1. New Page 1 Designed to share research information as well as provide a location where others who are either suffering from this condition or attempting to treat it can share information and experiences. http://www.melorheostosis.com

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2. New Page 1 Links to research, articles, personal histories of patients and a discussion board.Category Health Conditions and Diseases melorheostosis...... http://206.139.180.51/default.htm

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3. Melorheostosis a CHORUS notecard document about melorheostosis melorheostosis. rare condition of cortical thickening of unknown etiology most commonly seen in the long bones http://chorus.rad.mcw.edu/doc/01061.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system Feedback Search melorheostosis rare condition of cortical thickening of unknown etiology most commonly seen in the long bones 3-59 years sx: usu. pain of varying severity, occ. limited ROM, contracture insidious onset and chronic course xray findings: cortical sclerosis and thickening that may encroach on the medullary canal looks like wax flowing down a candle Brian Funaki, MD - 6 February 1995 Last updated 14 March 2001 Medical College of Wisconsin

4. Uhrad.com - Musculoskeletal Imaging Teaching Files The suggested diagnosis is melorheostosis. Information on melorheostosis Designed to share research information as http://www.uhrad.com/msiarc/msi043.htm

uhrad.com - Musculoskeletal Imaging Teaching Files Case Forty Three - Melorheostosis Click On Images for Enlarged View Clinical History: Patient presents with lower extremity pain and swelling. Findings: Images #1 and 2 are plain films of the tibia demonstrating peripherally located hyperostosis producing a wavy sclerotic bony contour along the tibial diaphysis. There are similar findings involving the first metatarsal as well as the navicular and first cuneiform bone. In addition, there are soft tissue calcifications adjacent to the navicular and cuneiform. Diagnosis: Melorheostosis. Discussion: Melorheostosis is a rare disorder of bone which generally presents in early childhood. There are no known hereditary factors. The initial clinical presentation includes diffuse joint pain as well as swelling with associated limitation of motion. Other potential complications include muscle contractures as well as soft tissue involvement including calcifications. More severe cases will demonstrate growth disturbance which may lead to scoliosis, contractures, and deformities which may be severe. Radiologic manifestations are most commonly limited to a single limb, although multiple limbs may on occasion be involved. Melorheostosis most commonly involves the lower extremity, and is rarely see in the skull, facial bones, and ribs. The findings most commonly consist of osseous excrescences extending along the length of a bone simulating the appearance of "candle wax" dripping down the side of a candle. In the carpal and tarsal bones, there may be more discrete rounded regions of bony sclerosis as well as adjacent soft tissue calcifications. Nucleide scintigraphy cases of melorheostosis demonstrate a region of increased nucleide uptake. MR imaging demonstrate regions of decreased signal intensity on all pulse sequences.

5. MELORHEOSTOSIS OF THE HAND: A COMPREHENSIVE REVIEW ABSTRACT. melorheostosis is an uncommon disorder characterized by soft tissue contractures and sclerosis of bone. http://www.worldscinet.com/hs/03/0301/S0218810498000167.html

What's New New Journals Browse Journals Search ... Advertising Enquiries Hand Surgery, Vol. 3, No. 1 (June 1998) 123-130 doi:10.1142/S0218810498000167 MELORHEOSTOSIS OF THE HAND: A COMPREHENSIVE REVIEW J. Michael Wiater, Jeffrey C. King, Dean S. Louis and James Smith The Hand Service in the Section of Orthopaedic Surgery at the University of Michigan, Ann Arbor, MI Department of Orthopaedic Surgery, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, MI ABSTRACT Melorheostosis is an uncommon disorder characterized by soft tissue contractures and sclerosis of bone. The sclerosis appears to flow along the long axis of the bone, akin to candle wax dripping down one side of a candle. Numerous reports of lower extremity involvement exist, but there are few detailed reports of melorheotosis involving the hand. This condition is benign but slowly progressive and can usually be managed conservatively. Loss of function of the hand from swelling, pain, or stiffness, however, may necessitate operative intervention. Two recent cases prompted a review of the literature relating to melorheostosis and the hand. Footnotes: Correspondence to: Dr Dean S. Louis, Section of Orthopaedic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, USA 48109.

6. Melorheostosis This 26 y/o male came to the ER complaining of increasing arm pain. An xray was performed. A selected image shown above demonstrates findings of melorheostosis. http://home.earthlink.net/~radiologist/tf/120301.htm

This 26 y/o male came to the ER complaining of increasing arm pain. An x-ray was performed. A selected image shown above demonstrates findings of melorheostosis. Rotate the image (or your monitor) to the left (or your head to the right) and you will see the "flowing wax" appearance better. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol 2000;10(9):1423-33 PMID:10997431 Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J 1999 Oct;50(5):324-30 PMID:10555508 Rozencwaig R, Wilson MR, McFarland GB Jr. Melorheostosis. Am J Orthop 1997 Feb;26(2):83-9 PMID:9040882 Azuma H, Sakada T, Tanabe H, Handa M. Melorheostosis of the hand: a report of two cases. J Hand Surg [Am] 1992 Nov;17(6):1076-8 PMID:1430941 Williams JW, Monaghan D, Barrington NA. Cranio-facial melorheostosis: case report and review of the literature. Br J Radiol 1991 Jan;64(757):60-2 PMID:1998841 Perlman MD. Melorheostosis: a case report and literature review. J Foot Surg 1990 Jul-Aug;29(4):353-6 PMID:2229911

7. Electronic Journal Of Hand Surgery - Edition 2 A case study of a girl who had progressive and abnormal growth of the index finger of her left hand which was not enlarged at birth but grew steadily after birth. The suggested diagnosis is melorheostosis. http://www.leeds.ac.uk/handsurgery/EJHS/overgr.htm

Case Report for discussion This girl had progressive and abnormal growth of the index finger of her left hand which was not enlarged at birth but grew steadily after birth. The hand did not resemble a typical macrodactyly in that there was peculiarities of cortical bone growth as seen in the scans and these abnormalities were particularly confined to the ulnar surface. Surgical exploration did not reveal any evidence of lipomatous infiltration at the digital nerves. Suggested explanations have included fibrous dysplasia and there are no endocrine or metabolic abnormalities. Does anybody have a suggestion for diagnosis or investigation here? Responses received on this case report: Melorheostosis is a rare, non familial condition condition characterized by inequality of extremity length, joint deformities and hyperostosis. The clinical features of the condition in children differs from that in adults in a few ways: 1. Asymmetric limb contractures are presenting features in children whereas adults present with painful mass 2. Pain is not a feature in children whereas it is in adults

8. CLASSIFIEDS.TERADEX.COM - Health/Fitness/Diseases/Rare Disorders/Melorheostosis CLASSIFIEDS.TERADEX.COM Health/Fitness/Diseases/Rare Disorders/melorheostosis http://classifieds.teradex.com/Health_Fitness/Diseases/Rare_Disorders/Melorheost

preloadImages('as_free_x-mail','','as_ad-space'); Add your Web Site Add Search to your Site Search: Current Group Entire Site Results per page: Output format: Long Short URL Match: All Any Boolean CLASSIFIEDS Health/Fitness Diseases Rare Disorders ... Melorheostosis Page 1 of 1 Submit Classifieds Ad Edit Ads Ad Headline User ID ... Classified Ads Open adlistings Submit Classifieds Ads! Sign Up User Name: Password: Edit in Real Time, Classifieds Ad Placement E-Mail: webmaster@teradex.com Aaex Corp.

9. PERSONAL INFORMATION AND EXPERIENCE Personal Histories. Shared by melorheostosis Patients. Alice, Adult, 2/23/2001,Left arm and shoulder (melorheostosis and osteopoikilosis), Lansing, Michigan. http://206.139.180.51/PIF master.htm

Personal Histories Shared by Melorheostosis Patients The following information is shared by fellow m elorheostosis patients about their own personal experience in dealing with this rare condition. It is in no way intended as a recommendation of any particular treatment, surgery, therapy or course of action, nor as a substitute for the expertise and judgment of your physician or other health care professional. Name Child/Adult Date Submitted Area of Body Affected Location Michelle Adult Right foot; knees, back and pelvis Fareham, Hampshire, England Michele Adult Right ankle and foot Edgewater, New Jersey Jody (Jill, mother) Child Left arm and hand Portland, Oregon Pamula Adult Left tibia, fibula Madison Heights, VA Michael Adult Left leg and foot Stevens Point, WI Elaine Adult Foot, femur, hand Hamden, Connecticut Steve Adult Right hip to foot Stamford, CT Krystal Austin (Terry, mother) Adult Foot Brownsville, TN Jessica (Becky, mother) Child Hand, wrist, forearm and shoulder Fort Madison, Iowa Elizabeth Adult Left knee Reading, Berkshire, UK Maria Daniela Adult Right leg Santa Rosa, Argentina

10. MESSAGES.TERADEX.COM - Health/Fitness/Diseases/Rare Disorders/Melorheostosis MESSAGES / Health/Fitness / Diseases / Rare Disorders / melorheostosis. Page 1 of 1 http://messages.teradex.com/Health_Fitness/Diseases/Rare_Disorders/Melorheostosi

preloadImages('as_free_x-mail','','as_ad-space'); Add your Web Site Add Search to your Site Search: Current Group Entire Site Results per page: Output format: Long Short Match: All Any Boolean MESSAGES Health/Fitness Diseases Rare Disorders ... Melorheostosis Page 1 of 1 Post New Message Subject User ID Date/Time ... Message Boards Open messagelistings Post Message! Sign Up User Name: Password: Post in Real Time, Message Board E-Mail: webmaster@teradex.com Aaex Corp.

11. Melorheostosis The etiology and incidence of melorheostosis is unknown. Bone dysplasia series. melorheostosisreview and update. Can Assoc Radiol J. 1999 Oct;50(5)32430. http://www.stevensorenson.com/residents6/melorheostosis.htm

Home Up Cleidocranial dysostosis [ Melorheostosis ] Osteopathia striata Osteopetrosis Osteopoikilosis Proximal focal femoral deficiency ... Camurati-Engelmann disease The etiology and incidence of melorheostosis is unknown. It is often discovered as an incidental finding on radiographs acquired for other reasons. Other patients may have bone pain, limited range of motion, and joint fusion. The disease consists of cortical hyperostosis ("candle wax") in a dermatomal distribution. The location is usually diaphyseal. The process often crosses joints and may result in flexion contractures. The overlying skin may become thickened. REFERENCES Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J. 1999 Oct;50(5):324-30. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol. 2000;10(9):1423-33 BACK

12. MELORHEOSTOSIS Features Listed For melorheostosis. McKusick 155950. Cortical hyperostosis/thickening;Dislocated patella; Joint stiffness/arthritis; Melorrheostosis; http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?1111

13. Melorheostosis only. melorheostosis,, Print this article, sequences. Other diseases withwhich melorheostosis has been associated are listed in Table 1. http://www.amershamhealth.com/medcyclopaedia/Volume III 1/MELORHEOSTOSIS.asp

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Melorheostosis, a rare bone disorder whose initial manifestations include swelling of joints, pain, and limitation of motion. Eventually profound muscle contractures, tendon and ligament shortening, and soft tissue involvement with severe growth disturbances may ensue. Scoliosis, joint contracture and foot deformities may be seen. Frequently the radiographic alterations are limited to a single limb, more often the lower extremity. Cortical hyperostosis having the appearance of bone excrescences extending along its length resembles candle wax flowing down the side of a lit candle ( Fig.1

14. Melorheostosis only. melorheostosis,, Print this article, nonhereditary ankylosis. GL TheEncyclopaedia of Medical Imaging Volume VII. melorheostosis, Fig. 1 http://www.amershamhealth.com/medcyclopaedia/Volume VII/MELORHEOSTOSIS.asp

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Melorheostosis, nonhereditary condition of unknown aetiology usually confined to one limb, most commonly the leg, and usually involving at least 2 bones in a dermatomal distribution. Clinically the limb is stiff and painful, there may be thickening of the overlying skin and soft tissue contractures and fibrosis. Radiographs show dense cortical hyperostosis along long bones with a "dripping candlewax" appearance which may appear to flow from one bone to the next ( Fig.1 ). In a child the hyperostosis appears predominantly endosteal as opposed to an adult in whom it is usually more dramatic and causes an increase in the width of the bone. Epiphyses, carpal or tarsal bones tend to show more discrete rounded sclerotic foci (similar to osteopoikolosis) and flat bones may show radiating sclerotic patches. Radiographs may also show soft tissue calcification or ossification and joint ankylosis. GL The Encyclopaedia of Medical Imaging Volume VII Melorheostosis, Fig. 1

15. Melorheostosis melorheostosis. rare condition of cortical thickening of unknown etiology most commonly seen in the long bones http://chorus.rad.mcw.edu/to-go/01061.html

melorheostosis rare condition of cortical thickening of unknown etiology most commonly seen in the long bones 3-59 years sx: usu. pain of varying severity, occ. limited ROM, contracture insidious onset and chronic course xray findings: cortical sclerosis and thickening that may encroach on the medullary canal looks like wax flowing down a candle Home Musculoskeletal system

16. TOUS: CAS MELORHEOSTOSIS Les dossiers classés en melorheostosis . ABNORMALITIES melorheostosis,HAND,ABNORMALITIES. BONES melorheostosis,BONES, SCLEROSIS,BONES, MRSTUDIES. http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/tous/MELORHEOSTOSIS.html

ABNORMALITIES : MELORHEOSTOSIS,HAND, ABNORMALITIES BONES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES HAND : MELORHEOSTOSIS,HAND, ABNORMALITIES MR STUDIES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES SCLEROSIS : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES Total: 2 cas cliniques Sommaire des Index de Radiologie

17. OSTEO-ARTICULAIRE: CAS MELORHEOSTOSIS OSTEOARTICULAIRE Les dossiers classés en melorheostosis . SCLEROSIS melorheostosis,BONES, SCLEROSIS,BONES, MRSTUDIES. Total 2 cas cliniques http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/O/MELORHEOSTOSIS.html

ABNORMALITIES : MELORHEOSTOSIS,HAND, ABNORMALITIES BONES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES HAND : MELORHEOSTOSIS,HAND, ABNORMALITIES MR STUDIES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES SCLEROSIS : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES Total: 2 cas cliniques

18. Osteopoikilosis - Melorheostosis - HUM-MOLGEN We are searching for families with autosomal dominant osteopoikilosis (with orwithout individuals with melorheostosis)in order to determine the genetic http://www.hum-molgen.de/bb/Forum2/HTML/000104.html

home genetic news bioinformatics biotechnology ... DIAGnostics - Clinical Research (professional requests) osteopoikilosis - melorheostosis profile register preferences faq ... next oldest topic Author Topic: osteopoikilosis - melorheostosis philippe Member posted 04-16-2002 01:48 PM We are searching for families with autosomal dominant osteopoikilosis (with or without individuals with melorheostosis)in order to determine the genetic localisation of this disease. Please contact Philippe Debeer Centre for Human Genetics, Herestraat 49 B-3000 Leuven Belgium e-mail hilippe.debeer@med.kuleuven.ac.be IP: 134.58.253.114 All times are ET (US) next newest topic next oldest topic Administrative Options: Close Topic Archive/Move Delete Topic Hop to: Select a Forum or Archive List of Forums: Biotechnical requests and sources DIAGnostics - Clinical Research (professional requests) Ethical, legal and social implications Open Topic Forum List of Archives: Genetic News Contact Us HUM-MOLGEN HUM-MOLGEN Powered by: Ultimate Bulletin Board, Version 5.44a By posting requests at HUM-MOLGEN you reach more than 8.000 mailing list subscribers and a 6 digit number of www users. Therefore post high quality messages only, including full name and institutional address.

19. 1Up Health > Health Links Directory > Conditions And Diseases: Rare Disorders: M The suggested diagnosis is melorheostosis. melorheostosis.com Links to research,articles, personal histories of patients and a discussion board. http://www.1uphealth.com/links/rare-disorders-melorheostosis.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Rare Disorders : Melorheostosis Description See Related Categories Health: Conditions and Diseases: Musculoskeletal Disorders Sites Electronic Journal of Hand Surgery A case study of a girl who had progressive and abnormal growth of the index finger of her left hand which was not enlarged at birth but grew steadily after birth. The suggested diagnosis is melorheostosis. Information on Melorheostosis Designed to share research information as well as provide a location where others who are either suffering from this condition or attempting to treat it can share information and experiences. Melorheostosis.com Links to research, articles, personal histories of patients and a discussion board. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement.

20. 1Up Health > Health Links Directory >Conditions And Diseases:Rare Disorders:Melo 1UpHealth Health Directory Conditions_and_Diseases Rare_Disorders melorheostosisA rare disorder which affects both bone and soft tissues. http://www.1uphealth.com/links/desc-647.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Melorheostosis A rare disorder which affects both bone and soft tissues. While the disorder is benign, it can result in severe functional limitations, extensive pain, and significant deformity. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites. Home Contact Us Privacy Links Directory

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