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         Ollier Disease:     more detail
  1. Molecular Profiling of Solitary and Ollier Disease-related Central Chondrosarcomas: An Investigation of DNA Aberrations, mRNA and Protein Expression by Leida B. Rozeman, 2005
  2. Allergy: The Facts (Oxford Medical Publications) by Robert J. Davies, Susan Ollier, 1989-05-18

41. Uhrad.com Pediatric Imaging Teaching Files
Discussion Enchondromatosis (ollier's disease) is a non hereditary disorder of enchondral ossification with lesions
http://www.uhrad.com/pedsarc/peds055.htm
uhrad.com - Pediatric Imaging Teaching Files
Case Fifty Five - Multiple Enchondromatosis
Click on Images for Enlarged View Clinical History: Trauma to second right digit. Findings: Multiple lucent metaphyseal lesions of the proximal and middle phalanges of the fourth and fifth digits, as well as the distal metacarpals of the fourth and fifth digits. Diagnosis: Multiple enchondromatosis. Discussion: Enchondromatosis (Ollier's Disease) is a non hereditary disorder of enchondral ossification with lesions distributed throughout the tubular and flat bones of the body. The presenting clinical manifestations are masses that increase in size as the child grows, asymmetric limb shortening and either genu varus or genu valgus deformities. Radiographs of the young child could be normal in the first few years of life and later demonstrate radiolucent streaking within the metaphysis of involved bones, or at infancy may demonstrate radiolucent masses which can be round, triangular or linear. Stippled calcifications occur with age within the enchondromas. There may be considerable expansion of the tubular bones especially in the hands, and pathologic fractures may occur. Cartilaginous areas extending from the physis can lead to a growth interference resulting in limb shortening and deformities. Enchondromas typically stabilize or regress in adulthood. However, sarcomatous transformation has been described. Six types of enchondromatosis have been described, of which three are more common. If the multiple enchondromas are purely unilateral or unevenly distributed throughout the metaphyses of the long bones, sparing the cranium and spine, it is called Ollier's Disease. If the enchondromas are seen with multiple cutaneous hemangiomas (soft tissue calcifications/phleboliths) it is called Maffucci's Syndrome. If there is symmetric involvement throughout the body including the cranium, hands and feet, it is known as generalized enchondromatosis. The Ollier's and Maffucci's are more common in boys (2:1). The less frequent types include metachondromatosis which affects the short tubular bones of the hands and feet, and spondyloenchondroplasia in which the enchondromas are associated with platyspondyly, and enchondromas with irregular vertebral bodies.

42. Foot Problems > Diseases Of The Foot > Ollier's Disease
diseases of the foot ollier's disease. ollier's disease is usually associated with a bony prominence under the toenail.
http://www.footandleg.com/prob_diseases_ollier.php
1650 Mulkey Rd, Austell, GA 30106
Foot Problems Diseases of the foot Ollier's Disease Arthritis Cancer ... Sever's Disease Diseases of the foot - Ollier's Disease
Ollier's Disease is usually associated with a bony prominence under the toenail.
Some form of injury or trauma to the toe results in the formation of the bony irregularity or prominence.
Officite
Only a small percentage of the population is born with foot problems. It's neglect and a lack of awareness of proper care - including ill fitting shoes - that bring on problems.

43. The Contact A Family Directory - OLLIER'S DISEASE
printer friendly, ollier'S disease, ollier'S disease SELFHELP GROUP.Andrew Harter ollier's disease Self-Help Group Tithings New Barn
http://www.cafamily.org.uk/Direct/o12.html
printer friendly OLLIER'S DISEASE home more about us in your area conditions information ... how you can help search this site Ollier's Disease: Enchondromatosis An Enchondroma is an island of unossified hyaline cartilage situated within bone (cartilage is the precursor of bone). They are usually multiple, affecting one or several bones. Characteristically, it is an asymmetric disorder, confined to one side of the body. The bones most commonly affected are the long bones, pelvis and bones of the hand. The islands of cartilage appear early in childhood and can develop, but it is very unusual for additional lesions to appear after puberty. Ollier's Disease is a very rare disorder which affects both sexes. It presents either as a lump or swelling or deformity of the long bone in early childhood. As the bones are weakened, they may fracture but healing is normal. The severity varies but otherwise the child develops normally. The main complications are the nature of the lump or swelling, the deformity of the affected bone and the shortening of the affected bone. The deformity can be corrected by osteotomy and the shortening can be addressed by leg lengthening in the knowledge that the bones will heal normally. Differential diagnoses of fibrous dysplasia and diaphyseal aclasis need to be considered. There is practically no likelihood of malignancy. Maffucci Syndrome in which there are cutaneous haemangionates associated with the enchondromas does carry a definite risk of malignancy. However, this is a separate and even rarer condition.

44. Foot Problems > Diseases Of The Foot > Ollier's Disease
diseases of the foot ollier's disease. ollier's disease is usually associated with a bony prominence under the toenail.
http://www.thefootspecialists.com/prob_diseases_ollier.php
3800 Highland Ave, Suite #103, Downers Grove, IL 60515
Foot Problems Diseases of the foot Ollier's Disease Arthritis Cancer ... Sever's Disease Diseases of the foot - Ollier's Disease
Ollier's Disease is usually associated with a bony prominence under the toenail.
Some form of injury or trauma to the toe results in the formation of the bony irregularity or prominence.
Officite
Walking puts up to 1.5 times your bodyweight on your foot.

45. The Family Village / Library / Ollier's Disease
Library O P. ollier's disease. Related Disorders plans. OSFHG publishesthe ollier's disease Self-Help Group Newsletter, quarterly. They
http://www.familyvillage.wisc.edu/lib_olli.htm
Ollier's Disease
Related Disorders: Multiple Enchondromatosis, Multiple Cartilaginous, Ollier Osteochondromatosis, Unilateral Chrondromatosis, or Muffucci Syndrome.
Who to Contact
Where to Go to Chat with Others

Learn More About It

Web Sites
...
Search AltaVista for "Olliers Disease"
Who to Contact
Olliers/Maffucci's Self-Help Group
1824 Millwood Road
Sumter, South Carolina 29150
(803) 775-1757 or
Email addresses: Olliers@aol.com
Legend37CD@aol.com
(Susan Challen) Vice President
Web: http://uhsweb.edu/olliers/olliers.htm
Mission - to establish means of communication for those burdened with the disease, and to inform the world at large about those people's plight. Additionally, they wish to help people with the disease cope with its physical and psychological burden, provide a forum to discuss Ollier problems or help others to cope with theirs, collect data on research conducted on the disease and/or in related fields, and raise awareness of our existence, activities and plans. OSFHG publishes the Ollier's Disease Self-Help Group Newsletter, quarterly. They have developed a pamphlet that provides information on the disease and the organization. They provide a new parent packet, please send a stamped self-addressed envelope. The Group has a bibliography of articles on the disease that is available to members upon request. The Group collects information on physicians and researchers who treat/study the condition and disseminates this information through the newsletter.

46. Health Library - Ollier's Disease
ollier's disease. Founded 1985.Mutual support and exchange of ideas for personswith ollier's or Maffucci's disease, their families and physicians.
http://yalenewhavenhealth.org/Library/HealthGuide/SelfHelp/topic.asp?hwid=shc29o

47. Pediatric Orthopaedic Core Curriculum
cortical defect Fibrous dysplasia Giant cell tumor Hereditary multiple exostoses(HME) ollier's disease (multiple enchondromatosis) Osteochondroma Osteoid
http://www.posna.org/CoreCurriculum/CoreCurriculum.htm
Pediatric Orthopaedic Core Curriculum
General

Regional
You'll need Adobe Acrobat Reader to see and print these files General
Prenatal testing
Developmental milestones

Growth

Enchondral ossification
...
Walking gait

Genetics
Genetics
Chromosomal disorders
Autosomal dominant disorders Autosomal recessive disorders ... Sex-linked recessive disorders Congenital Deficiencies Congenital deficiency of the upper limb Skeletal Dysplasias Achondroplasia Infantile hyperostosis Arthrogryposis Multiple epiphyseal dysplasia (MED) ... Short stature Diseases of Muscle Becker muscular dystrophy Congenital muscular dystrophy Congenital myopathies Duchenne muscular dystrophy ... Myotonic dystrophy Blood Dyscrasias Hemophilia Sickle cell disease and related hemoglobinopathies (return to top) Benign Tumors Aneurysmal bone cyst Chondroblastoma Eosinophilic granuloma Fibrous cortical defect ... Unicameral bone cyst Malignant Tumors Ewing's sarcoma Osteosarcoma Neurologic Disorders Cerebral palsy Friedreich ataxia Hereditary motor sensory neuropathy Poliomyelitis ... Thyroid disorders Infection Acute osteomyelitis Chronic osteomyelitis Septic arthritis Subacute osteomyelitis Trauma Child abuse Fractures associated with head injury Fractures of the physis Overuse injuries ... The multiply injured child (Other systems) Miscellaneous Heavy metal intoxication Idiopathic chondrolysis Juvenile arthritis Marfan syndrome ... Prosthetics and orthotics Regional

48. Health Library - Ollier's Disease
ollier's disease. Founded 1985.Mutual support and exchange of ideas for personswith ollier's or Maffucci's disease, their families and physicians.
http://www.laurushealth.com/library/healthguide/selfhelp/topic.asp?hwid=shc29oll

49. Ollier's Disease (Dyschondroplasia, [Multiple] Enchodromatosis, Osteochondromato
HOME ollier's disease (Dyschondroplasia, Multiple Hereditary Enchodromatosis,Osteochondromatosis). Simultaneous occurrence of
http://www.bdid.com/ollier.htm

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Ollier's Disease (Dyschondroplasia, [Multiple] Hereditary Enchodromatosis, Osteochondromatosis)

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50. Birth Disorder Information Directory - O
Lethal Type See Young McKeever Squier Syndrome. ollier's disease (Dyschondroplasia,Multiple Enchodromatosis, Osteochondromatosis)
http://www.bdid.com/defecto.htm

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51. Ollier's Disease (www.whonamedit.com)
ollier's disease Synonyms Chondrodysplasia, dyschondroplasia, enchondromatosis,hemichondrodysplasia, hemichondrodystrophy, internal
http://www.whonamedit.com/synd.cfm/1813.html

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Ollier's disease Synonyms:
Chondrodysplasia, dyschondroplasia, enchondromatosis, hemichondrodysplasia, hemichondrodystrophy, internal chondromatosis, multiple enchondromata, multiple enchondromatosis, multiple enchondromata syndrome, osteochondromatosis syndrome.
Associated persons:
Angelo Maffucci

Louis Xavier Édouard Léopold Ollier
Description: A disorder of the growing ends of bones in which round nonossified cartilaginous masses scattered throughout the skeleton produce asymmetrical and very variable deformities, asymmetric leg shortening being common. The lesions are first noted from 1 to 4 years of age, rarely at birth, with little progression after adolescence. Both sexes may be affected. The majority of cases have been sporadic but a familial tendency has been reported in a few instances. Enchondromatosis is usually bilateral. The term Ollier syndrome applies in cases with unilateral involvement. The combination of multiple enchondromata with haemangiomata and phleboliths is known as Maffucci syndrome. Bibliography:
  • L. X. E. L. Ollier:

52. Louis Xavier Édouard Léopold Ollier (www.whonamedit.com)
Associated with KlippelTrénaunay-Weber syndrome,ollier's disease,ollier'slayer,ollier-Thiersch graft. Who named it? ollier’s disease.
http://www.whonamedit.com/doctor.cfm/477.html

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Louis Xavier Édouard Léopold Ollier
French surgeon, born December 2, 1830, Vans, département Ardèche; died November 26, 1900, Lyon.
Associated eponyms:
Klippel-Trénaunay-Weber syndrome

A rare syndrome characterized by unilateral congenital capillary and cavernous haemangiomatous malformations of the arteriovenous system, syndactyly, overgrowth of certain fingers, and osteohypertrophic changes of one extremity. Ollier's disease A disorder of the growing ends of bones. Ollier's layer The inner layer of the periosteum, closest to the bone. Ollier-Thiersch graft A split-thickness skin graft. Biography: Louis Xavier Édouard Léopold Ollier is particularly remembered for his work on bone and joint surgery. He was born in Vans, Ardèche, where both his father and his grandfather had been doctors. He initially studied natural science at Montpellier and in 1849 was assistant in botany in the faculty of medicine. He was an intern of Lyon Hospital in 1851, graduated in medicine with distinction in 1856, and in 1857 obtained his doctorate at Paris with a dissertation based on histological studies of 400 malignant naoplasms. In 1860, aged only 30 years, Ollier became chirurgien-en-chef at the Hôtel-Dieu in Lyon. This building situated at the end of the bridge over the river Rhône, was one of the oldest hospitals in Europe.

53. Dyschondroplasia: Ollier's Disease And Maffucci's Disease
Dyschondroplasia ollier's disease and Maffucci's disease This pageis for informational purposes only. What is ollier's disease?
http://www.pathguy.com/oll.htm
Dyschondroplasia: Ollier's Disease and Maffucci's Disease This page is for informational purposes only. I have placed it here as a public service. I believe it is accurate, but I cannot accept liability for the contents of this page. A visitor would be very foolish to trust information from a single source, or to consider any reading a substitute for a personal physician. Please send your suggestions and corrections to erf@alum.uhs.edu What is Ollier's disease?
In Ollier's disease, masses of cartilage (enchondromas) grow inside some of the bones. No two people with Ollier's are alike, and the disease ranges from trivial to mutilating. What is an enchondroma?
An enchondroma is a bit of cartilage (gristle) that has been left behind during the early development of a bone. As the bone lengthens, it gets dragged toward the shaft of a bone, where it begins growing on its own. They are probably not true tumors. The commonest site for enchondromas is the hands, followed by the feet and forearms. The skull, spine, and breastbone are seldom affected. What problems result from enchondromas?

54. Ollier's Disease
ollier's disease. Definition ollier's disease is a condition that ischaracterized by multimple enchondromas throughout the skeleton.
http://orthopedics.about.com/library/glossary/bldef-olliers.htm
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Ollier's Disease Back to Last Page Full Glossary Related Terms Benign Tumor
Cartilage

Enchondroma

Definition: Ollier's Disease is a condition that is characterized by multimple enchondromas throughout the skeleton. Patient's with Ollier's Disease will regularly see the orthopedist for monitoring of their symptoms. Approximately 30% of patients with Ollier's disease will develop malignancies of their tumors. It is important to recognize these changes in order for prompt treatment of the lesion. Related Resources: Bone Tumors
Information about common bone tumors and treatment methods. Back to Last Page Full Glossary Email this page! Sponsored Links Electric wheelchairs at No Cost to you!

55. Enchondroma
There is a syndrome called ollier's disease in which patients havemany enchondromas. These must be carefully monitored as there
http://orthopedics.about.com/library/glossary/bldef-enchondroma.htm
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Orthopedics
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Enchondroma Back to Last Page Full Glossary Related Terms Benign Tumor
Cartilage

Ollier's Disease

Definition: An enchondroma is a benign tumor of cartilage. This type of tumor causes the formation of islands of mature cartilage in abnormal locations. Usually these tumors occur in the hands or in the long bones of the arms and legs. They are most often asymptomatic, and do not cause pain. If you do experience symptoms, these tumors can be removed; however, this is a risk of recurrence following surgery. There is a syndrome called Ollier's Disease in which patients have many enchondromas. These must be carefully monitored as there is about a 30% risk of these patients developing a malignant form of the enchondroma called chondrosarcoma. Another familial disorder of multiple enchondromas is called Mafucci syndrome. In this disease there is almost a 100% certainty of the development of malignant tumors. Related Resources: Bone Tumors
Information about common bone tumors and treatment methods.

56. Ollier
Translate this page ollier's disease ist eine sehr seltene Krankheit, bei der sich Tumore in den langenArm- und Bein-knochen bilden und das normale Knochen-Wachstum hindern.
http://www.ollier-maffucci.org/german_group.htm
The Ollier/Maffucci Self-Help Group French German Spanish ... Inspirations
Ollier/Maffucci Selbst-Hilfe Gruppe Inhalt Unsere Mission, Ziele und kurzfristigen Aufgaben Was ist Ollier's oder Maffucci's Disease? * Online Newsletters in Englisch * Wie erreicht man die Ollier/Maffucci Selbsthilfe Gruppe? ... Unsere Mission ist Kommunikationsmöglichkeiten für unsere Mitglieder zu schaffen und die Welt über die Krankheit und Probleme der Patienten zu informieren Unsere Ziele sind:
  • Kranken zu helfen ihre physischen und psychologischen Bürden besser zu ertragen
  • Ein Forum zu schaffen in dem Ollier/Maffucci Patienten Freud' und Leid austauschen können
  • Informationen über diese und verwandte Krankheiten zu sammeln
  • Die Gruppe, ihre Aktivitäten und Dienstleistungen publik zu machen.
Unsere kurzfristigen Aufgaben sind
  • Ollier's News vierteljährlich zu veröffentlichen
  • Nähere Kontakte mit unsern Mitgliedern zu unterhalten
  • Mitgliederlisten und Krankenberichte auf dem letzten Stand zu halten
  • Unser 'Website' (Flugblatt) am Internet periodisch zu verbessern
  • Unsere Ollier/Maffucci Bibliothek kontinuierlich auszubauen
  • Eine Datenbasis von Ärzten und Krankenhäusern aufzustellen
Anfang Disease Englisch Kontakte ... Home Was ist Ollier's oder Maffucci's Disease?

57. Bilateral Presentation Of The Ollier's Disease....
Bilateral presentation of the ollier's disease A case report, and literature review.ABSTRACT. Key words Enchondromas, osteochondromas, ollier´s disease.
http://www.imbiomed.com.mx/HG/Hgv64n3/english/Zhg013-05.html
Article in Spanish
Pacheco LRC, Torres GB, Ugalde VJA, Del Vecchyo CC, Sastré ON
Enfermedad de Ollier de presentación bilateral
Reporte de un caso y revisión de la literatura
Rev Med Hosp Gen Mex
Bilateral presentation of the Ollier's disease
A case report, and literature review
ABSTRACT Among the cartilaginous tumors, the enchondromas and osteochondromas are benign lesions formed by mature hyaline cartilage that affect the tubular bones of the hand and most commonly, the middle and proximal phalanges, and can be multiple o single lesions. When the enchondromas appear in the early childhood, are multiple lesions with no specific hereditary pattern, are known as Ollier's disease. Another feature of this disease is the unilateral appearance, affecting mainly hands and feet. In this article we present the case of a 18 years old male, with diagnosis of Ollier's disease since he was 2 years old, with affection of both hands and feet, most severely affected in the right upper extremity. The patient was treated with functional aesthetic amputation of 4 th and 5 th fingers and tumor resection of 2 nd and 3 rd fingers of his right hand. There are very few cases reported in the literature with such a severe deformity of the hand, and in spite of what have been described previously, in this case, the disease has not been self limited, to the contrary, it has recurred even more aggressively each time, now affecting the four extremities, thus raising the chance of malignant transformation, which makes indispensable to have a close follow up of the patient for a long time.

58. Wheeless' Textbook Of Orthopaedics
Main Menu Home Page Multiple Enchodromatosis (ollier's disease). Discussion Themalignant potential of enchondromatosis ollier's disease. An
http://www.ortho-u.net/o6/93.htm
Main Menu Home Page
Multiple Enchodromatosis (Ollier's Disease)
- Discussion: - originally was described by Ollier in late 1800's; - characterized by multiple enchondroma lesions primarily located w/ in the metaphyseal regions of tubular bones; - usually diagnosed in childhood; - pts w/ Ollier's dz have increased risk of a secondary chondrosarcoma developing later in life; - risk is about 25% by age 40 yrs; - Clinical Findings: - most pts have bilateral involvement, w/ predominance on one side; - enchondromas most frequently involve the short tubular bones of hands - Radiographs: - in most cases, there will be diaphyseal lesions or metaphyseal lesions which do not cross the growth plate, at least, not until growth plate closure; - in some cases enchondromatosis will affect patients in the metaphyseal and epiphyseal regions; - when enchondromas cross the growth plate, severe limb length deformities and angular deformities will develop; The malignant potential of enchondromatosis Ollier's Disease. An assessment of angular deformity, shortening, and

59. Wheeless' Textbook Of Orthopaedics
Main Menu Home Page ollier's disease. An assessment of angular deformity, shortening,and. A retrospective review of twentyone patients with ollier's disease.
http://www.ortho-u.net/l8/205.htm
Main Menu Home Page
Ollier's Disease. An assessment of angular deformity, shortening, and
pathological fracture in twenty-one patients. Shapiro-F J-Bone-Joint-Surg-Am. 1982 Jan; 64(1): 95-103 A retrospective review of twenty-one patients with Ollier's disease showed that the lesion involved the femur and tibia most frequently, and that those bones accounted for the large majority of clinical problems. Angular deformities were common; 80 per cent of the affected femora had clinically significant varus or valgus angulation in the distal part and 42 per cent of the affected tibiae had proximal or distal deformity. The apex of the angulation, when present, was metaphyseal, with the concavity on the side that was more extensively involved by the enchondromas. Osteotomies were done frequently to correct angulation; all healed well. Deformity in the distal part of the femur frequently required repeat osteotomy to achieve a straight bone at skeletal maturity, The extent of shortening, which always was present in the involved limb, closely

60. Health Library - Ollier's Disease
Search. ollier's disease. Founded 1985.Mutual support and exchange of ideas forpersons with ollier's or Maffucci's disease, their families and physicians.
http://yourhealth.stlukesonline.org/Library/HealthGuide/SelfHelp/topic.asp?hwid=

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