61. Birth Disorder Information Directory - A Alexander('s) Disease/Syndrome List of Sites; Also see Leukodystrophy. Alkaptonuria(,Hereditary) (Alkaptonuric ochronosis, Homogentisic Acid Oxidase Deficiency http://www.bdid.com/defectag.htm

HOME Ag-Am Aganglionosis Total Intestinal Aganglionosis total intestinal AGANGLIONOSIS, TOTAL INTESTINAL Aganthia with Holoprosencephaly and Situs Inversus Aganthia holoprosencephaly situs inversus AGNATHIA-HOLOPROSENCEPHALY Agammaglobulinemia List of Sites Agenesis of the Cerebellar Vermis List of Sites Agenesis of the Corpus Callosum List of Sites Related Books Aglossia Adactylia (Oromandibular Limb Hypoplasia) Aglossia adactylia AGLOSSIA-ADACTYLIA Also see Hanhart Syndrome Agnathia -Holoprosencephaly See Holoprosencephaly-Agnathia Agyria-Pachygyria Type I See Miller-Dieker (Lissencephaly) Syndrome Aicardi Syndrome List of Sites Aicardi-Goutieres Syndrome (Encephalopathy-Basal Ganglia Calcification) Aicardi-Goutieres syndrome Encephalopathy, Familial Infantile, with Calcification of Basal Ganglia and Chronic Cerebrospinal Fluid Lymphocytosis Related Books Cutis verticis gyrata thyroid aplasia mental retardation ... CUTIS VERTICIS GYRATA, THYROID APLASIA, AND MENTAL RETARDATION Aksu Stockhausen Syndrome (Branchial Arch Defects) branchial arch defects Al-Awadi Farag Teebi Syndrome (Primary Hypogonadism with Partial Alopecia) Al awadi farag teebi syndrome HYPOGONADISM, PRIMARY, AND PARTIAL ALOPECIA

62. Q176-Ochronosis Q176ochronosis(23-04-02) name joy email joy@hotmail.com. Dear Joy. ochronosis isone of common side effect of long term high potency hydroquinone treatment . http://www.thaicosderm.org/q176ochronosis.htm

close this window to go back to Thaicosderm) Q176-Ochronosis(23-04-02) name: joy email: joy@hotmail.com question: I wanna know how to treat melasma that called ochronosis ,which type of laser can get rid of this melasma and how many times to clear it. thank you answer: Dear Joy Ochronosis is one of common side effect of long term high potency hydroquinone treatment . Clinically there is slate gray to browish discoloration of the face. Under microscope examination there is homogenous brownish material in the dermis. This may be denatured collagen or other proteins. This condition is rather difficult to treat with medication. The best treatment is now by doing laser ablation with either Carbondioxide laser or Erbium :YAG laser. Laser will remove skin down to the dermis follow by regeneration of new healthy skin. There usually is post treatment hyperpigmentation which will eventually fade away. This condition is one of the strong reason why we should not use hydroquinone for long term treatment of melasma. Niwat Polnikorn MD

63. Page Not Found corticosteroids, HE 40x (1696). 2.12.8 ochronosis. Clinical signs endogenousochronosis (alcaptonuria) autosomal recessive metabolic disease; http://atlases.muni.cz/atl_en/main nenadory cizmat.html

Page not Found Technical administrator MU The page you ask for does not exist on our server. If you entered the URL manually please check it for mistyping. If you arrived to this page by clicking a link on some other page please contact the author of the referring page.

64. SkinCareRx.com - Skin Bleaching Solutions 70% of patients who use skin creams containing Hydroquinone for an extended periodof time (onethree years) develop Exogenous ochronosis, an irreversible http://ska.safeserver.com/bleachingrx.html

Search By Brand Birch Trees Belli Cellex-C Fake Bake Glytone Kinerase La Roche-Posay NeoStrata NuCelle N.V. Perricone Cosmeceuticals Physician's Choice (pHaze) Physician's Complex Procyte/Neova RoC Solbar Sunblock StriVectin-SD Super-Skin Sun Laboratories Total Block Sunblock TriCeram WellSkin Home About the Doctor Newsletter Bulletin Boards ... Contact Us skin type oily dry combination sensitive ... normal specialty acne aging age spots and freckles dark skin ... stretch marks treatments alpha-hydroxy acids bleaching creams copper peptide green tea ... vitamin-c skincare body washes eye creams moisturizers sunblocks ... sunless tanner information bargain hunters cosmetic laser section skin care tips vitamins in skin care ... advertising Bleaching Creams Skin Bleaching Solutions: Pigment Control Products: Phaze13: Pigment Gel (not for use on dark pigmented or sensitive skin) *contains 2% hydorquinone, kojic acid, citric acid, lactic acid* HQ free version is available Bleaching System: Physician's Complex 6% Bleaching Cream contains 2% hydroquinone, 2% kojic acid, 2% bearberry extract, 10% AHA blend with salicylic acid

65. Recommended Skin Care For Skin With Melasma There is one other possible, and rare, permanent side effect known as ochronosis.ochronosis is a permanent grey or blueblack discoloration http://ska.safeserver.com/melasmarx.html

Search By Brand Birch Trees Belli Cellex-C Fake Bake Glytone Kinerase La Roche-Posay NeoStrata NuCelle N.V. Perricone Cosmeceuticals Physician's Choice (pHaze) Physician's Complex Procyte/Neova RoC Solbar Sunblock StriVectin-SD Super-Skin Sun Laboratories Total Block Sunblock TriCeram WellSkin Home About the Doctor Newsletter Bulletin Boards ... Contact Us skin type oily dry combination sensitive ... normal specialty acne aging age spots and freckles dark skin ... stretch marks treatments alpha-hydroxy acids bleaching creams copper peptide green tea ... vitamin-c skincare body washes eye creams moisturizers sunblocks ... sunless tanner information bargain hunters cosmetic laser section skin care tips vitamins in skin care ... advertising Melasma The Symptoms, Causes and Treatments Recommended Skin Care for Skin with Melasma: Mandelic Acid System: *safe on sensitive and dark skin types IV and up * Pigment Control Products: Physician's Complex 6% Bleaching Cream (not for use on dark skin) contains 2% hydroquinone, 2% kojic acid, 2% bearberry extract, 10% AHA blend Azelaic Acid: Super-Skin Lightening Gel or Super-Skin Brightening Cream *Hydroquinone-Free * Contains Kojic Acid and Azelaic Acid Sun Protection: Belli Anti-Chloasma Sunscreen SPF 25 Sunscreen is the #1 protection against melasma. Tinted formula contains Titanium Dioxide and zinc oxide for broad spectrum protection

66. Ochronosis - AnsMe.com Dictionary (define) http://define.ansme.com/words/o/ochronosis.html

Search: Web Sites Dictionary - Define Dictionary - Sounds Like Dictionary - Relations Dictionary - Rhymes Dictionary - Translate Sponsors Index Ochotona Ochotona collaris Ochotona princeps Ochotonidae ... Ochroma lagopus ochronosis Ochs Ocimum Ocimum basilicum Ockham ... ocotillo Dictionary - ochronosis Show Definition Sounds Similar Relations Rhymes Translate Definition for ochronosis ochronosis (noun) an accumulation of dark pigment in cartilage and other connective tissue; usually a symptom of alkaptonuria or phenol poisoning Source: WordNet ® 1.7, © 2001 Princeton University All other brands are property of their respective owners. Directory Dictionary AIM Smileys Contact Us

67. Error Page DISEASE Alkaptonuria, Synonym(s) Homogentisic acid oxydase deficiencyochronosis, hereditary, CIM E70.2, Hereditary ochronosis, or http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=56

68. Blaue Skleren Und Thoraxschmerzen (Blue Sclerae And Chest Pain) ochronosis http://www.smw.ch/oeil/2000/130-17-199-00.html

Gubler Ch . Blaue Skleren und Thoraxschmerz. Schweiz Med Wochenschr 2000;130:635. Blaue Skleren und Thoraxschmerz Blue sclerae and chest pain Die typische Pigmentierung von Ohren und Skleren, das Nachdunkeln des Urins und die lange Anamnese der Polyarthrose mit pathognomischen Zeichen in den konventionellen Röntgenuntersuchungen [1] ergeben die Diagnose einer Alkaptonurie. Diese seltene metabolische Erkrankung, autosomal-rezessiv vererbt, ist gekennzeichnet durch das Fehlen der Homogentisinsäure-Oxidase mit konsekutiver Akkumulation von Homogentisinsäure bzw. Ablagerung, bevorzugt im Bindegewebe, genannt «Ochronose». In diesem Fall kam es zu einer kardiovaskulären Ochronose [2] mit typischer Ablagerung in den Arterien (inkl. Koronarien) und an der Aortenklappe. Aufgrund der schweren Aortenstenose wurde ein Aortenklappenersatz durchgeführt, intraoperativ zeigt die native Klappe eine dunkelblaue Verfärbung (Abb. 4). Literatur Abbildung 1 Urin der Patientin und Vergleichsurin eines Gesunden.

69. Non-Inflammatory Arthroses 3. ochronosis Spinal features of ochronosis Degenerative arthritis resultingfrom alkaptonuria (genetic defect of the homogentisic acid oxidase system); http://www.orthoteers.co.uk/Nrujp~ij33lm/Ortharth2.htm

ARTHROSIS INDEX Go Back to SYLLABUS Find in this Page: enter a search term and hit 'enter' (may take a few seconds) Search the Orthoteer Site: Non-Inflammatory Arthroses Osteoarthritis Neuropathic Arthropathy Acute Rheumatic Fever Ochronosis ... Secondary Pulmonary Hypertrophic Osteoarthropathy 1. Neuropathic Arthropathy ( Charcot Joint) Joint destruction secondary to loss of sensory innervation of the joint. Causes: Diabetes Tabes dorsalis Hansen's Disease / Leprosy Myelomeningocele Congenital insensitivity to pain ( Hereditory Sensory Neuropathy Clinical: Painless , swollen joint mimics infection Radiographs: Advanced destruction Scattered 'chunks' of bone Heterotopic ossification Treatment: Charcot Joint is a contraindication for total joint arthroplasty. 2. Acute Rheumatic Fever Beta haemolytic streptococcus infection in children Jones diagnostic criteria: Major Criteria Minor Criteria carditis fever polyarthritis arthralgia erythema marginatum prior RF subcutaneous nodules on the extensor surfaces incr. ESR

70. Ochronosis ochronosis. A Medical Encyclopedia Article provided by North Arundel Hospital.A resource with information on over 4000 medical topics including . Next . http://www.marylandwellness.com/medical-terms/03114.htm

Ochronosis A Medical Encyclopedia Article provided by North Arundel Hospital A resource with information on over 4000 medical topics including: Ochronosis Previous Next

71. Health Content Encyclopedia Article Alkaptonuria Alternate Names. Alcaptonuria; Homogentisic acid oxidase deficiency;ochronosis Definition. Alkaptonuria is a rare inherited disorder http://www.centralbap.com/adamcontent/ency/article/001200.asp

72. Zebra Card GU-010: Urine Stain Darkened By Washing 105. Cardiovascular findings in alkaptonuric ochronosis. 109. ochronosisthe pigmentation of cartilages, sclerotics, and skin in alkaptonuria. http://www.zebracards.com/GU-010.html

Zebra Cards Update Genitourinary GU-010 Nav Urine stain that darkens after washing Differential Diagnosis Top Nav alkaptonuria Discussion not available online Top Nav Update Comments Top Nav Pink staining of diapers can be caused by: (1) uric acid crystals, (2) hemoglobinuria, (3) dyes from sweets, (4) anthocyanins from beetroot or berries, (5) drugs, (6) porphyria, (7) contamination with the Serratia marcesans bacterium, and (8) alkaptonuria. [ Fluorescence of a diaper under Wood's light is typically encountered only in congenital erythropoietic porphyria, one of the rarest porphyrias. [ This old book contains a paragraph about the "blue diaper syndrome," linking it to idiopathic hypercalcemia in infants. The metabolic defect involves tryptophan metabolism and results in a high urinary excretion of indican and indole derivatives, one of which turns blue when oxidized. [ Describes the case of Harwa, an Egyptian granary custodian who died about 1500 BC, but spent 60 years of this century on display in Chicago's Field Museum of Natural History. [ More about Harwa. [

73. Untitled Document April 2002. Diagnosis Exogenous ochronosis (from hydroquinone in Ambi ). ReferencesKramer KE, Lopez A, Stefanato CM, Phillips TJ. Exogenous ochronosis. http://internalmed.wustl.edu/divisions/dermsub/caseofmonth/4-2002a.html

April 2002 Diagnosis: Exogenous ochronosis (from hydroquinone in "Ambi") Also see Case of the Month for August 1997. Histopathology: reveals yellow-brown inclusions in the papillary dermis. These have been said to resemble "bananas". Discussion: Exogenous ochronosis is a well-recognized side effect from the use of topical hydroquinone. It is most commonly seen in darkly pigmented individuals, however, caucasians may also develop the condition. Hydroquinone is readily available in over the counter preparations and from the internet. "Ambi" cream contains the active ingredient of Hydroquinone 2%. Treatment consists of stopping the offending agent; a gradual improvement may occur over time. Recently the use of a Q-switched laser has been reported to be beneficial. References: Kramer KE, Lopez A, Stefanato CM, Phillips TJ. Exogenous ochronosis. J Am Acad Dermatol Learn more about available OTC hydroquinones at drugstore.com. http://www. drugstore. com/templates/stdplist/default. asp?catid= 13564 My thanks to Dr. Brent Moody for his help in the preparation of this case.

74. Joints lupus, Lyme disease, hemochromatosis, hemophilia, inflammatory bowel disease (mostforms and also postileal-bypass), ochronosis ( alkaptonuria ), rheumatic http://home.earthlink.net/~pcss/joints.htm

JOINTS Last update August 14, 1998 Ed Friedlander, M.D., Chairman, Department of Pathology University of Health Sciences , Kansas City MO Jan. 24, 1996 INDEX AIDS food hypersensitivity neck pain salmonella ... rheumatoid lung INTRODUCTION Most patients with arthritis do not know which type they have (Mo. Med. 87: 145, 1990), and, appropriately, most cases of joint disease never get examined by a pathologist. Yet joint problems are the #1 recognized cause of occupational disability, and cause suffering comparable in prevalence and severity (though not in kind) to alcoholism and major mental illness. This unit includes a major systemic disease (rheumatoid arthritis) and several important single-organ problems. You have completed the learning objectives when you know the handout at recall level, and have examined the photos in Big Robbins or your own favorite pathology text. "Joint diseases" involve the diarthrodial (hinge, synovial) joints. (Rule: Disease does not affect non-moving joints like skull sutures or the pubic symphysis). Don't forget the major autoimmune diseases and fibromyaligia syndrome in evaluating musculoskeletal or joint pain. Anatomy: joint capsule (pain-sensitive) lined by synovium (vascular tissue with an inner layer of synovial cells) which out-pouches to form bursae.

75. SpringerLink: Virchows Archiv - Abstract Volume 436 Issue 1 (2000) Pp 74-81 case report A morphological study of bone and articular cartilage in ochronosis. Keywords ochronosis · Bone · Cartilage · Arthropathy · Alkaptonuria. http://link.springer-ny.com/link/service/journals/00428/bibs/0436001/04360074.ht

Virchows Archiv ISSN: 0945-6317 (printed version) ISSN: 1432-2307 (electronic version) Table of Contents Abstract Volume 436 Issue 1 (2000) pp 74-81 case report : A morphological study of bone and articular cartilage in ochronosis M. Di Franco, G. Coari, E. Bonucci Rheumatology Unit, Department of Medical Therapy, University La Sapienza, Rome, Italy (2) Department of Experimental Medicine and Pathology, Section of Pathological Anatomy, Policlinico Umberto I, Viale Regina Elena 324, University La Sapienza, I-00161 Rome, Italy e-mail: bonucci@axrma.uniroma1.it Tel.: +390-6-4957685, Fax: +390-6-4957685 Received: 17 May 1999 / Accepted: 24 June 1999 Abstract Key words Article in PDF format (1320 KB) Online publication: January 11, 2000 SpringerLink Helpdesk

76. Xray Diagnosis. ochronosis. Discussion. ochronosis is the bluishblack discolorationof certain tissues, such as the ear cartilage and ocular http://www.indianradiologist.com/gpscorner4.htm

Rookies Quiz 4 A 65-year-old male presents with back ache. What is your diagnosis ? Fig 1 Fig 2 SCROLL FOR ANSWER Imaging Findings Findings reveal degenerative changes involving the vertebrae and the intervertebral discs, which show narrowing and calcification. Diagnosis Ochronosis Discussion Ochronosis is the bluish-black discoloration of certain tissues, such as the ear cartilage and ocular tissue, seen with alkaptonuria, a metabolic disorder. It was defined by Virchow who described histologically the connective tissue in alkaptonuria, given the cartilage's ochre, or yellow, hue under the microscope. Alkaptonuria is a rare, autosomal recessive, metabolic disorder caused by deficiency of homogentisic acid oxidase, the only enzyme capable of catabolizing homogentisic acid. This deficiency results in accumulation and deposition of homogentisic acid in cartilage, causing the characteristic diffuse bluish-black pigmentation. Exogenous ochronosis, in which bluish-black pigmentation of cartilage is noted iatrogenically by exogenous agents, such as phenol, trinitrophenol, benzene and hydroquinone. In alkaptonuria, the accumulation of HGA inhibits collagen cross-linking by affecting a crucial enzyme in collagen synthesis, leading to a diminution of structural collagen integrity. This results in ochronotic arthropathy, which occurs in men aged in their fourth and fifth decades; women develop similar complications in their sixth decade. The larger joints are most affected with early calcification, narrowing and collapse of the intervertebral discs. In addition to joint disease, there are reports suggesting increased incidence of cardiovascular disease due to cartilaginous changes of vessel walls.

77. Alkaptonuria Resource Updates Bluish patches on the ears and axillae with dark urine ochronosis and alkaptonuria.Int J Dermatol. Diagnostic image (45). ochronosis Ned Tijdschr Geneeskd. http://www.health.xq23.com/inst/Research_Updates/Alkaptonuria.html

Alkaptonuria resources. Information for medical researchers, health professionals, bioscientists, and policy makers. Recommended References. [see index for total category] KEY ABSTRACTS: PUBMED Citations: Innovations and emerging technologies in Alkaptonuria, Patent List (when available) for Alkaptonuria: 6,399,383: Human papilloma virus vectors 6,309,823: Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same 6,277,974: Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death 6,245,566: Human embryonic germ cell line and methods of use 6,218,169: Aromatic amino acid catabolism enzymes 6,214,384: Nanosheres comprising a biocompatible polysaccharide 6,156,501: Arrays of modified nucleic acid probes and methods of use 6,086,913: Liposomal delivery of AAV vectors 6,048,964: Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 6,027,880: Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis 5,976,567: Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer

78. Abstract 23. Exogenous ochronosis, a littleknown side effect of creams containinghydroquinone. Two patients with exogenous ochronosis, an http://www.pigmentdisorders.com/abstracts/23.htm

Netherlands Institute for Pigment Disorders - Abstract - 23. Exogenous ochronosis, a little-known side effect of creams containing hydroquinone Two patients with exogenous ochronosis, an unfamiliar side effect of hydroquinone-containing bleaching creams, are presented. This disorder is characterized by progressive darkening of the area to which the cream is applied. Histologically there is deposition of yellow-brown pigment in the dermis, in addition to degeneration of collagen and elastic fibres. The chemical composition of the ochronotic material and the pathogenesis of this paradoxical effect of hydroquinone are unknown. Hydroquinone containing creams should not be used for longer than two years. If there is no improvement within six months, application should be discontinued.

79. Alphabetical Topic Index (AZ) Jump To A B C D E F G H I J K L M Oc ochronosis ochronosis Ocular Hypotension Ocular Hypotension Ocular Motility DisordersOcular Motility Disorders Oculocerebrorenal Syndrome Oculocerebrorenal http://www.uscuh.com/apps/Intermap/topiclist/SectionO.html

Alphabetical Topic Index (A-Z): Jump To: A B C D ... Ov O Ob Obesity Obesity Overview Obesity, Morbid Obesity, Morbid Obsessive-Compulsive Disorders Obsessive-Compulsive Disorders Obstetrics Gestational Diabetes Ectopic Pregnancy Bottle Feeding Your Infant All About Breast-Feeding ... Back To Top ^ Oc Ochronosis Ochronosis Ocular Hypotension Ocular Hypotension Ocular Motility Disorders Ocular Motility Disorders Oculocerebrorenal Syndrome Oculocerebrorenal Syndrome Oculomotor Nerve Diseases Oculomotor Nerve Diseases Back To Top ^ Od Odontodysplasia Odontodysplasia Odontogenic Cyst Nonodontogenic Cysts Odontogenic Cyst, Calcifying Odontogenic Cyst, Calcifying Odontoma Odontoma Back To Top ^ Ol Olfaction Disorders Olfaction Disorders Oligodendroglioma Oligodendroglioma Oligohydramnios Oligohydramnios Oligomenorrhea Oligomenorrhea Oligospermia Oligospermia Oliguria Oliguria Olivopontocerebellar Atrophies Olivopontocerebellar Atrophies Back To Top ^ On Onchocerciasis, Ocular Onchocerciasis, Ocular Oncology AIDS-Related Lymphoma Breast Cancer Overview And Evaluation Stage Breast Cancer Stages I And II And IIIA Breast Cancer ... Localized Cervical Cancer Treatment Onychomycosis Onychomycosis Back To Top ^ Oo Oophoritis Oophoritis Back To Top ^ Op Open Bite Open Bite Ophthalmia Neonatorum Ophthalmia Neonatorum Ophthalmia, Sympathetic

80. Alkaptonuria Alkaptonuria. Back to previous level ochronosis Search PUBMED for ochronosisAll Review Therapy Diagnosis; Alkaptonuria / ochronosis Med. Coll. http://www.ohsu.edu/cliniweb/C18/C18.452.648.66.187.html

Alkaptonuria Back to previous level Ochronosis Search PUBMED for Ochronosis: All Review Therapy Diagnosis ... SPONDYLOEPIPHYSEAL DYSPLASIA, LATE; SEDL

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