1. Questions And Answers About Juvenile Rheumatoid Arthritis Children can develop almost all types of arthritis that affect adults, but the mostcommon type that affects children is juvenile rheumatoid arthritis (JRA). http://www.niams.nih.gov/hi/topics/juvenile_arthritis/juvarthr.htm

Health Information Health Topics Order Publications Studies with Patients Patient Research Registries ... NIAMS Coalition Members Search NIAMS Health Topics Publication Date: July 2001 Questions and Answers About Juvenile Rheumatoid Arthritis What Is Arthritis? What Is Juvenile Rheumatoid Arthritis? What Causes Juvenile Rheumatoid Arthritis? What Are the Symptoms and Signs of Juvenile Rheumatoid Arthritis? ... Where Can People Get More Information About Juvenile Rheumatoid Arthritis? What Is Arthritis? Arthritis means "joint inflammation" and refers to a group of diseases that cause pain, swelling, stiffness, and loss of motion in the joints. "Arthritis" is often used as a more general term to refer to the more than 100 rheumatic diseases that may affect the joints but can also cause pain, swelling, and stiffness in other supporting structures of the body such as muscles, tendons, ligaments, and bones. Some rheumatic diseases can affect other parts of the body, including various internal organs. Children can develop almost all types of arthritis that affect adults, but the most common type that affects children is juvenile rheumatoid arthritis (JRA). What Is Juvenile Rheumatoid Arthritis?

2. Rheumatology - Juvenile Rheumatoid Arthritis A good, though brief (less than 1024 chars), description of your site. juvenile rheumatoid arthritis is a chronic inflammatory disease that always involves the joints, but may produce http://www.mc.vanderbilt.edu/peds/pidl/rheum/jra.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Rheumatology JUVENILE RHEUMATOID ARTHRITIS (Systemic Onset) Juvenile rheumatoid arthritis is a chronic inflammatory disease that always involves the joints, but may produce extensive connective tissue and visceral lesions. Despite extensive research the etiology of JRA remains unclear. JRA is arbitrarily defined as beginning before the age of 16 years. Approximately 20% have acute systemic JRA which is characterized by febrile onset, variable joint manifestations, rash, generalized lymphadenopathy, splenomegaly, liver disease, and rarely by GI tract disease. Other children with JRA primarily have arthritis that is present at the onset of illness. In 30% only a single joint, usually the knee, is involved; in 50% multiple joints are involved. The disease is termed polyarticular if more than 4 joints are involved and pauciarticular if 4 or fewer joints are affected. The acute systemic onset of JRA is often referred to as Still's disease because of Still's classic description of the disease in 1897. The systemic symptoms of JRA may precede the onset of overt arthritis for a variable periods of time ranging from months to years. The most characteristic features of systemic JRA are a high-spiking fever and the rheumatoid rash. The temperature peaks once or twice daily, often in the late afternoon or evening, to a level of 39

3. MEDLINEplus: Juvenile Rheumatoid Arthritis juvenile rheumatoid arthritis. Contents of this page http://www.nlm.nih.gov/medlineplus/juvenilerheumatoidarthritis.html

Skip navigation Other health topics: A B C D ... List of All Topics Juvenile Rheumatoid Arthritis Contents of this page: From the NIH General/Overviews Anatomy/Physiology Coping ... Organizations Search MEDLINE for recent research articles on Juvenile Rheumatoid Arthritis You may also be interested in these MEDLINEplus related pages: Arthritis Rheumatoid Arthritis Bones, Joints and Muscles Child and Teen Health From the National Institutes of Health Questions and Answers About Juvenile Rheumatoid Arthritis (National Institute of Arthritis and Musculoskeletal and Skin Diseases) General/Overviews Juvenile Rheumatoid Arthritis (Nemours Foundation) Juvenile Rheumatoid Arthritis (JRA) (Arthritis Foundation) Anatomy/Physiology Anatomy of a Joint (University of Utah, Health Sciences Center) Clinical Trials ClinicalTrials.gov: Arthritis, Juvenile Rheumatoid (National Institutes of Health) Coping Coping with Juvenile Rheumatoid Arthritis (American Academy of Orthopaedic Surgeons) Dealing with Emotional Issues (Arthritis Foundation) School Success (Arthritis Foundation) Disease Management Exercise (Arthritis Foundation) Kid Power (Arthritis Foundation) Questions and Answers about Arthritis and Exercise (National Institute of Arthritis and Musculoskeletal and Skin Diseases) Research Progress and Opportunities in Juvenile Arthritis (Arthritis Foundation) Stem-Cell Transplants with Dramatic Results for JRA (Arthritis Foundation) Specific Conditions/Aspects Dental Care (Arthritis Foundation) Eye Care (Arthritis Foundation) Financial Assistance (Arthritis Foundation)

4. Juvenile Rheumatoid Arthritis (JRA) juvenile rheumatoid arthritis. What Is It? If your question is notanswered here, please contact one of our information specialists. http://www.arthritis.org/conditions/DiseaseCenter/jra.asp

Welcome! Log In Create Profile advanced search Español ... 51 Ways to Be Good to Your Joints Juvenile Rheumatoid Arthritis What Is It? Types of JRA Pauciarticular Polyarticular ... Quality of Life Issues Related Items From Arthritis Today Arthritis 101: JRA AJAO JRA Medications Other types of JA AF Research Progress and Opportunities in JA Free Brochures Arthritis in Children When Your Student Has Arthritis Decision Making for ... Arthritis Books Raising a Child With Arthritis: A Parent's Guide Newsletter Kids Get Arthritis Too Juvenile Rheumatoid Arthritis What Is It? If your question is not answered here, please contact one of our information specialists. JRA is the most common form of arthritis in children. It may be a mild condition that causes few problems over time, but it can be much more persistent and cause joint and tissue damage in other children. JRA can produce serious complications in more severe cases. Arthritis is best described by four major changes in the joints that may develop. The most common features of JRA are: joint inflammation, joint contracture (stiff, bent joint), joint damage and/or alteration or change in growth. Other symptoms include joint stiffness following rest or decreased activity level (also referred to morning stiffness or gelling), and weakness in muscles and other soft tissues around involved joints. However, because JRA affects each child differently, your child may not experience all of these changes. Children also vary in the degree to which they are affected by any particular symptom.

5. AnnasJRA Information and support to parents and children who deal with juvenile rheumatoid arthritis. http://www.geocities.com/tlzeigler/AnnasJRA.html

to Anna's JRA Page about Juvenile Rheumatoid Arthritis~ Our daughter Anna was diagnosed with a mild case of JRA in July 1999. Anna has pauci-articular JRA, which means that she has four or fewer joints affected. For Anna, the JRA is limited to her left knee. As Anna's Mom, I have gone through all kinds of emotions since she was diagnosed (even with a mild case!). I have spent hours at the computer researching every page I could find with some sort of information on JRA. That's why I wanted to do this page. I want to include many links to the varied sites available to make research less time-consuming for other parents and families. For any parent whose child has been diagnosed with a chronic illness, I think it is crucial for you to surround yourself with friends and family who will listen to you and encourage you and keep you from feeling totally overwhelmed by everything. For me, it was my quest for information which helped me feel a little more in control, and my friends and family who helped me to regain my emotional balance. I found a message board where other JRA moms (and a few dads occasionally) talk and ask questions and share information and give advice. It has been an additional great system of support, hope, and encouragement.

6. Index A mother describes her son's experience with juvenile rheumatoid arthritis, plus links to information http://www.geocities.com/Heartland/Village/8414/

The internet has been a valuable source of information and support for me, so I wanted to create a website that might in some ways be helpful to others. If you know a child who has Juvenile Rheumatoid Arthritis (JRA) or if you want to learn more about this condition, you may find it interesting to read about our personal experience. I'm not a medical professional ... and I don't play one on the web ... but I felt that others might benefit from the sort of information that I can share. You can also get information here about a popular email-based support and information group for people involved with Juvenile Arthritis, called The JRA List At the very least, I hope that my collection of related internet links may be useful to you in helping to sort through the millions of arthritis-related websites in existence, while you search for more information and the answers to your questions about JRA. One of the main reasons for putting together this website is my personal commitment to helping spread awareness of Juvenile Rheumatoid Arthritis (JRA). Until 1995, I didn't even know what those initials stood for. Unfortunately, most people still don't. Despite increasing numbers of cases, JRA has still not received a lot of public recognition. For many, it remains a more personal struggle. Hopefully, this will change. When there's greater public awareness of a significant health problem it's more likely there will be funding made available for its' study. With continued research comes the development of new, safer, and more effective medications. It is my hope that one day ... in the not so distant future ... a cure will be discovered. Possibly even a vaccine that will help prevent JRA in future generations of children.

7. THE MERCK MANUAL, Sec. 19, Ch. 270, Musculoskeletal And Connective Tissue Disord juvenile rheumatoid arthritis (JRA) is similar to adult RA (see Ch. http://www.merck.com/pubs/mmanual/section19/chapter270/270b.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 19. Pediatrics Chapter 270. Musculoskeletal And Connective Tissue Disorders Topics Rheumatic Fever Juvenile Rheumatoid Arthritis Common Hip, Knee, And Foot Disorders Inherited Connective Tissue Disorders ... The Osteochondroses Juvenile Rheumatoid Arthritis Arthritis beginning at or before age 16. Juvenile rheumatoid arthritis (JRA) is similar to adult RA (see Ch. 50 ). The disease tends to affect large and small joints and may interfere with growth and development. Micrognathia (receded chin) due to impaired mandible growth may occur. Symptoms and Signs Systemic onset (Still's disease) occurs in about 20% of patients. High fever, rash, splenomegaly, generalized adenopathy, serositis, and a striking neutrophilic leukocytosis and thrombocytosis occur often. At times these manifestations precede the appearance of the arthritis. Rheumatoid factor and antinuclear antibodies are absent. Pauciarticular onset occurs in about 40% of patients, usually young girls. Antinuclear antibodies are present in up to 75% of affected children. Chronic iridocyclitis occurs in nearly 20% of these patients; it is often asymptomatic and is detected only with periodic slit-lamp examinations. A subgroup of affected older boys includes many who have HLA-B27 antigen. Most of these boys subsequently develop classic features of one of the seronegative spondyloarthropathies: ankylosing spondylitis, inflammatory bowel disease, psoriatic arthropathy, or Reiter's syndrome.

8. Jessie's JRA Page A mother shares her personal story after her daughter is diagnosed with juvenile rheumatoid arthritis. Includes links to JRA information. http://www.geocities.com/beegal68/jessiesjra.html

To Jessie's JRA page A Mother and Daughter Journey... (Please,Click the picture above to enter) You are visitor number since July 2001 This page was created with the help of the Meta Tag Analyzer Script's provided by Dynamic Drive All Graphic's provided by Grace Lee at www.cutecolors.com

9. Juvenile Rheumatic Disease Group Website Online support for parents of children with a JRD, including juvenile rheumatoid arthritis, juvenile scleroderma, juvenile dermatomyositis, juvenile systemic lupus, and other rheumatic disorders. Includes resources. http://www.geocities.com/beegal68/JRD-Website.html

Welcome to the Juvenile Rheumatic Disease (JRD) Website ~Click the picture above to enter~ Graphic's provided by www.graphicgarden.com You are visitor number since October 2001 A Free Online Support Group Script's provided by Dynamic Drive This page was created with the help of the Meta Tag Analyzer Please, help save a child's life and read the above "Amber Alert". If you would like an Amber Alert ticker for your website, please, click the ticker!

10. Enbrel - Pharmaceutical Drugs Lawyer Enbrel lawyer provides litigation information about the juvenile rheumatoid arthritis drug, Enbrel. http://www.nessmotley.com/practiceareas/pharmaceutical_drugs/pharmaceutical_drug

search: legal services Overview Asbestos/Mesothelioma Bankruptcy ... Additional Resources If you have questions or want to explore your legal rights, please contact us See Also: Healthcare Fraud Pharmaceutical Drugs Litigation Enbrel Ness Motley filed in August one of the first cases against the manufacture of the biological product, Enbrel (etanercept). Enbrel (etanercept) was approved by the U.S. Food and Drug Administration on November 2, 1998, as a second-line agent for the treatment of juvenile rheumatoid arthritis. At the time Enbrel was co-marketed by Immunex, Corp. (in 2001 Amgen, Inc. bought Immunex Crop. of Seattle and Enbrel for some $16 billion, the largest biotech buyout ever) and Wyeth-Ayerst Pharmaceuticals. Although Enbrel has been touted in the press and through marketing as a wonder "drug", it is a potent product whose long term effects and mechanism of action are not known or fully understood. The adverse effects that are known are serious and fatal. Patients have neither been warned adequately of these risks nor their severity. Enbrel is a biological product (a genetically engineered antibody), which reduces the actions of chemicals in the body that are involved in inflammatory and immune responses. Specifically

11. MEDLINEplus Medical Encyclopedia: Juvenile Rheumatoid Arthritis juvenile rheumatoid arthritis. The cause of juvenile rheumatoid arthritisis unknown. Growth may be affected during periods of active disease. http://www.nlm.nih.gov/medlineplus/ency/article/000451.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Juvenile rheumatoid arthritis Contents of this page: Alternative names Definition Causes, incidence, and risk factors Symptoms ... Prevention Alternative names Juvenile chronic polyarthritis; JRA; Still's disease Definition Return to top A chronic , inflammatory disease that may cause joint or connective tissue damage. The onset occurs before age 16. Causes, incidence, and risk factors Return to top JRA is thought to belong to the collagen classes of disease (those diseases that involve connective tissue). It is a complicated disease. The primary manifestation is arthritis , but the disease may involve other body systems such as the heart and lining around the heart (pericardium), lungs and lining around the lungs (pleura), eyes, and skin. Systemic arthritis affects 20% of those with juvenile arthritis and includes fever rash , and enlarged spleen splenomegaly ) in addition to joint inflammation . JRA is generally divided into five broad groups depending on whether a large number of joints are involved or just a few, whether the rheumatoid factor (a blood test) is positive or negative, and whether there is eye involvement or not.

12. Why Do Kids Get Arthritis? Why do kids get arthritis? This is a juvenile rheumatoid arthritis sufferer's page. http://expage.com/page/achildwitharthritis

hy do kids get arthritis? anielle's Page to help us all deal with Arthritis a little better!!!! This website was created for all kids that want to chat about arthritis and how it effects lives (all lives)of those that know the disease and educate those that don't! My Story Hi my name is Danielle! I am 9 years old and I have had systemic onset juvenile rhuematoid arthritis since I was 3years old!! I had a state of remission when I was 6, it lasted for almost 3 years and returned again in Nov. 1999. I have had a hard time with the disease this time, during my remission I did anything I wanted to do and now I have a hard time doing anything. I love to play soccer but it was difficult for me this spring, I never played with active arthritis until then, and it was painful sometimes especially at the end of the day. I am going into the 4th grade this year, I like school, I have to miss alot when my disease is really active which was alot this year... I have a sister and 2 brothers, and we fight like all siblings do, but we have fun together also. I am interested in meeting others like me or anyone who wants to chat about or learn about arthritis so drop me a line!!!!!

13. Tylers JRA Story A mother's story of her son's journey with juvenile rheumatoid arthritis. http://www.geocities.com/beegal68/TylersJRAStory.html

14. Virtual Children's Hospital: CQQA: Juvenile Rheumatoid Arthritis (JRA) Common Questions, Quick Answers on juvenile rheumatoid arthritis (JRA) http://www.vh.org/Patients/IHB/Peds/CQQA/jra.html

Pediatrics Common Questions, Quick Answers Juvenile Rheumatoid Arthritis (JRA) Donna D'Alessandro, M.D. Lindsay Huth, B.A. Peer Review Status: Internally Reviewed Creation Date: May 2002 Last Revision Date: May 2002 Common Questions, Quick Answers What is juvenile rheumatoid arthritis? What causes it? Who can get it? ... When should I call the doctor? What is juvenile rheumatoid arthritis? Juvenile rheumatoid arthritis is also known as JRA. It is arthritis that affects children age 16 or younger. In JRA, the body's immune system starts to attack instead of protect the body's tissues. The attack can cause redness, swelling, and pain in the joints. There are three main types of JRA. They include pauciarticular, polyarticular, and systemic. Ask your doctor. What causes it? The cause is not known. It may be due to both genetic factors (from parents) and environmental factors (for example, from infections). Who can get it? Children age 16 and under can get JRA. It is more common in females. What are the signs and symptoms? Symptoms of JRA usually show up around the age of 4 or 5. To be diagnosed for JRA, symptoms must last at least 6 weeks. They may include:

15. Rheumatology - Pauciarticular Juvenile Rheumatoid Arthritis Rheumatology. PAUCIARTICULAR juvenile rheumatoid arthritis. Pauciarticularjuvenile rheumatoid arthritis falls into 2 distinct categories. http://www.mc.vanderbilt.edu/peds/pidl/rheum/jra_pauc.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Rheumatology PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS Juvenile rheumatoid arthritis is a chronic inflammatory disease that always involves the joints, but may produce extensive connective tissue and visceral lesions. Despite extensive research the etiology of JRA remains unclear. No autoantibody specific for the disease has been documented. Much evidence points to a major role for immunologic reactivity in perpetuating rheumatoid inflammation. Unidentified initiating factors probably stimulate a synovitis that triggers the local synthesis if IgG and rheumatoid factor (IgM anti- IgG) by plasma cells within the joint. Activation of the complement system within the joint space generates several materials that attract PMN's into the joint cavity, where they phagocytize the immune complex, thus leading to the formation of the rheumatoid arthritis cells. The neutrophils, following phagocytosis, are stimulated to discharge hydrolase from lysosomal granules. These enzymes together with fibrinogen may initiate the destructive changes characteristic of rheumatoid joint disease. JRA is arbitrarily defined as beginning before the age of 16 years. It is slightly more common in females than in males and is said to affect as many as 250,000 children in the United States. Although JRA may begin at any age, an increased incidence of onset generally occurs from 1- 3 years of age and later from 8- 12 years of age. Approximately 20% have acute systemic JRA which is characterized by febrile onset, variable joint manifestations, rash, generalized lymphadenopathy, splenomegaly, liver disease, and rarely by GI tract disease.

16. Juvenile Rheumatoid Arthritis Welcome to my humble website featuring Juvenile Rheumatiod Arthritis. Please enjoy the articles and information I have http://www.seffera.net/jra

Medical Links E-Mail Me Welcome to my humble website featuring Juvenile Rheumatiod Arthritis Please enjoy the articles and information I have provided, I do plan to add more in the near future. If you'd like to suggest a link for my links page, please do. I don't have many links yet and I'd like to link to others who also have JRA.. Myra

17. Juvenile Arthritis Awareness Juvenile arthritis awareness. A web site dedicated to the educationof juvenile rheumatoid arthritis. Introduction, The Facts about http://www.fyldecoast.co.uk/grace/grace.htm

50 Wood Street St Annes Tel Number: 01253 720303 Fax Number: 01253 728070 Reg Charity No:1061998 Patron: Dr Eileen Baildam Consultant Paediatrician (Booth Hall Childrens Hospital Manchester) Current appeal: Any good quality clothes and bric-a-brac!!!! Please deliver them to the shop or contact us and we'll arrange collection. Welcome to our web-site. We hope this will give you a greater understanding of juvenile chronic arthritis and the problems you may face as a parent. Please stay a while and have a browse through the various pages. We hope our information is of help to you. Please feel free to print a copy. If you do find it useful we would ask you to send a donation towards our hydro-pool fund. The site is constantly evolving and we'd love to hear your comments. Sign My Guestbook View My Guestbook Index Page ... Contact Us These pages have been donated at cost price to GRACE by Blackpool and the Fylde Coast Internet Magazine. All design was free of charge. Web Design by Snoop

18. Questions And Answers About Juvenile Rheumatoid Arthritis - FCIC can develop almost all types of arthritis that affect adults, but the most commontype of arthritis that affects children is juvenile rheumatoid arthritis. http://www.pueblo.gsa.gov/cic_text/health/juvarth/juvarthr.htm

Return to Federal Citizen Information Center Home Page Printer-friendly page Questions and Answers About Juvenile Rheumatoid Arthritis Publication Date: May 1998 What Is Arthritis? What Is Juvenile Rheumatoid Arthritis? How Is Juvenile Rheumatoid Arthritis Different From Adult Rheumatoid Arthritis? What Causes Juvenile Rheumatoid Arthritis? ... Acknowledgments What Is Arthritis? Arthritis means joint inflammation, and refers to a group of diseases that cause pain, swelling, stiffness and loss of motion in the joints. "Arthritis" is often used as a more general term to refer to the more than 100 rheumatic diseases that may affect the joints but can also cause pain, swelling, and stiffness in other supporting structures of the body such as muscles, tendons, ligaments, and bones. Some rheumatic diseases can affect other parts of the body, including various internal organs. Children can develop almost all types of arthritis that affect adults, but the most common type of arthritis that affects children is juvenile rheumatoid arthritis. What Is Juvenile Rheumatoid Arthritis?

19. ACR Virtual Newsroom Cancer Drug May Help Rheumatoid Arthritis Sufferers, 10/25/02. ACR Pediatric30 New Tool in Fight Against juvenile rheumatoid arthritis, 7/10/02. http://www.rheumatology.org/press/index.asp

Association of Rheumatology Health Professionals Research and ... Site Map Newsroom Read the press releases from the 2002 meeting, Oct. 24-29. Selected photos from the meeting are available for use by journalists filing stories. If you have any questions about the meeting, please email us . Media registration for the Oct. 24-28, 2003 ACR/ARHP Annual Scientific Meeting in Orlando will open in June 2003. Press Release Archive Prevalence Statistics Arthritis in the News If you need help with a story, please send your request to the ACR media relations staff . Please include your deadline as well as phone and fax numbers. To be added to the ACR's distribution list, send us your contact information. ACR Media Relations Staff ACR National Office Tammy McCoy Director of Communications and Marketing 1800 Century Place, Suite 250

20. The Health Library — Musculoskeletal System juvenile rheumatoid arthritisMEDLINEplus. juvenile rheumatoid arthritisNIAMS.juvenile rheumatoid arthritisLucile Packard Children's Hospital. http://healthlibrary.stanford.edu/resources/internet/bodysystems/musculoskeletal

Diseases and Disorders Use these links to jump directly to your topic of interest: Arthritis and Other Rheumatic Diseases Bone Diseases Cartilage Diseases Diagnostic Procedures ... Spine (Neck and Back) Disorders Musculoskeletal System: Page 1 Page 2 Page 3 Page 4 Page 5 ... Page 6 General Musculoskeletal Organizations National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Osteoporosis and Related Bone Diseases (NIORBD) American Academy of Orthopaedic Surgeons (AAOS) American College of Rheumatology ... Muscular Dystrophy Association (MDA) Overview Bones, Joints and Muscles Topics:MEDLINEplus Anatomy Bones, Muscles, and Joints, Basic Anatomy:The Nemours Foundation Body Guide: Muscular System:Wake Forest Medical Center Body Guide: Skeletal System:Wake Forest Medical Center Anatomy of a Joint:University of Utah Musculoskeletal Diagnostic Procedures Arthography:Radiological Society of North America Bone Mass Measurement:National Osteoporosis Foundation Bone Radiography (X-Ray):Radiological Society of North America CT Scanning of the Body:Radiological Society of North America ... Ultrasound Imaging of the Musculoskeletal System:Radiological Society of North America Arthritis and Other Rheumatic Diseases Arthritis and Rheumatic Diseases:NIAMS Types of Arthritis:The Arthritis Society Arthritis:MEDLINEplus New Arthritis Drugs for Rheumatoid Arthritis and Osteoarthritis:NIAMS ... Arthritis : Questions You Have ... Answers You Need:netLibrary

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