61. Sickle Cell Disease - English And Spanish Versions — Fanlight Productions hospitalization. This program examines the devastating impact of sickle celldisease on these young people and their families and caregivers. I http://www.fanlight.com/catalog/films/906_scdesl.shtml

SEARCH TIPS View by... Subject Area Title A-Z New Releases Grade Level Special Offers Best Sellers Captioned Series Films in Spanish Adolescence Alzheimer's Caregiving Brain Disorders Cancer ... Join Email List Sickle Cell Disease - English and Spanish Versions From the Minority Coalition, United Food and Commercial Workers Union Use the shopping cart buttons at right to order both language versions of this film. To order either version individually, use the links below: Sickle Cell Disease: The Faces of Our Children (English) Anemia Falciforme: Los Rostros de Nuestros Niños (Dubbed in Spanish) Nearly 50 to 80,000 African-Americans (and a very much smaller number of whites) have sickle cell anemia, a genetic disease in which red blood cells become stiff, sticky and misshapen. In a "sickle cell crisis," which can occur for a variety of reasons, or for no apparent reason at all, the sickle-shaped cells can block blood vessels, causing severe pain in the chest, back, abdomen and joints. Repeated crises will eventually damage the kidneys, the heart and blood vessels, and other organs. One in ten children with sickle cell disease will have a stroke before they are fifteen; another ten percent have "silent" strokes, which nonetheless impair their school abilities and other functioning. Despite advances in treatment, this is in danger of becoming a "forgotten disease," with government funding for research and public information declining to a trickle compared to a few years ago. This program examines the devastating impact of sickle cell disease on these young people and their families and caregivers. It will be an important tool for increasing awareness in the community and among healthcare and social service providers in community clinics, hospitals, and other settings.

62. Sickle Cell Disease — Fanlight Productions hospitalization. This program examines the devastating impact of sicklecell disease on these young people and their families and caregivers. http://www.fanlight.com/catalog/films/305_scd.shtml

SEARCH TIPS View by... Subject Area Title A-Z New Releases Grade Level Special Offers Best Sellers Captioned Series Films in Spanish Adolescence Alzheimer's Caregiving Brain Disorders Cancer ... Available in English and Spanish Sickle Cell Disease The Faces of Our Children From the Minority Coalition Nearly 50 to 80,000 African-Americans, and a very much smaller number of whites, have sickle cell anemia, a genetic disease in which red blood cells become stiff, sticky and misshapen. In a "sickle cell crisis," which can occur for a variety of reasons or for no apparent reason at all, the sickle-shaped cells can block blood vessels, causing severe pain in the chest, back, abdomen and joints. Repeated crises will eventually damage the kidneys, the heart and blood vessels, and other organs. One in ten children with sickle cell disease will have a stroke before they are fifteen; another ten percent have "silent" strokes, which nonetheless impair their school abilities and other functioning. Despite advances in treatment, this is in danger of becoming a "forgotten disease," with government funding for research and public information declining to a trickle compared to a few years ago. This program examines the devastating impact of sickle cell disease on these young people and their families and caregivers. It will be an important tool for increasing awareness in the community and among healthcare and social service providers in community clinics, hospitals, and other settings. Spanish language version available:

63. Sickle Cell Disorder Sickle Cell Disorder. sickle cell disease describes a group of inherited disordersof red blood cells. sickle cell disease affects more than 50,000 Americans. http://gslc.genetics.utah.edu/units/newborn/infosheets/sicklecelldisorder.cfm

Genetic Science Learning Center at the Eccles Institute of Human Genetics University of Utah Home ... Full Medical Reports Sickle Cell Disorder Sickle Cell Disorder Sickle cell disease describes a group of inherited disorders of red blood cells. Red blood cells are responsible for delivering oxygen to different parts of the body; normally they are round and contain a molecule called hemoglobin, which carries oxygen. If the gene encoding hemoglobin is mutated, it causes a change in the shape of the molecule. When the mutated hemoglobin delivers oxygen to the tissues, the red blood cell collapses, resulting in a long, flat sickle-shaped cell. These cells clog blood flow, resulting in a variety of symptoms including pain, increased infections, lung blockage, kidney damage, delayed growth and anemia (low blood cell count). Genetics The gene encoding the beta chain of the hemoglobin molecule, located on chromosome 11, can be mutated in a variety of ways that result in different types of sickle cell disease. Some mutations are more common than others. The three most common types of sickle cell disease in the United States are hemoglobin SS (Hb SS), hemoglobin SC (Hb SC), and hemoglobin sickle beta-thalassemia (HbS beta-thalassemia). Inheritance Autosomal recessive.

64. Patterns Of Mortality In Sickle Cell Disease In Adults In France And England Patterns of mortality in sickle cell disease in adults in France and England. death;sickle cell disease; acute chest syndrome; vasoocclusion; pregnancy. http://www.nature.com/cgi-taf/DynaPage.taf?file=/thj/journal/v3/n1/full/6200147a

65. Sickle Cell Anemia Complications of sickle cell disease may include pain, stroke, increasedrisk of infection, and leg ulcers. Signs of sickle cell http://www.labtestsonline.org/understanding/conditions/sickle.html

TESTS test not listed? ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP ALT Amylase ANA Antibody Tests Apo A Apo B ApoE Genotyping AST Bilirubin Blood Culture Blood Gases BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Risk CBC CEA CF Gene Mutation Chlamydia Chloride Cholesterol CK CK-MB CMP Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C DHEAS Differential EGFR Electrolytes ESR Estrogen Estrogen Receptors Fecal Occult Blood Ferritin Flu Tests FSH Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone hCG HDL Hematocrit Hemoglobin Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody Home Tests Homocysteine HPV H-pylori hs-CRP Insulin Iron Tests LD LDH LDL Lead LH Lipase Lipid Profile Liver Panel Lp(a) Lyme Disease Magnesium Microalbumin Mono Monoclonal Protein Myoglobin Pap Smear Phosphorus Platelets Potassium Prealbumin Progesterone Progest. Receptors Prolactin PSA PT PTH Red Count Renin Rheumatoid Factor Rubella Semen Analysis Serum Iron Sickle Cell Sodium Strep Throat Sweat Chloride Syphilis Tau/Aß42 TB Skin Test Testosterone Ther. Drug Monitoring

66. Gene Therapy Used To Treat Sickle Cell Disease In Mice Gene Therapy Used to Treat sickle cell disease in Mice About 72,000 in the UnitedStates have two copies of the sickle cell gene and have the disease. http://news.nationalgeographic.com/news/2001/12/1213_TVsickle.html

Sign up for our free e-mail newsletter Also see: Today's Top Stories This Story National Geographic Today E-mail this story Sponsored in part by Gene Therapy Used to Treat Sickle Cell Disease in Mice Bijal P. Trivedi National Geographic Today December 13, 2001 Researchers have successfully used gene therapy to treat sickle cell disease in mice. The researchers, led by Philippe Leboulch,of Harvard MedicalSchool and the Massachusetts Institute of Technology, designed a new gene that can counter the effects of the sickle cell gene. Human Sickle Cell Photograph by R.L. Nagel, Albert Einstein College of Medicine, Bronx, NY. Courtesy of Dr. Philippe Leboulch More News Diary of the Planet The Environment Travel National Geographic Today Special Series Digital Lifestyles: feature by Sony EarthPulse National Geographic Out There ... Mount Everest Expedition Sickle cell disease, which can be fatal, is caused by a genetic mutation in the hemoglobin gene that causes red blood cells to become crescent or sickle-shaped and sticky. A person with one mutated copy sickle cell gene does not show any symptoms of the disease and does not require treatment. In fact, having one copy of the mutant gene is common in tropical countries where malaria is endemic because it actually protects against malaria; it is fairly common in people of African, Indian, Mediterranean and Middle Eastern descent.

67. Pain Resource Center :: Beckman Research Institute :: City Of Hope 3. Guideline for the Management of Acute Pain in sickle cell disease, Quick ReferenceGuide for Emergency Department Clinicians (2001 version) order form. http://mayday.coh.org/sickle.asp

Sickle Cell Pain Information A. City of Hope Publications B. Recommended Books 1. Sickle Cell Pain: Progress in Pain Research and Management, volume 11, 1998 version order form - Book written by Samir K. Ballas, MD. Published by: International Association for the Study of Pain. Website: http://www.painbooks.org/sickle.html 2. Sickle Cell Disease: Information for School Personnel - Sickle Cell Advisory Committee. Trenton, NJ: Special Child, Adult and Intervention Services, New Jersey Department of Health and Senior Services, September, 1999. C. Educational Materials/Curriculum 1. Sickle Cell Provider Video Course order form - Georgia Sickle Cell Center, Grady Health System, Atlanta, Georia. Includes a 10-hour course designed to educate health care providers about the latest developments in common clinical issues in sickle cell disease treatment. D. Guidelines/Clinical Pathways 1. Guideline for the Management of Acute and Chronic Pain in Sickle Cell Disease, 1999 version - American Pain Society publication guideline. Order guideline at http://www.ampainsoc.org/pub/sc.htm

68. ICT - Sickle Cell What is sickle cell disease? sickle cell disease is caused by a small changein a hemoglobin protein contained in red blood cells (RBC's). http://ict.louisville.edu/bedside/sc/

What is Sickle Cell Disease? Sickle cell disease is caused by a small change in a hemoglobin protein contained in red blood cells (RBC's). This change causes the shape of the RBCs to be flat and curved into a sickle shape instead of the normal doughnut shape. These sickled cells do not pass smoothly through the smallest blood vessels causing many serious medical problems including blood clots, severe pain, and stroke, as well as heart attack, and liver, kidney and spleen damage. More About Sickle Cell Disease Bone Marrow Transplantation for Sickle Cell The abnormal RBC's in sickle cell disease, like all other blood cells, are produced in the bone marrow. A bone marrow transplant (BMT) can cure sickle cell disease by replacing the marrow that is manufacturing the abnormal cells. However, until now BMT has not been widely used for this purpose because severe complications can result. The Institute's approach to BMT may make it much safer by treating the donor bone marrow to remove harmful cells. More About BMT and Mixed Chimerism Clinical Trial for Sickle Cell The Institute's clinical trial for sickle cell disease will use partial conditioning and a specially modified bone marrow transplant procedure to create "chimerism". This procedure allows both your own bone marrow and the new transplanted bone marrow to live together in your body. The purpose of this study will be to evaluate the effectiveness of "Mixed Chimerism" to treat sickle cell disease.

69. TUP: Hill, Shirley A.: Managing Sickle Cell Disease In Low-Income Families Managing sickle cell disease in LowIncome Families. Shirley A. Hill. Asmany as 30,000 African Americans have sickle cell disease (SCD). http://www.temple.edu/tempress/titles/1113_reg.html

A comprehensive account of SCD and its affect on low-income families Buy this book! View Cart Check Out Managing Sickle Cell Disease in Low-Income Families Shirley A. Hill cloth 1-56639-188-1 $69.50, Jul 94, Available paper 1-59213-195-6 $24.95, Apr 03, Not Yet Published Preorder other 1-59213-107-7 $.00 Available 240 pp 5.5x8.25 "Shirley Hill has written a fine and important book about the world of families with sickle cell disease (SCD). The excellent interview data presents a rich load of clear and interesting information about managing SCD in particular and about black families and illness in general." Peter Conrad , Brandeis University As many as 30,000 African Americans have sickle cell disease (SCD). Though the political activism of the 1960s and a major 1970s health campaign spurred demands for testing, treatment, and education programs, little attention has been given to how families cope with SCD. This first study to give SCD a social, economic, and cultural context documents the daily lives of families living with this threatening illness. Specifically, Shirley A. Hill examines how low-income African American mothers with children suffering from this hereditary, incurable, and chronically painful disease, react to the diagnosis and manage their family's health care. The 23 mostly single mothers Hill studies survive in an inner-city world of social inequality. Despite limited means, they actively participate, create, and define the social world they live in, their reality shaped by day-to-day caregiving. These women overcome obstacles by utilizing such viable alternatives as sharing child care with relatives within established kinship networks.

70. BBC News | HEALTH | Gene Therapy Hope For Sickle Cell Disease Scientists have been able to correct sickle cell diseasein mice using gene therapy. http://news.bbc.co.uk/hi/english/health/newsid_1708000/1708055.stm

CATEGORIES TV RADIO COMMUNICATE ... INDEX SEARCH You are in: Health Front Page World UK ... AudioVideo SERVICES Daily E-mail News Ticker Mobiles/PDAs Feedback ... Low Graphics Friday, 14 December, 2001, 14:24 GMT Gene therapy hope for sickle cell disease The sickle cell's distinctive shape Scientists have been able to correct sickle cell disease in mice using gene therapy. The American researchers who carried out the tests say there are several hurdles to be overcome before the therapy can be used in humans, but that it offers hope for the future. The research, detailed in the journal Science, shows how the gene therapy counteracts the faulty gene that causes red blood cells to "sickle", or become deformed. The treatment involves the "anti-sickling" variant being delivered into bone marrow; it then incorporates itself into the stem cells that give rise to red blood cells. 'Sticky' cells Sickle cell anaemia is an inherited blood disorder, which largely affects Afro-Caribbean and Asian patients, named after the distinctive shape formed by red blood cells. The shape is affected because a protein within the cells - haemoglobin which carries oxygen from the lungs to the rest of the body - is different to normal.

71. Division Of Genetics: Sickle Selections, URMC April 2002 Survey of Newborns with sickle cell disease, Birth Statistics, Camp KopeSchedule*. January 2002 sickle cell disease Cured in Mice by Gene Therapy*. http://www.urmc.rochester.edu/genetics/hemonews.htm

Home Services Counseling Services Sickle Cell Clinic Newsletters OncoGene News Sickle Selections Staff Department of Medicine Sickle Selections a quarterly newsletter from the University of Rochester Sickle Cell Program The following newsletters are available as Adobe Acrobat Reader 3.0 files - online versions that look just like the originals. The Adobe Acrobat Reader software is freely available for you to download and use from Adobe's software site. April 2002 Survey of Newborns with Sickle Cell Disease, Birth Statistics, Camp Kope Schedule* January 2002 Sickle Cell Disease Cured in Mice by Gene Therapy* October 2001 Hydroxyurea - Effects on Growth and Development* July 2001 Transcranial Doppler Ultrasonography (TCD)* April 2001 25 years of Newborn Screening for Sickle in NY State - some statistics.* January 2001 New Pneumococcal Vaccine (PREVNAR) Indicated for Young Children with Sickle Cell Disease* October 2000 Early Intervention Program Available for Children with Sickle Cell Disease; Influenza Vacine; Birth Statistics July 2000 Priapism: A Complication of Sickle Cell Disease April 2000 Summer Camp Established for Children with Sickle Cell January 2000 Hydroxyurea October 1999 Hemoglobin E without Hemoglobin A: Establishing a Diagnosis is Important!

72. Sickle Cell Disease - Health Risk Factors sickle cell disease. About sickle cell disease. sickle cell diseaseis an inherited disorder of the red blood cells. Red blood cells http://www.agingwell.state.ny.us/prevention/sickle.htm

Common Risk Factors Sickle Cell Disease About Sickle Cell Disease For More Information About Sickle Cell Disease Sickle cell disease is an inherited disorder of the red blood cells. Red blood cells carry oxygen to all parts of the body by using a protein called hemoglobin. Normal red blood cells contain only normal hemoglobin and are shaped like doughnuts. These cells are very flexible and move easily through small blood vessels. But in sickle cell disease, the red blood cells contain sickle hemoglobin, which causes them to change to a curved shape (sickle shape) after oxygen is released. Sickled cells become stuck and form plugs in small blood vessels. This blockage of blood flow can damage the tissue. Because there are blood vessels in all parts of the body, damage can occur anywhere in the body. The most common types of sickle cell disease are: Sickle cell anemia, Hemoglobin SC disease, and Sickle beta-thalassemia. Source: U.S. Agency for Healthcare Research and Quality

73. What Is Sickle Cell Disease? Provides easyto-understand explanations of sickle cell disease and a descriptionof how the body reacts to this inherited disorder. http://www.ahcpr.gov/consumer/bodysys/edbody12.htm

What Is Sickle Cell Disease? Sickle cell disease is an inherited disorder of the red blood cells. Red blood cells carry oxygen to all parts of the body by using a protein called hemoglobin. Normal red blood cells contain only normal hemoglobin and are shaped like doughnuts. These cells are very flexible and move easily through small blood vessels. But in sickle cell disease, the red blood cells contain sickle hemoglobin, which causes them to change to a curved shape (sickle shape) after oxygen is released. Sickled cells become stuck and form plugs in small blood vessels. This blockage of blood flow can damage the tissue. Because there are blood vessels in all parts of the body, damage can occur anywhere in the body. The most common types of sickle cell disease are: Sickle cell anemia. Hemoglobin SC disease. Sickle beta-thalassemia. Current as of August 2000 Internet Citation: Understanding Your Body: What Is Sickle Cell Disease? August 2000. Life Sciences Education and Health Literacy. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/consumer/bodysys/edbody12.htm Return to Understanding Your Body Consumers and Patients AHRQ Home Page Department of Health and Human Services

74. Hardin MD : Sickle Cell Anemia updated Friday, Mar 14, 2003 sickle cell pictures, pictures of sickle cell anemia,information on sickle cell anemia, sickle cell disease pictures, sickle http://www.lib.uiowa.edu/hardin/md/sicklecellanemia.html

Sickle Cell Anemia "We list the best sites that list the sites" Site Map Diseases Home Free journals ... Diseases Search Hardin MD See also: Home Blood Diseases Genetic Disorders All links on this page hand-checked Popular Women's Health Dermatology Nursing Pharm Infect Disease Anemia +Pictures Blood Diseases Genetic Disorders +Pictures Infectious Diseases Medical Pictures Skin Pictures A Hardin MD Focus Page Sickle Cell Anemia Pictures Sickle cell information center : World-wide resources The Georgia Comprehensive Sickle Cell Center at Grady Health System NOAH: Sickle cell disease Natalie Kupferberg, Ohio State University / NY Online Access to Health MEDLINE plus Sickle cell anemia National Library of Medicine MedWebPlus : Anemia, Sickle cell Steve Foote and Andy Kogelnik, y-DNA,inc, Atlanta, Georgia ClinicalTrials.gov : Anemia, Sickle cell National Library of Medicine, National Institutes of Health Open Directory Project : Health : ... : Blood disorders : Sickle cell (Other versions: Google AOL Michigan Electronic Library : Sickle cell disease Metta Lansdale Yahoo : Sickle cell disease LookSmart : Sickle cell anemia OMNI : Anemia, Sickle cell

75. CBC News:Father Calls Sickle Cell Anemia 'neglected' Disease The Sickle Cell Foundation of Alberta; sickle cell disease Mount Sinai Hospital.(Note CBC does not endorse and is not responsible for the content of external http://www.cbc.ca/storyview/AOL/2003/03/17/sickle_cell030317

You are here: Home Web Centres News Father calls sickle cell anemia 'neglected' disease Last Updated Mon, 17 Mar 2003 19:30:49 MONTREAL - Sickle cell anemia is the most common genetic disease in the world, but Canada has few specialized centres to treat adults. The debilitating disease mainly affects people of African descent. Sickle cell anemia causes malformed red blood cells that block tiny blood vessels. In sickle cell anemia, blood cells are elongated instead of round Oxygen flow to tissues is reduced, producing episodes of acute pain, as well as complications including blindness and heart, kidney and liver failure. Pediatric patients often have a procedure called erythropheresis, an exchange of red blood cells to keep the disease under control. Every four to six weeks, Melissa Maurice Carrenard, 21, has the procedure. When she left the children's hospital that specialized in her condition, general practitioners took over her care. Wilson Sanon's 11-year-old daughter has sickle cell anemia. Sanon said he's sending a cry of alarm for what he calls a neglected disease. No one knows how many people are affected by sickle cell anemia, because Health Canada doesn't keep any statistics on the disease.

76. The Sickle Cell Disease Program At St. Louis Children’s Hospital. The sickle cell disease Program at St. Louis Children’s Hospitalprovides comprehensive diagnosis sickle cell disease Program. http://www.stlouischildrens.org/articles/kids_parents.asp?ID=247

77. Wadsworth-Newborn Screening-Sickle Cell Anemia). If he inherits an 'IS gene from one parent and a IICII genefrom the other, he has SC Disease, a form of sickle cell disease. http://www.wadsworth.org/newborn/scell/scell.htm

The Family Connection SICKLE CELL TRAIT If you've been told, as the result of a blood test, that your child has Sickle Cell Trait, quite naturally, you're concerned. Questions are tumbling through your head. "What does it mean?" "Is the baby sick?" "Can it develop into Sickle Cell Anemia?" "Can other members of my family get it?" Your Baby is Not Sick First of all let us assure you that Sickle Cell Trait will not affect your baby's health. YOUR INFANT DOES NOT HAVE SICKLE CELL ANEMIA AND WILL NEVER DEVELOP THIS DISEASE. Your Baby Inherited the Trait Sickle Cell Trait, like hair color, general body build and other physical characteristics is passed down in the family from parent to child through the genes. Genes are the tiny bits of information contained in the father's sperm and the mother's egg that form a blueprint for the new life. Genes come in pairs; for each characteristic there is one gene from the mother and one form the father. One of these pairs of genes determines hemoglobin the substance that carries oxygen in your blood and gives it its red color. If your baby has Sickle Cell Trait, it means that the baby inherited a normal hemoglobin gene from one parent and a changed or altered hemoglobin gene from the other parent. We refer to the usual gene as "All and the changed gene as 'IS." Your baby, therefore, has AS hemoglobin.

78. Newborn Screening Brochurs And Educational Materials - New York State Department sickle cell disease (sickle cell anemia or homozygous S disease)a disorder ofthe hemoglobin (oxygencarrying part) of red blood cellsnot to be confused http://www.wadsworth.org/newborn/disorders.htm

Navigate Wadsworth Navigate Wadsworth Laboratory Services: Laboratory and Testing Programs / Clinical Testing - Genetic Disorders Return to Previous Page Disorders Identified by the New York State Newborn Screening Program Biotinidase deficiency (bio-TIN-i-dase)lack of an enzyme (biotinidase) prevents the body from properly absorbing or recycling the vitamin biotin. Severe skin rashes, vision and hearing impairment, and brain damage can be prevented by special biotin supplements given daily. Occurs in about 1 of every 80,000 newborns. Branched-chain ketonuria (branched-chain KEE-tone-u-ree-ah)also called maple syrup urine disease (MSUD) because the urine has a maple syrup-like odor resulting from the body's inability to break down some components of food protein. Again, this is due to the lack of an enzyme. Treatment with a special diet can prevent life-threatening complications. Occurs in about 1 of every 268,000 newborns. Galactosemia (ga-LAK-toe-see-me-a)a milk sugar (galactose) cannot be broken down by the body due to the lack of an enzyme. A diet low in galactose can prevent life-threatening complications. Occurs in about 1 of every 57,000 newborns. HIV (Human Immunodeficiency Virus) HIV is the virus that causes AIDS. The test checks for the presence of HIV antibodies. If a baby is HIV positive, this means that the mother is infected with HIV in all cases, and that the baby has been exposed to the virus. Only a quarter of babies who were exposed to HIV actually have infection. HIV positive newborns should have special medical care and need repeat testing to see if they are infected. Their mothers also need special medical care.

79. American Red Cross, Penn-Jersey Region Sickle Cell Disease Donate blood, help a child with sickle cell disease,American Red Cross PennJersey Region. http://www.pleasegiveblood.org/donating/sickle_cell.html

80. HuGE Review - Sickle Hemoglobin (Hb S) Allele And Sickle Cell Disease Sickle Hemoglobin (Hb S) Allele and sickle cell disease print version. Most individualswith sickle cell disease have African and Mediterranean ancestry. http://www.cdc.gov/genomics/hugenet/reviews/sickle.htm

HuGE Review Home About HuGE What's New? Pub Lit Database ... CDC Genomics This HuGE Review was published in the American Journal of Epidemiology 2000 May 1;151(9):839-845. PMID: 10791557; UI: 20250196. Sickle Hemoglobin ( Hb S ) Allele and Sickle Cell Disease print version by Allison Ashley-Koch , Quanhe Yang , and Richard S. Olney Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Office of Genomics and Disease Prevention, GA Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Birth Defects and Developmental Disabilities, Birth Defects and Genetic Diseases Branch, Atlanta, GA. July 1, 1998 (updated August 5, 1998) HuGE Review At-A-Glance Gene Gene variants Diseases ... Medical Literature Search At-A-Glance Beta globin is a major component of adult hemoglobin. The gene for beta globin is located on chromosome 11 and there are over 475 allelic variants. One of these variants, sickle hemoglobin ( Hb S ), is responsible for sickle cell disease, one of the most prevalent genetic diseases, affecting over 50,000 Americans. Most individuals with sickle cell disease have African and Mediterranean ancestry. It is believed that the high frequency of the (

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