21. Arond-Thomas Online | Patterns Of Cerebral Atrophy In Primary Progressive Aphasi Patterns of cerebral atrophy in primary progressive aphasia Rosen HJ, KramerJH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL.Department of Neuro. http://arond-thomasonline.com/template.asp?articleid=374&categoryid=55

22. Primary Progressive Aphasia-HELP!!! primary progressive aphasiaHELP!!! Email Address WM3DGIBSON@AOL.COM Mymother was recently diagnosed with primary progressive aphasia. http://neuro-www.mgh.harvard.edu/forum_2/GeneralNeurologyF/12.28.9911.13PMPrimar

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. Primary Progressive Aphasia-HELP!!! This article submitted by M Gibson on 12/28/99. Email Address: WM3DGIBSON@AOL.COM My mother has been through MRIs, CAT scans, blood tests, memory tests, etc. She has been to the hospital in Iowa City twice and yet all we get is that she has a speech deficit and she needs to learn sign language. The only test that has come back with ANY abnormality is a SPECT scan that has been run two times and shows a lack of nurishment to the left side of her brain. In May of 1996, an individual by the name of Ann Allan typed and article on Primary Progressive Aphasia about her mother. When my sister happened upon this article, it seemed almost erie as it mirrored my mother's condition. Ann, if you are out there and you read this, please contact me! I lost my father in June of 1996 to cancer and my sister and I feel that in a sense, if we don't find something to reverse mom's condition that we have already lost the "MOM" that we know.

23. Primary Progressive Aphasia No messages are screened for content. primary progressive aphasia. Shehas just been diagnosed with primary progressive aphasia. http://neuro-www.mgh.harvard.edu/forum_2/HuntingtonsDiseaseF/6.21.991.46AMPrimar

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. Primary Progressive Aphasia This article submitted by Doug on 6/21/99. Email Address: DWil13@ix.netcom.com (I had posted this in speech disorders forum a week ago, and had no response) Howdy! Hey, wondered if you folks could help my mother with some information. She has just been diagnosed with Primary Progressive Aphasia. Her words are mixed up, and she can't write like she used to, and this has been going on for about a year now. She was an English/Drama teacher for years, so it is very frustrating for her not to be able to be accurate with her spoken and written English. She just started taking Aricept but hasn't noticed any improvements yet. Also, her mother, my grandmother, had Huntingtons Chorea, and died of the complications of that disease. I can't help but think that there may be some conection between the two. My mother will be 65 in July, my grandmother was 59 when diagnosed with Huntingtons, and 71 when she died. Any advice and or information would be tremendously appreciated. My mother is on Web TV, and once I get more information, I will try to get her to post here herself.

24. Northwestern University, Communication Sciences And Disorders, Aphasia Laborator 189208 Click for Abstract. primary progressive aphasia Thompson, CK,Ballard, KJ, Tait , ME , Weintraub, S., Mesulam, M. (1997). http://www.csd.northwestern.edu/research/speech/aphasia/publications.html

Learning Disabilities Aphasia Laboratory Selected Publications Recovery of Sentence Comprehension and Production in Aphasia Verb Production in Aphasia and other Neurological Disorders On-line Sentence Processing fMRI ... Primary Progressive Aphasia Recovery of Sentence Production in Agrammatic Aphasia Thompson, C.K. (2001) Treatment of underlying forms: A linguistic specific approach for sentence production deficits in agrammatic aphasia. In R. Chapey (ed.) Language intervention strategies in adult aphasia (4th edition), Baltimore Lippincott noncanonical sentence comprehension and production in agrammatic aphasia. Journal of Speech, Language, and Hearing Research, 43 Click for Abstract Thompson, C. K., Tait M.E. wh -questions. Brain and Language, 67 Click for Abstract Journal of Speech, Language, and Hearing Research, 42 Click for Abstract Wh -movement structures in agrammatic aphasia: Optimal order for promoting generalization. Journal of the International Neuropsychological Society 4 Click for Abstract Thompson, C.K., Shapiro, L.P., Ballard, K., Jacobs, B., Schneider

25. Northwestern University Communication Sciences And Disorders Faculty Cynthia K. Individuals with primary progressive aphasia (PPA; a form of dementia)show linguistically predictable patterns of language decline. http://www.csd.northwestern.edu/faculty/thompson.html

Faculty Cynthia K. Thompson, Ph.D. Associate Professor Department of Communication Sciences and Disorders, and Neurology Speech and Language Pathology 2299 North Campus Drive Evanston, IL 60208-3570 Phone: (847) 491-5073 Fax: (847) 467-2776 Email: ckthom@northwestern.edu Professional Interests: Acquired aphasia and other language/cognitive disorders, treatment efficacy, functional communication, breakdown and recovery of sentence processing and production in agrammatic aphasia, fMRI studies of lexical and syntactic processing, and language decline in dementia. Current Research: Studies also are underway using functional magnetic resonance imaging (fMRI) to examine brain sites involved in aspects of sentence processing. This work is supported by the McDonnell-Pew Foundation Program in Cognitive Neuroscience. Results to date have indicated that, in non-brain-damaged subjects, complex sentence processing involves frontal lobe areas (i.e., pars opercularis and surrounding areas), while simple sentence processing may be accomplished without engaging, to the same extent, these anterior brain sites. Studies examining recovery of language processing in aphasia using fMRI are also planned. Dr. Thompson's Aphasia and Neurolinguistics Research Laboratory:

26. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso Sites. primary progressive aphasia A description of what this is,the symptoms and its course. Understanding Primary Progressive http://www.1uphealth.com/links/dementia-primary-progressive-aphasia.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Dementia : Primary Progressive Aphasia Description Sites Primary Progressive Aphasia A description of what this is, the symptoms and its course. Understanding Primary Progressive Aphasia An article with a description, assistance available and where to obtain additional information. WebMD Live Chat Transcript: Living with aphasia with Martha Taylor Sarno, MD. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites. Home Contact Us Privacy Links Directory

27. Alzheimer PDG. PD. PiD. Prion. PSP. PEP. SSP. ToD. primary progressive aphasia (PPA). PPA isa langagebased dementia characterized by a progressive impairment of verbal skills. http://www.lille.inserm.fr/u422/PPA.html

Alzheimer Brain dis eases Research ... GD Bri C BD DS GSS F TD FTDP-17 H ... F H-S d IBM L BD MSA NPiD c PDG P D PiD P rion P SP PEP SSP ToD Primary Progressive Aphasia (PPA) PPA is a langage-based dementia characterized by a progressive impairment of verbal skills. Core: impaired fluency, agrammatism, impaired comprehension of word scanning, naming deficits. PPA is divided into non fluent and fluent (mesulam et al) PPA belongs to the "Pick spectrum" of tauopathies. Accueil Liens vers sites apparentés Lexique

28. Neurological Disorders Pick's disease. Postencephalitic parkinsonism. primary progressive aphasia.Progressive supranuclear palsy. Subacute sclerosis panencephalitis. http://www.lille.inserm.fr/u422/diseases.html

Alzheimer Brain dis eases Research ... GD Bri C BD DS GSS F TD FTDP-17 H ... F H-S d IBM L BD MSA NPiD c PDG P D PiD P rion P SP PEP SSP ToD Cerebral aging - A molecular classification in one slide Tauopathies: a slide-show - Neurological disorders with neurofibrillary tangles: a review Argyrophilic grain disease Alzheimer's disease ALS/PDC of Guam ... Corticobasal degeneration Down syndrome Myotonic dystrophy Pick's disease Postencephalitic parkinsonism Primary progressive aphasia ... Progressive supranuclear palsy Subacute sclerosis panencephalitis Neurological disorders without neurofibrillary tangles (alphabetical) Amyotrophic lateral sclerosis Fronto-temporal dementias Huntington Disease Lewy body disease ... Parkinson's diseas e Prion diseases Other diseases (Pr Pasquier)

29. School Of Communication At Northwestern University Manuscript submitted for publication. Click for Abstract. primary progressive aphasiaThompson, CK, Ballard, KJ, Tait, ME, Weintraub, S., Mesulam, M. (1997). http://www.northwestern.edu/csd/research/speech/aphasia/publications.html

30. Cynthia Thompson in work examining the decline of lexical and syntactic aspects of language in individualswith dementia specifically primary progressive aphasia (PPA), a http://www.northwestern.edu/nuin/faculty/Thompson_C/

Cynthia K. Thompson Aphasia and Neurolinguistic Research Laboratory Professor, Departments of Communication Sciences and Disorders; and Neurology Ph.D., University of Kansas Contact Info Phone: (847)491-5073 E-mail ckthom@northwestern.edu The neurobiology of recovery of language in aphasia also is being addressed using functional magnetic resonance imaging (fMRI). FMRI studies of lexical and syntactic processing are undertaken prior to and following recovery of specific linguistic processes in aphasic subjects. Areas of significant activation derived in pre-treatment scans are compared to those following treatment. The neural correlates of lexical and syntactic processing in normal subjects also are examined in the Aphasia and Neurolinguistic Research Lab. This work is supported by the McDonnell-Pew Foundation Program for Neuroscience. Dr. Thompson also is engaged in work examining the decline of lexical and syntactic aspects of language in individuals with dementia specifically Primary Progressive Aphasia (PPA), a progressive language deficit of unknown etiology. RECENT ABSTRACTS Figure 1. SPM image (lateral) showing areas of significant activation during complex object cleft as compared to subject cleft sentence processing. Blue = areas of significant activation under object cleft sentence condition; red = areas of significant activation under subject cleft conditions; green = areas of significant activation under both sentence conditions.

31. PRÝMER PROGRESÝF AFAZÝ Case Report. primary progressive aphasia*. Gülden AKDAL, Beril DÖNMEZ,Raif ÇAKMUR, Ahmet GENÇ. Keywords primary progressive aphasia. *33. http://med.ege.edu.tr/norolbil/2000/NBD08300.html

Journal of Neurological Sciences (Turkish) Table of Contents NOROL BIL D 17: 1 , 2000 http://www.med.ege.edu.tr/norolbil/2000/NBD08300.html Case Report PRIMARY PROGRESSIVE APHASIA* Gülden AKDAL Beril DÖNMEZ Raif ÇAKMUR Ahmet GENÇ Department of Neurology, School of Medicine, Dokuz Eylul University, Izmir, Turkey ABSTRACT Primary progressive aphasia has been clinically defined as progressive language deficit leading to the dissolution of almost all language functions with relative preservation of other cognitive functions. This syndrome was first recognized by Mesulam in 1982. We report a 72-year-old male patient whose motor aphasia started at the age of 70 years. Magnetic resonance imaging showed left frontotemporal atrophy and single photon emission tomography showed hypoperfusion bilatheral frontal and pariototemporal lobes, more marked in the left. The clinical symptoms and the neuroimaging findings fit the diagnosis of primary progressive aphasia. But neuropathological investigations should be made for differential diagnosis. Key-words: Primary progressive aphasia *33. Ulusal Nöroloji Kongresinde sunulmuþtur.

32. Pick's Disease Fact Sheet different names which are explained below Frontotemporal lobar degeneration,frontotemporal dementia, semantic dementia and primary progressive aphasia. http://www.angelfire.com/ia/dougkeck/picksinfo.html

Pick's Disease Fact Sheet (frontotemporal lobar degeneration) Information for PDSG booklet What is it? A progressive dementia occurring in middle life characterised by slowly developing changes in character and social behaviour, or impairment of language, due to degeneration of the frontal and temporal lobes of the brain. Where does the name come from? Arnold Pick was the doctor who was the first to describe the disease in 1892. Other names for the disease Many doctors now prefer to reserve the name "Pick's" for just one of the types of changes in the brain tissue (histology) that may be seen with the disease. You may come across several different names which are explained below: Frontotemporal lobar degeneration, frontotemporal dementia, semantic dementia and primary progressive aphasia. Frontotemporal lobar degeneration Many doctors now prefer this name for the disease. Patients who would have previously been told they had Pick's Disease may now be told they have frontotemporal lobar degeneration. The name refers to the parts of the brain that are affected: the frontal and temporal lobes (at the front and side of the brain respectively). Frontotemporal lobar degeneration can present with three different patterns of symptoms: frontotemporal dementia, semantic dementia or primary progressive aphasia. In frontotemporal dementia the frontal lobes (controlling behaviour, organisation and planning) are affected first, whilst in semantic dementia it is the temporal lobes (controlling language) that are affected first. In primary progressive aphasia, the disease starts in an area at the back of the frontal lobes and front of the temporal lobes.

33. NIDCD News And Events: Language And Aging: Presenter: Sandra Weintraub Language and Aging. Presenter Sandra Weintraub, Ph.D. Alzheimer's Disease andprimary progressive aphasia Clues to the Organization of Language. Biography. http://www.nidcd.nih.gov/news/meetings/02/aging/weintraub.asp

Home News and Events Calendar of Events Events Archive ... Language and Aging Language and Aging Presenter: Sandra Weintraub, Ph.D. Alzheimer's Disease and Primary Progressive Aphasia: Clues to the Organization of Language Biography Dr. Sandra Weintraub is Professor of Psychiatry and Neurology at Northwestern University Medical School and the Director of Neuropsychology in the Cognitive Neurology and Alzheimer's Disease Center Abstract Top Page last updated: December 2, 2002 Home Contact Us Privacy Public Use ... Free Publications National Institute on Deafness and Other Communication Disorders National Institutes of Health 31 Center Drive, MSC 2320 Bethesda, MD USA 20892-2320 E-mail: nidcdinfo@nidcd.nih.gov

34. Baylor Neurology Case Of The Month Patient 35. Summary and Discussion George M. Ringholz, MD, Ph.D. DiagnosisProgressive Nonfluent Aphasia (formerly primary progressive aphasia) http://www.bcm.tmc.edu/neurol/challeng/pat35/summary.html

Patient #35 Summary and Discussion George M. Ringholz, M.D., Ph.D. Diagnosis: Progressive Non-fluent Aphasia (formerly Primary Progressive Aphasia) This patient's condition began with dysnomia and progressed to a severe expressive language disorder over the course of approximately five years. His current status also reflects early deficits in frontal lobe executive functioning (maintenance of task set and planning and execution of complex drawings). There is relative preservation of visuospatial skills. The deficits in memory seen affect both verbal and non-verbal domains. However, the patient does not show global memory impairment in terms of his orientation to time. There is relative preservation of personality and no history of socially inappropriate behavior, apathy, restricted affect, or amimia. These findings are suggestive of a primary progressive aphasia that has begun to involve the frontal lobes. A familial form of frontotemporal dementia with parkinsonism (FTDP-17) also has been identified. Clinical features include personality changes, hyperorality, nonfluent aphasia, bradykinesia, rigidity, and impairment of executive functions. The inheritance is autosomal dominant with a pathological locus mapped to a 2 cM interval on 17q21-22. The gene for the microtubule-associated protein tau is located in this region, and tau-positive neuronal inclusions have been demonstrated in many of these family members. More than 10 exonic and intronic mutations in the tau gene have been identified in patients with familial FTDP-17. Missense mutations including P301L, V337M, and R406W have been shown to disrupt cytoskeletal networks of microtubules and/or result in an accelerated aggregation of tau into filaments.

35. Patient 35 Selftest associated protein (tau) D. alphasynuclein E. Presenilin-1 4. Which clinical scenariois most consistent with a diagnosis of primary progressive aphasia? http://www.bcm.tmc.edu/neurol/challeng/pat35/selftest.html

Patient #35 Progressive Non-fluent Aphasia 1. Typical frontotemporal lobe degeneration syndromes include all of the following EXCEPT: A. Frontotemporal dementia B. Lewy body dementia C. Semantic dementia D. Progressive nonfluent aphasia 2. One of the familial forms of FTDP (frontotemporal degeneration with parkinsonism) has been mapped to which chromosomal locus? A. B. C. D. 3. Which candidate gene for FTDP lies within the region specified in question (2)? A. beta-amyloid precursor protein (beta-APP) B. Apolipoprotein E C. Microtubule-associated protein (tau) D. alpha-synuclein E. Presenilin-1 4. Which clinical scenario is most consistent with a diagnosis of primary progressive aphasia? A. Early mutism, early amnesia, and late behavioral changes B. Early loss of social skills followed by anomia and apraxia C. Memory loss followed by rapid onset of aphasia D. Progressive impairment of expressive language, with mutism and behavioral changes as late features 5. Supportive features for a diagnosis of progressive aphasia include all EXCEPT: A.

36. Dr Karen Croot Neurology, 56, 944950. Croot, K. (2000) primary progressive aphasia A tutorial.Acquiring Knowledge in Speech, Language and Hearing, 2, 90-92. http://www.psych.usyd.edu.au/staff/karenc/

37. Prof. J.B. Orange primary progressive aphasia The future of neurolinguistic and biologic characterization. Pragmaticsin frontal lobe dementia and primary progressive aphasia. http://www.uwo.ca/fhs/csd/jborange_srp.html

Prof. J.B. Orange - Selected Recent Publications (last 3 years) Peer Reviewed Brain and Language, 71 Brain and Language, 71 Neurology, 53, Topics in Geriatric Rehabilitation, 14 Journal of Applied Communication Research, 26 Asha Division 2 Newsletter - Neurophysiology and Neurogenic Speech and Language Disorders, 8 Journal of Neurolingusitics, 11 Journal of Speech-Language Pathology and Audiology, 21 Books, Monographs, and Chapters Orange, J.B. (in press). Family caregivers, communication and Alzheimer's disease. In M.L. Hummert and J. Nussbaum (Eds.) Aging, communication, and health: Multidisciplinary perspectives. Mahwah, NJ: Lawrence Erlbaum Associates. Neurogenic communication disorders: a functional approach (pp. 220-246). NY: Thieme. Clinics in Geriatric Medicine: Communication between older adults and their physicians. (pp. 153-173). Philadelphia, PA: W.B. Saunders. Stroke rehabilitation - Physical medicine and rehabilitation: State of the art reviews. Volume 12 (3) Pragmatics in neurogenic communication disorders (pp. 153-177). Oxford, UK: Pergamon Press.

38. TEMPLATE Kertesz, A., and JB Orange. 2000. primary progressive aphasia The Future of Neurolinguisticand Biologic Characterization. Brain and Language 71 116119. http://www.uwo.ca/western/publications/199900/health/dcd.html

CORCORAN, J.A. Corcoran, J.A., M. Stewart, M. Glynn, and D. Woodman . 2000. Stories of Parents of Children with Hearing Loss: A Qualitative Analysis of Interview Narratives (Chapter 14). A Sound Foundation Through Early Amplification: Proceedings of an International Conference. Chicago, IL October 1998 . R.C. Seewald. Phonak AG. 167-173. DOYLE, P.C. Brown, S.I., and P.C. Doyle . 1999. The Woman Who is Laryngectomized: Parallels, Perspectives, and Reevaluation of Practice. Journal of Speech-Language Pathology and Audiology Doyle, P.C. 1999. Laryngectomy Rehabilitation: Past, Present, and Future. Journal of Speech-Language Pathology and Audiology 23 (2): 50-53. An introduction to "Please Listen to Me" by Shirley Gunderson. Doyle, P.C. 1999. Postlaryngectomy Speech Rehabilitation: Contemporary Considerations in Clinical Care . Journal of Speech-Language Pathology and Audiology Doyle, P.C. 1999. Voice Rehabilitation Following Conservation Laryngectomy: Treatment Considerations. Communication and It's Disorders: A Science in Progress. Proceedings of the 24th Congress International Association of Logopedics and Phoniatrics, Volume I. Amsterdam, The Netherlands 23 August 1998-27 August 1998 . P. Dejonckere, and H.F.M. Peters. Nijmegen University Press. 305-307.

39. Searchalot Directory For Primary Progressive Aphasia Related Web Sites. primary progressive aphasia A description ofwhat this is, the symptoms and its course. Understanding Primary http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders

Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases Neurological Disorders ... Dementia : Primary Progressive Aphasia Related Web Sites Primary Progressive Aphasia - A description of what this is, the symptoms and its course. Understanding Primary Progressive Aphasia - An article with a description, assistance available and where to obtain additional information. WebMD Live Chat Transcript: - Living with aphasia with Martha Taylor Sarno, MD. All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo!

40. Bibliografia 5.Karbe H, Kertesz A, Polk M. Profiles of language impairment in primary progressiveaphasia. The pathology and nosology of primary progressive aphasia. http://www.neuropsy.it/articoli/dir05/06.html

@import "http://www.neuropsy.it/wai.css"; Sezione intestazione vai alla sezione contenuti vai alla sezione navigazione Il portale di neuropsicologia clinica un progetto hyperlabs.net Sezione navigazione Vai alla sezione contenuti Vai alla sezione intestazione Articolo precedente: Spettro clinico e neuropatologico dell'afasia progressiva primaria Paragrafi Neuropsy.it Cos'è Neuropsy.it La Neuropsicologia clinica Contatti Sezioni Links Casi clinici Articoli scientifici Test neuropsicologici Patologie Neoplasie Alzheimer Parkinson Traumi cranici ... Depressione Gruppo di discussione neuropsy.it , il gruppo di discussione su yahoo Inserisci la tua e-mail qui Sezione contetuti Vai alla sezione intestazione vai alla sezione navigazione neuropsy.it articoli ... Afasia primaria progressiva, atrofia anteriore sinistra, e patologia ippocampale neurofibrillare : osservazioni in un caso insolito Bibliografia Peter A. Engel, M.D., and Peter D. Fleming, M.D. - Departement of medicine, Division of Geratrics, University of Connetticut, Farmington; Division of Geriatrics, Albany Veterans Administration Medical Center and Medical College, New York; Departement of Pathology (Neurophatology), University of Massachusetts, Worcester; and Department of Medicine, Harvard Medical School, Boston, Massachusetts, U.S.A. 1.Green J, Morris JC, Sandson J, et al. Progressive aplasia: a precursor of global dementia. Neurology 1990; 40:423-9.

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