.

52. Open Directory - Health: Conditions And Diseases: Musculoskeletal Disorders
Costochondritis (5); Feet (24); Fractures@ (23); isaacs syndrome@ (3); Melorheostosis@(3). Nail Patella Syndrome@ (9); Neuromuscular Diseases@ (129
http://www.mptdo.com/Health/Conditions_and_Diseases/Musculoskeletal_Disorders/
about dmoz add URL update URL become an editor ... help the entire directory only in Conditions_and_Diseases/Musculoskeletal_Disorders Top Health Conditions and Diseases : Musculoskeletal Disorders Description See also: This category in other languages: Danish Dutch French German ...
  • Accurheum.com - Dedicated to the accurate diagnosis and treatment of rheumatic diseases, live chat with healthcare professionals, up to date rheumatology news, links to information and a message board.
  • AskMe Orthopedics - Experts volunteer to answer questions related to orthopedics.
  • Bone, Muscle and Joint - CBSHealthWatch by Medscape, offers health management tools and information for beginner and advanced readers, as well as what your doctor reads.
  • Common Knee Injuries - A brief look at sprains, cartilage tears, knee cap: "Chondromalacia", anterior cruciate ligament tears and Osgood-Schlatter's. Written by Edward M. Staub, M.D.
  • Common Shoulder Injuries - Covers disorders of Tendinitis, Rotator Cuff Tear, Impingement Syndrome, dislocation and shoulder separation.

53. Przypadek Zespo³u Isaacs'a
A case of isaacs' syndrome isaacs' syndrome (neuromiotonia) is clinicaly characterized by muscle stiffness, cramps,
http://www.neurologiapolska.pl/streszczenia/aaa8.htm
Przypadek zespo³u Isaacs'a Jolanta Balcewicz, Karina Kierkus Oddzia³ Neurologii WSS im. M. Kopernika w £odzi Abstract A case of Isaacs' syndrome We start treatment with phenytoin receiving improvement-cramps retired. Streszczenie Zespó³ Isaacs'a (neuromiotonia) charakteryzuje siê klinicznie sztywno¶ci± i skurczami miê¶ni, trudno¶ci± w ich rozlu¼nianiu po ruchu dowolnym oraz wzmo¿on± potliwo¶ci±. Mimowolne skurcze miê¶ni nie ustêpuj± podczas snu. Zespó³ mo¿e rozwijaæ siê spontanicznie, mieæ charakter dziedziczny lub towarzyszyæ polineuropatii. 73-letni chory przyjêty zosta³ do Oddzia³u Neurologii WSS im. M. Kopernika w £odzi z powodu bolesnych skurczów ³ydek wystêpuj±cych przez ca³± dobê, pieczenia i drêtwienia podudzi, os³abienia si³y miê¶niowej kkd podczas chodzenia. Badaniem przedmiotowym stwierdzano liczne fascykulacje w kkd i pojedyncze w kkg, zaniki mm.naramiennych, sztywno¶æ i bolesne skurcze miê¶ni kkd, brak odr. skokowych, zaburzenia czucia powierzchniowego typu ,,skarpetek'', nadmiern± potliwo¶æ. Wykonano badanie EMG,które wykaza³o w spoczynku sta³± czynno¶æ bioelektryczn± miê¶ni pod postaci± wy³adowañ PJR, fascykulacji i miokimii, co potwierdzi³o rozpoznanie zespo³u Isaacs'a. Rozpoczêto leczenie fenytoin± uzyskuj±c poprawê skurcze ³ydek ust±pi³y.

54. Patient 2 Selftest
Patient 2 isaacs' syndrome 1. The following symptom/sign is commonlyseen in isaacs' syndrome A. increased reflexes B. percussion
http://www.bcm.tmc.edu/neurol/challeng/pat2/selftest.html
Isaacs' Syndrome
1. The following symptom/sign is commonly seen in Isaacs' syndrome
A. increased reflexes
B.
percussion myotonia
C.
muscle cramping
D.
proximal muscle weakness
2. Characteristic EMG findings in a patient with Isaacs' syndrome may include
A. doublets
B.
neuromyotonic discharges
C.
myokymic discharges
D.
all of the above
3. Therapy for Isaacs' syndrome may include all of the following except
A. phenytoin
B. tegretol
C.
benzodiazepines
D. plasma exchange
4. The following is true about Stiffman's syndrome
A. the muscle stiffness persists in sleep
B. is associated with anti-GAD antibodies
C. myokymia is seen on EMG
D. phenytoin and carbamazepine are beneficial in the treatment of stiffness
5. The underlying cause of Isaacs' syndrome is thought to be
A. altered myelination
B. antibodies influencing the potassium channel
C. vasculitis
D. impaired axoplasmic transport
Department of Neurology, Baylor College of Medicine Comments to: neurons URL:http://www.bcm.tmc.edu/neurol/index.html

55. Rd.com: Health Channel
A description of isaacs' syndrome, its alternate names and resources.
http://www.readersdigesthealth.com/kbase/nord/nord758.htm
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56. NORD
A general discussion, the synonyms and further resources for isaacs' syndrome.
http://www.stepstn.com/cgi-win/nord.exe?proc=GetDocument&rectype=0&recnu

57. Health Library - Isaacs' Syndrome
isaacs' syndrome. isaacs' syndrome is a peripheral motor neuron disorder characterizedby muscular stiffness and cramping, particularly in the limbs.
http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

58. Health Library
Periods. Irritable Bowel syndrome (IBS). isaacs' syndrome. Isletcell cancer Health Professional Information - CancerNet. Islet
http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/_SearchResults.

59. NORD - National Organization For Rare Disorders, Inc.
isaacs' syndrome. To purchase fulltext report ($7.50) Copyright 1991, 1995, 1996Synonyms of isaacs' syndrome Continuous Muscle Fiber Activity syndrome;
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Isaacs' Syndr

60. Health Library - Isaacs' Syndrome
Search. isaacs' syndrome. isaacs' syndrome is a peripheral motor neuron disordercharacterized by muscular stiffness and cramping, particularly in the limbs.
http://yourhealth.stlukesonline.org/Library/HealthGuide/IllnessConditions/topic.

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