81. Current Projects Publication Title nephroblastoma study SIOP No 9/GPOH. Project 71. Shorttitle Wilm's tumor study. Sponsor Prof. R. Ludwig, research grant. http://www.biometrie.uni-heidelberg.de/mb/currentprojects.htm

Current projects Title: Topotecan (T) / Cisplatin (DDP) 3 days versus Topotecan / Cisplatin 5 days in patients with metastatic small cell lung cancer (SCLC) Project: Short title: SCLC EDII Topo/Cis 3 days vs. 5 days - Pilot study Sponsor: GlaxoSmithKline Project staff: K. Jensen, C. Conradt Cooperation: Prof. Dr. M. Wolf, Dr. U. Seifart, Marburg Description: Topotecan is a new and active drug in SCLC. In first line therapy and in sensitive relapse, response rates of 40% have been reported. A combination with a DNA cross linking agent was suggested to be highly effective, in particular as Topotecan also inhibits DNA repair. Therefore, a phase II trial was initiated to a) assess the activity of T/DDP in patients suffering from ED SCLC and b) to compare the conventional 5-day regime with an experimental 3-day schedule. Time scale: Publication: Jensen K, Klose C (2002

82. CancerGene NOV Name, nephroblastoma overexpressed gene. Locus, 8q24.1. Keywords, CTGF subfamily;IGFBP superfamily; growth factor. Diseases, Kidney Neoplasms; nephroblastoma. http://caroll.vjf.cnrs.fr/cancergene/CG118.html

Infobiogen Search CancerGene CancerGene Homepage Search CancerGene Citations CancerGene Card Symbol NOV Aliases CCN3; IGFBP9; NOVH Name nephroblastoma overexpressed gene Locus OMIM GDB SwissProt LocusLink NOV Class PROTOONCOGENE Keywords CTGF subfamily; IGFBP superfamily; growth factor Diseases Kidney Neoplasms; Nephroblastoma Note The NOV gene is a member of the CCN family of growth factors which includes CTGF ( CG:286 OMIM:602369 ), and recently described WISP-1 ( CG:1068 ), WISP-2 ( CG:1069 ), and WISP-3 ( CG:1070 ) genes. ( UI:99061933 CCN stands for connective tissue gr owth factor /cysteine-rich 61/nephroblastoma overexpressed ( UI:99220318 There is a unrelated homonym gene NOV/PLXN1( CG:590 OMIM:601055 Comments The CCN family of genes presently consists of six distinct members encoding proteins that participate in fundamental biological processes such as cell proliferation, attachment, migration, differentiation, wound healing, angiogenesis, and several pathologies including fibrosis and tumorigenesis. Whereas CYR61 and CTGF ( CG:286 ) were reported to act as positive regulators of cell growth, NOV (nephroblastoma overexpressed) provided the first example of a CCN protein with negative regulatory properties and the first example of aberrant expression being associated with tumour development. The subsequent discovery of the ELM1, rCOP1, and WISP (

83. Nephroblastoma (codes) nephroblastoma (codes). Prenatal diagnosis of congenital Wilms' tumor (nephroblastoma)presenting as fetal hydrops ULTRASOUNDIN-OBSTETRICS-AND-GYNECOLOGY. http://malattierare.pediatria.unipd.it/pubblicaMR/mr_dx_ing.asp?mr=375

84. AAP Is Chemotherapy Helpful For Children With Cystic Partially AAP Is Chemotherapy Helpful for Children with Cystic Partially Differentiatednephroblastoma? By Maria Bishop Special to DG News http://www.pslgroup.com/dg/220e4a.htm

85. Wilm's Tumor - Overview Wilm's tumor. Alternative names nephroblastoma; Kidney tumor. DefinitionWilm's tumor is a cancerous tumor of the kidney that occurs in children. http://www.audrainmedicalcenter.com/ency/article/001575.htm

Disease Injury Nutrition Poison ... Prevention Wilms' tumor Definition: Wilms' tumor is a cancerous tumor of the kidney that occurs in children. Alternative Names: Nephroblastoma; Kidney tumor Causes, incidence, and risk factors: Wilms' tumor is one of the most common tumors of the abdomen in children and the most common type of kidney tumor. The exact cause of tumor formation in most children is unknown. It is associated with certain birth defects including urinary tract abnormalities, absence of the iris (aniridia), and hemihypertrophy (enlargement of one side of the body). It is more common among some siblings and twins, which suggests a possible genetic cause. The tumor may become quite large, but usually remains encapsulated (self-enclosed). It may spread to other body tissues, especially the lungs. The frequency of disease occurrence is estimated to be about 1 out of 200,000 to 250,000 children. The peak time of occurrence is at 3 years old, and Wilms' tumor is rare after the age of 8 years. Review Date: 7/17/2002 Reviewed By: Scott Howard, M.D., M.S., Department of Pediatric Hematology/Oncology, St. Jude Children’s Research Hospital, Memphis, TN. Review provided by VeriMed Healthcare Network.

86. Gross Specimen List For Urinary System Station 13, Wilm's Tumor nephroblastoma Note well demarcated,View 1. Wilm's Tumor nephroblastoma Note well demarcated, View 2. http://erl.pathology.iupui.edu/C604query.cfm?Table=UT2

87. CancerSourceRN.com Reference Center HonCode HonCode, Reference Center Home. Publish Date 12/1/1999 nephroblastomasee WILMS' TUMOR. Search for a glossary term Browse http://www.cancersourcern.com/resources/glossary/detail.cfm?ID=1737

88. Papb1995 ?). 1.Establishment and characterization of a cell line(NB-YK) derived from a transplantable rat nephroblastoma. K.Shibuya http://group.lin.go.jp/nibs/seika/paper/papb1995.html

‚PDEstablishment and characterization of a cell line (NB-YK) derived from a transplantable rat nephroblastoma K.ShibuyaCH.KizakiCM.TajimaCN.ShibuyaCJ.YamateC• T.Nunoya @ Nippon Institute for Biological Science @ J Vet Med Sci. 57: 1117-1120, 1995 SummaryF A new cell line, NB-YK, was established from a transplantable rat nephro-blastoma (NB-Y) which was derived from a spontaneous nephroblastoma in an aged F344 rat and cytological, morphological, and immunocytochemical characteristics and intermediate filament proteins of NB-YK were examined. ‚QDCharacterization of pseudorabies virus glycoprotein gII expressed by recombinant baculovirus. X.Xuan CT.Nakamura CT.Ihara CI.Sato CK.Tuchiya CE.Nosetto CA.Ishihama C• S.Ueda 1)Nippon Institute for Biological Science, 2)The Tokyo University, 3)University of La Plata, 4)National Institute of Genetics Virus Res., 36: 151-161,1995 SummaryF The gene encoding the complete glycoprotein gll (homologue of gB of herpes sirnplex virus) of pseudorabies virus (PrV) was inserted into a baculovirus transfer vector, and a recombinant virus expressing gll was isolated. Three gll-related recombinant baculovirus-expressed peptides of 100, 60, and 45 to 50 kDa were detected with a polyclonal antibody against gll; these correspond to the authentic subunits glla and its cleavage products gllb and gllc, respectively. These proteins were subjected to N-terminal sequencing, and the results showed that the protease cleavage sites were identical to those of authentic gll. The expressed gll was shown to be transported to the surface of infected cells as judged by an indirect immunofluorescence test. Antibodies raised in mice immunized with the recombi-nant gll neutralized the infection of PrV in vitro.Mice inoculated with the recombinant gll were completely protected from lethal challenge with PrV.

89. Wilms' Tumor (nephro- Blastoma) Please Note That Information On Wilms' Tumor (nephro blastoma), Please note that information on this canceris available from the following National Cancer Institute resources http://rex.nci.nih.gov/INFO_CANCER/WILMS_TUMOR.htm

Wilms' Tumor (nephro- blastoma) Please note that information on this cancer is available from the following National Cancer Institute resources: PDQ a National Cancer Institute database that provides up-to-date cancer information statements, listing of research studies (clinical trials) and directories of physicians and organizations involved in cancer care. PDQ was developed by the NCI with help from cancer experts across the nation. The information in PDQ is reviewed each month. Cancer Facts is a series of fact sheets on current treatment topics. National Cancer Institute Publications These materials are designed to help patients, their families nad the general public with their questions about cancer treatmetns. The Cancer Information Service (CIS) the National Cancer Institute's nationwide information and education program. Through the CIS toll-free number, information specialists are available to talk with you, answer your questions, and provide local resources and services. Choose from the following topics concerning this type of cancer and select the desired information resource: Treatment PDQ [Patients] or [Health Professionals] Cancer Facts Detection PDQ [Patients] or [Health Professionals] Risk Factors PDQ [Patients] or [Health Professionals] Prevention PDQ [Patients] or [Health Professionals] Patient Care PDQ [Patients] or [Health Professionals] General Information PDQ [Patients] or [Health Professionals] All Topics PDQ More Questions...

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