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         Primary Progressive Aphasia:     more detail
  1. Primary Progressive Aphasia
  2. False recognition of incidentally learned pictures and words in primary progressive aphasia [An article from: Neuropsychologia] by E. Rogalski, D. Blum, et all 2007-01
  3. Number words are special: Evidence from a case of primary progressive aphasia [An article from: Journal of Neurolinguistics] by F. Domahs, L. Bartha, et all
  4. Category and letter fluency in semantic dementia, primary progressive aphasia, and Alzheimer's disease [An article from: Brain and Language] by C.A. Marczinski, A. Kertesz, 2006-06-01

61. Dementia
More likely to have change in level of consciousness. primary progressive aphasiaprogressive aphasia without true dementia. Jacob Creutzfeld Disease
http://neuroland.com/deg/dementia.htm
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Neuro Med
Overview of Dementia Population is aging Prevalence of dementia increases with age Amnesia: Isolated memory loss Amnesia may be the first sign of dementia Delirium is a deficit of attention Diagnostic Criteria for Dementia Impaired social or occupational function Impaired memory, plus
one or more area of the following cognitive functions Abstract/problem solving Judgment Language Personality Clear consciousness Differentiate Depression from Dementia Depression Dementia Relatively rapid onset Depressive symptoms start before dementia Patient complains more than family Appears depressed Response of "I don't know" Inconsistent Cognitive impairment Response to antidepressant very slow onset depressive symptoms develop after cognitive decline Patient tends to deny any memory problem May or may not appear depressed Try to give an excuse or general answer Cognitive impairment fairly consistent Antidepressant may have no effect Causes of Dementia Alzheimer's dementia Multiinfarct dementia Normal Pressure Hydrocephalus 3 main symptoms: Dementia, Gait Apraxia, Incontinence

62. Neurologic Manifestations
Staffordshire Univ. (UK); Aphasia A Language Disorder J Xiong;primary progressive aphasia Newsletter NorthWestern U (US); The
http://www.mic.ki.se/Diseases/c10.597.html
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Neurologic Manifestations
Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider.

63. The Health Library — Nervous System And Brain
Aphasia Fact SheetNational Aphasia Foundation. primary progressive aphasiaNationalAphasia Foundation. Facts and ReadingsNational Aphasia Foundation.
http://healthlibrary.stanford.edu/resources/internet/bodysystems/nervoussystem6.
Diseases and Disorders Use these links to jump directly to your topic of interest: Anatomy Autoimmune Nervous System Diseases Brain Diseases Brain Injury ... Transplantation Nervous System and Brain: Page 1 Page 2 Page 3 Page 4 ... Page 9 Spinal Cord Injury Spinal Cord Injuries: MEDLINEplus Spinal Cord Injuries:AANS Spinal Cord Injury:NINDS Spinal Cord Injury : Emerging Concepts:NINDS Workshop (1996) ... Myelin and Spinal Cord Repair:Society for Neuroscience Spinal Cord Diseases Spinal Cord Diseases: MEDLINEplus
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See Genetics and Birth Defects, Spina Bifida
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Spinal Muscular Atrophy:MEDLINEplus Spinal Muscular Atrophy:NINDS Understanding SMA:Families of Spinal Muscular Atrophy Infantile Progressive Spinal Muscular Atrophy (SMA1):Muscular Dystrophy Association ... Spinal and Bulbar Muscular Atrophy:GeneReviews, University of Washington
Syringomelia
Syringomelia:MEDLINEplus Syringomelia Fact Sheet:NINDS What is Syringomyelia?:American Syringomyelia Alliance Project

64. Cuadernos De Neurología
Translate this page 11. Mesuam M. primary progressive aphasia. Ann Neurol 22 (4) 533-534, 1987. 12. 14.WeintraubS. primary progressive aphasia. Arch Neurol 47 1329-1335, 1990.
http://escuela.med.puc.cl/paginas/publicaciones/Neurologia/cuadernos/1994/pub_11
AFASIA PROGRESIVA PRIMARIA
Dra. Ximena Rossat
Escuela de Medicina
I.- CARACTERISTICAS CLINICAS
1. Edad de Comienzo.
a.- Lenguaje
II.- EXAMENES DE LABORATORIO.
1.- Electroencefalograma
III.- CARACTERISTICAS NEUROPATOLOGICAS.
DIFERENCIAS CLINICAS CON DETERIORO SENIL TIPO ALZHEIMER
Sin embargo si el paciente con APP es seguido por largo tiempo, hasta los estados terminales de su enfermedad, es frecuente que se puedan presentar algunas anteraciones cognitivas y del comportamiento.
BIBLIOGRAFIA.
1. Basso A,Progressive language impairment without dementia. J.of Neurology, Neurosurgery and Psychiatric 51: 1201-1207, 1988. 2. Benson F. Aphasia. Alexia and Agraphia. Churchill Livingstone 1979. 3. Damasio A. Aphasia. The New England Journal of Medicine 326: 531-539, 1992. 4. Green. Progressive Aphasia. Neurology 40: 423-429, 1990. 6. Heath , Slowly progressive aphasia without generalized dementia. Ann of Neurol 13:687- 688,1983.- 7.= Kirshner H. Progressive aphasia without dementia. Ann Neurol 22: 527-532, 1987. 8. Mandell A. Creutzfelf-Jakob disease presenting as isolated aphasia. Neurology 39:55-58,1989.

65. Brain SPECT In Progressive Aphasia
CLINICAL INVESTIGATIONS. Frontotemporal Decreases in rCBF Correlatewith Degree of Dysnomia in primary progressive aphasia. Elmer
http://www.snm.org/about/oldjnmabs/2000/v41n2p228.html
Publication: Media CLINICAL INVESTIGATIONS Frontotemporal Decreases in rCBF Correlate with Degree of Dysnomia in Primary Progressive Aphasia Elmer C. San Pedro, Georg Deutsch, Hong Gang Liu, and James M. Mountz Department of Radiology, Division of Nuclear Medicine, University of Alabama at Birmingham Medical Center, Birmingham, Alabama Primary progressive aphasia (PPA) is an uncommon degenerative dementia characterized by gradual impairment of language function with initial sparing of the memory domain. Using semiquantitative Tc-hexamethyl propyleneamine oxime (HMPAO) brain SPECT as a measure of regional cerebral blood flow (rCBF), we investigated the relationship between reduced Tc- HMPAO uptake and the severity of dysnomia in PPA. Methods: Seven right-handed patients with PPA had their dysnomia assessed by the Boston Naming Test (BNT), a subtest of the Boston Diagnostic Aphasia Examination. Neuroimaging studies, including Tc-HMPAO brain SPECT, CT, and MRI, were performed. Correlational analysis between reduced rCBF and BNT was performed. Results: Brain SPECT showed a reduction in Tc-HMPAO uptake involving the frontal and temporal lobes in all 7 patients. CT and MRI showed mild to moderate cerebral atrophy in 4 patients. Low scores on the BNT correlated with low frontotemporal

66. Diagnostic Medical Testing In Psychiatric Disorders - Dementia - Frontotemporal
clinical diagnostic groups encompassed under the term Pick Complex and includesPick’s disease, semantic dementia, primary progressive aphasia, and frontal
http://www.upcmd.com/dot/diseases/01080/disinfo_picks.html

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Dementia
Mild Cognitive Impairment
Synonyms-Specific Diseases
DSM-IV and ICD9 Coding Frontotemporal Dementia (FTP)
Definition-Classification Clinical Findings Neuropathologic Features Diagnosis
  • Frontotemporal dementia is a primary neuropathologic "dementing diseases" along with Alzheimer disease, vascular dementia, and Lewy body dementia considered in the diagnosis of patients with dementia [ ref
  • Frontotemporal dementia is defined by clinical and neurologic criteria defined by the "Lund and Manchester Groups" in 1994 [ ref ] and includes as a subset (~25% of all cases) the eponymic entity Pick’s disease which is characterized neuropathologically by Pick bodies, tau-immunoreactive intraneuronal inclusion bodies and Pick cells – large ballooned neurons [ ref
  • Frontotemporal dementia includes a group of clinical diagnostic groups encompassed under the term "Pick Complex" and includes Pick’s disease, semantic dementia, primary progressive aphasia, and frontal dementia – for a complete listing, see
  • Pick disease as defined by Pick inclusions and Pick cells is clustered in families with ~50% of cases having a familial inheritance pattern [ ref ] – for more information about genetics, see

67. A Psychology Press Journal: Aphasiology - Table Of Contents
Title Case Study Phonological and Articulatory Disturbances in a Case ofprimary progressive aphasia Authors M. Helen Southwood, A. Chatterjee.
http://www.tandf.co.uk/journals/archive/p-archive/aphvol12.html
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Aphasiology Volume 12, 1 Volume 12, 7
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Volume 12, 12
Volume:- 12 Issue:- 1 Issues in Chinese Aphasia. Guest Editors: Brendan Weekes and May Jane Chen Publication Date : 6th January 1998
    Title: Special Issue: Aphasiology
    Authors: B..S Weekes, M. J. Chen. Pages 1-3.

68. WebGuest - Open Directory : Health : Conditions And Diseases : Neurological Diso
Sites Understanding primary progressive aphasia An article with a description,assistance available and where to obtain additional information.
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69. Hodges & Patterson
Brain. Review pc (1995) primary progressive aphasia and semantic dementia.Neurocase, 1, 3954. Sinnatamby R, Antoun NA, Freer CEL
http://www.iias.or.jp/research/res_gengo/gengo98rpt/Hodges.html
IIAS Lecture Japan November 1998 "Semantic Dementia and the Progressive Aphasic Syndromes: Clinical and Neuroradiological Features" John R Hodges and Karalyn Patterson
MRC Cognition and Brain Sciences Unit, Cambridge, UK
Pick's disease, Progressive Aphasia and Semantic dementia
Although the term semantic dementia is recent, the syndrome has been recognised for many years. In 1892 Arnold Pick reported a patient with amnestic aphasia and left temporal lobe atrophy. Many other such patients were reported in the PickÕs disease literature of the early 20th century. Patients with "loss of word meaning" were also reported from Japan under the heading of "Gogi aphasia". In 1975 Warrington reported what she termed Òselective impairment of semantic memoryÓ and proposed that the combination of transcortical aphasia and associative agnosia observed in three patients with cortical atrophy reflected a fundamental loss of semantic memory about the items which thereby affected naming, word comprehension, and object recognition. Semantic memory is the term applied to the component of long-term memory which contains the permanent representation of our knowledge about things in the world and their inter-relationship, facts and concepts as well as words and their meaning. Mesulam's 1982 paper rekindled neurological interest in the focal dementias when he reported clinical syndrome of "slowly progressive aphasia without generalised dementia" in six patients with a 5 to 10 year history of insidiously worsening aphasia in the absence of signs of more generalised cognitive failure. Since 1982 there have now been over 40 papers reporting some 100 patients who fulfil the criteria for progressive aphasia. Although the language deficits seen in such patients are heterogeneous, two broad groups can be identified: progressive fluent aphasia with features corresponding to those reported above (which we prefer to call semantic dementia) and progressive non-fluent aphasia in which there is selective breakdown in the phonological and syntactic aspects of language. The latter syndrome will not be discussed further here

70. Mental Health Foundation Homepage
Primary brain tumour. Primary Health Care. Primary Health Care (2). Primary process.primary progressive aphasia (PPA). Prions. Prison inreach. Prodromal. Projection.
http://www.mentalhealth.org.uk/wordbank.cfm?wbletter=P

71. Re: Primary Progressive Aphasia
Re primary progressive aphasia. In Reply to Re Primary ProgressiveAphasia posted by mark pellington on March 06, 19100 at 000304
http://www.caregiver.on.ca/wwwboard/messages/1642.html
Re: Primary Progressive Aphasia
Follow Ups Post Followup Caregiver Network Bulletin Board FAQ Posted by Amanda on April 20, 19100 at 12:11:36: In Reply to: Re: Primary Progressive Aphasia posted by mark pellington on March 06, 19100 at 00:03:04: : : Can anyone direct me to a chat room for caregivers of those with Primary Progressive Aphasia?
I am also looking for a chat room for caregivers of those wit PPA. My husband has been disbled for approx. five years now and it is getting more difficult to stay on top of his needs.
Follow Ups:

72. 630.html
The pathology and nosology of primary progressive aphasia. Neurology, 44, 20652072. Primaryprogressive aphasia. Archives of Neurology, 47, 1329-1335.
http://www.wvu.edu/~speechpa/630.html
SPEECH PATHOLOGY AND AUDIOLOGY 630 Adult Neurogenic Communication Disorders Dr. Linda Shuster, Instructor COURSE OUTLINE Week Topics Reading Course overview
Neural plasticity and recovery Ch. 1,*
Musso et al., 1999 Cognitive foundations of language
Effects of aging on communication
Harris, online,
Symptoms and medical diagnosis of causes of neurogenic communication disorders Ch. 2, 3
Golper, Ch. 2, 4 The nature of aphasia Ch. 2, 20 Nature of aphasia (cont.) Ch. 2, 20 Assessing aphasia Ch. 4, 9,
James, et al., online Assessment (cont.) Ch. 4, 9 Treatment of aphasia Ch. 5-32,
Reyes, online
Eng, online Treating aphasia (cont.) Ch. 5-32,
SPRING BREAK Ch. 36 The speech motor system and neurogenic speech disorders Ch. 36 Neurogenic speech disorders (cont.) Ch. 36 The nature and treatment of cognitive-linguistic disorders in traumatic brain injury Ch. 33 Traumatic brain injury (cont.) Ch. 33 Right hemisphere impairment Ch. 34 Language in dementia Ch. 35 * All readings are from the required text unless otherwise indicated READINGS Required Textbook: Recommended Textbook: Duffy, J.R. (1995). Motor speech disorders. Baltimore: Mosby.

73. Listings Of The World Health Conditions And Diseases
Listings World Health Conditions and Diseases Neurological Disorders Dementiaprimary progressive aphasia. Listings World,
http://listingsworld.com/Health/Conditions_and_Diseases/Neurological_Disorders/D

74. JSMRM Journal Abstracts, Volume 22 Number 2
MRI and MRS Findings of primary progressive aphasia. Simplified Return toheadline. MRI and MRS Findings of primary progressive aphasia. Tetsuya
http://wwwsoc.nii.ac.jp/jmrm/abstract/JMRM22-2.html
Abstracts of Vol.22 No.2
HEADLINE
SENSE:Current Status;and Future Development in Particular for Applications in Abdominal Imaging Advantages of fMRI at Ultra High Magnetic Field Abdominal MR Imaging on 3T Clinical Application of MR Amniofetography ... Simplified Measurement of Free RadicalS with ESR Using Disposable Capillary Cell Method : Comparison with the Conventional Method Using Flat Cell
SENSE:Current Status;and Future Development in Particular for Applications in Abdominal Imaging
Return to headline
Advantages of fMRI at Ultra High Magnetic Field
Return to headline
Abdominal MR Imaging on 3T
Tetsuji TSUKAMOTO MR Laboratory, Advanced Technology Center, GE Yokogawa Medical Systems 4-7-127 Asahigaoka, Hino-shi, Tokyo 191-8503 The main advantage of using 3T MR for abdominal imaging is the higher signal to noise ratio that can be achieved as compared to conventional clinical scanners. This advantage can be used for high spatial resolution imaging and fast imaging, such as high band width acquisitions and parallel imaging, while maintaining reasonable signal to noise ratio of the images. Since abdominal imaging on 3T has only recently become available, its clinical applications are still in the early stages. Therefore, both the optimization of miscellaneous pulse sequences and imaging protocols will need to be focused on in clinical research and case studies. High field MR technology is the key to unveiling more functional and molecular level information in vivo. This is not attainable on 1.5T or lower field MRI systems.

75. 2002 American Journal Of Alzheimer's Disease And Other Dementias Abstracts
primary progressive aphasia A review of the neurobiology of a common presentationof Pick complex Andrew Kertesz, MD, FRCPC; David G. Munoz, MD, FRCPC January
http://www.alzheimersjournal.com/pn02024.html
American Journal of Alzheimer's Disease and Other Dementias , Volume 17, Numbers 1-6
January/February 2002, Volume 17, Number 1
Editorial
The forgotten stepchild
Christopher V. Rowland, Jr., MD
January/February 2002; page 5 Newsbriefs
January/February 2002; pages 6-9
Shannon Rogan, BS; Carol F. Lippa, MD
January/February 2002; pages 11-17 Abstract Slowly progressive aphasia with striatal involvement
Nages Nagaratnam, FRACP; Gary Cheuk, FRACP; Kujan Nagaratnam, FRACP
January/February 2002; pages 18-22 Abstract We have described four patients with slowly progressive aphasia with striatal involvement occurring at different stages in the course of the illness. There were two males and two females, and their ages ranged from 68 to 76 (mean: 72) years. The extrapyramidal signs included tremors, bradykinesia, rigidity, and focal dystonia, and one had weakness resembling stroke. There is a heterogeniety among patients with slowly progressive aphasia and the clinical features correspond to the functional anatomy of the areas involved rather than to the pathology. Key words: aphasia, bradykinesia, dementia, dystonia, extrapyramidal signs, rigidity, striatal involvement, tremors

76. The Contact A Family Directory - Index P
see Dystonia Primary Gout see Purine Pyrimidine Metabolic Diseases PrimaryImmunodeficiencies primary progressive aphasia see Frontotemporal Dementia
http://www.cafamily.org.uk/Idx/p.html
printer friendly home more about us in your area ... how you can help search this site Please use the Index below to access the condition on which you require information. If you do not find what you want in the Index then try our search facility in the navigator on the left. Contact a Family also has information on many other specific conditions and rare disorders. If you cannot find the information you require in The Contact a Family Directory Online , you may wish to use our Contact a Family Helpline service. PAIS see Androgen Insensitivity Syndrome
PAVMs see Hereditary Haemorrhagic Telangiectasia
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PDH see Metabolic Diseases and see Mitochondrial Cytopathies and Related Disorders
PEHO Syndrome

PEO see Mitochondrial Cytopathies and Related Disorders
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PET see Pre-eclampsia
PFIC see Liver Disease PID see Primary Immunodeficiencies PKD see Polycystic Kidney Disease (Adult) PKU see Phenylketonuria PNP see PR PS see PSP see Progressive Supranuclear Palsy Paediatric HIV Infection see HIV Infection and AIDS Pallid Infantile Syncope see Reflex Anoxic Seizures Pallister Hall Syndrome Pallister-Killian Syndrome Pancreatitis Panic Attack see Anxiety Disorders Panuveitis see Uveitis Paraneoplastic Pemphigus see Pemphigus Vulgaris Paramyotonia congenita see Muscular Dystrophy and neuromuscular disorders Paraplegia see

77. Diseases/Treatments In The Department Of Neurology, Mayo Clinic In Rochester, Mi
Postural orthostatic tachycardia syndrome (POTS). Primary lateral sclerosis.primary progressive aphasia (PPA). Prion disease. Progressive bulbar palsy.
http://www.mayoclinic.org/neurology-rst/diseases.html
search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Specialties Neurology Neurology Overview Diseases/Treatments Special Interest Groups Outreach Services ... All Medical Specialties - Rochester
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Diseases and Conditions Treated in Neurology
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78. Psicología Conductual: Volume 4 Number 3
Translate this page A review of primary progressive aphasia (Mesulam syndrome) (1982-1996). RaúlEspert, José Francisco Navarro, Joan Deus, Marién Gadea y Javier Chirivella.
http://www.apicsa.com/revista/vol4n3in.html
Elija / Choose... vol1; num 1 (esp) vol1; num2 (esp) vol1; num3 (esp) vol2; num1 (esp) vol2; num2 (esp) vol2; num3 (esp) vol3; num1 (esp) vol3; num2 (esp) vol3; num3 (esp) vol4; num1 (esp) vol4; num2 (esp) vol4; num3 (esp) vol5; num1 (esp) vol5; num2 (esp) vol5; num3 (esp)
Towards a psychobiology of obsessive-compulsive disorder
Obsessive-compulsive disorder is an uncommon psychopathological condition, characterized by a set of disturbing symptoms that usually disrupts the ongoing behaviour. A growing body of evidence from genetic, brain imaging techniques and psychopharmacological studies links this syndrome to frontal lobe and basal ganglia dysfunction and to the serotonin system. In this article we review the most recent studies exploring the biological, neuropsychological and clinical aspects of obsessive-compulsive disorder.
Frontal lobes functioning in chidhood M. Angels Jurado y Katia Verger
Memory and basal ganglia: a review
Presymptomatic detection of the neurophsychological deficit
in Huntington disease: controversies
Cerebral asymmetry: right hemisphere and language

The dominance of left hemisphere for language is a well-estabished fact. This superiority is not absolute. The possible contribution of the right hemisphere to verbal processing has been studied from different approaches. in this article we present a review of the literature, with special attention to a) the effects of right hemisphere damage on language, b) studies with commissurotomized patients and c) studies with neurologically normal subjects. Taken as a whole, the data support the idea that language processing is not an exclusive competence of left hemisphere. The integrity of the right hemisphere is necessary for lexico-semantic processing and for an adequate relation language-context. The definition of the actual contribution of the right hemisphere is a work that remains to be doner.

79. Comunicaciones
Introduction Primary progressive dysphasia (or primary progressive aphasia) isan heterogeneous clinical syndrome, both respect to neuropsychological and
http://www.uninet.edu/union99/congress/libs/dem/d16.html
COMMUNICATION
TOPIC: DEMENTIA Authors:
*Department of Neurology
**Service of Nuclear Medicine
***Department of Radiology
Universitary clinic of Navarra. Pamplona. Spain.
E-Mail: aoliverosc@meditex.es
Abstract
Introduction: Primary progressive dysphasia (or primary progressive aphasia) is an heterogeneous clinical syndrome, both respect to neuropsychological and clinical, and neuropathological data. Patients may present various types of aphasia and, if the course of the disease is long enough, most patient eventually progress to any type dementia. Sometimes the neuropsychological pattern showed by the dysphasia may lead to suspect the kind of dementia the patient is going to develop.
Patients/Method: We present a 59 years old woman, right handed, who had previously presented gastroenterologic symptoms and a mayor depressive syndrome, treated successfully. On examination she showed a progressive disease, started 4 years before with language problems, being mainly incapable to denominate objects and people, and having lost a fluid speech, with paraphasias, syntactic rounds; and difficulty remembering names. Afterwards she started to show distraibility and severe alterations trying to remember, plus a progressive worsening of speech and language. After she started to exhibit behavioural problems, difficulties in understanding of language and dyslexia with dysgraphia, and complete temporo-spatial disorientation. She manifested neither alucinations nor gait problems.
Results: The first neuropsychological study showed fundamentally a non-fluent progressive dysphasia. In the last study we performed we found a global dementia, with a pattern of deficits very similar to the typical findings of Alzheimerís Disease. CT Scan and MRI confirmed the existence of diffuse cortical atrophy, more intense in perirrolandic regions. 18FDG PET showed right posterior temporo-parietal hypometabolism and more profound left fronto-temporo-parietal hypometabolism.

80. Health Care Information Resources Aphasia Links
Aphasia Global Aphasia Q A from the Stroke Information Directory; Aphasia- primary progressive aphasia and Related Disorders from the Northwestern
http://www-hsl.mcmaster.ca/tomflem/aphasia.html
The address of this page is: http://hsl.mcmaster.ca/tomflem/aphasia.html
Aphasia Links
For more information, see: Alzheimer's Disease , also in the Illness section of this resource.
For more information, see: Cerebrovascular Accident , also in the Illness section of this resource.
For more information, see: Dementia , also in the Illness section of this resource.
For more information, see: Speech disorders , also in the Illness section of this resource.
For more information, see: Speech therapists , in the section of this resource.
For more information, see: Speech therapy , also in the Illness section of this resource.
  • Aphasia - Aphasia Hope Foundation increasing awareness of the problem of aphasia in the U.S.
  • Aphasia - National Aphasia Association promoting public education, research, rehabilitation and support in the U.S.
  • Aphasia - Aphasia Institute providing programmes at the Pat Arato Aphasia Centre in Toronto, ON
  • Aphasia - from the Stroke Information Directory
  • Aphasia - Primary Progressive Aphasia and Related Disorders from the Northwestern Alzheimer's Disease Center
  • Aphasia - NINDS Aphasia Information Page a basic FAQ from the U.S. NINDS
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