41. Ochronosis ochronosis. Homogentisic acid. Dark urine.Bluegray color of pinnae, tendons, TM's. http://www.docderm.com/pearls/ochronosis.htm

Ochronosis Homogentisic acid Dark urine Blue-gray color of pinnae, tendons, TM's

42. Diagnose-Me: Conditions: Ochronosis / Alkaptonuria ochronosis / Alkaptonuria, Signs, symptoms and indicators, Signs, symptoms indicatorsof ochronosis / Alkaptonuria Symptoms Nails, Blue and brown fingernails. http://www.diagnose-me.com/cond/C451501.html

Home FAQ Start The Analyst Last updated: Dec 20, 2002 Ochronosis / Alkaptonuria Signs, symptoms and indicators Ochronosis is the muscoskeletal manifestation of alkaptonuria - a rather rare (one in 200,000 births) inherited disorder of protein metabolism characterized by an inability of the body to metabolize the amino acids tyrosine and phenylalanine . It affects especially the large joints (hip, knees and vertebral column) by a progressive degenerative arthrosis The outward signs are the ocular (eye) and the skin pigmentations, the genito-urinary calculi (stones) and cardiovascular ochronosis (especially the aortic valve). The symptoms mostly begin within the third or fourth decade. It was Scribonius who described the first known case of ochronosis in 1584. He mentioned a schoolboy who passed urine black as ink. In 1902, Albrecht and Zdareck discovered the link with alkaptonuria. The incidence of alkaptonuria is 1 per million with the highest prevalence in Slovakia by inbreeding. [ Laoussadi S., Menkes C.-J. Arthroses D’Etiologie rare. Rev. Rhum. Ed. Fr., nr 9 bis, Vol. 61, Nov. 1994 There is no cure for ochronotic arthropathy. The

43. Alkaptonuria V W X Y Z . Back Home Next. Alkaptonuria. Alkaptonuria andochronosis Notebook. Alliance of Genetic Support Groups national http://www.ability.org.uk/Alkaptonuria.html

Our Aims Services Stats ... Z Alkaptonuria Alkaptonuria and Ochronosis Notebook Alliance of Genetic Support Groups - national coalition of consumers, professionals and genetic support groups to voice the common concerns of children, adults and families living with, and at risk for, genetic conditions. Online Genetic Syndrome Support Groups - Sites are listed alphabetically by disease/conditon. Peter's Anomaly Support Group - An online support group for people dealing with Peter's Anomaly Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

44. MSN Health - is a rare hereditary disorder in which homogentisic acid accumulates in the bodyand destroys connective tissue and bone, creating a condition called ochronosis http://content.health.msn.com/NR/internal.asp?GUID={298CAEF4-5E7A-4EFF-B7C3-4FBB

45. MEDLINEplus Medical Encyclopedia: Alkaptonuria Alternative names Alcaptonuria; Homogentisic acid oxidase deficiency;ochronosis. Definition Return to top Alkaptonuria is a rare http://www.nlm.nih.gov/medlineplus/ency/article/001200.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Alkaptonuria Contents of this page: Alternative names Definition Causes, incidence, and risk factors Symptoms ... Prevention Alternative names Alcaptonuria; Homogentisic acid oxidase deficiency; Ochronosis Definition Return to top Alkaptonuria is a rare inherited disorder of metabolism characterized by urine which turns black when exposed to air. Another characteristic is the development of arthritis in adulthood. Causes, incidence, and risk factors Return to top Alkaptonuria is an autosomal recessive inherited disorder. It is a disorder of tyrosine (an amino acid) metabolism resulting from a defect in the enzyme homogentisic acid oxidase. Homogentisic acid is excreted in the urine and turns a brown color upon exposure to air. This is the result of a dark pigment with an ochre color (earthy red or yellow) which led to the name ochronosis. The bones and cartilage of the body can be brown colored. Symptoms Return to top Infant/child: Family history of alkaptonuria Urine in diaper may darken after several hours (can become almost black) Adult: Progressive arthritis , especially of the spine Darkening of the ear (from black staining of the cartilage in the ear) Dark spots on the sclera (white of the eye) and cornea Signs and tests Return to top Urinalysis is positive for reducing substance. Further urine testing shows a positive ferric chloride test.

46. Arch Dermatol -- Page Not Found DIAGNOSIS Endogenous ochronosis (alkaptonuria). Figure 5. DISCUSSION Endogenousochronosis is a rare autosomal recessive metabolic disease. http://archderm.ama-assn.org/issues/v134n1/ffull/dof0198-2b.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

47. Arch Dermatol -- Page Not Found Diagnosis Endogenous ochronosis (alkaptonuria). MEDLINE 6. Cherian S. Palmoplantarpigmentation a clue to alkaptonuric ochronosis. J Am Acad Dermatol. http://archderm.ama-assn.org/issues/v136n4/ffull/dof0001-3b.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

48. DERMATOLOGICAL EXPERIENCES Exogenous ochronosis two clinical cases. The clinical features of cosmeticsinducedlesions in two clinical cases of exogenous ochronosis are described. http://crs.ifo.it/ISG/Migrazioni/pubblicazioni/EsperienzeDermatologiche1-1Ing.ht

DERMATOLOGICAL EXPERIENCES Vol IV number 1 - January 2002 - 87-91 Exogenous ochronosis: two clinical cases A. Morrone, G. Franco, L.M. Muscardin* Servizio di Medicina Preventiva delle Migrazioni del Turismo e di Dermatologia Tropicale. Istituto San Gafficano-IRCCS - Roma. *Laboratorio di Dermatopatologia Polo Dermatologico S. Gallicano IRCCS Roma Summary Persons with dark skin often use depigmenting agents to lighten the color of their skin for cosmetic purposes. Very often, however, topical depigmenting agents can produce the opposite effect, leading to brownish coloring of the site of application. Two cases of hyperpigmentation of the face are described, which, on histologic examination revealed the cause as exogenous ochronosis. At history taking it was discovered that for indefinitely long periods of time both women had regularly applied hydroquinone-based skin-bleaching creams. The mechanism producing hyperpigmentation is not yet fully understood. The clinical features of cosmetics-induced lesions in two clinical cases of exogenous ochronosis are described. Key words: Exogenous ochronosis The chronic use of skin-bleaching creams, particularly hydroquinone- and corticosteroid-based products, can produce complex dermatologic pictures, especially if the products are applied regularly and for long periods of time. Various products from questionable sources are available on the market, often from African countries (Nigerian, the Ivory Coast, South Africa) or Europe, and are produced and sold outside the norms of health safety regulations.

49. Health Ency.: Disease: Alkaptonuria Alternative names Alcaptonuria; Homogentisic acid oxidase deficiency;ochronosis. Definition Alkaptonuria is a rare inherited disorder http://www.accessatlanta.com/shared/health/adam/ency/article/001200.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease A Alkaptonuria Overview Symptoms Treatment Prevention Alternative names: Alcaptonuria; Homogentisic acid oxidase deficiency; Ochronosis Definition: Alkaptonuria is a rare inherited disorder of metabolism characterized by urine which turns black when exposed to air. Another characteristic is the development of arthritis in adulthood. Causes and Risks Alkaptonuria is an autosomal recessive inherited disorder. It is a disorder of tyrosine (an amino acid) metabolism resulting from a defect in the enzyme homogentisic acid oxidase. Homogentisic acid is excreted in the urine and turns a brown color upon exposure to air. This is the result of a dark pigment with an ochre color (earthy red or yellow) which led to the name ochronosis. The bones and cartilage of the body can be brown colored. Ency. home Disease A Please read this Important notice Also Check Out Subscribe to The Atlanta Journal-Constitution Home Autos Classifieds ... Our Sponsors By using AccessAtlanta.com you accept the terms of our Visitor Agreement . Please read it. Privacy statement Registered site users: edit your profile

50. Ochronosis ochronosis. A Medical Encyclopedia Maryland Medical System. A resourcewith information on over 4000 medical topics including ochronosis. http://www.umm.edu/medical-terms/03114.htm

Ochronosis A Medical Encyclopedia Article provided by the University of Maryland Medical System A resource with information on over 4000 medical topics including: Ochronosis Previous Next

51. NYU SoM - Dept. Of Dermatology Diagnosis Exogenous ochronosis. Comment Unlike its hereditary counterpart,alkaptonuria (endogenous ochronosis), there are no systemic features. http://www.med.nyu.edu/Derm/conf/021202-2.html

Tuesday Evening Clinical Conferences February 12, 2002 Case #2 Patient: F.G., 53-year-old woman Duration: Four years Distribution: FaceFace History: The patient presented to the Bellevue Hospital Center Dermatology Clinic in June, 2001, with a history of dark patches that developed on the cheeks and progressed over a four-year period. She admitted to using many creams on her face prior to their development but was unsure of their names. She denied arthralgias and had no family history of a similar disorder. Past medical history included hypertension controlled by amlodipine and atenolol. A biopsy was performed which confirmed the clinical diagnosis. Subsequently, the patient was advised to discontinue all previous topical preparations and use a cover make up. She also had rosacea for which she was given a topical metronidazole preparation. Physical Examination: Speckled, blue-black patches along with erythematous patches and telangiectases were present in a malar distribution bilaterally.

52. Alkaptonuria Support Groups@ (3). Alkaptonuria and ochronosis Notebook Notebookof information plus a hotline for messages and support. Help http://www.foundhealth.com/Health/Conditions_and_Diseases/A/Alkaptonuria/

Advertisement Foundhealth.com Search All Terms Any Term Tips Browse foundhealth.com Health calculators Fast Food Database Speakers Bureau How to evaluate sites Submit a site Contact us Home - main directory Top Health Conditions and Diseases A : Alkaptonuria Support Groups Alkaptonuria and Ochronosis Notebook - Notebook of information plus a hotline for messages and support. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the Open Directory made available on foundhealth.com have been modified. Home Health Tools Fast Food Database Vitamins and Minerals ... foundhealth.com The content provided on this web site is for information purposes only. It is intended to provide educational material and is not designed to provide medical advice. Please consult your health care provider regarding any medical issues you have relating to symptoms, conditions, diseases, diagnosis, treatments and side- effects. Terms and conditions.

53. Ochronosis ochronosis. A Medical Encyclopedia Article provided by Kernan Hospital. A resourcewith information on over 4000 medical topics including ochronosis. http://www.kernanhospital.com/medical-terms/03114.htm

Ochronosis A Medical Encyclopedia Article provided by Kernan Hospital A resource with information on over 4000 medical topics including: Ochronosis Previous Next

54. Argyria ochronosis, Localized argyria with pseudoochronosis. Ochre swollen homogenizedcollagen bundles resembling ochronosis have not been previously described. http://www.thedoctorsdoctor.com/diseases2/argyria.htm

55. Ochronosis ochronosis. A Medical Encyclopedia Article provided by North Arundel Hospital. Aresource with information on over 4000 medical topics including ochronosis. http://www.mcadd.net/medical-terms/03114.htm

Ochronosis A Medical Encyclopedia Article provided by North Arundel Hospital A resource with information on over 4000 medical topics including: Ochronosis Previous Next

56. Beet Home Beet Ring Beet Board Whats New Whats Cool Music / Art browse words by letter a b c d e f g h i j k l m n o p q r s t u v w x y z or searchthesauri dictionary search words. ochronosis. Web Development Solutions! http://www.beetfoundation.com/words/o/alt.ochronosis.html

Beet Home Beet Ring Beet board Whats New ... Contact browse words by letter a b c d ... z or search thesauri dictionary search words ochronosis Advanced Web Development Solutions! ezine/newsletter list management and publishing Consumer Discount Buyers Guide There's a new Mail in town. It's called IncrediMail. Click here to download Grep of noun ochronosis ochronosis Overview of noun ochronosis The noun ochronosis has 1 sense (no senses from tagged texts) 1. ochronosis (an accumulation of dark pigment in cartilage and other connective tissue usually a symptom of alkaptonuria or phenol poisoning) Overview of noun ochronosis The noun ochronosis has 1 sense (no senses from tagged texts) 1. ochronosis (an accumulation of dark pigment in cartilage and other connective tissue usually a symptom of alkaptonuria or phenol poisoning) browse words by letter a b c d ... z or search thesauri dictionary search words

57. Ochronosis ochronosis Next . http://www.marylandchemotherapy.com/medical-terms/03114.htm

Ochronosis A Medical Encyclopedia Article provided by Maryland General Hospital A resource with information on over 4000 medical topics including: Ochronosis Previous Next

58. 51-14 Environ Dermatol Vol.5.1.2025 Full text PDF Exogenous ochronosis and pigmentedcolloid milium induced by bleaching skin cream Preya KULLAVANIJAYASuwirakorn http://www.med.nagoya-u.ac.jp/Environderm/edj/vol5/51-20.htm

59. Environmental Dermatology Vol.5.1,1998 YASHIRO (3) Key words topical medicaments, allergic contact dermatitis, patch testingEnviron Dermatol Vol.5.1.2025, 1998 Exogenous ochronosis and pigmented http://www.med.nagoya-u.ac.jp/Environderm/edj/vol5-1.htm

60. Alkaptonuria Information Page Diseases Database Alkaptonuria aka/or Homogentisate 1,2dioxygenase deficiency aka/orHomogentisic acid oxidase deficiency aka/or ochronosis related http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=409

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