61. Neuromuscular Disease Research: Metabolic Myopathies Metabolic muscle disorders are related to defects in the enzymes that regulatecarbohydrates, lipids, or other metabolic pathways in the muscle fibers. http://www.bcm.tmc.edu/neurol/research/nmus/nmus3a5.html

Metabolic Myopathies The muscle biopsy also helps to confirm some abnormalities of the lipid metabolism. In those cases the muscle biopsy is essentially normal except for the presence of abnormal lipid deposits in the majority of the fibers with oil-red-O stain. In both glycogen and lipid storage myopathies, quantitative measurement of the deficient enzyme will confirm the diagnosis. There is no specific treatment for many of the metabolic muscle disorders. Once a particular defect is identified, attempts are made to instruct the patient to avoid precipitating factors. In some disorders, such as carnitine deficiency, a lipid myopathy, attempts have been made with variable success to treat the condition with oral carnitine. Click picture for larger version Oil-red-O stain showing increased number of lipid droplets. For Information : Y. Harati, M.D., F.A.C.P. Professor of Neurology, Baylor College of Medicine Director, Muscle and Nerve Pathology Laboratory 6550 Fannin, Suite 1800 Houston, Texas 77030 Telephone: 1-713-798-5993 Fax: 1-713-798-5030 Email: yharati@bcm.tmc.edu

62. PROCID : Prevention Of Muscle Disorders In Operation Of Computer Input Devices Translate this page Projekt Titel (orig.), PROCID Prevention of muscle disorders inoperation of computer input devices. Schlüsselwörter, (Englisch http://www.aramis-research.ch/d/6451.html

Basisinformation Kontaktpersonen Forschungsbereiche Beteiligte Personen ... 4th Swiss Global Change Day Projekt Titel (orig.) PROCID : Prevention of muscle disorders in operation of computer input devices Schlüsselwörter (Englisch) VDU work; ergonomics; muscular disorders; muscular pain; stress; neurophysiology; motor unit recruitment pattern; long-term analysis; biomedical signal processing; EMG decomposition; wavelets Startdatum Enddatum Kontaktpersonen Prof. Dr. George S. Moschytz Tel.Nr E-mail moschytz@isi.ee.ethz.ch Organisation ETH Zürich Institut für Signal- und Informationsverarbeitung Strasse ETH/ETF C108 PLZ / Ort Zürich Land Schweiz top Projektinformation Deutsch Englisch Italienisch x Schlüsselwörter x Alternative Projektnummern x Forschungsprogramme x Kurzbeschreibung x Weitere Hinweise und Angaben x Partner und Internat. Organisationen x Abstract x Datenbankreferenzen top Alternative Projektnummern (Englisch) EU project number: BMH4CT983903 top Forschungsprogramme (Englisch) EU-programme: 4. Frame Research Programme - 4.2 Agriculture and agroindustry top Kurzbeschreibung (Englisch) See abstract top Weitere Hinweise und Angaben (Englisch) Full name of research-institution/enterprise: top Partner und Internat. Organisationen

63. NCRR Reporter, Spring 2000, Tick-tock A better understanding of their functions could lead to improved strategiesfor treating and preventing heart disease and possibly muscle disorders. http://www.ncrr.nih.gov/newspub/apr00rpt/Tick.asp

Critical Resource Caption: (Photo courtesy of the University of Cincinnati College of Medicine) Calcium ions have long been known to play a critical role in the contraction of all three types of muscle cells smooth, skeletal, and cardiac. Muscle cells relax when calcium is moving into the sarcoplasmic reticulum (SR) and contract when the SR releases calcium. For the cells to relax following a contraction, calcium ions must be pumped back into the SR. In cardiac muscle cells, this pumping is accomplished via an enzyme known as sarco(endo)plasmic reticulum Ca -ATPase (SERCA). SERCA, in turn, is inhibited by the protein phospholamban, also found in the sarcoplasmic reticulum. Dr. Kranias and her colleagues have shown that during times of stress and exercise, phospholamban undergoes a chemical change, becoming phosphorylated, which lessens its inhibition of SERCA, thereby allowing the heart to relax more readily and pump blood more efficiently. Yet the biochemical mechanisms underlying these events are poorly understood. Studies of the phospholamban knockout mice have since provided significant insights into the role that calcium-cycling defects can play in heart failure. In one recent collaborative study, Dr. Kranias and her colleagues mated the phospholamban knockout mouse with a mouse model for human dilated cardiomyopathy, a disease marked by reduction in the force of heart muscle contractions. Phospholamban deficiency in the resulting offspring completely prevented development of the deadly heart disorder.

64. THE MERCK MANUAL, Sec. 14, Ch. 184, Muscular Disorders Muscular Dystrophies. A group of inherited, progressive muscle disorders,distinguished clinically by the selective distribution of weakness. http://www.merck.com/pubs/mmanual/section14/chapter184/184a.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 14. Neurologic Disorders Chapter 184. Muscular Disorders Topics Muscular Dystrophies Myopathies Channelopathies Muscular Dystrophies A group of inherited, progressive muscle disorders, distinguished clinically by the selective distribution of weakness. Duchenne dystrophy is the most common and important form (see below Facioscapulohumeral (Landouzy-Dejerine) muscular dystrophy is an autosomal dominant disorder characterized by weakness of the facial muscles and shoulder girdle, usually beginning at age 7 to 20 yr. The gene is located on chromosome 4q35 in most families, but the genetic defect has not been identified, and the pathogenesis is unknown. Difficulty in whistling, eye closure, and elevation of the arms due to weakness of the scapular stabilizer muscles occurs early. Anterior tibial and peroneal weakness develops in some patients. Although footdrop develops, ambulation is rarely lost. Life expectancy is normal. In limb-girdle muscular dystrophy

65. Musculoskeletal Diseases Regional Diagnostic Radiology Guidelines for Evaluating Acute Musculoskeletal Symptoms Arthritis Rheumatism Jan '96 About some muscle disorders - C for http://www.mic.ki.se/Diseases/c5.html

search help staff Musculoskeletal Diseases Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Alphabetical List of Diseases Search PubMed at NCBI/NLM Textbook of Orthopaedics CR Wheeless Educational textbook syllabus Borrill et al. ] - Orthoteers (UK) The Belgian OrthoWeb - (BE) Site Map of the Orthopaedics and Sports Medicine resource at Univ of Washington, Seattle (US) The American Academy of Orthopaedic Surgeons A Musculoskeletal Atlas and a set of educational cases (radiol.) - U of Washington (US) OrthoLinx A collection of Case discussions at OrthoGate.org An orthopedic Encyclopedia - for patients - DynoMed.com Anatomy Links - KIB (SE) ChiroWeb .com [chiropractics] An Orthopedics hyperguide [userID + pswd required] - stryker/SLACK Inc. Orthopaedic Images from OrthoTrauma.Net Some PowerPoint presentation [note: IE Explorer only] from Dept of Orthopaedic Surgery, Edinburgh (UK) Radiographic Anatomy Modules , and about some Orthopaedic Hardware - Univ of Washington/School of Medicine/Radiology Orthopedic Institute of Southern California (US) Teaching Module on Anatomy using Joint Fluoroscopy - University of Iowa (US) Bone, Joint, and Necrotizing Soft Tissue Infections

66. Muscle And Bone Disorders : General Information Muscle and Bone Disorders General Information. Informational Sites. MEDLINEplus muscle disorders Excellent source of authoritative information. http://hml.org/CHIS/topics/muscleinf.html

Muscle and Bone Disorders : General Information Contents: Informational Sites Clinical Trials Informational Sites MEDLINEplus - Muscle Disorders Excellent source of authoritative information. Factsheets, organizations, etc. Source: National Library of Medicine MEDLINEplus - Bone Diseases Excellent source of authoritative information. Factsheets, organizations, etc. Source: National Library of Medicine Medical Multimedia Group Provides access to interactive orthopedic patient education on such topics as artificial joint replacement, cumulative trauma disorders, and common knee, shoulder, foot, and back problems. Source: Medical Multimedia Group Southern California Orthopedic Institute Home Page This web site presents informational sources on the anatomy of the knee, shoulder, ankle, spine, hand, elbow, and hip, along with various orthopedic disorders, and even a section on pediatric orthopedics. Clinical Trials ClinicalTrials.gov - Bone Diseases Clinical studies sponsored primarily by the National Institutes of Health. Source: National Library of Medicine National Institutes of Health ClinicalTrials.gov - Muscular Diseases

67. DISORDERS OF THE NEUROMUSCULAR JUNCTION AND MUSCLE DISORDERS OF THE NEUROMUSCULAR JUNCTION AND MUSCLE These are usually disordersof slow onset with weakness and muscle wasting in specific patterns. http://www.sun.ac.za/neurology/lectures/nmj.htm

DISORDERS OF THE NEUROMUSCULAR JUNCTION AND MUSCLE NEUROMUSCULAR JUNCTION 1 MYASTHENIA GRAVIS 1.1 Epidemiology. Seen twice as frequently in women; there is a peak incidence in the 2nd and 3rd decades and a second in the 6th and 7th. 1.2 Pathophysiology and Aetiology The disease is idiopathic but there are HLA associations and other auto- immune diseases, notably thyrotoxicosis, are associated. The disorder is a result of antibodies to the acetylcholine receptor. This is the nicotinic type of acetylcholine receptor, found in striated muscle. The antibodies are associated with: i) Hyperplasia of the thymus gland ii) Neoplasms of the thymus gland (thymoma) The antibodies bind the to the receptors and also cause destruction of the endplate region by inducing a complement cascade. 1.3 Symptoms: Characteristically there is a fluctuating weakness of voluntary muscles, particularly affecting the cranial nerves. Thus common symptoms are double vision, dysphagia and ptosis. Since the proximal muscles, in particular, are affected there is often difficulty with combing hair, getting up from a chair etc. The onset is usually subacute, but acute onset(with respiratory failure) does occur. Note that only striated muscle is affected and that therefore myasthenia does not involve the pupils or sphincters. Common presentations include i) involvement of facial and bulbar muscles and proximal weakness;

68. ClinicalTrials.gov - Linking Patients To Medical Research: Results Search results for muscle disorders ALLFIELDS are shown below. Show all trials,including those no longer recruiting patients. 211 studies were found. http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Muscle Disorders

69. Muscular Reading 2 muscle disorders are caused by disruption of normal innervation, degenerationand replacement of muscle cells, injury, lack of use or disease. Atrophy. http://www.mhhe.com/biosci/ap/seeleyap/muscular/reading2.mhtml

Disorders of Muscle Tissue Muscle disorders are caused by disruption of normal innervation, degeneration and replacement of muscle cells, injury, lack of use or disease. Atrophy Muscular atrophy refers to a decrease in size of muscles. Individual muscle fibers decrease in size, and there is a progressive loss of myofibrils. Disuse atrophy is a muscular atrophy that results from lack of muscle use. Bedridden people, people with limbs in casts, or those who are inactive for other reason experience disuse atrophy in the muscles that are not used. Disuse atrophy is temporary if a muscle is exercised after it is taken out of a cast. However, extreme disuse of a muscle results in muscular atrophy in which there is a permanent loss of skeletal muscle fibers and the replacement of those fibers by connective tissue. Immobility that occurs in bedridden elderly people can lead to permanent and severe muscular atrophy. Denervation atrophy results when nerves that supply skeletal muscles are severed. When motor neurons innervating skeletal muscle fibers are severed, the result is flaccid paralysis. If the muscle is reinnervated, muscle function is restored, and atrophy is stopped. However, if skeletal muscle is permanently denervated, it atrophies and exhibits permanent flaccid paralysis. Eventually muscle fibers are replace by connective tissue, and the condition cannot be reversed. Transcutaneous stimulators are used to supply electrical stimuli to muscles that have had their nerves temporarily damaged or to muscles that are put in casts for a prolonged period to time. The electrical stimuli keep the muscles functioning and prevent permanent atrophy of the muscles while the nerves resupply the muscles or until the cast is removed.

70. Pediatrics Profiles | Edward G. Buckley M.D. 2. Management of complicated eye muscle disorders New surgical techniques arebeing evaluated in the treatment of paralytic and restrictive strabismus. http://www.dukeeye.org/pediatrics/profiles/Buckley.html

Professor of Ophthalmology Chief, Pediatric Ophthalmology and Strabismus Service Phone Fax Appointments Medical school Duke University School of Medicine Residency Duke University Eye Center Fellowship Pediatric Ophthalmology and Neuro-Ophthalmology: Bascom Palmer Eye Institute Further information at http://www.egbuckley.eyemd.org/ Research Interests 1. Congenital cataracts: Investigation is underway to determine the efficacy and safety of intraocular lens implants in children. This includes both primary and secondary implants. 2. Management of complicated eye muscle disorders: New surgical techniques are being evaluated in the treatment of paralytic and restrictive strabismus. Investigations into the possibility of developing a material which could serve as an "artificial muscle" are in progress. 3. Retinopathy of prematurity: Efforts are currently underway to study the efficacy, timing, and long-term safety of treament. 4. Retinoblastoma: Investigating new chemotherapy and radiation treaments to preserve vision. 5. Botulinum toxin: Work is underway to ascertain the usefulness of botulinum toxin in the treatment of headaches.

71. Periodic Paralysis Association Centre Karolinska Institute Neuromuscular Diseases Center for Muscleand muscle disorders UNIVERSITY OF MINNESOTA Motor Control http://www.periodicparalysis.org/PPRC/Links/

72. Muscle Disorders (Myopathies) - The NEW Center :: Medical Links Home The NEW Center Patient Education Links muscle disorders (Myopathies).There are 23 Links in the muscle disorders (Myopathies) Category, Page 1 of 2. http://www.thenewcenter.com/resources/medical-links.asp?CategoryID=42&theLinkCou

73. NIH Guide: NOVEL THERAPEUTIC AND PATHOGENETIC STUDIES OF OCULOMOTOR DISORDERS three muscle types is essential to the identification of pathogenetic mechanismsthat distinguish craniofacial disease from other skeletal muscle disorders. http://grants1.nih.gov/grants/guide/rfa-files/RFA-EY-03-001.html

NOVEL THERAPEUTIC AND PATHOGENETIC STUDIES OF OCULOMOTOR DISORDERS RELEASE DATE: October 28, 2002 RFA: EY-03-001 National Eye Institute (NEI) ( http://www.nei.nih.gov http://grants.nih.gov/grants/funding/modular/modular.htm clh@nei.nih.gov o Direct your questions about peer review issues to: Samuel C. Rawlings, Ph.D. Chief, Scientific Review Branch Division of Extramural Research National Eye Institute Building EPS, Room 350 6120 Executive Blvd, MSC 7164 Bethesda, MD 20892-7164 Telephone: (301) 451-2020 FAX: 301-402-0528 Email: rawlings@nei.nih.gov o Direct your questions about financial or grants management matters to: William W. Darby Grants Management Officer National Eye Institute Building EPS, Room 350 6120 Executive Blvd, MSC 7164 Bethesda, MD 20892-7164 Telephone: (301) 451-2020 FAX: 301-496-9997 Email: wwd@nei.nih.gov SUBMITTING AN APPLICATION Applications must be prepared using the PHS 398 research grant application instructions and forms (rev. 5/2001). The PHS 398 is available at http://grants.nih.gov/grants/funding/phs398/phs398.html

74. Strategic Plan - Muscle Biology Research These proteins are keys to understanding the skeletal muscle system and its diseasesand present the targets for drugs that might treat muscle disorders. http://www.niams.nih.gov/an/stratplan/musclebio.htm

About NIAMS Mission Strategic Plan Employment Opportunities Outreach Programs ... Committees Search NIAMS Strategic Plan Muscle Biology Research Vision: A CompIete Picture of Healthy Muscle Skeletal muscle is necessary for movement and well being. It visibly responds in size and tone to use or disuse. Its characteristics effect how the body uses energy and its demands require adaptations of the cardiovascular system. Chronic inactivity of skeletal muscle is associated with systemic metabolic dysfunction and diseases such as obesity and insulin-resistant diabetes. A major goal is to understand skeletal muscle as an integrated whole-body system. In the next several years combined use of cell physiology, genetic techniques, biophysics, whole animal measurements, and computer modeling will help generate fundamentally new theories of how muscular systems are designed and function to maintain health. Highlights of Research Needs and Opportunities Include: Muscle Genetics and Disease Genetic analysis is a unifying force in the study of muscle. Genetic approaches are helping to elucidate the critical roles of proteins such as ion channels that control electrical activity and cell homeostasis, motor proteins that generate force and cause contraction, trophic factors that sustain survival and growth of cells, substances that direct developing muscle, transporters that carry essential substances into cells, and receptors that detect signaling molecules. These proteins are keys to understanding the skeletal muscle system and its diseases and present the targets for drugs that might treat muscle disorders.

75. Muscle Disorders And Addison's Disease Message Boards on Health Related Topics. addisons disease messageboard. muscle disorders and Addison's Disease. http://www.healthboards.com/addisons-disease/74.html

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76. Re: Muscle Disorders And Addison's Disease Re muscle disorders and Addison's Disease. In Reply to muscle disorders andAddison's Disease posted by Tonda Helm on September 02, 1999 at 230115 http://www.healthboards.com/addisons-disease/76.html

**** Menu **** Home Acne ADD Addiction Addison's Disease Aging Issues AIDS Allergies ALS Alternative Medicine Alzheimer's Anemia Arthritis Asthma Autism Back Problems Bowel Disorders Cancer Caregivers Carpal Tunnel Syndrome Cerebral Palsy Children's Health Chronic Fatigue Common Cold Cosmetic Surgery Cystic Fibrosis Dental Problems Depression Diabetes Digestive Disorders Disabilities Down Syndrome Eating Disorders Epilepsy Fibromyalgia Foot Problems General Health Gulf War Syndrome Headaches Hearing Disorders Heart Disorders Hepatitis Herpes High Blood Pressure High Cholesterol HIV/AIDS Immune Disorders Infectious Diseases Infertility Inner Ear Disorders Irritable Bowel Kidney Disorders Leukemia Lupus Lyme Disease Menopause Men's Health Mental Health Multiple Sclerosis Muscular Dystrophy Myositis Neuromuscular Diseases Neuropathy Osteoporosis Pain Management Parkinson's Polio Pregnancy Rare Disorders Reflex Sympathetic Dystrophy Restless Leg Syndrome Sexual Health Sexually Transmitted Diseaases SIDS Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Thyroid Disorders TMJ Disorder Tuberculosis Viagra Weight Loss Women's Health Message Boards on Health Related Topics addisons disease message board Re: Muscle disorders and Addison's Disease Click Here to Visit our Sponsor FREE HealthBoards.com info from vendors! Select:

77. Orofacial Pain muscle disorders may involve the masticatory musculature as well as otherskeletal muscles of the head and neck. Subgroup classifications http://www.orofacialpain.com/orofacialpain/default.htm

78. The Voice Oriented Examination - Disease Classification Of Voice Disorders muscle disorders which are nonneurologic in etiology would include the Vocal Underdoersyndrome where, over time, they may come to lack muscle bulk and may http://www.voicedoctor.net/diagnose/classify.html

Disorders of voice speech Functional precipitator Mucosal disorders Muscular disorders ... Endocrine Take a look at the list to the left, but first indulge me for a few moments as I present my arguments for this categorization. No grouping of diseases seems to be entirely discrete. There is admittedly overlap and uncertainty about some diseases. There will probably be times when you will find this rigid stratification of disease not acceptable to your needs. Additionally, this classification is of voice disorders as opposed to speech disorders. The first level of classification The first level of classification I would like to make is by causes of laryngeal disease. I will assert this is a beneficial grouping as treatment generally depends on the cause of the disease. Functional precipitator For example, the subcategories of a Functional precipitator of disordered voice usage are caused primarily by an excessive use type of behavior. These behavioral diseases are a group of illness where the behavioral process occurs first (the excessive use) and then an anatomic change (e.g. swelling) may follow. To me, this implies that the behavioral process must be corrected first. If it is not and the anatomic abnormality is corrected first, the problem will likely recur. At a minimum, a change in behavior (reduction of excessive use) should stop progression of the injury and potentially may even correct the injury. If the behavioral problem is corrected and the anatomic problem is so chronic that it does not resolve, then surgical intervention may be indicated.

79. PERSONAL HEALTH; Statins: Miracles For Some, Menace For A Few This complication occurs far less often with the five statins still on the market,but any and all of them can occasionally cause muscle disorders, even years http://web.mit.edu/mwpstr/www/brody/

PERSONAL HEALTH; Statins: Miracles for Some, Menace for a Few JANE E. BRODY The New York Times December 10, 2002, Tuesday, Late Edition - Final Section F; Page 7; Column 1; Health Fitness PERSONAL HEALTH; Statins: Miracles for Some, Menace for a Few By JANE E. BRODY Statins have been hailed as miracle drugs for their ability to prevent deaths from heart attacks by lowering cholesterol. Some doctors go so far as to say the statins have had a greater effect on heart disease than anything else introduced in the last 50 years. Last year, a national group of experts issued guidelines saying statins should be prescribed to some 36 million Americans, three times as many as were taking them then, to reduce their risk of heart disease. In addition to protecting people at high risk, statins protect people who have already suffered one heart attack. Three large studies have shown that statins reduce the risk of second heart attacks by 30 percent and the risk of death from second heart attacks by 40 percent. There are also strong hints that statins may protect against strokes, Alzheimer's disease and osteoporosis and may perhaps one day be useful in treating multiple sclerosis and other autoimmune diseases.

80. Plugged In Can creatine supplements help people with muscle disorders? Keep the change. Latestand greatest online articles on metabolic muscle disorders. Vital signs. http://www.spiralnotebook.org/pluggedin/

Pain smarts 14 sites with the latest information on pain. Mouse hunt Curious questions and answers about muscle. Sausages and cells Robert K. Naviaux, M.D., on the diversity of mitochondrial disorders. Location, location, location Progress report on mapping the human genome. Making the grade Muscle fatigue vs. muscle weakness. Double take Two online articles from United Mitochondrial Disease Foundation. Mind over mattress 15 online articles and resources on sleep deprivation and sleep disorders. The virtual enzyme How enzymes work and what happens when they don't. More power to you Can creatine supplements help people with muscle disorders? Keep the change List of known disease-causing mutations in the gene. When exercise cramps your style Why CPT deficiency cramps are different from common cramps.

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