1. MEDLINEplus: Smallpox smallpox CDC Chief Gets Her smallpox Shot (03/12/2003, Reuters Health) http://www.nlm.nih.gov/medlineplus/smallpox.html

Skip navigation Other health topics: A B C D ... List of All Topics Smallpox Contents of this page: News General/Overviews Pictures/Diagrams Prevention/Screening ... Teenagers Search MEDLINE for recent research articles on Smallpox You may also be interested in these MEDLINEplus related pages: Biodefense and Bioterrorism Infections Poisoning, Toxicology, Environmental Health Latest News Third Death After Smallpox Shot, Restrictions Urged (03/28/2003, Reuters Health) U.S. May Be Pushing Smallpox Shots Too Hard (03/27/2003, Reuters Health) Drug Makers Partnered in New Smallpox Research Deal (03/26/2003, Reuters Health) Temporary Deferral Recommended for Heart Patients Volunteering for Smallpox Vaccination (03/25/2003, Centers for Disease Control and Prevention) Smallpox Vaccine Shipment Numbers (01/27/2003, Centers for Disease Control and Prevention) CDC Begins Shipping Smallpox Vaccine to the States (01/22/2003, Centers for Disease Control and Prevention) More News on Smallpox General/Overviews Smallpox (World Health Organization) Also available in: Spanish Smallpox Overview (Centers for Disease Control and Prevention) Also available in: Spanish Smallpox Questions and Answers: The Disease and the Vaccine (Centers for Disease Control and Prevention) Update on Smallpox (Food and Drug Administration) What Is Smallpox?

2. Graeme | Smallpox Zone | Science: Smallpox Information about history, pathology, treatment, prevention, eradication with references. http://seercom.com/bluto/smallpox/

@import url(http://www.seercom.com/main.css); about skepticism science glossary ... writing zones critical thinking smallpox eggsperiment nina ... email smallpox smallpox figure 0: The Plague in Rome, by Jules-Elie Delaunay, 1869. This page is the main page for a website that is an overview of the smallpox virus and the disease it causes. welcome This site started as a 2nd year microbiology presentation, but I have adapted it to become as informative as possible for people interested in the disease and its current context. Please feel free to send questions by email. If you can't find what you need on the site, use the search tool. I review the search terms from time to time, and your question may be added to the faq, so check back later. next: introduction history pathology prevention ... new glossary virus elsewhere nih ama cdc GTK ... new

3. JAMA -- Page Not Found June 1999 article makes recommendations to the medical community for responding to a terrorist attack using smallpox. Find vaccination and treatment suggestions. http://jama.ama-assn.org/issues/v281n22/ffull/jst90000.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

4. Smallpox Article discusses how the disease's easy transmission, coupled with a large unvaccinated population, could make it a troublesome biological weapon. http://www.hopkins-biodefense.org/pages/agents/agentsmallpox.html

Anthrax Botulinum Toxin Plague Smallpox ... VHF Smallpox Fact Sheet Info Smallpox, because of its high case-fatality rates and transmissibility, now represents one of the most serious bioterrorist threats to the civilian population. Over the centuries, naturally occurring smallpox, with its case-fatality rate of 30 percent or more and its ability to spread in any climate and season, has been universally feared as the most devastating of all the infectious diseases. Smallpox was once worldwide in scope; before vaccination was practiced almost everyone eventually contracted the disease. In 1980, the World Health Assembly announced that smallpox had been eradicated and recommended that all countries cease vaccination. That same year, the Soviet government embarked on an ambitious program to grow smallpox in large quantities and adapt it for use in bombs and intercontinental ballistic missiles. That initiative succeeded. Russia still possesses an industrial facility that is capable of producing tons of smallpox virus annually and also maintains a research program that is thought to be seeking to produce more virulent and contagious strains. An aerosol release of smallpox virus would disseminate readily given its considerable stability in aerosol form and epidemiological evidence suggesting the infectious dose is very small. Even as few as 50-100 cases would likely generate widespread concern or panic and a need to invoke large-scale, perhaps national emergency control measures.

5. SmallPOX '99 Main Page The Small Press in Ottawa Expo held yearly. Includes general information. http://www.geocities.com/SoHo/4758/SmallPOX99.html

SmallPOX '99 The Small Press in Ottawa eXpo! Catch SmallPOX! Again! SmallPOX'99, the Small Press in Ottawa eXpo slams into the nation's capital for it's second annual creative epidemic of small press and self-published comicbooks, zines, and chapbooks, on Saturday, July 31st, 1999 at the FIRST BAPTIST CHURCH HALL, 140-A Laurier Avenue West at Elgin Street from 2 'til 8PM This awesome eclectic showcase of talent from Ottawa and beyond welcomes back the bulk of enthusiastic exhibitors who made our inaugural event such an eye-popping success! Plus, more mavericks, mavens, and madmen from the cutting edge of the indie publishing world have already snapped up their spot at SmallPOX'99 And, there's still time to book your spot this year. But, hurry. Space is limited again this year! So, avoid disappointment. Reserve your full or half table space now, by completing and submitting our easy to use, online registration form! BOOK NOW! General Info SmallPOX'98 Site Bookmark this site and visit us often! SmallPOX'99 is proudly co-sponsored by Crosstown Traffic Broken Pencil Magazine , and The United Fanzine Organization USA This page was last updated on June 5th, 1999. (c)S.Bourne.

6. Vaccinia (Smallpox) Vaccine Vaccinia (smallpox) Vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001 http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5010a1.htm

Vaccinia (Smallpox) Vaccine Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001 Advisory Committee on Immunization Practices Membership List, March 2001 CHAIRMAN John F. Modlin, M.D. Professor of Pediatrics and Medicine Dartmouth Medical School Lebanon, New Hampshire EXECUTIVE SECRETARY Dixie E. Snider, Jr., M.D., M.P.H. Associate Director for Science Centers for Disease Control and Prevention Atlanta, Georgia MEMBERS Dennis A. Brooks, M.D., M.P.H. Johnson Medical Center Baltimore, Maryland Richard D. Clover, M.D. University of Louisville School of Medicine Louisville, Kentucky Jaime Deseda-Tous, M.D. San Jorge Children's Hospital San Juan, Puerto Rico Charles M. Helms, M.D., Ph.D. University of Iowa Hospital and Clinics Iowa City, Iowa David R. Johnson, M.D., M.P.H. Michigan Department of Community Health Lansing, Michigan Myron J. Levin, M.D. University of Colorado School of Medicine Denver, Colorado Paul A. Offit, M.D. Children's Hospital of Philadelphia Philadelphia, Pennsylvania

7. CDC Smallpox Home Home page for all CDC smallpox information. Includes basic informationas well as information for health and lab professionals. smallpox, http://www.bt.cdc.gov/agent/smallpox/index.asp

Biological Agents Smallpox Basics for the Public Vaccination ... FAQ Public Inquiries English (888) 246-2675 TTY (866) 874-2646 Mon-Fri 8am-11pm EST Sat-Sun 10am-8pm EST Centers for Disease Control and Prevention 1600 Clifton Rd. Atlanta, GA 30333 USA Smallpox CDC HOTLINES: Public: Clinicians: English 877-554-4625 Announcements and Featured Content NEW! What's New Clinician Registry for Terrorism Updates by E-mail (for clinicians) Change in Vaccination Program: Temporary Deferral Recommended for Volunteers with History of Heart Disease NEW! NEW! Pre-Vaccination Information Packet updated Mar 27, 2003 Basics for the Public Vaccination Information About the Disease Prevention, causes, how it spreads... About the Vaccine updated How it works, benefits, risks...

8. SmallPOX Cancelled The Small Press in Ottawa eXpo's page and directory. Find out more about our annual indie books convention. http://smallpox.htmlplanet.com

Free Web site hosting - Freeservers.com SmallPOX2000 Cancelled Due to the lack of confirmed participating exhibitors by July 1, the third annual Small Press in Ottawa eXpo on July 29-30 has been cancelled. A heartfelt thanks goes out to everyone who has supported and helped promote this show over the years. The success of SmallPOX was a direct result of your efforts and enthusiasm. Please contact rob mclennan for information on the next Small Press book fair in Ottawa. There are no plans for a SmallPOX2001.

9. Amherst And Smallpox Smallp ox. Hiding smallpox. Jenner. Vaccine critics. Vaccine failure http://www.nativeweb.org/pages/legal/amherst/lord_jeff.html

Jeffrey Amherst and Smallpox Blankets Lord Jeffrey Amherst's letters discussing germ warfare against American Indians "... every Tree is become an Indian...." Colonel Henry Bouquet to General Amherst, dated 29 June 1763. Lord Jeff Lord Jeffrey The town of Amherst, Massachusetts , was named for Lord Jeff even before he became a Lord. Amherst College was later named after the town. It is said the local inhabitants who formed the town preferred another name, Norwottuck , after the Indians whose land it had been; the colonial governor substituted his choice for theirs. Frank Prentice Rand, in his book, The Village of Amherst: A Landmark of Light [Amherst, MA: Amherst Historical Society, 1958], says that at the time of the naming, Amherst was "the most glamorous military hero in the New World. ... ...the name was so obvious in 1759 as to be almost inevitable." [p. 15] Amherst College china plates depicting mounted Englishman with sword chasing Indians on foot were in use until the 1970's. Click on the pictures to see full-size images. The history of the naming of the town of Amherst, New York

10. Smallpox Vaccine Research At The Medical College Of Wisconsin Medical College of Wisconsin researchers have been studying vaccinia virus, which makes up the smallpox vaccine, as a way of understanding how viruses and vaccines work at the cellular level. http://healthlink.mcw.edu/article/1009470534.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Infections/Infectious Diseases Public Health Vaccines/Immunizations By keywords: Vaccinia Virus vaccines smallpox immunizations Receive Health Link via email! Subscribe now >> Smallpox Vaccine Research at the Medical College of Wisconsin Researchers at the Medical College of Wisconsin have been studying vaccinia virus, which makes up the smallpox vaccine, for years as a way of understanding how viruses and vaccines work at the cellular level. That research, funded largely by the federal government, may lead to advances in preventing and treating smallpox, which could have ramifications in times of bioterrorism. Vaccinia as Smallpox Vaccine Vaccinia virus was one of the first vaccines ever developed. Smallpox had killed hundreds of millions of people through the centuries, but in the late 1700s medical practitioners noticed that milkmaids who had been exposed to cowpox were immune to smallpox. They began taking cowpox from cows and scratching it into the arms of people to protect them against smallpox. At some point, cowpox virus was replaced by vaccinia virus, which is 90% identical to smallpox but only rarely causes health problems. Modern public health systems worldwide joined in a campaign to vaccinate populations against smallpox, and the dread disease was eradicated globally by the 1970s, at which point vaccination against the disease was discontinued. However, it is theoretically possible that a smallpox-like virus could re-emerge in nature as a result of the many poxviruses that exist in animal species. Furthermore, laboratories in the US and former Soviet Union are known to have stocks of the virus, perhaps refined as weapons. Other nations, potentially some that support terrorism, may also have stores of weaponized smallpox or the ability to produce it. Though unlikely, a smallpox attack would be highly contagious and could overwhelm communities if it occurs.

11. WHALE  Smallpox By Whale A look at this diseases severity and infectiousness, vaccine damage and failures and links Category Health Conditions and Diseases Infectious Diseases Viral...... Hiding smallpox Jenner Vaccine critics Vaccine failure Vaccine damage, ArticlesBooks booklets Quotes, Therapies prevention Allopathy Bedbugs Homeopathy http://www.whale.to/vaccines/smallpox.html

Smallp ox Hiding smallpox Jenner Vaccine critics Vaccine failure ... Home

12. Smallpox A focused selection of information to help the general public understand the issues with this disease. http://smallpox.phages.org

window.defaultStatus = "Smallpox Information Center" Urgent: Terrorism Smallpox Protection Steps - Pills to save. Smallpox Information Center A public information service provided the medical community of Phages.org Frequently Asked Questions Brief Synopsis of Smallpox Smallpox lesions on skin are shown in this photograph taken in 1973 in Bangladesh. Smallpox infection was eliminated from the world in 1977. Smallpox is caused by variola virus with an incubation period of about 12 days following exposure. Initial symptoms include high fever, fatigue, and head and back aches. A characteristic rash, most prominent on the face, arms, and legs, follows in 2-3 days. The rash starts with flat red lesions that evolve at the same rate. Lesions become pus-filled and begin to crust early in the second week. Scabs develop and then separate and fall off after about 3-4 weeks. The majority of patients with smallpox recover, but death occurs in up to 30% of cases. Routine vaccination against smallpox ended in 1972. Microbiology and other forms Smallpox, a DNA virus, is a member of the genus orthopoxvirus. The orthopoxviruses are among the largest and most complex of all viruses.

13. CDC Smallpox Home Displays a smallpox resource page from the CDC, with links to fact sheets and medical reports about smallpox. With images of smallpox and the smallpox vaccine. http://www.bt.cdc.gov/Agent/Smallpox/Smallpox.asp

Biological Agents Smallpox Basics for the Public Vaccination ... FAQ Public Inquiries English (888) 246-2675 TTY (866) 874-2646 Mon-Fri 8am-11pm EST Sat-Sun 10am-8pm EST Centers for Disease Control and Prevention 1600 Clifton Rd. Atlanta, GA 30333 USA Smallpox CDC HOTLINES: Public: Clinicians: English 877-554-4625 Announcements and Featured Content NEW! What's New Clinician Registry for Terrorism Updates by E-mail (for clinicians) Change in Vaccination Program: Temporary Deferral Recommended for Volunteers with History of Heart Disease NEW! NEW! Pre-Vaccination Information Packet updated Mar 27, 2003 Basics for the Public Vaccination Information About the Disease Prevention, causes, how it spreads... About the Vaccine updated How it works, benefits, risks...

14. CDC Smallpox | Smallpox Overview CDC overview of smallpox. Includes basic information on disease transmission,symptoms, and history. smallpox FACT SHEET smallpox Overview. http://www.bt.cdc.gov/agent/smallpox/overview/disease-facts.asp

Biological Agents Smallpox Basics for the Public Vaccination ... FAQ Public Inquiries English (888) 246-2675 TTY (866) 874-2646 Mon-Fri 8am-11pm EST Sat-Sun 10am-8pm EST Centers for Disease Control and Prevention 1600 Clifton Rd. Atlanta, GA 30333 USA Smallpox Home Smallpox Basics SMALLPOX FACT SHEET Smallpox Overview Download PDF version formatted for print (174 KB/2 pages) For more about smallpox, see... Smallpox Basics The Disease Smallpox is a serious, contagious, and sometimes fatal infectious disease. There is no specific treatment for smallpox disease, and the only prevention is vaccination. The name smallpox There are two clinical forms of smallpox. Variola major is the severe and most common form of smallpox, with a more extensive rash and higher fever. There are four types of variola major smallpox: ordinary (the most frequent type, accounting for 90% or more of cases); modified (mild and occurring in previously vaccinated persons); flat; and hemorrhagic (both rare and very severe). Historically, variola major has an overall fatality rate of about 30%; however, flat and hemorrhagic smallpox usually are fatal. Variola minor is a less common presentation of smallpox, and a much less severe disease, with death rates historically of 1% or less.

15. Smallpox: Clinical And Epidemiologic Features Describes in detail the disease characteristics. http://www.cdc.gov/ncidod/EID/vol5no4/henderson.htm

Past Issue Vol. 5, No. 4 Download Article PDF ASCII Help Feedback Journal Information About the Journal Instructions to Authors Suggested Citation Other Journal Resources Announcements Translations Image Library Current Issue Perspectives Synopses Research Dispatches ... News and Notes Journal Quick Search Enter Keywords: Advanced search Past Issues Volume 6, 2000 Number 3 Number 2 Number 1 Volume 5, 1999 Number 6 Number 5 Number 4 Number 3 Number 2 Number 1 Volume 4, 1998 Number 4 Number 3 Number 2 Number 1 Volume 3, 1997 Number 4 Number 3 Number 2 Number 1 Volume 2, 1996 Number 4 Number 3 Number 2 Number 1 Volume 1, 1995 Number 4 Number 3 Number 2 Number 1 Subscribe To Subscribe to the EID Listserve to receive email notifications of Journal updates please click here For Subscriptions to hard copies... More on Infectious Diseases MMWR Disease Information Educational Materials Special Issue Smallpox: Clinical and Epidemiologic Features D. A. Henderson Johns Hopkins Center for Civilian Biodefense Studies, Baltimore, Maryland, USA Clinical and Epidemiologic Characteristics of Smallpox Smallpox is a viral disease unique to humans. To sustain itself, the virus must pass from person to person in a continuing chain of infection and is spread by inhalation of air droplets or aerosols. Twelve to 14 days after infection, the patient typically becomes febrile and has severe aching pains and prostration. Some 2 to 3 days later, a papular rash develops over the face and spreads to the extremities (

16. The Demon In The Freezer The story of how smallpox, a disease of officially eradicated twenty years ago, became the biggest bioterrorist threat we now face. http://cryptome.org/smallpox-wmd.htm

17 July 1999 Source: Hardcopy The New Yorker , July 12, 1999, pp. 44-61. Thanks to Richard Preston and The New Yorker See also: "The Bioweaponeers": http://cryptome.org/bioweap.htm A REPORTER AT LARGE THE DEMON IN THE FREEZER How smallpox, a disease of officially eradicated twenty years ago, became the biggest bioterrorist threat we now face. BY RICHARD PRESTON T HE smallpox virus first became entangled with the human species somewhere between three thousand and twelve thousand years ago possibly in Egypt at the time of the Pharaohs. Somewhere on earth at roughly that time, the virus jumped out of an unknown animal into its first human victim, and began to spread. Viruses are parasites that multiply inside the cells of their hosts, and they are the smallest life forms. Smallpox developed a deep affinity for human beings. It is thought to have killed more people than any other infectious disease, including the Black Death of the Middle Ages. It was declared eradicated from the human species in 1979, after a twelve-year effort by a team of doctors and health workers from the World Health Organization. Smallpox now exists only in laboratories. Smallpox is explosively contagious, and it travels through the air. Virus particles in the mouth become airborne when the host talks. If you inhale a single particle of smallpox, you can come down with the disease. After you've been infected, there is a typical incubation period of ten days. During that time, you feel normal. Then the illness hits with a spike of fever, a backache, and vomiting, and a bit later tiny red spots appear all over the body. The spots turn into blisters, called pustules, and the pustules enlarge, filling with pressurized opalescent pus. The eruption of pustules is sometimes called the splitting of the dermis. The skin doesn't break, but splits horizontally, tearing away from its underlayers. The pustules become hard, bloated sacs the size of peas, encasing the body with pus, and the skin resembles a cobbled stone street.

17. NIP: Smallpox/home Page smallpox National Immunization Program's smallpox subsite home page smallpox subsite. smallpox Home http://www.cdc.gov/nip/smallpox

Smallpox subsite Smallpox Home Public News Providers NIP: NIP HOME First time visitor? About NIP ... Acronyms NIP sub-sites: ACIP Flu Vaccine Immunization Registries Vaccines for Children Program ... VACMAN NIP Site Search National Immunization Hotline English Spanish TTY Get Adobe Reader Smallpox home page Smallpox The smallpox subsite has moved to CDC's Public Health Emergency Preparedness and Response Website If you are not automatically redirected click here National Immunization Program (NIP) NIP Home Contact Us Help Glossary ... Accessibility This page last modified on September 30, 2002 Department of Health and Human Services Centers for Disease Control and Prevention CDC Home CDC Search CDC Health Topics A-Z

18. JAMA -- Page Not Found smallpox as a Biological Weapon Medical and Public Health Management Author InformationDonald A. Henderson, MD, MPH; Thomas V. Inglesby, MD; John G. Bartlett http://jama.ama-assn.org/issues/v281n22/abs/jst90000.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

19. Osborn Scientific Group Developer and manufacturer of rapid anthrax, ricin, botulism toxin, smallpox, plaque and infectious disease tests. http://osborn-scientific.com

Credible and Immediate Bioterrorism Threat Detection *New* Press Release out August 20, 2002. Click here to go to the Press Release section! Osborn Scientific Group specializes in the development, manufacturing, and marketing of the most accurate and cost efficient tests to determine the credibility of a biological threat. Quickly determining credibility is the key to expediting emergency or treatment procedures in the presence of a truly infectious biological threat, and minimizing unnecessary business interruption in the case of a biowarfare threat hoax or false alarm (the vast majority of cases). Osborn Scientific Group holds extensive expertise in the development of rapid diagnostics using immunoassay technology, and leverages that expertise and the following credentials to ensure the highest quality products for our customers: ISO 9001 and EN-46001 certified FDA-inspected and cGMP certified Select Agent Registered Facility (CDC) Home About Us Products News ... Contact Us

20. CDC Smallpox Obtain the CDC's 2001 "Interim smallpox Response Plan Guidelines" in PDF format, including epidemiological investigations, Vaccination and decontamination. http://www.bt.cdc.gov/DocumentsApp/Smallpox/RPG/index.asp

Biological Agents Smallpox Basics for the Public Vaccination ... FAQ Public Inquiries English (888) 246-2675 TTY (866) 874-2646 Mon-Fri 8am-11pm EST Sat-Sun 10am-8pm EST Centers for Disease Control and Prevention 1600 Clifton Rd. Atlanta, GA 30333 USA Smallpox Home Smallpox Response Plan and Guidelines Version 3 of the Smallpox Response Plan and Guidelines is now available at the following URL: http://www.bt.cdc.gov/agent/smallpox/response-plan Top of Page Home Search ... Health Topics A-Z In general, all information presented in these pages and all items available for download are for public use. However, you may encounter some pages that require a login password and ID. If this is the case, you may assume that information presented and items available for download therein are for your authorized access only and not for redistribution by you unless you are otherwise informed. This page last reviewed October 25, 2002

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