41. COLLEGE DE FRANCE syndromede Takatsuki , ou syndrome de Crow-Fukase , ou poems syndrome , est un http://www.ifrance.com/ihpst/AFLcollege2001/AFL2903.htm

42. Neuromuscular Diseases 97; poems syndrome poems syndrome clinical synopsis WU/STL (US);poems syndrome A Case Report and Discussion Mullai et al. - Cancer http://www.mic.ki.se/Diseases/c10.668.html

search help staff Neuromuscular Diseases Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Motor Cortex illustration Earles et al. ] - Furman Univ. (US) EMG and Nerve Conductions Homepage JF Jabre The Neuromuscular Disease Information Center - REHABinfo Network/UC-Davis (US) Neuromuscular Diseases - MDA (US) About some Neuromuscular Diseases - Wake Forest Univ. Neuromuscular Disorders Information - Musc Dystrophy Group of (UK)+ N. Ireland Neuromuscular Disease Center , and one-page summaries of Differential Diagnoses of Neuromuscular Syndromes - School of Medicine/Washington Univ., St Louis (US) Diagnostic Criteria for Neuromuscular Disorders - European Neuromuscular C. Motor Neuron Disease Lower and Upper Motor Neuron Disorders - Merck Manual Motor Neuron Awareness S Killeen ] - (IE) Clinical Features of Motor Neuron Disease - Bethlehem Health Care, Inc. (AU) Motor Neuron Disease and Animal Models - WUSTL (US) About Primary Lateral Sclerosis - NINDS/NIH (US) Primary Lateral Sclerosis F Reyerse Primary Lateral Sclerosis (PLS) C Armon ] - eMedicine A question + answer re Primary Lateral Sclerosis by the experts at MDA A two pages Open letter to Dr. Prahl about his anti-PLS drug C-3036

43. Rezidivierende Zerebrovaskuläre Insulte - Manifestation Des POEMS-Syndroms? (Re Translate this page Recurrent strokes – manifestation of the poems syndrome? Recurrent strokesmay therefore represent a further complication of the poems syndrome. http://www.smw.ch/archive/1998/128-26-280-98.html

Kasuistik Peer reviewed article Cet article n'a pas été résumé en français Das POEMS-Syndrom ist eine Multisystemerkrankung mit Polyneuropathie, Organomegalie, Endokrinopathie, Plasmazelldyskrasie und Hautveränderungen. Nebst vielen weiteren Manifestationen kann es im Rahmen dieses seltenen Syndroms auch zu einer Makroangiopathie und zu akuten arteriellen Verschlüssen kommen. In der Literatur wurde solchen Gefässmanifestationen bislang nur wenig Beachtung geschenkt, und die meisten Fallbeschreibungen betreffen Befall der Koronar- und Extremitätenarterien; die Assoziation mit rezidivierenden zerebrovaskulären Insulten ist bisher noch nicht beschrieben worden. Wir berichten von einem 59jährigen Patienten mit dem Vollbild eines POEMS-Syndroms, welches mit einem multizentrischen Morbus Castleman einherging. Trotz Fehlen vaskulärer Risikofaktoren traten Myokardinfarkte und ischämische Zehennekrosen auf, und es kam zu rezidivierenden ischämischen Insulten unter oraler Antikoagulation. Zerebrovaskuläre Insulte stellen somit wahrscheinlich eine weitere Komplikation des POEMS-Syndroms dar. The POEMS syndrome is a multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, plasma cell dyscrasia and skin changes. Along with many further manifestations this rare syndrome may also include macroangiopathy and acute vascular obliteration. In the literature such vascular problems have received only little attention and most case reports refer to involvement of the coronary and lower limb arteries. To our knowledge, the association with recurrent strokes has not been described.

44. Endocrine Surgeon What is poems syndrome? This is an autoimmune condition characterisedby Polyneuropathy dysfunctioning peripheral motor and sensory http://www.endocrinesurgeon.co.uk/pancreas/pancreas11-2.html

Summaries of latest endocrine news......Up-to-date information at your fingertips...... Click on arrow to select.... Introduction to Endocrinology Thyroid Parathyroids Adrenals Pancreas Pituitary Multiple Endocrine Neoplasia Carcinoid tumours Erectile dysfunction Pineal Gland and Melatonin Osteoporosis Endocrine Anaesthetics A to Z of diagnostic tests Miscellaneous What is POEMS syndrome? This is an autoimmune condition characterised by: P olyneuropathy - dysfunctioning peripheral motor and sensory nerves O rganomegaly - enlargement of organs such as the liver and spleen E ndocrinopathy - dysfunctioning endocrine glands producing adrenal insufficiency, hypothyroidism and type II diabetes mellitus due to pancreatic damage M proteins - antibody proteins produced by plasmacytomas (tumours in the bone marrow) that target the nerves producing the polyneuropathy S kin changes - changes such as hyperpigmentation and excessive hair growth can occur Radiotherapy and chemotherapy are used to eliminate the plasmacytomas that are producing the M protein causing the neurological signs. Hormone replacement therapy can be used to replace missing hormones from malfunctioning endocrine glands.

45. Hit-parade.com : Le Seul Classement Des Sites Francophones Par Audience Translate this page Hit-parade.com vous propose le top 15 des sites francophones Clinique VétérinaireLa Capside poems syndrome UEJF Section Nice Association des jeunes de http://class.hit-parade.com/pros/homepages/classement.asp?p3=9

46. Hit-parade.com : Le Seul Classement Des Sites Francophones Par Audience Translate this page francophones www.jenniferlopezmp3.fr.st Le site de Spinel Sun Canal-medieval-scasamleroi REF-UNION 85 (Radio-Club Vendéen) poems syndrome PanicFuel.com http://class.hit-parade.com/pros/homepages/enhausse.asp?p3=16

47. Quest Diagnostics: Clinical Spotlight Neuropathy is commonly seen in the osteosclerotic forms of myeloma, in poems syndrome(polyneuropathy, organomegaly, endocrinopathy, myeloma, and skin changes http://www.questdiagnostics.com/hcp/hcp_home_spotlight_latov.html

Peripheral Neuropathy and Monoclonal Gammopathy Norman Latov, MD, PhD Professor of Neurology and Neuroscience Weill Medical College of Cornell University New York, NY USA Introduction Classification of Monoclonal Gammopathies The monoclonal gammopathies are routinely classified according to immunoglobulin class and associated lymphoproliferative or plasma cell disorder (Table 1). Table 1. Monoclonal Gammopathy Classification IgM monoclonal gammopathies: Nonmalignant IgM monoclonal gammopathy Waldenström’s macroglobulinemia Chronic lymphocytic leukemia B-cell lymphoma IgG or IgA monoclonal gammopathies: Nonmalignant IgG or IgA monoclonal gammopathies Multiple myeloma Osteosclerotic myeloma Light or heavy chain diseases: Heavy chain myeloma ( g , µ, or a Light chain myeloma (k or l In most cases, the monoclonal gammopathies associated with neuropathy are nonmalignant, but 20 to 35% of the IgM monoclonal gammopathies are associated with Waldenström’s macroglobulinemia, and 8 to 17% of the IgA and IgG monoclonal gammopathies are associated with myeloma. The rate of transformation from the nonmalignant to the malignant state is approximately 2% per year. Estimates as to the incidence of neuropathy range from 3-32% in patients with all types of monoclonal gammopathy, 5-50% in IgM monoclonal gammopathies, and 6-25% in IgG and IgA monoclonal gammopathies. Although IgG or IgA monoclonal gammopathies are more frequent than IgM monoclonal gammopathies in the normal population, more patients with neuropathy have IgM than IgG or IgA monoclonal gammopathies. This is consistent with the greater incidence of neuropathy in the IgM monoclonal gammopathies.

48. POEMS Syndrome Website Results :: Linkspider UK poems syndrome Websites from the Linkspider UK. poems syndrome Directory.Complete Results for poems syndrome Related Topics. POEMS http://www.linkspider.co.uk/Health/ConditionsandDiseases/NeurologicalDisorders/P

POEMS Syndrome Websites from Linkspider UK Keyword: POEMS Syndrome Linkspider UK Directory POEMS Syndrome Search for Directory Tree: Top Health Conditions and Diseases Neurological Disorders ... Peripheral Nervous System : POEMS Syndrome (3) Add URL Advertise Here! Personalize Amazon ... Weather See Also: Health: Conditions and Diseases: Blood Disorders Health: Conditions and Diseases: Rare Disorders Mayo Clinic Rochester - Information about POEMS syndrome, what it is, symptoms, diagnosis, treatment and who gets it. NORD - POEMS Syndrome - Offers the synonyms, a general discussion and resources. Readers Digest Health - A description of POEMS syndrome with further resources and a look at the alternative names.

49. Medline Record 93064883 Abstract The poems syndrome is an infrequently reported multisystem disorderwhich presents usually as an obscure polyneuropathy, with almost all cases http://www.aeiveos.com/Aging/Authors/byrne-e/93064883.html

Title: Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin change (POEMS) syndrome with IgG kappa paraproteinemia. Author(s): Romas E; Storey E; Ayers M; Byrne E Address: Department of Clinical Immunology, St Vincent's Hospital, Melbourne, Victoria. Source: Pathology 1992 Jul;24(3):217-20 Abstract: The POEMS syndrome is an infrequently reported multisystem disorder which presents usually as an obscure polyneuropathy, with almost all cases reported in Japan. A 64 yr old caucasian man presented with a 12 mth history of a severe sensorimotor neuropathy in association with dermato-endocrine features. Detection of a monoclonal IgG kappa paraprotein and mixed osteosclerotic/lytic bone lesions consistent with a plasma cell dyscrasia led to diagnosis of the POEMS syndrome. Unique ultrastructural features were present on sural nerve biopsy in addition to the unusual association with monoclonal kappa-light chain. This case illustrates that the POEMS syndrome may also occur in caucasian subjects Major Indexes: POEMS Syndrome [pathology] Minor Indexes: Caucasoid Race IgG [blood] Immunoglobulins, kappa-Chain [blood]

50. POEMS Translate this page En anglais poems syndrome. Synonymes syndrome de Crow-Fukase, syndrome deTakatsuki. Le syndrome de POEMS qui touche la main se caractérise par http://www.vulgaris-medical.com/textp/poems.html

POEMS Voir également Castleman (tumeur ou maladie de), En anglais : POEMS syndrome. Synonymes : syndrome de Crow-Fukase, syndrome de Takatsuki. Acronyme (sigle prononcé comme un mot ordinaire, sans l’épeler) de : P : Polyneuropathie O : Organomégalie E : Endocrinopathie M : Monoclonale S : Anomalie cutanée (en anglais : Skinchanges) Syndrome (association de symptômes) rare dont l'origine est inconnue et qui a tout d'abord été décrit au Japon. Il se caractérise par une neuropathie (atteinte du système nerveux) périphérique (à différencier du système nerveux central regroupant le cerveau, le cervelet et la moelle épinière entre autres). Symptômes Hépato splénomégalie : augmentation de volume du foie et de la rate Adénopathie : affection des ganglions Gynécomastie : augmentation des glandes mammaires Impuissance Aménorrhée : absence de règles Hyperpigmentation : augmentation de la coloration cutanée Epaississement de la peau Le labo Il montre une dysglobulinémie monoclonale. La dysglobulinémie est une maladie rencontrée parfois chez le sujet âgé ou chez certains malades présentant une atteinte du système lymphoïde (rate, thymus, ganglions, organes lymphoïdes), une maladie auto-immune (le malade fabrique des anticorps contre ses propres tissus) ou une cirrhose du foie. Cette pathologie inconnue peut frapper 2 à 3 % de la population de plus de 70 ans. Elle est causée par la présence d'une certaine quantité de protéines anormales dans le sang. Ce sont des anticorps (immunoglobulines) provenant d’une lignée unique, appelés également clones de cellules plasmocytaires. Les plasmocytes sont issus d’une variété de globules blancs fabriqués dans la moelle osseuse.

51. Listings Of The World Health Conditions And Diseases Listings World Health Conditions and Diseases Neurological Disorders PeripheralNervous System poems syndrome. Listings World, http://listingsworld.com/Health/Conditions_and_Diseases/Neurological_Disorders/P

52. AtAllergy: Allergy Resources Search Engine Myasthenia Gravis Mycosis Fungoides - Myelocytic Acute Leukemia - Myeloid Leukemia- Non-Hodgkin Lymphoma - poems syndrome - Paraproteinemias - Pemphigus http://www.atallergy.com/allergy/index2.php3

Global Search Add Url Free Medline Contact Us ... Conferences Bookmark this page for your Future Medline/Internet Searches Try the Medline Search Designed for Allergy With FAST results Allergy Internet Search Medline Search Designed for Allergy Enter Keyword to search help Or And Match entire phrase Enter Keyword to search help Common Terminology Premier Allergy Sites General Allergy (MESH 1998 © NLM) AIDS Dementia Complex AIDS-Associated Nephropathy AIDS-Related Complex ... Immunologic Deficiency Syndromes General Allergy (MESH 1998 © NLM) Immunoproliferative Disorders Immunoproliferative Small Intestinal Disease Infectious Mononucleosis ... Allergy

53. Peripheral Nervous System Diseases Links to information about peripheral nervous system diseases by Cliniweb International.Category Health Conditions and Diseases Peripheral Nervous System...... Review Therapy Diagnosis. poems syndrome Search PUBMED for POEMSSyndrome All Review Therapy Diagnosis. Sciatica Search PUBMED for http://www.ohsu.edu/cliniweb/C10/C10.772.html

Peripheral Nervous System Diseases Back to previous level Acrodynia Search PUBMED for Acrodynia: All Review Therapy Diagnosis Amyloid Neuropathies Search PUBMED for Amyloid Neuropathies: All Review Therapy Diagnosis ... Autonomic Nervous System Diseases [5 more specific term/s, 4 more link/s] Search PUBMED for Autonomic Nervous System Diseases: All Review Therapy Diagnosis ... Cranial Nerve Diseases [8 more specific term/s, 31 more link/s] Search PUBMED for Cranial Nerve Diseases: All Review Therapy Diagnosis ... Demyelinating Diseases [2 more specific term/s, more link/s] Search PUBMED for Demyelinating Diseases: All Review Therapy Diagnosis ... Diabetic Neuropathies [1 more specific term/s, 1 more link/s] Search PUBMED for Diabetic Neuropathies: All Review Therapy Diagnosis ... Nerve Compression Syndromes [4 more specific term/s, 4 more link/s] Search PUBMED for Nerve Compression Syndromes: All Review Therapy Diagnosis ... Neuralgia [4 more specific term/s, 20 more link/s] Search PUBMED for Neuralgia: All Review Therapy Diagnosis ... Neuritis [5 more specific term/s, more link/s] Search PUBMED for Neuritis: All Review Therapy Diagnosis ... Neuropathies, Hereditary Motor and Sensory

54. Paraproteinemias Myeloma, multiple, multiple sites U. of Washington. poems syndromeSearch PUBMED for poems syndrome All Review Therapy Diagnosis. http://www.ohsu.edu/cliniweb/C20/C20.683.780.html

Paraproteinemias Back to previous level Amyloidosis [2 more specific term/s, more link/s] Search PUBMED for Amyloidosis: All Review Therapy Diagnosis ... amyloidosis: bone manifestations Cryoglobulinemia Search PUBMED for Cryoglobulinemia: All Review Therapy Diagnosis ... Heavy Chain Disease [1 more specific term/s, more link/s] Search PUBMED for Heavy Chain Disease: All Review Therapy Diagnosis ... Monoclonal Gammopathies, Benign [1 more specific term/s, more link/s] Search PUBMED for Monoclonal Gammopathies, Benign: All Review Therapy Diagnosis Multiple Myeloma Search PUBMED for Multiple Myeloma: All Review Therapy Diagnosis ... Myeloma, multiple, multiple sites: U. of Washington POEMS Syndrome Search PUBMED for POEMS Syndrome: All Review Therapy Diagnosis Waldenstrom Macroglobulinemia Search PUBMED for Waldenstrom Macroglobulinemia: All Review Therapy Diagnosis

55. CJNS - Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy And S Abstract A patient with a three year history of poems syndromepolyneuropathy, hepato-splenomegalyM-protein, skin changes, optic disc edema, peripheral oedema http://www.canjneurolsci.org/21febtoc/polyneur.htm

Abstract Close Window Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy and Skin Changes (Poems) Syndrome I. Milanov and D.Georgiev Abstract: A patient with a three year history of POEMS syndrome-polyneuropathy, hepato-splenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described. The patient had a twenty year history of psoriasis and impotence was the first sign of the disease. The pathophysiology of this multisystem disorder is unknown, although the M-protein is essential. No improvement was found after radiation, chemo-therapy and steroid treatment. Can. J. Neurol. Sci. 1994; 21: 60-63 For information about this web site e-mail to: journal@cjns.org

56. SpringerLink: Acta Neuropathologica - Abstract Volume 87 Issue 3 (1994) Pp 302-3 of myelinated fibres. Up to now UML have been reported only in 7 patientswith poems syndrome in the literature. UML have also been http://link.springer-ny.com/link/service/journals/00401/bibs/4087003/40870302.ht

Acta Neuropathologica ISSN: 0001-6322 (printed version) ISSN: 1432-0533 (electronic version) Table of Contents Abstract Volume 87 Issue 3 (1994) pp 302-307 Uncompacted myelin lamellae in polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome. Ultrastructural study of peripheral nerve biopsy from 22 patients C. Vital (1), R. Gherardi (2), A. Vital (1), N. Kopp (3), J. F. Pellissier (4), M. Soubrier (5), P. Clavelou (5), R. Bellance (6), M. B. Delisle (7), M. M. Ruchoux (8), J. J. Hauw (9) (3) Lyon, France (4) Marseille, France (5) Clermont-Ferrand, France (6) Fort-de-France, France (7) Toulouse, France (8) Tours, France Received: 12 July 1993 / Revised, accepted: 11 October 1993 Abstract. Key words: Castleman disease - Monoclonal gammopathy - Myelin - Peripheral neuropathy - POEMS syndrome Correspondence to: C. Vital Article not available online Last change: October 3, 1997 helpdesk.link@springer.de

57. Haematologica/journal Of Hematology - Issue #1, 1999 - The Irreplaceable Image Skin changes in poems syndrome Giuseppe Longo, Giovanni Emilia, Umberto TorelliCorrespondence Giuseppe Longo, MD, Department of Medical Sciences Section of http://www.haematologica.org/abstr/longo841.html

Medline reference of this article PDF version Skin changes in POEMS syndrome Giuseppe Longo, Giovanni Emilia, Umberto Torelli Correspondence: Giuseppe Longo, M.D., Department of Medical Sciences Section of Internal Medicine, University of Modena, via del Pozzo 71, 41100 Modena, Italy. E-mail: longo@unimo.it full text T he so-called POEMS syndrome is a multisystemic disorder characterized by the association of polyneuropathy, organomegaly, endocrinopathy and skin changes. These disorders seem to be secondary to a plasma cell dyscrasia leading to production of a monoclonal component. Several other signs can occur, e.g. anasarca, pyrexia, finger clubbing, sweating and hematologic disorders. The syndrome has been described mainly in Asians, although some Caucasian cases have been reported. We report the images of skin changes which appeared in a 39-year-old Caucasian male; all the other above mentioned signs were also present. The diagnosis of POEMS syndrome was established in April 1987. The patient developed a progressive peripheral polyneuropathy with demyelination, hepatosplenomegaly, sclerotic bone lesions, scleroderma and IgG l References Soubrier MJ, Dubost JJ, Sauvezie BJM, the French Study Group on POEMS Syndrome. POEMS syndrome: a study of 25 cases and review of the literature. Am J Med 1994; 97:543-53.

58. Chin Med J (Taipei) 1996;58:366-9. Intravenous Immunoglobulin Therapy in poems syndrome A Case Report. YeuJhyChang, Chin-Chang Huang, Chun-Che Chu. plasmapheresis, poems syndrome. http://www.vghtpe.gov.tw/~cmj/5805/580510.htm

Next Prev Chi TOC ... Home Chin Med J (Taipei) 1996;58:366-9. Intravenous Immunoglobulin Therapy in POEMS Syndrome: A Case Report Yeu-Jhy Chang, Chin-Chang Huang, Chun-Che Chu Department of Neurology, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan, R.O.C. Abstract One course of intravenous immunoglobulin was tried on a patient with the syndrome of polyneuropathy, organomegaly, endocrinopathy, M-protein and skin lesions and Castleman's disease. No effect was noted. [Chin Med J (Taipei) 1996;58:366-9.] Keywords: intravenous immunoglobulin, nerve conduction velocity. plasmapheresis, POEMS syndrome Received: February 9, 1996. Accepted: June 6, 1996. Reprint requests to: Chin-Chang Huang, M.D. Department of Neurology Chang Gung Memorial Hospital 199, Tung Hwa North Road Taipei, Taiwan, R.O.C. Table of Contents Next Article Previous Article Chinese Version ... Chinese Medical Association (Taipei)

59. Campus N¡19 - IM3 Créteil - A Digérer Par Le Lecteur IM3 cytokines imbalanced by their antagonists in poems syndrome. R http://www.im3.inserm.fr/campus/20/r&d_im3.html

Retour au sommaire Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome Blood 87: 1458-1465, 1996 Differential regulation of G Protein expression in rats exposed to chronic hypoxia R Kacimi, JM Moalic, A Aldaschev, DE Vatner, JP Richalet, B Crozatier Am. J. Physiol. 269 : H1865-1873, 1995 CD5- CD56+ T-cell receptor silent peripheral T-cell lymphomas are natural killer cell lymphomas JF Emile, ML Boulland, C Haioun, P Kanavaros, T Petrella, MH Delfau Larue, A Benssusan, JP Farcet, P Gaulard. Blood 1996 ; 87 : 1466-1473. Molecular and Cellular Biology, 1995, 15:5898-5905 Retour au sommaire

60. Monoclonal Antibodies poems syndrome; Scleromyxedema; Waldenström's macroglobulinemia. Neoplastic Systemic Disorders. poems syndrome; Scleromyxedema Mprotein l; Skin. http://www.geocities.com/HotSprings/Spa/3960/mprotein.html

MONOCLONAL ANTIBODIES (M-proteins) Monoclonal Gammopathies of Unknown Significance (MGUS) General characteristics General clinical features Specific associated clinical syndromes ... Osteosclerotic myeloma Monoclonal Gammopathies of Unknown Significance (MGUS) General characteristics Types of light chain: k l Urine monoclonal: Rare Skeletal lesions (X-ray): Absent CBC: Normal Organomegaly: None Immunoglobulin (Ig) heavy chain class Patient group IgG IgM IgA IgD Biclonal Light chain All M-proteins Testing Optimal clinical method: Immunofixation ? 24 hour urine for Bence-Jones protein After M-protein found X-ray skeletal survey Antigen target of IgM M-protein Cryoglobulins Bone marrow biopsy Indications Very elevated immunoglobulin class of M-protein Low level of other immunoglobulin class Abnormal skeletal survey General clinical features Associated systemic disorders: 35% Neoplasms 26%: May occur at time of dx or during follow-up Myeloma 14% Lytic Osteosclerotic Lymphoma 5% Plasmacytoma 4% Chronic lymphocytic leukemia 3% Amyloidosis 9%: often with myeloma No associated systemic disorders: 65% Monoclonal gammopathy of unknown significance (MGUS) Light chain: kappa more often than lambda Normals: MGUS occur more commonly with increasing age Neuropathy Occurs in 5% of MGUS IgM MGUS most common Specific syndromes associated with IgM binding to neural antigens 50% have anti-MAG binding Treatment of neuropathy: General principles Sensory symptoms treated symptomatically unless disabling CIDP treated with same regimen as idiopathic disease Cyclophosphamide + Plasma exchange protocol may be effective

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