41. Modafinil ( Provigil ) Information about this moodbrightening and memory-enhancing psychostimulant which enhances wakefulness and vigilance. Discusses mode of action and uses in treating narcolepsy, as well as experimental uses. http://www.modafinil.com/

From THE GOOD DRUG GUIDE ...modafinil ('Provigil') is a memory-improving and mood-brightening psychostimulant. It enhances wakefulness and vigilance, but its pharmacological profile is notably different from the amphetamines methylphenidate Ritalin ) or cocaine . Modafinil is less likely to cause jitteriness, anxiety, or excess locomotor activity - or lead to a hypersomnolent 'rebound effect' - than traditional stimulants . Subjectively, it feels smoother and cleaner than the amphetamines too. Current research suggests modafinil, like its older and better-tested analogue adrafinil , is a safe, effective and well-tolerated agent. It is long-acting and doesn't tend to cause peripheral sympathetic stimulation. Yet its CNS action isn't fully understood. Modafinil induces wakefulness in part by its action in the anterior hypothalamus . Its dopamine -releasing action in the nucleus accumbens is weak and dose-dependent; the likelihood of dose-escalation and tolerance is apparently small. Modafinil has central alpha 1 adrenergic agonist effects i.e. it directly stimulates the receptors. More significant, perhaps, is its ability to increase excitatory

42. Narcolepsy - Overview- Sleepchannel narcolepsy is primarily characterized by intermittent, uncontrollableepisodes of falling asleep during the daytime. Three additional http://www.sleepdisorderchannel.net/narcolepsy/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement NARCOLEPSY Overview Causes Symptoms Diagnosis ... Treatment CONDITIONS Bruxism Delayed Sleep Phase Syndrome Insomnia Jet Lag Narcolepsy Obstructive Sleep Apnea Periodic Limb Movement Disorder REM Behavior Disorder (RBD) Restless Leg Syndrome Shift Work Sleep Stages Sleepwalking DISCOVERY Videos INTERACT SleepChannelForum Alternative Treatment Forum Links Clinical Trials Events ABOUT US Healthcommunities.com Pressroom Testimonials Narcolepsy affects an estimated 25 in every 100,000 people in the United States. This sleep disorder is primarily characterized by intermittent, uncontrollable episodes of falling asleep during the daytime. Three additional symptoms are typically associated with narcolepsy: cataplexy (short-lived intermittent muscle weakness), hypnogogic and hypnopompic hallucinations (hallucinations while falling asleep or waking), and sleep paralysis (paralysis while falling asleep or waking). Narcolepsy usually begins when a person is in their teens or early twenties. Stimulants and antidepressants are used to treat narcolepsy and subsequent cataplexy. Although it has been linked with blood pressure management and depression, the genesis of narcolepsy is unknown. However, recent advances in narcolepsy study suggest the possibility of a cure. Incidence Narcolepsy usually begins in the teens or early twenties (10 to 20 years old), but this varies; both young children and the elderly experience sleep attacks as well. Approximately 125,000 people in the United States alone suffer from this disorder, with an equal incidence among both women and men. Excessive daytime sleepiness and sudden sleep onset are the hallmarks of narcolepsy. Whether narcolepsy is a life-long disorder or not is controversial. Some evidence suggests that it is, while other studies have shown that symptoms fade in older age.

43. Living With Narcolepsy A site dedicated to narcolepsy and the people who live with it, including a description of symptoms, Category Health Conditions and Diseases Sleep Disorders narcolepsy......Living With narcolepsy. So Please, if you would like to share your personalexperiences with narcolepsy with others, send us your story! http://www.expage.com/page/livingwithnarcolepsy

Living With Narcolepsy Going through life in a purple haze Hello! Welcome to my place. How do you like it? Well having a web page is new to me, but I thought this one was well worth the effort. Now, lets get a few things straight. I am Not a health professional, but Narcolepsy and I are old friends, well, ok, maybe not Friends, but we have lived together for more than 15 years, 17 to be exact. A lot of you who visit this page may have had it alot longer, or maybe you have just started experiencing the symptoms of this disorder. Whatever the case, I am glad that you are here and I hope that this page will contain some helpful insights and information to help you deal with your disorder. Reminder UPDATE Hi friends. I just wanted to say Hi to my readers and once again apologize for my long absence. I am trying to get back to working on this site as my mother is recovering quite well from her anyuerism and stroke and requires less of my time. For those of you interested in working on this site, the help would be most appreciated as so many updates to this page must be made in order to serve our readers.

44. Untitled Document Located in uptown Toronto, Silent Partners Sleep Laboratory is a seven bed laboratory with state of the art equipment. We diagnose and treat many different kinds of sleep disorders including snoring, sleep apnea, insomnia, periodic leg movement and restless leg syndromes, narcolepsy and parasomnias. http://www.silentpartners.org

We are currently renovating our website. Silent Partners Sleep Clinic 1849 Yonge Street # 20 Toronto, ON Canada sleep@silentpartners.org tel. 416.487.7533 fax. 416.487.5490

45. NHLBI, Narcolepsy Image of the Cover linked to PDF file Facts About narcolepsy. narcolepsyis a chronic sleep disorder with no known cause. The main http://www.nhlbi.nih.gov/health/public/sleep/narcolep.htm

Facts About Narcolepsy Narcolepsy is a chronic sleep disorder with no known cause. The main characteristic of narcolepsy is excessive and overwhelming daytime sleepiness, even after adequate nighttime sleep. A person with narcolepsy is likely to become drowsy or to fall asleep, often at inappropriate times and places. Daytime sleep attacks may occur with or without warning and may be irresistible. These attacks can occur repeatedly in a single day. Drowsiness may persist for prolonged periods of time. In addition, nighttime sleep may be fragmented with frequent wakenings. 4 pages. NIH Publication No. 96-3649 You may obtain the document in following ways: View online (in formats below) [ASCII document, 20 K] [PDF document, 176 K, need Acrobat Reader to review] Information for visitors using screen readers Information about PDF Printed Copies Order online Order by telephone, fax, or mail Price Information Single copy Free Each additional copy 25 copies 100 copies NHLBI Home Page Sleep Information for the General Public Please send us your feedback, comments, and questions

46. Sleep Disorders s, symptoms, treatment, of various sleep disorders. Over a hundred articles on the topic. Sleep apnea, narcolepsy, sleep paralysis, insomnia. New Material added weekly....... http://sleepdisorders.about.com

zfp=-1 About Sleep Disorders Search in this topic on About on the Web in Products Web Hosting Sleep Disorders with Florence Cardinal Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS How To Index Top Picks "Clippings " - Read the News ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement In The Spotlight Mon, Mar 31, 2003 Spring Ahead - Lose an Hour Ah spring! It's a time of renewal, of green grass, flowers and birds nesting in the maple tree. Unfortunately, it's also the season when Daylight Saving Time returns and we all lose an hour of sleep. More: Sleep Deprivation - More articles and links on losing sleep Top Picks: Best of the Best - Guide Picks for books, CDs, more Sleep Is Important in Times of Crises Sleep is important in times of crises, be it something as horrific as the current war in Iraq, or something more personal, like the death of a loved one. Yet, these are the times when sleep is difficult if not almost impossible to attain. More: Getting To Sleep - More tips on sleeping well.

47. Drugs & Vitamins | Drug Library | DrugDigest Information from DrugDigest on dosage, usage, side effects, and interactions of this medication used to treat excessive daytime sleepiness associated with narcolepsy. http://www.drugdigest.org/DD/DVH/Uses/0,3915,550410|Modafinil,00.html

Drug Library Check Interactions Compare Drugs Supplements Using Medicine Drug Comparisons Side Effect Comparisons Health Conditions Treatment Options Archived News Subscribe to eBulletins showLayer('mainNav'); Search Conditions Modafinil Active Ingredients: Modafinil Representative Brand Names: Provigil Who is this for? This medication is used to treat excessive daytime sleepiness associated with narcolepsy Precautions NOTE: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product. Learn About Who is this for? When should I be careful taking it? What side effects should I watch for? Does this interact with drugs I am taking? How should I take it? ... Sitemap

48. Narcolepsy narcolepsy ORGANIZATIONS AND INFORMATION. Updated August 5, 1999 MEDIA ALERT! NATIONALnarcolepsy REGISTRY ANNOUNCED BY THE NATIONAL SLEEP FOUNDATION (NSF). http://www.stanford.edu/~dement/narco.html

NARCOLEPSY ORGANIZATIONS AND INFORMATION Updated August 5, 1999 MEDIA ALERT! STANFORD FINDS NARCOLEPSY GENE! Narcolepsy Network Cure Narcolepsy Now Narcolepsy Institute ... Modafinil/Provigil There is a new discussion group on narcolepsy. It is for people who experience excessive daytime sleepiness, cataplexy, hypnagogic hallucinations and other symptoms of narcolespy. (9/21/98) Web Forum to Discuss Narcolepsy Life of a Sleepy Person IV Conference in March of 1999! What is narcolepsy? The cause of narcolepsy is unknown. The neurological disorder is characterized by excessive sleepiness that is typically associated with cataplexy (a sudden loss of muscle tone and paralysis of voluntary muscles that is associated with a strong emotion) and other REM sleep abnormalities such as sleep paralysis, (Imobility of the body that occurs in the transition from sleep to wakefulness.) and hypnagogic hallucinations ( pre-sleep dreams). What are the symptoms? excessive sleepiness or sudden muscle weakness cataplexy (a sudden loss in muscle tone and deep tendon reflexes leading to muscle weakness, temporary paralysis or a complete postural collapse. Cataplexy is usually brought on by an outburst of emotion - notably laughter, anger or startle.) sleep paralysis hypnagogic hallucinations automatic behaviors (like driving home and not remembering how you got there!)

49. The Best Is Yet.net: Narcolepsy In Our Family Virginia Ramage Smith describes the experience of narcolepsy in a family member.Category Health Conditions and Diseases Sleep Disorders narcolepsy......One woman's experience of narcolepsy in a family member, plus Need greatretirement or nursing care in your own neighborhood? Negotiate http://www.thebestisyet.net/cgi-bin/cgiwrap/pando19/start.cgi/viewfrom11.htm

BBB Sunday, March 30, 2003 Subscribe to our Free newsletter all about aging - delay it - even reverse it; stretching your retirement dollars - for seniors and their families; view from the chair; and, updates, new features, and specials available ONLY through our newsletter. Subscribe Here! Your First Name: Your Last Name: Your Email Address: Popular Articles On Having My Cataracts Removed Prevent or Delay Alzheimer's Disease What to Expect from a Care Manager Know the Early Warning Signs of Dementia Getting Off the Grid Where Does Your State Rank? Osteoporosis ... 10 Ways to Cut the Costs of Prescription Drugs Like most of us, Virginia Ramage Smith has opinions, and she's not shy about sharing them. Unlike most of us, she is chairman of a corporate board and a full-time caregiver for her husband, a victim of Alzheimer's disease. She shares her opinions and experiences weekly in this column. Read more of her articles in our VRS section.

50. Narcolepsy Gene Found Stanford Researchers Nab narcolepsy Gene For Sleep Disorders. Mignot and his colleaguesbegan hunting for the narcolepsy gene in dogs more than a decade ago. http://www.stanford.edu/~dement/ngene.html

Stanford Researchers Nab Narcolepsy Gene For Sleep Disorders August 5, 1999 STANFORD - After a decade-long search, a Stanford-led team has identified a gene that causes the sleep disorder narcolepsy - a breakthrough that brings a cure for this disabling condition within reach, the scientists say. The researchers, led by Emmanuel Mignot, MD, PhD , associate professor of psychiatry at Stanford University School of Medicine, used a technique called positional cloning to pinpoint the gene in dogs, one of the few species besides humans known to develop narcolepsy. Mignot predicts the finding will not only help the roughly 135,000 Americans who suffer from narcolepsy, but in time it will shed light on two of the biggest mysteries in sleep research: how and why we sleep. "This discovery is the exciting culmination of 36 years of research on narcolepsy at Stanford," said William Dement, MD, PhD , director of the Sleep Disorders Research Center at Stanford. "Narcolepsy is the only known neurological disorder that affects the brain and sleep in such a dramatic way," said Mignot, who is director of Stanford's Center for Narcolepsy.

51. Midwest Sleep And Neurodiagnostic Institute Information and education on various sleep disorders such as sleep apnea, narcolepsy and insomnia. http://www.mwsleep.com/

Site Maintained by Encumpas.com Inc. www.encumpas.com Please report problems to: Webmaster@MWSleep.com Visitors Since 03/23/99: FastCounter by bCentral Make your hotel accomidations at the Candlewood Suites or just $59.00 USD. Click to get door to door driving directions Welcome! ( R o c k f o r d , I l l i n o i s ) Taking a new direction in sleep medicine training. The Midwest Sleep and Neurodiagnostic Institute will utilize cutting edge technology in providing customized training programs for technicians and physicians. The Midwest Sleep and Neurodiagnostic Institute believes our first responsibility is to provide educational support through innovation and a sharing of knowledge. NEW OFFICES! Midwest Sleep and Neurodiagnostic Institute Suite #207 5301 East State Street Rockford, IL 61108 Toll Free:1-877-398-MSNI Phone: 815-398-9606 Fax: 815-398-9616 2003 course updates are here!!

52. Site On Narcolepsy http://www.gta.igs.net/~ecahoon/

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53. Brians Narcolepsy & IH Website Index narcolepsy IH Website This is the main index. What is narcolepsy? narcolepsyis a disorder, characterized by an uncontrollable need to sleep. http://members.aol.com/BriSleep/narcolepsy.html

htmlAdWH('7003021', '120', '30'); htmlAdWH('7001998', '234', '60'); Main Create Edit Help This is the main index (This site is created on a screen setting of 800x600 at 16K , 16bit or 16million colors, depending on how your graphics card is set. For best visuals using AOL go to your Settings, Preferences, Internet settings, Web Graphics and select Never Compress Graphics.) Update Hi folks!! Well as you the website users demand it, I'm going back to work on the site, I've got a massive increase in requests to post Doctors and Connections, not mentioning (but I just did, see how that slips in) all those that have been sent over the past + - year. The main reasons I've been gone so long from this post is that #1 I used to have a financial supporter which inspired me to work harder, I lost that support early this year to no fault of the backer or this website but from a thing I'm seeing more and more of, PWN becoming poisoned by their own meds, almost allergic in a way the doctors call it a Toxic Reaction. What basically happens is that the meds you've been taking for years suddenly make you terribly ill, the only choice you have is to stop taking them. If you're looking for the previous posts that were here, including the requests for help and editors, etc. they're down at the bottom of the page before the counter.

54. Sleep Information For Patients And The General Public Covers sleepiness,insomnia, sleep apnea and narcolepsy. http://www.nhlbi.nih.gov/health/public/sleep/index.htm

Health Information Garfield Star Sleeper Campaign Awake At the Wheel Materials Facts About Problem Sleepiness ... Test Your Sleep I.Q. Video Public Service Announcements Sleep Apnea Video PSA [QuickTime Format 2179 Kb] To view the video, you will need the QuickTime viewer. If you do not have QuickTime, you may download a free copy from Apple Healthbeat Radio Programs Additional Resources National Center on Sleep Disorders Research Web Site List of Publications Information Center Sleep Information for Professionals ... Contact the NHLBI Please send us your feedback, comments, and questions by using the appropriate link on the page, Contact the NHLBI Note to users of screen readers and other assistive technologies: please report your problems here.

55. Narcolepsy & Sleep Disorders News narcolepsy Sleep Disorders news. Free online information aboutnarcolepsy for patients, physicians, and researchers. http://members.aol.com/path2pub/home.htm

Free online information about narcolepsy for patients, physicians, and researchers. Treatment / Drug List Sample Newsletter Issue Narcolepsy On-line Discussion (exchange email with patients, family members, etc. ) Republished Articles Key articles from past issues. view on-line or download. GHB (Xyrem, Gamma-hydroxybutyrate) Clinical test sites updated 6/6/01 Clinical trial description added 6/6/01 Humor and occasionally wicked satire Cartoons by Dr. Kraski Guest Book and Notification Service [get email notices of new articles added or public policy positions taken (including Legislative threats to treatment.)]. Please take a look at this as a means to advance our mutual interests You'll need the (free) Acrobat Reader to view starred items. Please report technical problems to our Web-Mistress Initiated: Updated: 06/04/01 Modified: 04/28/2001 Thanks for visiting test Books and Reviews Go To Sleep Home Pages A "top of the line" site providing extensive coverage of sleep, sleep disorders research, and sleep related organizations

56. Eastern New Mexico Sleep Disorder Center Diagnosis and treatment of sleep apnea, insomnia, narcolepsy restless legs syndrome and periodic limb movements. Located in Roswell and serving the southwestern US. Offers information and contact details. http://www.sleepingsolution.com

"We don't rest until you do" Insomnia Narcolepsy Sleep Apnea Restless Legs Syndrome ... Periodic Limb Movement s Diagnosis Treatment About Us Contact ... Links Do you have a sleep disorder? You may be surprised at the answer. Answer the questions to the right and see for yourself. Sleep Disorder Symptoms If you or someone you know has any of the signs or symptoms to the right, obstructive sleep apnea may be the cause. If you check yes to one or more, see your Primary Care Physician and get a referral to the ENMSDC. See below for a description of the most common sleep disorders. yes no Excessive daytime sleepiness Kicking legs Recurrent waking from sleep Unrefreshing sleep Daytime fatigue Trouble concentrating Morning headaches Snoring, choking, gasping or pauses of breathing during sleep Insomnia At Least 15% of the population suffers from insomnia - difficulty falling or staying asleep - every year. Insomnia can be caused by a number of medical or behavioral factors such as stress, anxiety, depression, sleep apnea, restless legs or periodic limb movements during sleep, alcohol, caffeine, drugs or poor sleep habits.

57. Texas Sleep Disorders Center - John D. Seifert M.D. Treatment of snoring, sleep apnea, insomnia, night terrors, sleep walking, bed wetting and narcolepsy. http://Texassleepdisorders.com

At Texas Regional Sleep Disorder Center, our approach to snoring and sleep apnea is comprehensive. Snoring is caused by an obstruction of air while one Is sleeping as it passes through the nose and to the back of the throat, or pharynx. Many times the snoring is not serious enough to cause any physical illness. Other times the snoring is a symptom of a very severe obstruction of breathing and the body has to work to breath to maintain normal bodily functions. If one has sleep apnea, breathing can stop for up to five minutes and during this time, when the breathing has stopped, the pulse increases and the blood pressure increases so as to give emergency needs of oxygen to the body. If this process Is allowed to progress then the individual having this is more prone to permanent high blood pressure, cardiovascular disease, leading to stroke and sudden death. Sleep apnea can affect people of all ages. Children get sleep apnea from enlarged tonsils and adenoids. This can happen in a newborn. This is usually manifested in children by fatigue, irritability, and of course, the audible snoring and breathing sensations. Breathing obstruction can be either in the nose or in the oral pharynx. In the nose, it is caused by cartilaginous or bony obstruction of the nasal septum which divides the nose into right and left compartments. It also can be caused by chronic sinusitis when one assumes the recumbent position, the infectious material rolls out of the paranasal sinuses and stops us the nose making one breathe through their mouth. After a period of time, this gasping for air through the mouth causes elongation of the soft palate and uvula, and later the tongue will press against the soft palate and uvula which has been elongated by this sleep apnea process, and breathing will stop.

58. Index Support group for people with sleep disorders.Category Health Conditions and Diseases Sleep Disorders narcolepsy......The Florida Narcolespy Association PO Box 15352 Sarasota, Fl 342771352,Welcome! The Florida Narcolespy Association is a collective http://www.flnarcolepsy.org/

The Florida Narcolespy Association PO Box 15352 Sarasota, Fl 34277-1352 Welcome! The Florida Narcolespy Association is a collective of people that "helps" or "comforts" others. This is the idea behind the Florida Narcolespy Association to be there to lend a hand toward those afflicted, as well as their families, doctors and friends. Home Sleep Net ~ Everything you wanted to know about sleep but were too tired to ask The Sleep Medicine Home Page ~ A master TOC to sleep on the web by Dr. Michael Thorpy, Director of the Sleep-Wake Disorders at Montefiore Hospital, Bronx, New York. Sleepwell ~ Reservoir of information on sleep disorders. Cephalon ~ An international biopharmaceutical company dedicated to the discovery, development and marketing of products to treat neurological disorders and cancer. Breaking news about Modofinal/Provigil. Talk About Sleep ~ All sleep, all the time! The information of the FNA site is not intended to be medical advice. If you think that you have a sleep disorder you should seek care from a qualified health care professional.

59. VCUHS Sleep Disorders Center Located in Richmond, Virginia. Information on apnea, narcolepsy, insomnia, RLS, and links to other sites. http://www.vcu.edu/sleepwell

VCU Health System Virginia Commonwealth University last updated: May 3, 2002

60. Sleepnet.com's Narcolepsy Forums Sleepnet.com's Pathway to the narcolepsy Forums. If you are not familiar with narcolepsyplease visit the narcolepsy Homepage. narcolepsy Forum23 new postings. http://www.sleepnet.com/narco/narcoinf.html

Sleepnet.com's Pathway to the Narcolepsy Forums If you are not familiar with Narcolepsy please visit the Narcolepsy Homepage. Site Map and Over 400 Definitions and Abbreviations used in sleep. Questions about medications? Check out Medline Plus Drug Information Narcolepsy Forum23 new postings or view archives by forum below Narcolepsy Forum22 Narcolepsy Forum21 Narcolepsy Forum20 Narcolepsy Forum19 ... Narcolepsy Forum1

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