41. THE MERCK MANUAL, Sec. 11, Ch. 135, Leukopenia And Lymphocytopenia alone. neutropenia (Granulocytopenia; Agranulocytosis). Secondary neutropeniaDrugs are one of the most common causes of neutropenia. The http://www.merck.com/pubs/mmanual/section11/chapter135/135a.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 11. Hematology And Oncology Chapter 135. Leukopenia And Lymphocytopenia Topics Leukopenia Lymphocytopenia Leukopenia Leukopenia is usually characterized by a reduced number of blood neutrophils, although a reduced number of lymphocytes, monocytes, eosinophils, or basophils may also contribute to the decreased total cell count. Neutropenia accompanied by monocytopenia and lymphocytopenia is often a more serious disorder than neutropenia alone. NEUTROPENIA (Granulocytopenia; Agranulocytosis) A reduction in the blood neutrophil (granulocyte) count, often leading to increased susceptibility to bacterial and fungal infections. Ch. 151 Etiology Acute neutropenia (occurring over a few days) often develops when neutrophil use is rapid and production is impaired. Chronic neutropenia (lasting months or years) usually arises from reduced production or excessive splenic sequestration of neutrophils. Neutropenia may be classified by whether it arises secondary to factors extrinsic to marrow myeloid cells or whether an intrinsic defect appears to be present in the myeloid progenitors (see Table 135-1 Secondary neutropenia: Drug-induced neutropenia has several underlying mechanisms (immune, toxic, idiosyncratic, or hypersensitivity reactions) and should be differentiated from the severe neutropenia that predictably occurs after large doses of cytoreductive cancer drugs or radiotherapy (see

42. Anemia, Neutropenia, And Thrombocytopenia: Pathogenesis And Evolving Treatment O Anemia, neutropenia, and Thrombocytopenia Pathogenesis and Evolving Treatment Optionsin HIVInfected Patients CME Author Alexandra M. Levine, MD Disclosures http://www.medscape.com/viewprogram/669

Focus On... ADHD ALLHAT Alzheimer's Disease Anthrax Asthma Biologic Therapies Bipolar Disorder Breast Cancer Depression Erectile Dysfunction Genital Herpes GERD Geriatric Care Heart Failure Heart Failure: CRT Hepatitis C HIPAA Home Defib in SCA Hyperlipidemia IBS InfluenZone Insulin Pump Tx Kidney Disease Menopause Micro Complications Multiple Sclerosis Osteoporosis Ovarian Cancer Pain Management Pancreatic Cancer Patient Safety Rheum Arthritis Schizophrenia Secondary Anemia Serious Mental Ill Sports Medicine UTI-Zone Weight Management Related Topics Health Diversity Hospice Care Medical Privacy Welcome, March 31, 2003 Anemia, Neutropenia, and Thrombocytopenia: Pathogenesis and Evolving Treatment Options in HIV-Infected Patients CME Author: Alexandra M. Levine, MD Disclosures Release Date: Updated June 5, 2002 Valid for credit through June 5, 2003 Credit Hours Available Physicians - up to 1.0 AMA PRA category 1 credit(s); Pharmacists - up to 1.0 contact hour(s) (0.1 CEUs) Contents of This CME Activity Anemia, Neutropenia, and Thrombocytopenia: Pathogenesis and Evolving Treatment Options in HIV-Infected Patients Abstract Requirements for Normal Hematopoiesis Basic Abnormalities of Hematopoiesis Induced by HIV Anemia in HIV Infection Neutropenia Thrombocytopenia Thrombotic Disease Conclusion References Post Test and Evaluation The material presented here does not reflect the views of Medical Education Collaborative, Medscape or the companies providing unrestricted educational grants. These materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified health care professional should be consulted before using any therapeutic product discussed. All readers and continuing education participants should verify all information and data before treating patients or employing any therapies described in this continuing medical education activity.

43. Ask The Experts - Treating Neutropenia In African-Americans? Other HIVRelated Opportunistic Conditions Ask The Expert Treating neutropeniain African-Americans? from Medscape HIV/AIDS Question. http://www.medscape.com/viewarticle/413277

44. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Neutropenia Similar pages Severe Chronic neutropenia FactsheetSevere Chronic neutropenia. Download Factsheet. (124k). Feedback. OrmondStreet for treatment. What is Severe Chronic neutropenia (SCN)? http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Neutropenia

45. Neutropenia neutropenia. neutropenia. neutropenia A blood disorder you don’t often hearabout, but can affect anyone. Severe Chronic neutropenia International Registry. http://www.health-nexus.com/neutropenia.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Neutropenia Neutropenia Neutropenia - A blood disorder you don’t often hear about, but can affect anyone. An extensive look at this disorder with information about the blood, the causes of neutropenia, the different types, symptoms and the treatment. Severe Chronic Neutropenia International Registry Chronic Neutropenia - NORD Neutropenia; Treatment, Prevention, Cure - Neutropenia:Search information from many of the best Neutropenia health sites. Quickly find information: treatments, prevention, support and more Neutropenia OnLine Forum - Neutropenia OnLine is a forum with info and discussion for patients with neutropenia, their families and friends.

46. EMedicine - Neutropenia : Article By Daniel D Shin, MD neutropenia neutropenia is a decrease in circulating neutrophils in the peripheralblood. The absolute neutrophil count (ANC) defines neutropenia. http://www.emedicine.com/med/topic1640.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Neutropenia Last Updated: February 7, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Schultz disease, agranulocytosis, granulocytopenia, leukopenia, neutropenic fever AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Daniel D Shin, MD , Fellow, Department of Internal Medicine, Division of Infectious Diseases, Stanford University Coauthor(s): John E Godwin, MD, MS , Associate Director, Associate Professor, Department of Internal Medicine, Division of Hematology/Oncology, Foster McGaw Hospital, Loyola University at Chicago Medical Center Daniel D Shin, MD, is a member of the following medical societies: Infectious Diseases Society of America Editor(s): Karen Seiter, MD , Associate Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College; Francisco Talavera, PharmD, PhD

47. EMedicine - Autoimmune And Chronic Benign Neutropenia : Article By Susumu Inoue, Autoimmune and Chronic Benign neutropenia Chronic (ie, lasting 6 mo, as opposedto acute) benign neutropenia can be regarded as a synonym of autoimmune http://www.emedicine.com/ped/topic184.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Hematology Autoimmune and Chronic Benign Neutropenia Last Updated: February 5, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: AIN, autoimmune granulocytopenia, autoimmune neutropenia of infancy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Susumu Inoue, MD , Director of Pediatric Hematology-Oncology, Professor, Department of Pediatrics, Michigan State University College of Human Medicine and Hurley Medical Susumu Inoue, MD, is a member of the following medical societies: American Society of Clinical Oncology American Society of Hematology American Society of Pediatric Hematology/Oncology International Society for Experimental Hematology , and Society for Pediatric Research Editor(s): Gary R Jones, MD Robert Konop, PharmD , Clinical Assistant Professor, Department of Pharmacy, Section of Clinical Pharmacology, University of Minnesota;

48. Neutropenia Translate this page neutropenia FEBRIL. 1- Enfermedad tumoral obstrucción, ulceración, neutropenia(en los hematológicos), trastornos de la inmunidad humoral. http://www.paliativos.com/neutrop.html

Cuidados Paliativos NEUTROPENIA FEBRIL En el enfermo oncológico hay muchas causas de fiebre - enfermedad tumoral, metástasis (fundamentalmente hepáticas) - infecciones (representan el 50-70% de los episodios febriles en el paciente oncológico) - secundaria a drogas (bleomicina, antibióticos, alopurinol, fenitoína,...) - secundaria a radioterapia - reacciones transfusionales - enfermedades intercurrentes FACTORES QUE FAVORECEN LA INFECCIÓN EN PACIENTES ONCOLÓGICOS Enfermedad tumoral : obstrucción, ulceración, neutropenia (en los hematológicos), trastornos de la inmunidad humoral. Alteración de los mecanismos defensivos normales A- Rotura de barreras anatómicas: tumores de la esfera ORL, tratamientos catéteres. Los gérmenes más frecuentes son Strep. piogenes, Staph. aureus, Pseudomona aeruginosa, Serratia, Staph. coagulasa-nagativos B- Cambios en la flora microbiana debidos a la enfermedad, tratamientos, ingresos,... C- Trastornos de la inmunidad celular: linfoma de Hodgkin (virus de la varicela-zóster-VVZ); Listeria, Salmonella, Nocardia, Mycobacterias, virus del herpes simple (VHS), VVZ

49. Neutropenia neutropenias. Chronic neutropenia NORD. Neupogen - Has information about neutropenia,a common side effect of chemotherapy. neutropenia Support Assoc. Inc. http://www.ability.org.uk/Neutropenia.html

Our Aims Services Stats ... Z Neutropenias Chronic Neutropenia - NORD Neupogen - Has information about neutropenia, a common side effect of chemotherapy. Neutropenia Support Assoc. Inc Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

50. Neutropenia Translate this page neutropenia. 1 - Considerações. neutropenia existe quando a contagemde neutrófilos é inferior a 1500/mcL. Entretanto http://ioh.medstudents.com.br/neutropenia.htm

Neutropenia DROGAS QUE PODEM CAUSAR NEUTROPENIA Sindrome de Felty candida ou aspergillus 3 - Tratamento

51. Febrile Neutropenia, Brussel, Belgium, Bordet febrile neutropenia, complication of cancer chemotherapy 6th internationalsymposium 2003, prof klasersky, jules bordet institute, brussels, belgium. http://www.febrileneutropenia.org/

th Home Practical Information Scientific ... Meeting th International Symposium on Febrile Neutropenia Brussels, December 17-19, 2003 Auditorium "Jacques Thierry" Febrile neutropenia remains a major complication of cancer chemotherapy administration and its frequency is likely to increase as the numbers of cancer patients are growing. Our strategy to cope with febrile neutropenic patients is definitely influenced by the availability of new agents that can be used for preventive or therapeutic purposes. In that respect, new antifungals and novel granulocyte stimulating agents will probably influence our clinical behaviour. On the other hand, the approach of febrile neutropenia is influenced by the characteristics of the patients who present it. It is now clear that the population of febrile neutropenic patients is an heterogenous one and that all these patients do not require the same attitude. Thus, exploring our therapeutic armamentarium and defining the factors which safely predict the course of febrile neutropenia is definitely needed for an optimal management of that condition. Furthermore, as new techniques continuously appear in cancer medicine and supportive care, the issue related to febrile neutropenia need to be periodically evaluated.

52. IBMFS - Severe Congenital Neutropenia Severe Congenital neutropenia (SCN). SCN patients have very low whiteblood counts. Since white cells help the body to fight off http://marrowfailure.cancer.gov/SCN.html

What are the IBMFS disorders? Amegakaryocytic Thrombocytopenia Diamond-Blackfan Anemia Dyskeratosis Congenita Fanconi's Anemia ... Pearson's Syndrome Severe Congenital Neutropenia Shwachman-Diamond Syndrome Thrombocytopenia Absent Radii Other Bone Marrow Failure Syndromes Severe Congenital Neutropenia (SCN) SCN patients have very low white blood counts. Since white cells help the body to fight off infection, children with this disorder develop serious infections during infancy. The physical appearance is normal. The gene involved in most cases has been identified. It is called "ELA2." Males and females are affected equally. What are the major findings on physical examination? These patients have normal physical examinations. What is the age at diagnosis? The diagnosis is usually made in the first year of life. What is the pattern of bone marrow failure? The bone marrow of patients with SCN fails to produce a specific type of white blood cell known as a "

53. Aidsmap - Glossary neutropenia (newtro-pee-nee-uh) A shortage of neutrophils. Search for neutropeniaon aidsmap.com, Copyright © NAM Publications 1999-2003. All rights reserved. http://www.aidsmap.com/main/glossary.asp?lett=N&Explanation=neutropenia

54. Neutropenia A definition of neutropenia in the glossary of the About's Gynecologic Cancerssite, with related resources. neutropenia. The Danger Signs of neutropenia. http://www.baymoon.com/~gyncancer/library/glossary/bldefneutropenia.htm

Neutropenia Full Glossary Related Terms ANC chemotherapy Definition: A low number of neutrophils (type of white blood cell) in the blood. This can happen after a chemotherapy treatment, when the cells in the bone marrow can be damaged by the drug(s). Since these cells are very important in protecting the body from infection, a person receiving chemotherapy must be alert to the possible signs of low white count, as well as taking protective measures against infection. The degree of neutropenia is reflect in the absolute neutrophil count (ANC). For more information as to the specifics of that count, see that glossary definition. Pronunciation: new troh PEE nee ah • (noun) Also Known As: low white cell count, low neutrophil count Common Misspellings: newtropenia Related Resources: Protecting Yourself During Chemotherapy The Danger Signs of Neutropenia Full Glossary GO TO Gyn Cancer Resource Page HPV/Dysplasia Resource Page Laura's Gyn Cancer Home gyncancer@baymoon.com The material on this page and Web site is for informational and educational purposes only, and should not substitute for medical advice. Anyone having questions about the application of information appearing here to a specific person or situation should obtain advice from a qualified physician.

55. Barth Syndrome - X-linked Cardiomyopathy And Neutropenia An article about Barth Syndrome with a description, clinical manifestations, etiology, epidemiology, Category Health Conditions and Diseases Barth Syndrome......Barth Syndrome X-linked Cardiomyopathy and neutropenia. Richard I. Kelley,MD, PhD. The neutropenia was severe and variable but not truly cyclical. http://www.med.jhu.edu/CMSL/Barth_Summary.html

Barth Syndrome - X-linked Cardiomyopathy and Neutropenia Richard I. Kelley, MD, PhD Division of Metabolism, Kennedy Krieger Institute Department of Pediatrics, Johns Hopkins Medical Institutions History and Overview or " TAZ, " mutations in Barth syndrome was further supported by the finding of disabling mutations of TAZ in 14 additional Barth syndrome families [Johnston et al, 1997]. The recognition of homology of TAZ Clinical Manifestations TAZ Genetic and Molecular Pathology TAZ mutations that yield different effects in different tissues. However, in a detailed study of 14 Barth syndrome families, there was no evident phenotype-genotype correlation [Johnston et al, 1997]. To date, more than 50 different mutations in the TAZ gene have been found, of which 60% are frame-shift, stop, or splice-site mutations predicted to disrupt completely the function of the Barth proteins. Another 30% lead to a change in the charge of the protein. A substantial fraction of the mutations are de novo mutations, in a proportion not inconsistent with the one-third new mutation rate predicted for X-linked recessive diseases (Haldane fraction) (I. Gonzales, R. Kelley, unpublished). Epidemiology Differential Diagnosis Diagnostic Evaluation Prognosis and Complications Management Literature Cited Ades LC, Gedeon AK, Wilson MJ, Latham M, Partington MW, Mulley JC, Nelson J, Lui K, Sillence DO. 1993. Barth syndrome: clinical features and confirmation of gene localisation to distal Xq28. Am J Med Genet 45:327-334.

56. Definition For:Neutropenia neutropenia. Chapter 2 The condition of an absolute deficiency in the numberof circulating neutrophils. See Also neutropenia (Chapter 20a). http://www.kumc.edu/instruction/medicine/pathology/ed/keywords/kw_neutrope.html

Neutropenia Chapter: 2 The condition of an absolute deficiency in the number of circulating neutrophil s. See Also Neutropenia: (Chapter 20a)

57. Definition For:Neutropenia: neutropenia Chapter 20a Decrease in the number of WBC's in the peripheralblood. Severe neutropenia (absolute neutrophil count http://www.kumc.edu/instruction/medicine/pathology/ed/keywords/kw_neutrope1.html

Neutropenia: Chapter: 20a Decrease in the number of WBC's in the peripheral blood. Severe neutropenia (absolute neutrophil count See Also Neutropenia (Chapter 2)

58. Advanced Search Understanding the Treatment Options for neutropenia. neutropenia in childrenis likely to be benign and often resolves without intervention. http://www.aafp.org/afp/20001001/tips/9.html

Advanced Search Tips from Other Journals Previous Next Understanding the Treatment Options for Neutropenia per L). Classification of Neutropenias The rightsholder did not grant rights to reproduce this item in electronic media. For the missing item, see the original print version of this publication. Munshi and Montgomery used information obtained through a MEDLINE search for their review. Management and evaluation of neutropenia should depend on the severity of the neutropenia and on the presence of symptoms suggesting infection. Patients with severe neutropenia with fever or signs of infection and those with evidence of malignant disease should be hospitalized. The cause of neutropenia should be determined, potential sources of infection evaluated and antibiotic therapy started. The diagnostic evaluation includes history of prior infection, a review of prior blood counts and exploration for evidence of infection or rheumatologic conditions. Patients with mild neutropenia and no evidence of infection may be monitored with blood cell counts for six to eight weeks. Neutropenia in children is likely to be benign and often resolves without intervention. Laboratory tests include microscopic examination of a peripheral blood smear, appropriate cultures and specific chemical, bacteriologic and viral studies, and serologic testing for collagen vascular disease. Bone marrow aspiration is needed when the cause of neutropenia is not clear, when the neutropenia does not resolve or if there is evidence of multiple cytopenias.

59. Advanced Search Management of the Febrile Child with neutropenia. Children who areneutropenic secondary to cancer chemotherapy are usually admitted http://www.aafp.org/afp/20001001/tips/18.html

Advanced Search Tips from Other Journals Previous Next Management of the Febrile Child with Neutropenia and a diagnosis of a solid tumor. Aquino and colleagues examined the efficacy of using ciprofloxacin in the outpatient management of selected pediatric patients with fever during an episode of neutropenia. Patients were eligible for enrollment if they were one to 21 years of age, their malignancy was in remission, it had been seven or more days since their last chemotherapy course and they had an absolute phagocyte count of greater than 100 mm . In addition, the parents had to be reliable. After appropriate laboratory tests, the children received a single dose of intravenous ceftazidime (50 mg per kg). If the child was clinically well after being observed from two to 23 hours, enrollment was offered. Treatment began with ciprofloxacin therapy (20 mg per kg per day in two divided doses). The children were maintained on the ciprofloxacin therapy until they were afebrile for 24 hours, had negative blood cultures and evidence of bone marrow recovery. If the children appeared toxic, had positive blood cultures or were febrile for five or more days, they were admitted for inpatient treatment. Eighty-nine percent of the children were successfully treated as outpatients. Four percent of the children were admitted to a hospital because of positive blood cultures. Two of 45 children had to be admitted to the hospital because of noncompliance with the outpatient regimen. All those admitted had uncomplicated hospitalizations and recovered fully.

60. Neutropenia Bone Marrow Transplantation. neutropenia neutropenia Support AssociationInc. http//www.neutropenia.ca Offering information about http://www.medlina.com/neutropenia.htm

Academic Medicine Addiction Aging AIDS-HIV ... Women's Health The Web MEDLINA.com (partial) CDC WHO FDA NIH CATEGORIES Search: All Products Books Magazines Popular Music Classical Music Video DVD Baby Electronics Software Outdoor Living Wireless Phones Keywords: Home Up Hematology Books Lymphatic System Disorders ... Eosinophilia Neutropenia Blood Platelet Disorders Hematology Research Hematology Associations Blood Banks ... Bone Marrow Transplantation Neutropenia Neutropenia Support Association Inc. - http://www.neutropenia.ca Offering information about this disorder, about the association, links and news articles. Severe Chronic Neutropenia International Registry - http://depts.washington.edu A disease registry which was established in Australia, Canada, the European Community and the United States in March, 1994. Information for patients and families and health care providers. Neutropenia - http://www.neutropenia.ca An extensive look at this disorder with information about the blood, the causes, the different types, symptoms and the treatment. Neutropenia - http://www.tirgan.com

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