61. Porphyrias | BluePrint For Health You are here Home Health A to Z porphyrias. porphyrias. Barrett,Julia. This situation is the main characteristic of the porphyrias. http://blueprint.bluecrossmn.com/topic/topic100587325

Search COMPLEMENTARY CARE Acupuncture Massage therapy Fitness centers ... SITE AWARDS You are here: Home Health A to Z Porphyrias Porphyrias Barrett, Julia Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition The porphyrias are disorders in which the body produces too much porphyrin and insufficient heme (an iron-containing nonprotein portion of the hemoglobin molecule). Porphyrin is a foundation structure for heme and certain enzymes. Excess porphyrins are excreted as waste in the urine and stool. Overproduction and overexcretion of porphyrins causes low, unhealthy levels of heme and certain important enzymes, creating various physical symptoms. Description Biosynthesis of heme is a multistep process that begins with simple molecules and ends with a large, complex heme molecule. Each step of the chemical pathway is directed by its own task-specific protein, called an enzyme. As a heme precursor molecule moves through each step, an enzyme modifies the precursor in some way. If a precursor molecule is not modified, it cannot proceed to the next step, causing a buildup of that specific precursor. This situation is the main characteristic of the porphyrias. Owing to a defect in one of the enzymes of the heme biosynthesis pathway, protoporphyrins or porphyrins (heme precursors) are prevented from proceeding further along the pathway. These precursors accumulate at the stage of the enzyme defect causing an array of physical symptoms in an affected person. Specific symptoms depend on the point at which heme biosynthesis is blocked and which precursors accumulate. In general, the porphyrias primarily affect the skin and the nervous system. Symptoms can be debilitating or life threatening in some cases. Porphyria is most commonly an inherited condition. It can also, however, be acquired after exposure to poisonous substances.

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64. Porphyrias There are a several inherited disorders associated with the porphyrin syntheticpathway. There are three porphyrias with high photosensitivity. http://www.photodermatology.com/porphyriasgen.htm

PORPHYRIAS Biochemistry of porphyrin and Heme synthesis Porphyrins are synthesized by a multi-step reaction starting with succinyl-CoA and glycine. The first step of the reaction sequence is catalyzed by the enzyme gamma-aminolevulinate synthetase which is regulated through feedback inhibition by the ultimate endpoint of the sequence, heme. The chelation of iron in the final step produces heme which is utilized as a prosthetic group in hemoglobin, myoglobin, catalase, peroxidase, and cytochrome c There are a several inherited disorders associated with the porphyrin synthetic pathway. Ther e are three porphyrias with high photosensitivity Porphyria cutanea tarda Erythropoetic Protoporphyria Erythropoietic Porphyria

65. Directory :: Look.com porphyrias (19) See Also. information. Diagnosing the porphyrias An articleby Thomas G. DeLoughery, Associate Professor of Medicine. http://www.look.com/searchroute/directorysearch.asp?p=413829

66. Fayette Medical Center Digital Library porphyrias Clinical Resources. Chapter 27 Heme Biosynthesis and itsDisorders porphyrias and Sideroblastic Anemias Access document http://fayettemc-dl.slis.ua.edu/clinical/metabolism/inborn/porphyria.htm

Clinical Resources by Topic: Metabolic Disorders Porphyrias Clinical Resources Emergency Pediatrics Atlases Radiology ... Miscellaneous Resources See also: Genetic Testing Clinical Resources General Genetic Disorders Clinical Resources General Metabolic Disorders Clinical Resources Porphyrias Patient/Family Resources Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Lister Hill Library subscription INFO Chapter 27 - Heme Biosynthesis and its Disorders: Porphyrias and Sideroblastic Anemias: Access document Introduction: Access document Heme Biosynthesis: Access document Porphyrias: Access document Introduction: Access document Acute Intermittent Porphyria: Access document Other Acute Porphyrias: Access document Nonacute or Cutaneous Porphyrias: Access document Porphyria Cutanea Tarda or Cutaneous Hepatic Porphyria: Access document Erythropoietic Protoporphyria: Access document Congenital Porphyria: Access document Pseudoporphyria and Renal Dialysis: Access document Habif: Clinical Dermatology 3rd Ed.-1996 (MD Consult): Table of contents Lister Hill Library subscription INFO Chapter 19 - Light-Related Diseases and Disorders of Pigmentation: Access document Porphyrias: Access document Feldman: Sleisenger and Fordtran's Gastrointestinal and Liver Disease 7th Ed.-2002 (MD Consult):

67. Poetry Essay An Essay Comparing Porphyrias Lover, With My Last Duchess. Poetry Essay an Essay Comparing porphyrias Lover, With My Last Duchess. PoetryEssay an Essay Comparing porphyrias Lover, With My Last Duchess. http://www.coursework.info/i/4127.html

The UK's largest coursework and essay database All Categories This Category You are in: Coursework and Essays GCSE Literature Poetry and Sonnets Poetry Essay an Essay Comparing Porphyrias Lover, With My Last Duchess. Below is a short sample of the essay "Poetry Essay an Essay Comparing Porphyrias Lover, With My Last Duchess." . If you sign up you could be reading the rest of this essay in under two minutes. Registered users should log in to view the full essay All formatting has been removed from the sample of this essay. Inside Coursework.Info , all coursework and essays can be viewed with all of the original formatting retained - including pictures, tables, images and graphs, as well as the . You may also be interested in the word count, writing time and other details concerning this essay. If you're interested in knowing more about Coursework.Info , we encourage you to take the the Coursework.Info tour Jump to a Category Select a Category A-Level A-Level/Art A-Level/Biology A-Level/Chemistry A-Level/Classics A-Level/Economics A-Level/French A-Level/Geography A-Level/German A-Level/History A-Level/Law A-Level/Literature A-Level/Maths A-Level/Misc A-Level/Music A-Level/Physics A-Level/Politics A-Level/Psychology A-Level/Sociology A-Level/Spanish A-Level/Technology Uni Uni/Art Uni/Biology Uni/Chemistry Uni/Computer Science Uni/Counselling Uni/Economics Uni/Education Uni/Geography Uni/History Uni/History/Ancient Uni/Languages Uni/Law Uni/Literature Uni/Media Studies Uni/Misc Uni/Physics Uni/Politics Uni/Psychology Uni/Sociology GCSE

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71. Health/Conditions_and_Diseases/Nutrition_and_Metabolism_Disorders/Porphyrias Health / Conditions_and_Diseases / Nutrition_and_Metabolism_Disorders / porphyrias. Apersonal site about this disorder one of the family of porphyrias. http://www.health-information-resource.com/Health/Conditions_and_Diseases/Nutrit

Search: Category Description: The result of changes in the blood's nitrogen-containing substances, or porphyrins. Health Porphyrias Porphyria Page A patient guide for all people with this disorder. Compiled by Professor Michael Moore. URL: http://www.uq.edu.au/porphyria/ The American Porphyria Foundation Non-profit organization advancing awareness research and treatment of Porphyria. Fact sheets and links to related resources. URL: http://www.enterprise.net/apf/ Porphyrias A brief look at the two major types the symptoms and an example is given. URL: http://medic.bgu.ac.il/mirrors/netbiochem/hi6.htm HealthCentral - Porphyria General overview of this rare disease. URL: http://www.healthcentral.com/mhc/top/001208.cfm Porphyrias: Diagnosis and Treatment Clinical manifestations diagnosis etiology and treatment of six types of porphyrias are discussed. URL: http://www.medstudents.com.br/metdis/metdis3.htm Porphyria: The Woman Who Has The Vampire Disease Review by the FindArticles.com on this book on porphyria written by Lenore B. Weinstein. URL: http://www.findarticles.com/cf_0/m0FSP/3_21/53578846/p1/article.jhtml

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73. Porphyria Cuatanea Tarda Porphyria Overview. porphyrias are a group of diseases which are all deficienciesof any of the eight enzymes involved in heme synthesis. http://www.zevils.com/~matthewg/porphyria.html

Porphyria Cutanea Tarda - A Report by Matthew Sachs Porphyria Overview Porphyrias are a group of diseases which are all deficiencies of any of the eight enzymes involved in heme synthesis. One of the major causes of symptoms in patients with porphyria is the accumulation of heme precursors. To make heme, the body needs some raw materials in addition to the eight enzymes. Heme procursors collect mainly in the marrow and liver. The main heme precursors that cause problems in porphyria are toxic metabolites: delta-aminolevulinic acid and porphobilinogen, which are neurotoxins, and porphyrins. These precursors are transferred from the tissues where they accumulate into the blood plasma and from there they are excreted in urine and stools. Accumulation of these precursors can cause photosensitivity and nerve damage, even paralysis. The most common porphyrias are porphyria cutanea tarda (PCT), acute intermittent porphyria , and eryhtropoietic protoporphyria . These are veru different diseases, with distinct symptoms, tests needed for proper diagnosis, and treatments. Additionally, they all share some symptoms with rarer porphyrias. Thus, porphyria is often misdiagnosed. Test results from patients with porphyria will be markedly abnormal, but one needs to select and interpret tests with porphyria in mind. All porphyrias except for one are hereditary. PCT is not inherited directly. However, suspectibility to PCT is often inherited, in which case it is called familial (type II) PCT.

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Porphyrias Websites from Linkspider UK Keyword: Porphyrias Linkspider UK Directory Porphyrias Search for Directory Tree: Top Health Conditions and Diseases Nutrition and Metabolism Disorders : Porphyrias (19) Add URL Advertise Here! Personalize Amazon ... Weather See Also: Health: Conditions and Diseases: Genetic Disorders Health: Conditions and Diseases: Rare Disorders Porphyria Page - A patient guide for all people with this disorder. Compiled by Professor Michael Moore. The American Porphyria Foundation - Non-profit organization advancing awareness, research, and treatment of Porphyria. Fact sheets and links to related resources. Porphyrias - A brief look at the two major types, the symptoms and an example is given. HealthCentral - Porphyria - General overview of this rare disease. Porphyrias: Diagnosis and Treatment - Clinical manifestations, diagnosis, etiology and treatment of six types of porphyrias are discussed. Porphyria: The Woman Who Has The Vampire Disease - Review by the FindArticles.com on this book on porphyria written by Lenore B. Weinstein. King George II and Porphyria - Talks about the symptoms of porphyria affecting King George III who ruled England during the American revolution.

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80. WebMD - Discussion. Porphyria Cutanea Tarda (PCT) is the most common of the porphyrias. Theporphyrias are a group of at least seven disorders. The http://my.webmd.com/NR/internal.asp?GUID={9BBAA4D1-4EB8-4A6E-893C-1DC461FA685B}

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