21. Member Sign In subacute sclerosing panencephalitis from Emerging Infectious Diseases.Case Report. A 13year-old boy of Thai descent was referred http://www.medscape.com/viewarticle/414739_2

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22. Subacute Sclerosing Panencephalitis MAIN SEARCH INDEX subacute sclerosing panencephalitis. http://www.hendrickhealth.org/healthy/001311.htm

MAIN SEARCH INDEX Subacute sclerosing panencephalitis Definition Description Causes and symptoms Diagnosis ... Resources Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia . The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

23. An Unusual Case Of Adult-Onset Subacute Sclerosing Panencephalitis (SSPE) An Unusual Case of AdultOnset subacute sclerosing panencephalitis (SSPE) T.KARNAUCHOW 1 *, JP ROSSITER 1 , P. ROTA 3 , WJ BELLINI 3 , M. MELANSON 2 http://www.cacmid.ca/abstracts/a21.html

An Unusual Case of Adult-Onset Subacute Sclerosing Panencephalitis (SSPE) T. KARNAUCHOW *, J.P. ROSSITER , P. ROTA , W.J. BELLINI , M. MELANSON Departments of Pathology and of Neurology, Kingston General Hospital and Queen's University, Kingston, ON; Centers for Disease Control, Atlanta, GA OBJECTIVE: SSPE is a rare, progressive, fatal disease of the CNS caused by a persistent infection with measles virus (MV). Adult-onset SSPE is very uncommon, with >85% of cases occurring in the 5-15 year-old age group. We describe the case of a 31 year old Sri Lankan immigrant with SSPE. METHODS: Brain biopsy was examined by light and electron microscopy (EM) and by immunohistochemistry. MV was detected by RT-PCR, and sequencing of H and N genes was performed. RESULTS: A 31 year-old male presented with a one month history of right arm and hand weakness. His past medical history was significant for mild developmental delay, and for bilateral uveitis which stabilized with steroid treatment at the time of diagnosis (1990). Imaging studies showed multiple non-enhancing subcortical lesions, and electroencephalograms showed patterns suggestive of SSPE. MV CF IgG titers were 1:128 (serum), and 1:8 (CSF). Biopsy revealed numerous Cowdry type A inclusions in neurons within the cerebral cortex and in oligodendrocytes of the white matter. Unusually prominent white matter vacuolation was also observed. EM revealed an abundance of intracellular MV nucleocapsid structures. Diagnosis was confirmed by immunohistochemistry and by RT-PCR of MV RNA. Preliminary sequence analysis of H and N genes indicates that this is a wild-type MV, belonging to clade D. Further characterization of this virus will be reported.

24. Health Library - Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Synonyms Disorder Subdivisions GeneralDiscussion Resources Synonyms. Panencephalitis, Subacute Sclerosing; SSPE. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

25. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Definition Subacute sclerosingpanencephalitis is a rare, progressive brain disorder caused http://www.chclibrary.org/micromed/00066760.html

Main Search Index Definition Description Causes ... Resources Subacute sclerosing panencephalitis Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia. The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

26. Subacute Sclerosing Panencephalitis SSPE subacute sclerosing panencephalitis (SSPE). A disease of the white matterof the brain that rarely follows measles infection. cerebrospinal http://uscneurosurgery.com/glossary/s/subacute sclerosing panencephalitis SSPE.h

Subacute sclerosing panencephalitis (SSPE) A disease of the white matter of the brain that rarely follows measles infection. cerebrospinal fluid analysis clinical features diagnosis epidemiology Return to uscneurosurgery.com Homepage

27. Neurosurgical Terms S SSEP (Somatosensory evoked potentials). SSPE (subacute sclerosing panencephalitis).Sagittal. subacute sclerosing panencephalitis (SSPE). Subarachnoid space. http://uscneurosurgery.com/glossary/terms plain english s.htm

A B C D ... Z S S S S-100 protein SAH (Subarachnoid hemorrhage) SCM (Sternocleidomastoid) muscle SDH (subdural hematoma) ... Systemic lupus erythematosus (SLE) S S Return to uscneurosurgery.com Homepage

28. Encephalitis Information - Sub-sclerosing Panencephalitis (SSPE) Subacutesclerosing panencephalitis (SSPE). subacute sclerosing panencephalitis(SSPE) is a serious viral encephalitis of children and young adults. http://www.esg.org.uk/ESG/Support/the_illness/Types of Encephalitis/SSPE.htm

Home The Illness Recovery Children ... Contact Us The Illness Types of Encephailitis Types of Encephalitis Herpes Simplex Encephalitis ADEM (Acute Disseminated Encephalomyelitis) SSPE (Sub-sclerosing Pan Encephalitis) ... The Illness Subacute-sclerosing panencephalitis (SSPE) This paper was prepared by the Encephalitis Support Group with advice from Dr R. Appleton Consultant Paediatric Neurologist Alder Hey Children’s Hospital Liverpool Subacute sclerosing panencephalitis (SSPE) is a serious viral encephalitis of children and young adults. It is a late manifestation of measles virus infection, developing usually 6 and 12 years after natural measles infection. Cases can also follow immunization with measles vaccine but at a lesser frequency than after natural measles. The annual incidence is about 1 per million. Males are more commonly affected, as are those living in rural areas. Mortality is very high. Those who survive do so with considerable intellectual and also physical impairment The precise sequence of events that results in the development of this disease in a tiny proportion of the population is not known. The great majority of children who develop SSPE are known to have had an attack of classical measles, usually many years before. Over 50% of cases have had the disease at the unusually early age of under two years.

29. Subacute Sclerosing Panencephalitis With Prominent Neuro-ophthalmological Manife 239243, 0165-8107/01/2504-239$16.00 © Swets Zeitlinger. Subacute sclerosingpanencephalitis with prominent neuro-ophthalmological manifestation at onset. http://www.szp.swets.nl/szp/journals/no254239.htm

Neuro-Ophthalmology 2001, Vol.25, No.4, pp. 239-243 Subacute sclerosing panencephalitis with prominent neuro-ophthalmological manifestation at onset Christophe Valmaggia , Andreas Sommacal , Christian Fretz and Irene Gottlob Kantonsspital St. Gallen, Department of Ophthalmology, Switzerland Kantonsspital St. Gallen, Department of Pathology, Switzerland Kantonsspital St. Gallen, Department of Radiology, Switzerland University of Leicester, Department of Ophthalmology, England Subacute sclerosing panencephalitis (SSPE) is a rare disease caused by the measles virus, which gives rise to clinical symptoms between two and 20 years after the primary infection. The course of SSPE is generally fatal and includes progressive intellectual and behavioral decline followed by relentless neurological deterioration. No treatment is currently available. We report the case of a seven-year-old boy presenting with nausea and decreased visual acuity, showing a clinical evolution consistent with SSPE. The interval between the first symptoms and death was less than one year. At autopsy, findings consistent with viral encephalitis and the presence of intranuclear inclusion bodies in the brainstem ganglions supported the diagnosis of SSPE. Keywords: Measles , subacute sclerosing panencephalitis , visual disturbance .

30. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Definition SSPE is a progressive,debilitating, and fatal brain disorder caused by infection http://www.pennhealth.com/ency/article/001419.htm

Disease Injury Nutrition Poison ... Prevention Subacute sclerosing panencephalitis Definition: SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Alternative Names: SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Causes, incidence, and risk factors: Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported. SSPE tends to occur several years after having measles ( rubeola ), even though recovery from the illness appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents. Affected individuals frequently die one to two years after being diagnosed with this condition, but some may survive for longer periods.

31. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Alternative Names SSPE; Subacutesclerosing leukoencephalitis; Dawson´s encephalitis. Symptoms http://www.pennhealth.com/ency/article/001419sym.htm

Disease Injury Nutrition Poison ... Prevention Subacute sclerosing panencephalitis Alternative Names: SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Symptoms: Gradual onset of behavioral changes School problems Bizarre behavior Myoclonic jerking (quick muscle jerking or spasms Seizures Dementia (loss of cognitive, emotional, and social abilities) Unsteady gait Coma Patients may be rigid or flaccid, with weakness on both legs Signs and tests: There may be a history of measles in an unvaccinated child. Physical examination may show signs of optic nerve damage, damage to the retina (the part of the eye that perceives light and looks red when a photograph is taken with flash), poor motor cordination tests, and muscle twitching. Tests: Electro-encephalogram (EEG) : is a test of the electrical activity of the brain, which may show a wave pattern which is typical of SSPE Brain MRI , which provides high-quality pictures of the brain Serum antibody titer (concentration of the antibody) , measles ( rubeola ) shows elevated titer to measles virus Spinal tap for analysis of the protein (immunoelectrophoresis) in the collected fluid Anti-measles virus antibodies Review Date: 8/3/2002 Reviewed By: Lucas Restrepo, M.D., Department of Neurology, Johns Hopkins Hospital, Baltimore, MD. Review provided by VeriMed Healthcare Network.

32. Subacute Sclerosing Panencephalitis And Acquired Immunodeficiency subacute sclerosing panencephalitis (SSPE) had largely disappeared from the UnitedStates because of nearly universal measles vaccination, but it has reemerged http://www.aegis.com/pubs/aidsline/1996/sep/M9690835.html

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date. Subacute sclerosing panencephalitis and acquired immunodeficiency syndrome: role of electroencephalography and magnetic resonance imaging. J Neuroimaging. 1996 Apr;6(2):122-5. Unique Identifier : AIDSLINE MED/96205227 Koppel BS; Poon TP; Khandji A; Pavlakis SG; Pedley TA; Department of Neurology, New York Medical College, New York, USA. Abstract: Subacute sclerosing panencephalitis (SSPE) had largely disappeared from the United States because of nearly universal measles vaccination, but it has reemerged in children infected with human immunodeficiency virus (HIV). Two children with SSPE are described. The first was HIV positive and presented with seizures and encephalopathy at the age of 21 months. The second developed myoclonus and dementia at age 4 years; she was not infected with HIV, but her mother had acquired immunodeficiency syndrome. Magnetic resonance imaging findings were nonspecific and could have been compatible with HIV encephalopathy. Electroencephalography was characteristic of SSPE, showing high-voltage, periodic slow-wave complexes and background slowing. The diagnosis of SSPE was confirmed by brain biopsy or high measles antibody titers in the cerebrospinal fluid. Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS AIDS Dementia Complex/DIAGNOSIS Case Report Child, Preschool Diagnosis, Differential *Electroencephalography Female Human HIV Seropositivity Infant *Magnetic Resonance Imaging Male Subacute Sclerosing Panencephalitis/*DIAGNOSIS JOURNAL ARTICLE

33. Measles Virus-specific T Helper 1/T Helper 2-cytokine Production blood mononuclear cells in response to live measles, mumps or varicella virus weremeasured in 15 patients with subacute sclerosing panencephalitis and 15 http://www.aegis.com/pubs/aidsline/2000/oct/A00A1094.html

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date. Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis. J Neurovirol. 2000 Apr;6(2):121-6. Unique Identifier : AIDSLINE MED/20284033 Hara T; Yamashita S; Aiba H; Nihei K; Koide N; Good RA; Takeshita K; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University, Fukyoka, Fukuoka, Japan. Abstract: Keywords: JOURNAL ARTICLE Adolescence Adult Chickenpox Vaccine/IMMUNOLOGY Child Child, Preschool Comparative Study Disease Progression Enzyme-Linked Immunosorbent Assay Female Human Immunity, Cellular Interferon Type II/BIOSYNTHESIS/DEFICIENCY/*PHYSIOLOGY/SECRETION Interleukins/BIOSYNTHESIS/SECRETION Lymphokines/*BIOSYNTHESIS/SECRETION Male Measles Vaccine/*IMMUNOLOGY Measles Virus/*IMMUNOLOGY/PATHOGENICITY Mumps Vaccine/IMMUNOLOGY Subacute Sclerosing Panencephalitis/*IMMUNOLOGY/VIROLOGY Support, Non-U.S. Gov't Th1 Cells/*SECRETION Th2 Cells/*SECRETION Vaccines, Attenuated/IMMUNOLOGY National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD.

34. Health Library - Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Synonyms Disorder Subdivisions GeneralDiscussion Resources Synonyms. Panencephalitis, Subacute Sclerosing; SSPE. http://www.laurushealth.com/library/healthguide/illnessconditions/topic.asp?hwid

35. Subacute Sclerosing Panencephalitis - General Practice Notebook Notebook. subacute sclerosing panencephalitis. SSPE is believed tobe the result of persistence of the measles antigen in the CNS. http://www.gpnotebook.co.uk/cache/1033502731.htm

subacute sclerosing panencephalitis SSPE is believed to be the result of persistence of the measles antigen in the CNS. About half of cases have had a natural measles infection in their first two years of life. High titres of measles antibody are usually present in the blood and CSF. Death is inevitable but long periods of survival have been reported. Click here for more information...

36. 1Up Health > Subacute Sclerosing Panencephalitis > Causes, Incidence, And Risk F Comprehesive information on subacute sclerosing panencephalitis (Dawsonsencephalitis , SSPE, Subacute sclerosing leukoencephalitis). http://www.1uphealth.com/health/subacute_sclerosing_panencephalitis_info.html

1Up Health Subacute sclerosing panencephalitis Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Subacute sclerosing panencephalitis Information Subacute sclerosing panencephalitis Causes, Incidence, and Risk Factors Alternative names : Dawsons encephalitis , SSPE, Subacute sclerosing leukoencephalitis Definition : SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Causes, Incidence, and Risk Factors Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported. SSPE tends to occur several years after having measles ( rubeola ), even though recovery from the illness appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents.

37. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso Sites. Adam An Overview subacute sclerosing panencephalitis, a definitionand a look at the causes, incidence and risk factors. http://www.1uphealth.com/links/infections-subacute-sclerosing-panencephalitis.ht

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Infections : Subacute Sclerosing Panencephalitis Description See Related Categories Health: Conditions and Diseases: Rare Disorders Sites Adam - An Overview Subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. Mylifepath Offers a description of subacute sclerosing panencephalitis, including the symptoms, causes, diagnosis, treatment, prognosis and further reading. NORD - Subacute Sclerosing Panencephalitis Offers the synonyms, a general discussion and further resources. Virtual Hospital An article about subacute sclerosing panencephalitis written by Gary Baumbach, M.D. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.

38. Subacute Sclerosing Panencephalitis | Principal Health News You are here Home Health A to Z subacute sclerosing panencephalitis.subacute sclerosing panencephalitis. Turkington, Carol A. http://www.principalhealthnews.com/topic/topic100587517

About This Site Registration FAQ Contact Us ... Site Awards You are here: Home Health A to Z Subacute Sclerosing Panencephalitis Subacute Sclerosing Panencephalitis Turkington, Carol A. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia. The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

39. Subacute Sclerosing Panencephalitis : Meddie Health Search ITEMS LINKS Adam An Overview subacute sclerosing panencephalitis,a definition and a look at the causes, incidence and risk factors. http://www.meddie.com/search/Health/Conditions_and_Diseases/Neurological_Disorde

HOME ADD A LINK MODIFY A LINK NEW LINKS ... TOP RATED Search Meddie: the entire directory only this category More search options Home Health Conditions and Diseases ... Infections : Subacute Sclerosing Panencephalitis ITEMS: LINKS: Adam - An Overview Subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. (Rating: 0.00 Votes: 0) Rate It Mylifepath Offers a description of Subacute sclerosing panencephalitis, including the symptoms, causes, diagnosis, treatment, prognosis and further reading. (Rating: 0.00 Votes: 0) Rate It Virtual Hospital An article about subacute sclerosing panencephalitis written by Gary Baumbach, M.D. (Rating: 0.00 Votes: 0) Rate It HOME ADD A LINK MODIFY A LINK ... Design © ISC Enterprises Inc.

40. ýPublications (post-1985) ý Norrby, F., and Rozenblatt, S. (1985) The natural history of restricted synthesisand expression of measles virus genes in subacute sclerosing panencephalitis. http://www.tau.ac.il/lifesci/biotechnology/rozenblatt/publications/publications.

Shmuel Rozenblatt Publications (post 1985) Publications in refereed journals Rozenblatt, S., Eizenberg, O., Ben-Levy, R., Lavie, V. and Bellini, W.J. (1985) Sequence homology within the morbilliviruses. J Virol, medline Rozenblatt, S., Eizenberg, O., Englund, G. and Bellini, W.J. (1985) Cloning and characterization of DNA complementary to the canine distemper virus mRNA encoding matrix, phosphoprotein, and nucleocapsid protein. J Virol, medline Richardson, C.D., Berkovich, A., Rozenblatt, S. and Bellini, W.J. (1985) Use of antibodies directed against synthetic peptides for identifying cDNA clones, establishing reading frames, and deducing the gene order of measles virus. J Virol, medline Bellini, W.J., Englund, G., Rozenblatt, S., Arnheiter, H. and Richardson, C.D. (1985) Measles virus P gene codes for two proteins. J Virol, medline Haase, A.T., Gantz, D., Eble, B., Walker, D., Stowring, L., Ventura, P., Blum, H., Wietgrefe, S., Zupanic, M., Tourellotte, W., Gibbs, C.J. Jr., Norrby, F., and Rozenblatt, S. (1985) The natural history of restricted synthesis and expression of measles virus genes in subacute sclerosing panencephalitis. Proc. Natl. Acad. Sci. USA

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