21. Multiple Myeloma  Innovative Therapy The overall survival in multiple myeloma has not changed significantly over the past30 years. Supportive Care, Less Frequent Procrit Dosing in multiple myeloma. http://www.clevelandclinic.org/myeloma/mmstudy.html

The following are the Research Protocols for the different Management stages of Multiple Myeloma Newly Diagnosed Doxil, Vincristine, Decadron, and Thalidomide . This is a trial that evaluates the role of thalidomide in improving response rate as well as the quality of response to DVd Doxil, Vincristine and Decadron (DVd) vs. VAD in newly diagnosed myeloma Phase III Trial in Newly Diagnosed Multiple Myeloma patients. this study is to confirm the results of the phase II DVd trial performed at our institutions Refractory/Relapsed Phase II Study of Arsenic Trioxide in Patients with Multiple Myeloma Doxil, Vincristine, Decadron, and Thalidomide this study is designed to evaluate the role of Thalidomide in increasing the response rate to DVd Cycling Myeloma cells with rHu GM-CSF Phase II trial to treat Multiple Myeloma patients with Cytoxan and Vincristine after, Followed by GM-CSF Maintenance Phase II study of PS-341 alone or in combination with Dexamethasone this is a study for patients with Multiple Myeloma who have relapsed following front-line therapy and are refractory to their most recent therapy. there are no limits to the number of previous therapies. Neovestat (Shark Cartilage) this is a limited patient population study.

22. MyelomaExchange multiple myeloma ASSOCIATION. Myeloma Exchange. multiple myeloma is an incurablebut highly treatable form of cancer of the blood and immune system. http://www.webspawner.com/users/myelomaexchange/

MULTIPLE MYELOMA ASSOCIATION Myeloma Exchange Welcome to the Homepage of the Multiple Myeloma Association. Multiple Myeloma is an incurable but highly treatable form of cancer of the blood and immune system. It is a rare type characterized by the accumulation of malignant plasma cells in the bone marrow and excess monoclonal immunoglobulin (Ig) in the serum and/or urine. The cause of Myeloma is unknown. If you or your Loved one is newly diagnoised and you are unsure what questions to ask your Doctor click on Questions for patients with Multiple Myeloma to ask their physicians written by William S. Dalton, M.D. Dr. Dalton also has an article on Multiple Myeloma called What is myeloma? Forward thinking Ralph Manganiello founded the MMA. Mr. Manganiello created the MMA whose sole purpose and interest was the patient and the patient’s support system. The MMA is not influenced or supported by outside organizations or pharmaceutical companies. This association seeks to provide the community with an opportunity to access unbiased information and referrals through discussions and interactions with others. The Multiple Myeloma Association (MMA) The MMA homepage has “links” to websites that offer information that may enhance the care of the Myeloma patient. Knowledge is power but the understanding of this knowledge is crucial. In order to help understand what the patient is going through or what the patient may need, the MMA (through Mr. Manganiellos direction) has set up an e-mail support/discussion list. You have to become a member in order to use this service. The service is free of charge.

23. Multiple Myeloma - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/MedwebPage.cfm?ID=-402259958

24. MEDLINEplus: Multiple Myeloma All Topics. multiple myeloma. Contents of Organizations Statistics. SearchMEDLINE for recent research articles on • multiple myeloma. You may http://www.nlm.nih.gov/medlineplus/multiplemyeloma.html

Skip navigation Other health topics: A B C D ... List of All Topics Multiple Myeloma Contents of this page: News From the NIH General/Overviews Diagnosis/Symptoms ... Statistics Search MEDLINE for recent research articles on Multiple Myeloma You may also be interested in these MEDLINEplus related pages: Bone Marrow Diseases Lymphoma Blood/Lymphatic System Cancers Latest News More Evidence Curry Ingredient May Fight Cancer (03/13/2003, Reuters Health) From the National Institutes of Health Multiple Myeloma and Other Plasma Cell Neoplasms (PDQ): Treatment (National Cancer Institute) Also available in: Spanish What You Need to Know about Multiple Myeloma (National Cancer Institute) General/Overviews Multiple Myeloma (Patient Education Institute) - - requires Flash plug-in Also available in: Spanish Multiple Myeloma: Cancer of the Bone Marrow (International Myeloma Foundation) Myeloma What is Multiple Myeloma? (American Cancer Society) Alternative Therapy Clinical Trials ClinicalTrials.gov: Multiple Myeloma (National Institutes of Health) Diagnosis/Symptoms Can Multiple Myeloma Be Found Early?

25. Cancer Research UK: Multiple Myeloma Gives information about risk factors, diagnosis and treatment. A UK charity organization, contact details are provided. http://www.imperialcancer.co.uk/aboutcancer/specificcancers/23554

About us About cancer Press office Get involved ... Contact our information nurses Multiple myeloma If you or a friend or relative have been diagnosed with cancer, you will find much more detailed information on our patient information site, CancerHelp UK Summary Multiple myeloma is the 12th most common cancer in men, and the 13th most common cancer in women in the UK. Each year, there are over 3,200 new cases. Myeloma develops from cells within the bone marrow called plasma cells. Plasma cells produce proteins called antibodies, which help to fight infection. In myeloma, a single plasma cell develops faults and multiplies out of control. This makes the immune system much less effective at fighting infection. Myeloma cells produce excessive amounts of a single type of antibody, which is known as paraprotein, or monoclonal spike. Myeloma usually develops at a number of different sites within the body. This cancer is therefore called multiple myeloma. The most common sites for multiple myeloma are the pelvis, spine, rib cage, skull, shoulders and hips. Risk Factors Age Multiple myeloma is more common from the age of 50 onwards.

26. MEDLINEplus Medical Encyclopedia: Multiple Myeloma multiple myeloma. Definition Return to top multiple myeloma is a cancer of the plasmacells in bone marrow. Causes, incidence, and risk factors Return to top. http://www.nlm.nih.gov/medlineplus/ency/article/000583.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Multiple myeloma Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Cryoglobulinemia - of the fingers Immune system structures Antibodies Alternative names Return to top Plasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone Definition Return to top Multiple myeloma is a cancer of the plasma cells in bone marrow. Causes, incidence, and risk factors Return to top Multiple myeloma is characterized by the excessive growth and malfunction of plasma cells in the bone marrow. The growth of these extra plasma cells interferes with the production of red blood cells, white blood cells, and platelets . This causes anemia , susceptibility to infection, and increased tendencies toward bleeding. As the cancer cells grow and expand in the bone marrow, they also cause pain and destruction of the bones. If the bones in the spine are affected, compression of the nerves may result causing numbness or paralysis Renal failure (kidney failure) is a frequent complication caused by excess calcium in the blood that results from bone destruction. Multiple myeloma mainly affects older adults. Other risk factors are unknown. This disease is rare and only 3 new cases per 100,000 people per year occur.

27. International Myeloma Foundation (UK) Resource for those seeking information about the treatment and management of multiple myeloma. http://www.myeloma.org.uk/

28. Multiple Myeloma Education Network (MMEN) multiple myeloma Education Network connects patients who have multiple myeloma withfree replays of talk show discussions between leading medical specialists http://www.healthtalk.com/mmen/

(view a sample) Learn more about the dexamethasone and thalidomide combination trial for multiple myeloma. This week's highlights: Improve Your Chemotherapy Experience Hear highlights from our recent webcast: Chemotherapy side effects Medications to manage, lessen or prevent chemotherapy side effects Advocating for an improved chemotherapy experience for you and your family Information about The Leukemia and Lymphoma Society and Cancer Care ... Gene Found for Cancer's Spread Web Posted: 05-Mar-2003 Researchers hope discovery will lead to less-toxic therapies Record Number of Cancer Cases Predicted Web Posted: 14-Feb-2003 But death rates for top killer cancers expected to decline Thalidomide Proving Its Mettle as Cancer Fighter Web Posted: 27-Jan-2003 Yet another study shows it may help people with bone marrow cancer Multiple Myeloma News Archive "Advances in Treatment Options for Metastatic Colorectal Cancer" Find out how a rare - but serious - condition called myelofibrosis with myeloid metaplasia, or MMM , is being treated with thalidomide and prednisone. Related interviews Actor and cancer advocate Rob Lowe shares his personal experience with cancer and the importance of being well informed before you begin treatment.

29. Genome Links Myeloma An overview of multiple myeloma followed by links to informational articles, clinical trials and organizations. http://www.genomelink.org/myeloma

30. Multiple Myeloma Survivor Stories This site has treatment histories written by patients with MultipleMyeloma, a cancer of the bone marrow. Note In this list, the http://mm.acor.org/

[Note: In this list, the first year is the birth year, and "Class of..." refers to year MM was diagnosed.] Jack Aiello San Jose, CA; jackaiello@attbi.com 1949 / Class of ’95 / Type: IgG Kappa light chain / Last Update: 12/02 Anonymous #1 1927 / Class of '83 / Type: Solitary Plasmacytoma progressing to Myeloma / Last Update: 9/01 Marla Barnett , Texas; barrs05@aol.com 1958 / Class of 2000 / Family history of immune system diseases / Possible Aspartame toxicity / Last update: 1/03 Bill Bauknecht billbauknecht@aol.com 1938 / Class of '96 / Tumors, radiation, BMT, relapse, Thal / Last update: 3/00 Nancy Bengston, Grand Haven, MI; bridgenut@triton.net Don Biddison Lewiston, ID; biddi@aol.com 1929 / Class of '91 / Type: Kappa / BMT and recurrence / Last Update: 10/98 Martin Boling , Canberra, Australia; boling@bigpond.com.au 1951 / Class of 2000 / Type: MGUS prog. to IgG (Kappa LC) within 3 mo. / Last Update: 8/02 Helen Bos Sioux Center, IA; ahb@mtcnet.net Joanna Calvert-Mindell, Canterbury, Kent, England; joc-m@lineone.net

31. Larry's Marathon Larry Donohue will participate in the Team in Training Marathon to raise awareness of multiple myeloma and to raise funds for research and patient aid. http://members.tripod.com/ldonohuewa/marathon.htm

Multiple Myeloma Cancer of the Bone Marrow Multiple myeloma is a cancer of the bone marrow with low public awareness. There are estimated 13,500 new cases of myeloma in the U.S. each year which is approximately 20% of blood cancers and 1% of all types of cancer. Multiple myeloma is a cancer of plasma cells, cells that normally produces antibodies in response to infection. When myeloma cells build up in the bone marrow, this process disrupts the normal immune system as well as displacing blood forming cells resulting in anemia. Other complications include fatigue, loss of appetite and kidney damage. Treatments include observation and monitoring in some early forms and utilization of chemotherapies, radiation and stem-cell transplants in advancing stages. Although currently no one is claiming a cure for myeloma, it is an very treatable disease. Many patients go on to lead full lives for years, even decades, after diagnosis. With increasing research, the overall outlook for myeloma patients is improving steadily. This is the purpose of my participation in the Team in Training fundraising Marathon to benefit the Leukemia-Lymphoma Society.

32. Cancer.gov - What You Need To Know About™ Multiple Myeloma What You Need To Know About™ multiple myeloma, Information about detection, symptoms,diagnosis, and treatment of multiple myeloma. What Is multiple myeloma? http://www.cancer.gov/cancerinfo/wyntk/myeloma

Information about detection, symptoms, diagnosis, and treatment of multiple myeloma. NIH Publication No. 95-1575 Posted: 09/28/1998, Updated: 09/16/2002 Table of Contents Introduction What Is Multiple Myeloma? Normal Cells Cancer ... National Cancer Institute Information Resources Introduction Each year, nearly 13,000 people in the United States learn that they have multiple myeloma . This National Cancer Institute (NCI) booklet describes symptoms, diagnosis, and treatment of this type of cancer. It also has information to help you deal with this disease if it affects you or someone you know. Words that may be new to readers appear in italics . Definitions of these words and other terms related to multiple myeloma can be found in the Dictionary . For some words, a "sounds-like" spelling is also given. Other NCI booklets are listed in the Other Booklets section. Our materials cannot answer every question you may have about multiple myeloma and its treatment. They cannot take the place of talks with doctors, nurses, and other members of the health care team. We hope our information will help with those talks. Researchers continue to look for better ways to diagnose and treat multiple myeloma, and our knowledge is growing. For up-to-date information or to order this publication, call the NCI-supported

33. Thoughts On Life And Death Struggle with multiple myeloma by mother evokes inner response by her daughter. http://hometown.aol.com/lira29/Thoughts.html

htmlAdWH('7008160', '120', '30'); htmlAdWH('7004798', '234', '60'); Main Create Edit Help Welcome to the inner me At times we see our lives working out just fine, no problems that come to mind, everything is running smoothly, and then WHAM, something happens to make us step back and look at our lives in a totally different light. I would like to say that I am not someone who watches the news, nor do I read the newspaper. I find it depressing to read about the pain and suffering going on in the world. Maybe I'm being selfish, thinking only of myself, worrying about MY problems too much. However, when I do hear about tragedies, suffering, death, etc., I only feel as helpless as those who are suffering. What can I do? What can WE do, to help the less fortunate? I'm sure there are ways to help, but I haven't yet taken the time to find out how. I like to call this "laziness." Often I feel as if time doesn't allow for anything extra in my full day. But, NOW is the time. And Now, I will start to search for websites about such tragedies as the Colorado shootings. And maybe, just maybe, I will put aside some time for the victims of this sort, and try to help out some way. Even if it's in some small way. I feel the need to do something. Anything. Here's A Thought: Maybe we should develope a Crayola bomb as our next secret weapon. A

34. Cancer.gov - Multiple Myeloma/Other Plasma Cell Neoplasms Home Page multiple myeloma/Other Plasma Cell Neoplasms Home Page, What therapy.multiple myeloma Treatment patients health professionals . http://www.cancer.gov/cancer_information/cancer_type/plasma_cell_neoplasm/

Multiple Myeloma/Other Plasma Cell Neoplasms Home Page Information about detection, symptoms, diagnosis, and treatment of multiple myeloma. NIH Publication No. 95-1575 Full description of the NCI PDQ database Treatment Information about treatment, including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy Multiple Myeloma Treatment patients health professionals BMT and Peripheral Blood Stem Cell Transplantation Thalidomide for Multiple Myeloma Clinical Trials Information on clinical trials and current news on trials and trial-related data Multiple Myeloma Updates Search for Clinical Trials Cancer Literature New Cancer Literature Search Options Coming Soon! Related Information Other information, including reports about NCI priorities for cancer research and initiatives Leukemia/Lymphoma/Myeloma Progress Review Group Statistics Information related to cancer incidence, mortality, and survival Data Sources General Cancer Library Coping with Cancer Complications of cancer and its treatment for patients, survivors, and caregivers Support and Resources Support organizations, finances, insurance, home care, and hospice care

35. South African Myeloma Foundation I was diagnosed with multiple myeloma in May 1996. At present I am inremission and enjoying every moment. WHAT IS multiple myeloma? http://www.geocities.com/HotSprings/5137/

Welcome myeloma patients and research devotees! South African Myeloma Foundation Archives Links Dr. Jean Viviers Hello all. My name is Jean Viviers. I live in Johannesburg South Africa. I was diagnosed with Multiple Myeloma in May 1996. At present I am in remission and enjoying every moment. If you would like to learn more of the treatment regimes I followed please go to Who am I I have decided to use what I have learnt over the past years to help others. Thus I will start looking at individual cases and giving advise. Please go to Help needed? (not functional yet) WHAT IS MULTIPLE MYELOMA? If you live in Africa and would like to join our patient support group please contact me on Tel: Last modified on 18/12/2001

36. Treating Refractory Multiple Myeloma With VAD Plus Valspodar A 1999 article about treatment using the chemotherapy regimen of vincristine, doxorubicin and dexamethaso Category Health Conditions and Diseases multiple myeloma......Treatment of multiple myeloma With VAD Plus Valspodar. A review article by MohamadHussein, MD. Treating Refractory multiple myeloma With VAD Plus Valspodar http://www.cancernews.com/myeloma/therapies1999.htm

Click over the LOGO below to visit CancerNews.com This site is a service of CancerNews.com Treating Refractory Multiple Myeloma With VAD Plus Valspodar Published online November 1999 By Mohamad Hussein, M.D. Dr. Mohamad Hussein is a Board Certified Oncologist (specialist in the treatment of adult cancers), Staff at the Cleveland Clinic Cancer Center, and Director, Cleveland Clinic Multiple Myeloma Programs . He directs clinical trials and designs treatment programs for Chronic Leukemia's and Multiple Myeloma at the South West Oncology Group "SWOG", a national cooperative group devoted to the treatment of adult cancers. This article is provided for information purposes only. It is not intended to be used for medical advice. Please read Clinical trials have demonstrated the safety and efficacy of this novel MDR modulator in chemotherapy-refractory MM patients. Sonneveld et al reported the first phase I trial (a study evaluating the safety of the drug) of valspodar in 22 patients with VAD- or melphalan-refractory MM.(Sonneveld, Leukemia, 1996; 10:1741-1750) In this study, patients were treated with three cycles of VAD plus an escalating dose of valspodar (2.5 to 15 mg/kg). The dose-limiting toxicities were myelosuppression (bone marrow suppression) and neuropathy (nerve damage. Because valspodar inhibits the normal clearance of some chemotherapeutic agents (eg, doxorubicin) via the liver and kidneys, it increases the drug levels in patients. Consequently, dose reductions, depending on the specific agent, are required. This does not, however, compromise the therapeutic efficacy of the chemotherapy regimen.

37. Leukemia & Lymphomas Links to articles about treatment, research and organizations.Category Health Conditions and Diseases Hematologic Leukemia......Click over the LOGO below to visit the new CancerNews.com site Leukemia,Lymphoma and multiple myeloma multiple myeloma Updates Video Webcasts http://www.cancernews.com/leukemia.htm

Click over the LOGO below to visit the new CancerNews.com site Leukemia, Lymphoma and Multiple Myeloma Click Over the Profiler Link Below to Find Out About State of the Art Treatment Options for Leukemia/Lymphoma Featured Articles Management of Thalidomide Side Effects: The Cleveland Clinic Myeloma Research Program Experience Multiple Myeloma Updates Video Webcasts Leukemia Video News Clips Lymphoma Video News Clips International Myeloma Foundation -A non-profit organization. Site has information on treatment, research and patient support. -Information about Leukemia, Lymphoma, Hodgkin's Disease and Multiple Myeloma. Lymphoma Research Foundation of America -This is a national non-profit organization that provides funds for lymphoma research and patient education. The site has valuable information about these diseases. Cure For Lymphoma Foundation - Funds research and provides education and support to those whose lives have been touched by Hodgkin's disease and non-Hodgkin's lymphoma. The website features information on lymphoma, CFL programs and services, and a section on lymphoma advocacy. -Information about bone marrow, peripheral stem cell, and cord blood transplants. From the basics to the most recent news. This is a great resource!

38. Multiple Myeloma - Hematology - Medstudents multiple myeloma fits in the group of plasm cell disorders characterized by neoplasticproliferation of single clone of plasma cell engaged in the production http://www.medstudents.com.br/hemat/hemat6.htm

Hematology Medstudents' Homepage Multiple Myeloma Introduction Multiple Myeloma fits in the group of plasm cell disorders characterized by neoplastic proliferation of single clone of plasma cell engaged in the production of a monoclonal immunoglobulin, usually monoclonal IgG or IgA. The growth of the tumor, which takes place in the bone marrow, its protein products and the individual response to the disorder will result in all of the organics disfunctions seen in this disease. Skeletal destruction with bone pain, anemia, hypercalcemia and renal failure are some of the features. Epidemiology Multiple Myeloma accounts for 1% of all malignant disease and slightly more than 10% of hematologic malignancies. The annual incidence of Multiple Myeloma is 4 per 100.000 increasing with aging. The median age of patients at the time of diagnosis is 61 years. It is more commom in men and blacks. Etiology The cause of Multiple Myeloma is unclear. Exposure to radiation, benzene and other organic solvents, herbicides, and insecticides may play a role. A genetic predisposition may also be involved. Some trials shows that chronic antigenic stimulation leads to a transformation of the progenitor B-cell, a fact that may explain the higher incidence of Multiple Myeloma in farmers, woodmakers and oilworkers. Pathogenesis In the very beginning, cell production from the bone marrow stem cell results in two lineages with lymphoid characteristics : pre- T cell and pre-B cell. The first will migrate to the Thymus where they will be differenciated into T cells. The last cells will reach the peripheral blood as " tracer limphocytes " . This kind of cell is the result of a process of differentiation not related to antigen that produces a great variety of cells which express small amounts of immunoglobulin on their surface.

39. Myeloma Institute For Research And Therapy The Myeloma Institute for Research and Therapy is committed to accelerating curativetherapies for multiple myeloma and related disease entities through http://myeloma.uams.edu/

Job Opportunities t the Myeloma Institute we treat more patients with Myeloma than anywhere else in the world, and have one of the most active bone marrow transplantation centers for patients with numerous forms of cancer. Our specialized and experienced staff provides superb medical attention in an atmosphere of friendliness and compassion. Our clinical and basic program is unique in creating rapid application of scientific breakthroughs to patient treatment. The quality of our innovative clinical and basic research is known nationally and internationally. Our mission statement is embodied in everything we do: The Myeloma Institute for Research and Therapy, evolving from the breakthrough advances of the UAMS Myeloma program, is committed to accelerating curative therapies for Multiple Myeloma and related disease entities through innovative clinical and basic science research and outstanding patient care. We invite you to visit various areas of this site, to learn more about what we have to offer.

40. What Is Multiple Myeloma? multiple myeloma is characterized by malignant plasma cellsthat reproduce uncontrollably. What is multiple myeloma? http://myeloma.uams.edu/whatismyeloma.asp

What is Multiple Myeloma? Job Opportunities For additional information, please visit the National Cancer Institute. Multiple myeloma is a type of cancer that affects plasma cells, which are a type of white blood cell. Plasma cells and other white blood cells are part of the immune system, which helps the body protect itself from infection and disease. All white blood cells develop in the bone marrow, the spongy tissue that fills the centers of most bones. Some of these white blood cells remain in the bone marrow, and some migrate to other parts of the body. Some of the white blood cells, whether in the marrow or other parts of the body, develop into plasma cells when the immune system needs them to fight infection and disease. Plasma cells are important to the immune system because they produce antibodies. Antibodies are proteins that move throughout the blood stream to fight foreign, harmful substances. Each type of plasma cell produces a specific antibody to fight a specific foreign substance. Since the body has many different types of plasma cells, it can respond to, or fight against, many different foreign substances. When plasma cells become cancerous, they reproduce uncontrollably. These excess abnormal plasma cells are all alike; they are referred to as "monoclonal," meaning that they all have a common origin.

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