81. Arch Intern Med -- Page Not Found 158;102, January 12, 1998, Asymptomatic mitral and Aortic valve disease Is Seen inHalf of the Patients Taking lsquoPhenFen', Len Griffen, MD; Michael Anchors http://archinte.ama-assn.org/issues/v158n1/ffull/ilt0112-9.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

82. PREVALENCE OF MITRAL VALVE PROLAPSE IN SAUDI SICKLE CELL DISEASE PATIENTS IN DAM mitral valve prolapse in sickle cell disease presumptive evidence for alinked connective tissue disorder. Arch Intern Med 1985;145435-8. 12. http://www.kfshrc.edu.sa/annals/153/94229.html

May 1995 PREVALENCE OF MITRAL VALVE PROLAPSE IN SAUDI SICKLE CELL DISEASE PATIENTS IN DAMMAM - A PROSPECTIVE-CONTROLLED ECHOCARDIOGRAPHIC STUDY Akhtar Husain, MBBS, FACC; Gani O. A. Ladipo, MBChB, FRCP, FACC; Mohammed Fakhry Abdul-Mohsen, DM, MSc, MD; Huxley Knox-Macaulay, FRCP, FRCPE From the Department of Internal Medicine (Drs. Husain, Ladipo, Abdul-Mohsen), King Faisal University, Dammam and the Department of Hematology (Dr. Knox-Macaulay), King Fahd Hospital of the University, Al Khobar. Address reprint requests and correspondence to Dr. Akhtar Husain: P.O. Box 40033, Al Khobar 31952, Saudi Arabia. Accepted for publication 18 October 1994. Ann Saudi Med 1995;15(3):244-248. Material and Methods Study Population The study population consisted of consecutive patients with SCD and those with chronic anemia (other than SCD) who were either admitted to King Fahd Hospital of the University or attending the outpatient department. Control subjects were volunteers from hospital employees, blood donors and medical students. They all had their heights and weights recorded. Informed consent was obtained from all subjects who participated in the study after approval from the research committee of the College of Medicine and Medical Science, King Faisal University. Hematological Investigations All subjects had a complete blood count (CBC), hemoglobin electrophoresis (including quantitation of HbF and HbA2), determination of serum iron, serum ferritin and total iron binding capacity.

83. Mitral Insufficiency In Dogs: Pet Health Topics From The College Of Veterinary M Dogs with mitral insufficiency may not show signs or to severe heart failure, Earlyin the disease process, your a soft murmur when the affected valve starts to http://www.vetmed.wsu.edu/ClientED/mi.html

CVM Home Heart Valve Malfunction in the Dog (Mitral Insufficiency ) Topics Index Terminology This information is not meant to be a substitute for veterinary care. Always follow the instructions provided by your veterinarian. Mitral insufficiency is a leaking heart valve Anatomy of the heart of a dog Many dogs slowly develop degenerative thickening and progressive deformity of one or more heart valves as they age. In time, these changes cause the valve to leak. The mitral valve is most commonly affected. This valve separates the blood collecting chamber (left atrium) from the pumping chamber (left ventricle) leading to the body. Some dogs also develop these changes in the tricuspid valve, which separates the collecting (right atrium) and pumping (right ventricle) chamber leading to the lungs. Certain breeds have an inherited predisposition to this disease. Degenerative valvular disease is slowly progressive over years and is non-reversible. The volume of blood that leaks back into the atrium with each heartbeat tends to increase slowly over time. However, many dogs with this disease never develop signs of congestive heart failure even though they may have a loud murmur. Dogs with mitral insufficiency may not show signs or may develop mild to severe heart failure Reduced exercise ability may be the first sign of heart failure.

84. Understanding Mitral Valve Prolapse Syndrome Page Boudoulas, J. (1992). mitral valve prolapse Etiology, clinical presentationand neuroendocrinefunction. Journal Heart valve disease, 1, 175188. http://www.nursing.wright.edu/practice/mvp/default.htm

Understanding the Mitral Valve Prolapse Syndrome The following is an excerpt from Chapter I of book, See reviews on Amazon.com Taking Control: Living with the mitral valve prolapse syndrome (To order the book, click on the above link.) ©K.A. SCORDO 1996 "I'm only 25 years old. How could I be having a heart attack?" "I was given no explanation other than 'don't worry'." "We would race to the hospital only to be sent home." "I was beginning to believe I was crazy it was all in my head." "I feel like a second class citizen. How come no one is taking this seriously?" The story is all too familiar. First, you search for a diagnosis. After several visits with a physician and multiple tests, you're finally given a reason for the symptoms, and then tolddon't worry. Now the questions begin. "What do I have? Mitral valve what? What does that mean? Will it get worse? Does my valve have to be replaced? Am I having a heart attack because I have chest pain? Will this affect my pregnancy? Is this common? How can I feel better?" More than likely, you had similar thoughts and questions when you were first diagnosed with mitral valve prolapse. Perhaps you still have a number of questions. Let me begin by telling you, you are not alone. You are among millions of people with MVP or MVPers.

85. Health Ency.: Disease: Mitral Valve Prolapse Ency. home disease M mitral valve prolapse. mitral valve prolapseSee images. Ency. home disease M mitral valve prolapse. http://www.accessatlanta.com/shared/health/adam/ency/article/000180.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease M Mitral valve prolapse See images Overview Symptoms Treatment ... Prevention Alternative names: Barlow's syndrome; Floppy mitral valve; Myxomatous mitral valve; Billowing mitral valve; Systolic click-murmur syndrome; Prolapsing mitral leaflet syndrome Definition: A disorder in which the mitral heart valve billows out and does not close properly, allowing blood to leak (backflow) into the left atrium. Causes and Risks Mitral valve prolapse (MVP) is one cause of mitral regurgitation (leakage of blood from insufficient valve closure). It occurs in about .3% to 5% of the adult US population; women are affected twice as commonly as males. Mitral valve prolapse is the most common cause of mitral regurgitation requiring surgical treatment in the US. Some forms of MVP seem to be hereditary. MVP has been associated with Marfan's syndrome characteristics. Most individuals with mitral valve prolapse are thin women who may have minor chest wall deformities, scoliosis , or other disorders. There may also be an

86. PROFESSIONAL REFERENCE Allergy Immunlogy Cardiology Dermatology The five most common types of heart valve disease are mitral valve prolapse, mitralstenosis, mitral regurgitation, aortic stenosis, and aortic regurgitation http://praxis.md/index.asp?page=bhg_brief&chapter=BHG01CA16

87. Lahey Clinic | Heart Valve Disease: Keeping Blood On Course Some patients, however, are not candidates for balloon valvotomy becauseof advanced disease of the mitral valve. The alternative http://www.lahey.org/media/healet/spring2000/heart_valve_disease.stm

Health Magazine Lahey Homepage Appointment Request Physician Finder Site Map / Search ... Spring, 2000 Heart Valve Disease: Keeping Blood on Course Back Next Last spring, Sudbury pediatrician Michael Robinson, MD, noticed he was getting short of breath when he exercised. For Robinson, 62, who swims laps six mornings a week to keep fit, that was unusual. But he wasn't concerned until he fainted after sprinting up the stairs in his house. At that point Robinson knew something was definitely awry. "I'd known for years that I was born with a defect in one of my heart valves, and was aware it might someday cause problems," he says. "So I made an appointment right away with a cardiologist to get it checked out." Robinson went to William H. Gaasch, MD, a widely recognized expert in heart valve disease and interim chair of cardiology at Lahey Clinic Medical Center. Following a physical examination and diagnostic tests, Gaasch determined that Robinson had a condition called aortic stenosis. Stenosis is said to be present when a heart valve - in this case the aortic valve - becomes narrowed, or "stenotic," due to abnormalities present since birth or degeneration caused by aging. Less commonly it occurs as a result of rheumatic fever.

88. IMD 420D: Cardiology Case Studies - VALVE DISEASE CASE DISCUSSIONS The valve disease here is aortic stenosis (AS AS is surgical replacement using a prostheticvalve. in contrast to balloon valvuloplasty of mitral stenosis that http://medocs.ucdavis.edu/imd/420d/cases/valve.htm

VALVE DISEASE CASE DISCUSSIONS Case 1 Case 2 Case 3

89. Aortic Or Mitral Valve Regurgitation: 2003 Tips For Fen Phen Matrix Claimants fenfluramine and dexfenfluramine cause a fatal disease known as primary pulmonaryhypertension ( PPH ). Fen Phen Patients with mitral valve Regurgitation or http://www.fen-phen-legal-resources.com/matrix.htm

Read about key events in the Diet Drugs recall and litigation by clicking here CNN Special Report, August 22, 2001: Doctors caution use of weight-loss drugs CNN Health, July 8, 1997, "Doctors Say Fen-Phen Causes Heart Disease" (Adobe Acrobat format) Diet Drugs Press Articles by y ear: Tips for Matrix Compensation Claimants Fen Phen (also spelled Phen Phen) patients with qualifying heart valve damage (known as Matrix Claimants) need to understand their rights and obligations under the settlement. Overview: Identification and Function of Valves in the Human Heart Malfunction of one of the four valves within the heart can cause problems that affect the entire circulatory system. A leaky valve does not close all the way, allowing some blood to flow backward as the heart contracts. This backward flow decreases the amount of oxygen the heart can deliver to the tissues with each beat. Symptoms of heart valve disease include shortness of breath, swelling in the legs, chest pain and heart palpitations. Phen Phen Background During the period from March to August 1997, the Mayo Clinic in Rochester, Minnesota observed and reported an association between the use of fenfluramine and/or dexfenfluramine and valvular heart disease ("VHD"). On September 15, 1997, AHP and the FDA announced that there would be no further sales of Pondimin and Redux in the United States. Since the withdrawal. epidemiological studies have established a causal relationship between fenfluramine and dexfenfluramine and VHD. Epidemiological studies have also established that fenfluramine and dexfenfluramine cause a fatal disease known as primary pulmonary hypertension ("PPH").

90. InteliHealth: If you have mitral valve prolapse, rest assured that the condition is usually notserious. Millions of people have mild disease and need nothing further done. http://www.intelihealth.com/IH/ihtIH/WSIHW000/8059/28040/152191.html?d=dmtConten

91. Severe Mitral Valve Regurgitation - Primary Pulmonary Hypertension - Fen-Phen, R posterior leaflet and/or commissural fusion), except where there is no evidence ofrheumatic valve disease upon pathological examination of mitral valve tissue http://www.elslaw.com/redux_ahp.htm

- AHP Settlement January 3rd Deadline Other Deadlines ... - In the News Fen-Phen AHP Settlement Read about the nationwide Class Action Settlement that has been reached with American Home Products Corporation which will resolve the claims of individuals who took the diet drugs Pondimin and/or Redux. Learn more about the January 3, 2003 deadline. Learn more about other important deadlines Learn more about correcting incomplete or deficient claims Learn about your options if you don't have written proof of diet drug use Learn more about opting out of the settlement. Have your Screening Program results (Echocardiogram) independently evaluated. The class action settlement with AHP does not apply to persons suffering from primary pulmonary hypertension (PPH) caused by Fen-Phen. PPH patients must pursue their legal claims in independent lawsuits. Diet Drug Settlement With American Home Products Corporation Settlement Matrix Compensation Benefits Guide for Physicians, Attorneys and Class Members: A. A nationwide Class Action Settlement has been reached with American Home Products Corporation which will resolve the claims of individuals who took the diet drugs Pondimin and/or Redux. B.

92. Valve Disease PV Loops Cardiac valve disease significantly alters ventricular pressure and volumerelationships during the cardiac cycle. mitral stenosis. Aortic stenosis. http://www.cvphysiology.com/Heart Disease/HD009.htm

Cardiovascular Physiology Concepts Richard E. Klabunde, Ph.D. HOME Search Contents ... Tutorials Physiology Topics: Electrophysiology Electrocardiogram Hemodynamics Cardiac Cycle ... Capillary Exchange Clinical Topics: Abnormal Rhythm Valve Disease Heart Failure Edema ... Peripheral Artery Disease Ventricular Pressure-Volume Loop Changes in Valve Disease Cardiac valve disease significantly alters ventricular pressure and volume relationships during the cardiac cycle. A convenient way to analyze cardiac pressure and volume changes is by using ventricular pressure-volume loops . The following describes pressure-volume changes that occur during: Mitral stenosis Aortic stenosis Mitral regurgitation Aortic regurgitation Mitral Stenosis Mitral stenosis impairs left ventricular filling so that there is a decrease in end-diastolic volume ( preload ). This leads to a decrease in stroke volume by the Frank-Starling mechanism and a fall in cardiac output and aortic pressure. This reduction in afterload (particularly aortic diastolic pressure) enables the end-systolic volume to decrease slightly, but not enough to overcome the decline in end-diastolic volume. These changes just described do not include cardiac and systemic compensatory mechanisms that attempt to maintain cardiac output and arterial pressure. These compensatory responses include, but are not limited to systemic vasoconstriction, increased blood volume, and increased heart rate and inotropy.

93. CHS ~ 1999-2003 Questions And Answers: Heart Disease: Mitral Valve Prolapse 19992003 Questions and Answers. Heart disease mitral valve Prolapse(8). Question Dear Dr. Marsh, I would like to ask more explanation http://www.coloradohealthsite.org/chnqna.html?Heart Disease?Mitral Valve Prolaps

94. Types Of Heart Valve Disease And Heart Disorders Heart valve disease Diagnosing Heart valve disease After The a defect in the heartor heart valve. mitral valve Prolapse a common heart condition in which http://www.ethiconinc.com/cardio_prod/valve_types.html

95. The Health Library — Cardiovascular Aortic valve RegurgitationWebMD. Aortic valve StenosisWebMD. mitral valveDisease. Facts About mitral valve ProlapseNHLBI. mitral valve ProlapseWebMD. http://healthlibrary.stanford.edu/resources/internet/bodysystems/cardiovascular3

Diseases and Disorders Use these links to jump directly to your topic of interest: Anatomy Aneurysms Angiomas Aortic Diseases ... Varicose Veins Cardiovascular: Page 1 Page 2 Page 4 Page 5 ... Page 6 Coronary Disease Coronary Disease: MEDLINEplus Coronary Artery Disease:Texas Heart Institute Coronary Artery Disease: Mayo Clinic Coronary Artery Disease, Physician's Reference Guide:American Board of Family Practice ... Vulnerable Plaque:Texas Heart Institute Angina Chest Pain:Cardiology Channel Angina: MEDLINEplus Angina and Heart Disease:American Academy of Family Physicians Angina:Texas Heart Institute ... Transmyocardial Revascularization and Angina: American Heart Association Angioplasty Angioplasty:MEDLINEplus Coronary Angioplasty: Opening Clogged Arteries:Mayo Clinic Angioplasty: A Patient Guide:Heart Information Network Angioplasty, Percutaneous Transluminal Coronary (PTCA:): American Heart Association ... Restenosis:Angioplasty PTCA Home Page Coronary Bypass Surgery Heart Bypass Surgery:MEDLINEplus Coronary Artery Bypass Surgery: Texas Heart Institute Bypass Surgery: A Patient Guide:Heart Information Network Coronary Artery Bypass Grafting (CABG):Society of Thoracic Surgeons ... The Internal Mammary Artery:Heart Surgery Forum Heart Attack (Myocardial Infarction) Heart Attack:MEDLINEplus Heart Attack Basics:Mid-Atlantic Surgical Associates Heart Attack: A Patient Guide:Heart Information Network Heart Attack:Texas Heart Institute ... Acute Coronary Syndromes:netLibrary Heart Valve Diseases Overviews Heart Valve Diseases: MEDLINEplus Valve Disease:Cleveland Clinic Heart Center Valve Disease:Texas Heart Institute Types of Valve Disease:Texas Heart Institute ... Valvular Disorders of the Heart:Internet Medical Education See also

96. Columbia University Department Of Surgery In fact, many experts consider it a variation of normal function rather than a diseaseper se. mitral valve prolapse is characterized by failure of a mitral http://www.columbiasurgery.org/divisions/cardiac/dm_valve.html

Shortcuts Directions Events Find the Right Doctor Physician Directory Risk Assessments Search Second Opinion Send for Info Site Map HEART VALVE DISEASE DEFINITION The heart's 4 valves help direct the flow of blood through its chambers (see figure 16.5 ). All of these valves are composed of thin leaflets that when closed prevent a backflow of blood and when open permit the blood to move forward to its next destination. When a valve fails to close properly, as is the case in a common disorder called mitral valve prolapse, there is a regurgitation or backflow of blood. A valve that fails to open properly—a condition called valvular stenosis—impairs the forward flow of blood to the body. In either case, the heart has to work harder to pump enough blood to the body, eventually leading to heart muscle damage. Congestive heart failure, syncope (fainting), and arrhythmias are common signs of valve disease. CAUSE A number of conditions can lead to heart valve disease. Congenital defects and infections, such as rheumatic fever, are among the most common. Rheumatic heart disease, although greatly diminished since the advent of antibiotics to treat streptococcal infections, still affects more than 1 million Americans and causes about 6,000 deaths per year. DIAGNOSIS In many cases, people can have a diseased heart valve for many years without suffering any symptoms or even being aware of the problem. Diseased valves can be detected by murmurs or other unusual sounds heard through a stethoscope. Ultrasound examination of the heart, also called echocardiography, in which sound waves are used to map internal structures, is also helpful. The most precise diagnosis is made by cardiac catheterization and angiocardiography.

97. Valve Disease valve disease. We invite you to explore our indepth health informationon this topic by visiting the pages listed below http://216.68.156.42/regions/cincinnati/content/hm_heart_diseases_valve_disease.

QUICK FIND Health Information Find A Physician For Nurses Job Openings Supporting the Mission Mercy Healthcare Library Services HEART CARE MENU Heart Diseases Prevention Cardiac Rehabilitation Search Heart Center Heart Care Books Valve Disease We invite you to explore our in-depth health information on this topic by visiting the pages listed below: Aortic Valve Stenosis Heart Valve Repair Heart Valve Replacement Mitral Valve Insufficiency ... Tricuspid Valve Stenosis Return to Heart Diseases Information. Privacy Statement © Catholic Healthcare Partners

98. Radiology Case 534-831 Radiology teaching, mitral stenosis, radiology case examples http://www.sbu.ac.uk/dirt/museum/534-831.html

Clinical presentation: Adult male with a long history of breathlessness, on exertion. Diagnosis Differential Similar appearances to this image. There is a bulky heart. Its contour is not normal. The pleural silhouette of the aortopulmonary reflection extends down to a bulge on the left heart margin. This has a smaller radius of curvature than the left heart margin. There is a double contour to the right heart margin. The upper margin is the ascending aorta, which has a different radius of curvature from the lower. The centre of radius of the lower curve is behind the heart. The tracheal bifurcation is not well shown, but the left hilum is a little depressed. Its dense portion is normally above the right because of the presence of the ligamentum arteriosum. There is an ill-defined density behind the left heart. The silhouette of the left lower lobe vessels is lost. Clinical presentation: 40 year old woman with breathlessness, on exertion. She had rheumatic fever at the age of 9 years. Diagnosis Differential Similar appearances to this image.

99. Untitled An Educational Resource for Canine Cardiology http://www.usask.ca/wcvm/canine

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